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Volumn 14, Issue 12, 2015, Pages 1131-1141

IL-27-induced modulation of autoimmunity and its therapeutic potential

Author keywords

Arthritis; Autoimmunity; CD4+ T cell differentiation; Colitis; Diabetes; Interleukin 27; Lupus; Multiple sclerosis; Psoriasis; Uveitis

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 27; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STAT PROTEIN;

EID: 84945444431     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2015.08.001     Document Type: Review
Times cited : (150)

References (132)
  • 1
    • 18444385868 scopus 로고    scopus 로고
    • IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells
    • Pflanz S., Timans J.C., Cheung J., Rosales R., Kanzler H., Gilbert J., et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity 2002, 16:779-790.
    • (2002) Immunity , vol.16 , pp. 779-790
    • Pflanz, S.1    Timans, J.C.2    Cheung, J.3    Rosales, R.4    Kanzler, H.5    Gilbert, J.6
  • 2
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas A.K., Murphy K.M., Sher A. Functional diversity of helper T lymphocytes. Nature 1996, 383:787-793.
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 3
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441:235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6
  • 4
    • 34247555353 scopus 로고    scopus 로고
    • Differentiation and function of Th17 T cells
    • Stockinger B., Veldhoen M. Differentiation and function of Th17 T cells. Curr Opin Immunol 2007, 19:281-286.
    • (2007) Curr Opin Immunol , vol.19 , pp. 281-286
    • Stockinger, B.1    Veldhoen, M.2
  • 6
    • 9644279571 scopus 로고    scopus 로고
    • The role of IL-27 in the development of T-cell responses during parasitic infections
    • Hunter C.A., Villarino A., Artis D., Scott P. The role of IL-27 in the development of T-cell responses during parasitic infections. Immunol Rev 2004, 202:106-114.
    • (2004) Immunol Rev , vol.202 , pp. 106-114
    • Hunter, C.A.1    Villarino, A.2    Artis, D.3    Scott, P.4
  • 7
    • 85017949435 scopus 로고    scopus 로고
    • WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection
    • Hiroki Yoshida S.H., Senaldi Giorgio, Covey Todd, Faggioni Raffaella, Mu Sharon, Xia Min, et al. WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity 2001, 15:9.
    • (2001) Immunity , vol.15 , pp. 9
    • Hiroki Yoshida, S.H.1    Senaldi, G.2    Covey, T.3    Faggioni, R.4    Mu, S.5    Xia, M.6
  • 9
    • 30344488706 scopus 로고    scopus 로고
    • Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology
    • Rosas LE S.A., Roth K.M., Keiser T.L., Barbi J., Hunter C., de Sauvage F.J., et al. Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology. Am J Pathol 2006, 168:11.
    • (2006) Am J Pathol , vol.168 , pp. 11
    • Rosas Le, S.A.1    Roth, K.M.2    Keiser, T.L.3    Barbi, J.4    Hunter, C.5    de Sauvage, F.J.6
  • 10
    • 14844355133 scopus 로고    scopus 로고
    • The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis
    • Hölscher C H.A., Rückerl D., Yoshimoto T., Yoshida H., Mak T., Saris C., et al. The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. J Immunol 2005, 174:10.
    • (2005) J Immunol , vol.174 , pp. 10
    • Hölscher, C.H.A.1    Rückerl, D.2    Yoshimoto, T.3    Yoshida, H.4    Mak, T.5    Saris, C.6
  • 11
    • 48749121088 scopus 로고    scopus 로고
    • Interleukin-12 and interleukin-27 regulate macrophage control of Mycobacterium tuberculosis
    • Robinson CM N.G. Interleukin-12 and interleukin-27 regulate macrophage control of Mycobacterium tuberculosis. J Infect Dis 2008, 198:7.
    • (2008) J Infect Dis , vol.198 , pp. 7
    • Robinson, C.M.N.G.1
  • 12
    • 44849096815 scopus 로고    scopus 로고
    • IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD
    • Villarino A.V., Artis D., Bezbradica J.S., Miller O., Saris C.J., Joyce S., et al. IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD. Int Immunol 2008, 20:739-752.
    • (2008) Int Immunol , vol.20 , pp. 739-752
    • Villarino, A.V.1    Artis, D.2    Bezbradica, J.S.3    Miller, O.4    Saris, C.J.5    Joyce, S.6
  • 13
    • 84927662065 scopus 로고    scopus 로고
    • The immunobiology of interleukin-27
    • Yoshida H., Hunter C.A. The immunobiology of interleukin-27. Annu Rev Immunol 2015, 33:417-443.
    • (2015) Annu Rev Immunol , vol.33 , pp. 417-443
    • Yoshida, H.1    Hunter, C.A.2
  • 14
    • 0030067819 scopus 로고    scopus 로고
    • A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
    • Devergne O., Hummel M., Koeppen H., Le Beau M.M., Nathanson E.C., Kieff E., et al. A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. J Virol 1996, 70:1143-1153.
    • (1996) J Virol , vol.70 , pp. 1143-1153
    • Devergne, O.1    Hummel, M.2    Koeppen, H.3    Le Beau, M.M.4    Nathanson, E.C.5    Kieff, E.6
  • 15
    • 10744222574 scopus 로고    scopus 로고
    • WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27
    • Pflanz S., Hibbert L., Mattson J., Rosales R., Vaisberg E., Bazan J.F., et al. WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol 2004, 172:2225-2231.
    • (2004) J Immunol , vol.172 , pp. 2225-2231
    • Pflanz, S.1    Hibbert, L.2    Mattson, J.3    Rosales, R.4    Vaisberg, E.5    Bazan, J.F.6
  • 16
    • 79952317431 scopus 로고    scopus 로고
    • IL-27 induces the differentiation of Tr1-like cells from human naive CD4+ T cells via the phosphorylation of STAT1 and STAT3
    • Wang H., Meng R., Li Z., Yang B., Liu Y., Huang F., et al. IL-27 induces the differentiation of Tr1-like cells from human naive CD4+ T cells via the phosphorylation of STAT1 and STAT3. Immunol Lett 2011, 136:21-28.
    • (2011) Immunol Lett , vol.136 , pp. 21-28
    • Wang, H.1    Meng, R.2    Li, Z.3    Yang, B.4    Liu, Y.5    Huang, F.6
  • 17
    • 82755160805 scopus 로고    scopus 로고
    • Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27
    • Pot C., Apetoh L., Awasthi A., Kuchroo V.K. Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27. Semin Immunol 2011, 23:438-445.
    • (2011) Semin Immunol , vol.23 , pp. 438-445
    • Pot, C.1    Apetoh, L.2    Awasthi, A.3    Kuchroo, V.K.4
  • 18
    • 84876436991 scopus 로고    scopus 로고
    • Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4+ T cells
    • Iwasaki Y., Fujio K., Okamura T., Yanai A., Sumitomo S., Shoda H., et al. Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4+ T cells. Eur J Immunol 2013, 43:1063-1073.
    • (2013) Eur J Immunol , vol.43 , pp. 1063-1073
    • Iwasaki, Y.1    Fujio, K.2    Okamura, T.3    Yanai, A.4    Sumitomo, S.5    Shoda, H.6
  • 19
    • 84929665405 scopus 로고    scopus 로고
    • Asymmetric action of STAT transcription factors drives transcriptional outputs and cytokine specificity
    • Hirahara K., Onodera A., Villarino A.V., Bonelli M., Sciume G., Laurence A., et al. Asymmetric action of STAT transcription factors drives transcriptional outputs and cytokine specificity. Immunity 2015, 42:877-889.
    • (2015) Immunity , vol.42 , pp. 877-889
    • Hirahara, K.1    Onodera, A.2    Villarino, A.V.3    Bonelli, M.4    Sciume, G.5    Laurence, A.6
  • 20
    • 33751568890 scopus 로고    scopus 로고
    • IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways
    • Owaki T., Asakawa M., Fukai F., Mizuguchi J., Yoshimoto T. IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways. J Immunol 2006, 177:7579-7587.
    • (2006) J Immunol , vol.177 , pp. 7579-7587
