-
1
-
-
58149269468
-
Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States
-
Qato DM, Alexander GC, Conti RM, Johnson M, Schumm P, et al. (2008) Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States. JAMA 300: 2867-2878.
-
(2008)
JAMA
, vol.300
, pp. 2867-2878
-
-
Qato, D.M.1
Alexander, G.C.2
Conti, R.M.3
Johnson, M.4
Schumm, P.5
-
2
-
-
68249162213
-
Predicting drug-drug interactions: an FDA perspective
-
Zhang L, Zhang YD, Zhao P, Huang SM, (2009) Predicting drug-drug interactions: an FDA perspective. AAPS J 11: 300-306.
-
(2009)
AAPS J
, vol.11
, pp. 300-306
-
-
Zhang, L.1
Zhang, Y.D.2
Zhao, P.3
Huang, S.M.4
-
3
-
-
67650488269
-
Synergistic drug combi-nations tend to improve therapeutically relevant selectivity
-
Lehár J, Krueger AS, Avery W, Heilbut AM, Johansen LM, et al. (2009) Synergistic drug combi-nations tend to improve therapeutically relevant selectivity. Nat Biotechnol 27: 659-666.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 659-666
-
-
Lehár, J.1
Krueger, A.S.2
Avery, W.3
Heilbut, A.M.4
Johansen, L.M.5
-
4
-
-
65649124513
-
Drug interactions and the evolution of antibiotic resistance
-
Yeh PJ, Hegreness MJ, Aiden AP, Kishony R, (2009) Drug interactions and the evolution of antibiotic resistance. Nat Rev Microbiol 7: 460-466.
-
(2009)
Nat Rev Microbiol
, vol.7
, pp. 460-466
-
-
Yeh, P.J.1
Hegreness, M.J.2
Aiden, A.P.3
Kishony, R.4
-
5
-
-
34247277741
-
Antibiotic interactions that select against resistance
-
Chait R, Craney A, Kishony R, (2007) Antibiotic interactions that select against resistance. Nature 446: 668-671.
-
(2007)
Nature
, vol.446
, pp. 668-671
-
-
Chait, R.1
Craney, A.2
Kishony, R.3
-
6
-
-
33747620519
-
Systems biology and combination therapy in the quest for clinical efficacy
-
Fitzgerald JB, Schoeberl B, Nielsen UB, Sorger PK, (2006) Systems biology and combination therapy in the quest for clinical efficacy. Nat Chem Biol 2: 458-466.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 458-466
-
-
Fitzgerald, J.B.1
Schoeberl, B.2
Nielsen, U.B.3
Sorger, P.K.4
-
7
-
-
54249155522
-
Network pharmacology: The next paradigm in drug discovery
-
Hopkins AL, (2008) Network pharmacology: The next paradigm in drug discovery. Nat Chem Biol 4: 682-690.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 682-690
-
-
Hopkins, A.L.1
-
8
-
-
70349847876
-
Network analyses in systems pharmacology
-
Berger S, Iyengar R, (2009) Network analyses in systems pharmacology. Bioinformatics 25: 2466-2472.
-
(2009)
Bioinformatics
, vol.25
, pp. 2466-2472
-
-
Berger, S.1
Iyengar, R.2
-
9
-
-
59349083179
-
Mechanisms of drug combinations: Interaction and network perspectives
-
Jia J, Zhu F, Ma X, Cao Z, Li Y, et al. (2009) Mechanisms of drug combinations: Interaction and network perspectives. Nat Rev Drug Discov 8: 111-128.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 111-128
-
-
Jia, J.1
Zhu, F.2
Ma, X.3
Cao, Z.4
Li, Y.5
-
10
-
-
82355160710
-
Network-based analysis and characterization of adverse drug-drug interactions
-
Takarabe M, Shigemizu D, Kotera M, Goto S, Kanehisa M, (2011) Network-based analysis and characterization of adverse drug-drug interactions. J Chem Inf Model 51: 2977-2985.
-
(2011)
J Chem Inf Model
, vol.51
, pp. 2977-2985
-
-
Takarabe, M.1
Shigemizu, D.2
Kotera, M.3
Goto, S.4
Kanehisa, M.5
-
11
-
-
78650373804
-
Network medicine: A network-based approach to human disease
-
Barabási AL, Gulbahce N, Loscalzo J, (2011) Network medicine: A network-based approach to human disease. Nat Rev Genet 12: 58-68.
-
(2011)
Nat Rev Genet
, vol.12
, pp. 58-68
-
-
Barabási, A.L.1
Gulbahce, N.2
Loscalzo, J.3
-
12
-
-
14644396645
-
Functional cartography of complex metabolic networks
-
Guimerà R, Amaral LAN, (2005) Functional cartography of complex metabolic networks. Nature 433: 895-900.
-
(2005)
Nature
, vol.433
, pp. 895-900
-
-
Guimerà, R.1
Amaral, L.A.N.2
-
13
-
-
34547830837
-
A network-based method for target selection in metabolic networks
-
Guimerà R, Sales-Pardo M, Amaral L, (2007) A network-based method for target selection in metabolic networks. Bioinformatics 23: 1616-1622.
-
(2007)
Bioinformatics
, vol.23
, pp. 1616-1622
-
-
Guimerà, R.1
Sales-Pardo, M.2
Amaral, L.3
-
14
-
-
79959621970
-
Predicting selective drug targets in cancer through metabolic networks
-
Folger O, Jerby L, Frezza C, Gottlieb E, Ruppin E, et al. (2011) Predicting selective drug targets in cancer through metabolic networks. Molecular Systems Biology 7: 501.
-
(2011)
Molecular Systems Biology
, vol.7
, pp. 501
-
-
Folger, O.1
Jerby, L.2
Frezza, C.3
Gottlieb, E.4
Ruppin, E.5
-
15
-
-
84855272311
-
Prediction of drug combinations by integrating molecular and pharmacological data
-
Zhao X, Iskar M, Zeller G, Kuhn M, van Noort V, et al. (2011) Prediction of drug combinations by integrating molecular and pharmacological data. PLoS Comput Biol 7: e1002323.
-
(2011)
PLoS Comput Biol
, vol.7
-
-
Zhao, X.1
Iskar, M.2
Zeller, G.3
Kuhn, M.4
van Noort, V.5
-
16
-
-
84864369297
-
Mechanism-independent method for predicting response to multidrug combinations in bacteria
-
Wood K, Nishida S, Sontag ED, Cluzel P, (2012) Mechanism-independent method for predicting response to multidrug combinations in bacteria. Proc Natl Acad Sci USA 109: 12254-12259.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 12254-12259
-
-
Wood, K.1
Nishida, S.2
Sontag, E.D.3
Cluzel, P.4
-
17
-
-
2942659840
-
Complex networks: Augmenting the framework for the study of complex systems
-
Amaral LAN, Ottino JM, (2004) Complex networks: Augmenting the framework for the study of complex systems. Eur Phys J B 38: 147-162.
-
(2004)
Eur Phys J B
, vol.38
, pp. 147-162
-
-
Amaral, L.A.N.1
Ottino, J.M.2
-
19
-
-
76049100050
-
Missing and spurious interactions and the reconstruction of complex networks
-
Guimerà R, Sales-Pardo M, (2009) Missing and spurious interactions and the reconstruction of complex networks. Proc Natl Acad Sci U S A 106: 22073-22078.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 22073-22078
-
-
Guimerà, R.1
Sales-Pardo, M.2
-
20
-
-
33645396484
-
Functional classification of drugs by properties of their pairwise interactions
-
Yeh P, Tschumi AI, Kishony R, (2006) Functional classification of drugs by properties of their pairwise interactions. Nat Genet 38: 489-494.
-
(2006)
Nat Genet
, vol.38
, pp. 489-494
-
-
Yeh, P.1
Tschumi, A.I.2
Kishony, R.3
-
21
-
-
33847643207
-
Chemical combination effects predict connectivity in biological systems
-
Lehár J, Zimmermann GR, Krueger AS, Molnar RA, Ledell JT, et al. (2007) Chemical combination effects predict connectivity in biological systems. Mol Syst Biol 3: 80.
-
(2007)
Mol Syst Biol
, vol.3
, pp. 80
-
-
Lehár, J.1
Zimmermann, G.R.2
Krueger, A.S.3
Molnar, R.A.4
Ledell, J.T.5
-
22
-
-
33847611532
-
Networks from drug-drug surfaces
-
Yeh P, Kishony R, (2007) Networks from drug-drug surfaces. Mol Syst Biol 3: 85.
-
(2007)
Mol Syst Biol
, vol.3
, pp. 85
-
-
Yeh, P.1
Kishony, R.2
-
23
-
-
84925899978
-
Social structure from multiple networks. i. blockmodels of roles and positions
-
White HC, Boorman SA, Breiger RL, (1976) Social structure from multiple networks. i. blockmodels of roles and positions. Am J Sociol 81: 730-780.
-
(1976)
Am J Sociol
, vol.81
, pp. 730-780
-
-
White, H.C.1
Boorman, S.A.2
Breiger, R.L.3
-
25
-
-
0442296603
-
Estimation and prediction for stochastic blockstructures
-
Nowicki K, Snijders TAB, (2001) Estimation and prediction for stochastic blockstructures. J Am Stat Assoc 96: 1077-1087.
-
(2001)
J Am Stat Assoc
, vol.96
, pp. 1077-1087
-
-
Nowicki, K.1
Snijders, T.A.B.2
-
26
-
-
84255196314
-
Communities, modules and large-scale structure in networks
-
Newman MEJ, (2011) Communities, modules and large-scale structure in networks. Nat Phys 8: 25-31.
-
(2011)
Nat Phys
, vol.8
, pp. 25-31
-
-
Newman, M.E.J.1
-
27
-
-
11244297914
-
Modular epistasis in yeast metabolism
-
Segrè D, Deluna A, Church GM, Kishony R, (2005) Modular epistasis in yeast metabolism. Nat Genet 37: 77-83.
-
(2005)
Nat Genet
, vol.37
, pp. 77-83
-
-
Segrè, D.1
Deluna, A.2
Church, G.M.3
Kishony, R.4
-
28
-
-
80855124963
-
Systematic exploration of synergistic drug pairs
-
Cokol M, Chua HN, Tasan M, Mutlu B, Weinstein ZB, et al. (2011) Systematic exploration of synergistic drug pairs. Mol Syst Biol 7: 544.
-
(2011)
Mol Syst Biol
, vol.7
, pp. 544
-
-
Cokol, M.1
Chua, H.N.2
Tasan, M.3
Mutlu, B.4
Weinstein, Z.B.5
-
29
-
-
38549151817
-
Drugbank: A knowledgebase for drugs, drug actions and drug targets
-
Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, et al. (2008) Drugbank: A knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res 36: D901-D906.
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Wishart, D.S.1
Knox, C.2
Guo, A.C.3
Cheng, D.4
Shrivastava, S.5
-
30
-
-
78651287426
-
Drugbank 3.0: A comprehensive resource for 'omics' research on drugs
-
Knox C, Law V, Jewison T, Liu P, Ly S, et al. (2011) Drugbank 3.0: A comprehensive resource for 'omics' research on drugs. Nucleic Acids Res 39: D1035-D1041.
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Knox, C.1
Law, V.2
Jewison, T.3
Liu, P.4
Ly, S.5
-
31
-
-
0020083498
-
The meaning and use of the area under a receiver operating characteristic (ROC) curve
-
Hanley J, McNeil B, (1982) The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 143: 29-36.
-
(1982)
Radiology
, vol.143
, pp. 29-36
-
-
Hanley, J.1
McNeil, B.2
-
33
-
-
84255172340
-
Predicting adverse drug events using pharmacological network models
-
Cami A, Arnold A, Manzi S, Reis B, (2011) Predicting adverse drug events using pharmacological network models. Sci Transl Med 3: 114ra127.
-
(2011)
Sci Transl Med
, vol.3
-
-
Cami, A.1
Arnold, A.2
Manzi, S.3
Reis, B.4
-
34
-
-
35148838537
-
Drug-target network
-
Yildirim M, Goh K, Cusick M, Barabási A, Vidal M, et al. (2007) Drug-target network. Nat Biotechnol 25: 1119.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 1119
-
-
Yildirim, M.1
Goh, K.2
Cusick, M.3
Barabási, A.4
Vidal, M.5
-
35
-
-
84858968611
-
Systems biology analysis of protein-drug interactions
-
Colinge J, Rix U, Bennett K, Superti-Furga G, (2011) Systems biology analysis of protein-drug interactions. Prot Clin Appl 6: 102-116.
-
(2011)
Prot Clin Appl
, vol.6
, pp. 102-116
-
-
Colinge, J.1
Rix, U.2
Bennett, K.3
Superti-Furga, G.4
-
36
-
-
84859264011
-
A co-module approach for elucidating drug-disease associations and revealing their molecular basis
-
Zhao S, Li S, (2012) A co-module approach for elucidating drug-disease associations and revealing their molecular basis. Bioinformatics 28: 955-961.
-
(2012)
Bioinformatics
, vol.28
, pp. 955-961
-
-
Zhao, S.1
Li, S.2
-
37
-
-
34547140875
-
The human disease network
-
Goh KI, Cusick ME, Valle D, Childs B, Vidal M, et al. (2007) The human disease network. Proc Natl Acad Sci U S A 104: 8685-8690.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 8685-8690
-
-
Goh, K.I.1
Cusick, M.E.2
Valle, D.3
Childs, B.4
Vidal, M.5
-
38
-
-
84866276354
-
Predicting human preferences using the block structure of complex social networks
-
Guimerà R, Sales-Pardo M, (2012) Predicting human preferences using the block structure of complex social networks. PLoS One 7: e44620.
-
(2012)
PLoS One
, vol.7
-
-
Guimerà, R.1
Sales-Pardo, M.2
-
39
-
-
5744249209
-
Equation of state calculations by fast computing machines
-
Metropolis N, Rosenbluth AW, Rosenbluth MN, Teller AH, Teller E, (1953) Equation of state calculations by fast computing machines. J Chem Phys 21: 1087-1092.
-
(1953)
J Chem Phys
, vol.21
, pp. 1087-1092
-
-
Metropolis, N.1
Rosenbluth, A.W.2
Rosenbluth, M.N.3
Teller, A.H.4
Teller, E.5
-
40
-
-
34848890341
-
Extracting the hierarchical organization of complex systems
-
Sales-Pardo M, Guimerà R, Moreira AA, Amaral LAN, (2007) Extracting the hierarchical organization of complex systems. Proc Natl Acad Sci U S A 104: 15224-15229.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 15224-15229
-
-
Sales-Pardo, M.1
Guimerà, R.2
Moreira, A.A.3
Amaral, L.A.N.4
|