    • Owaki, T.1    Asakawa, M.2    Fukai, F.3    Mizuguchi, J.4    Yoshimoto, T.5
  • 21
    • 84876437530 scopus 로고    scopus 로고
    • IL-27 paves different roads to Tr1
    • Vasanthakumar A., Kallies A. IL-27 paves different roads to Tr1. Eur J Immunol 2013, 43:882-885.
    • (2013) Eur J Immunol , vol.43 , pp. 882-885
    • Vasanthakumar, A.1    Kallies, A.2
  • 24
    • 84862981070 scopus 로고    scopus 로고
    • Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1
    • Hirahara K., Ghoreschi K., Yang X.P., Takahashi H., Laurence A., Vahedi G., et al. Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1. Immunity 2012, 36:1017-1030.
    • (2012) Immunity , vol.36 , pp. 1017-1030
    • Hirahara, K.1    Ghoreschi, K.2    Yang, X.P.3    Takahashi, H.4    Laurence, A.5    Vahedi, G.6
  • 26
    • 70149083341 scopus 로고    scopus 로고
    • IL-27 abrogates receptor activator of NF-kappa B ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos
    • Furukawa M., Takaishi H., Takito J., Yoda M., Sakai S., Hikata T., et al. IL-27 abrogates receptor activator of NF-kappa B ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos. J Immunol 2009, 183:2397-2406.
    • (2009) J Immunol , vol.183 , pp. 2397-2406
    • Furukawa, M.1    Takaishi, H.2    Takito, J.3    Yoda, M.4    Sakai, S.5    Hikata, T.6
  • 27
    • 0027491655 scopus 로고
    • Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming
    • Seder R.A., Gazzinelli R., Sher A., Paul W.E. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc Natl Acad Sci U S A 1993, 90:10188-10192.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 10188-10192
    • Seder, R.A.1    Gazzinelli, R.2    Sher, A.3    Paul, W.E.4
  • 28
    • 0038326688 scopus 로고    scopus 로고
    • Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment
    • Takeda A., Hamano S., Yamanaka A., Hanada T., Ishibashi T., Mak T.W., et al. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J Immunol 2003, 170:4886-4890.
    • (2003) J Immunol , vol.170 , pp. 4886-4890
    • Takeda, A.1    Hamano, S.2    Yamanaka, A.3    Hanada, T.4    Ishibashi, T.5    Mak, T.W.6
  • 29
    • 0344304399 scopus 로고    scopus 로고
    • IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms
    • Lucas S., Ghilardi N., Li J., de Sauvage F.J. IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms. Proc Natl Acad Sci U S A 2003, 100:15047-15052.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15047-15052
    • Lucas, S.1    Ghilardi, N.2    Li, J.3    de Sauvage, F.J.4
  • 30
    • 49149119535 scopus 로고    scopus 로고
    • Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells
    • Batten M., Kljavin N.M., Li J., Walter M.J., de Sauvage F.J., Ghilardi N. Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells. J Immunol 2008, 180:2752-2756.
    • (2008) J Immunol , vol.180 , pp. 2752-2756
    • Batten, M.1    Kljavin, N.M.2    Li, J.3    Walter, M.J.4    de Sauvage, F.J.5    Ghilardi, N.6
  • 31
    • 33644536099 scopus 로고    scopus 로고
    • IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3
    • Owaki T., Asakawa M., Kamiya S., Takeda K., Fukai F., Mizuguchi J., et al. IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3. J Immunol 2006, 176:2773-2780.
    • (2006) J Immunol , vol.176 , pp. 2773-2780
    • Owaki, T.1    Asakawa, M.2    Kamiya, S.3    Takeda, K.4    Fukai, F.5    Mizuguchi, J.6
  • 32
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng W., Flavell R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997, 89:587-596.
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.1    Flavell, R.A.2
  • 33
    • 0032212793 scopus 로고    scopus 로고
    • Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism
    • Ouyang W., Ranganath S.H., Weindel K., Bhattacharya D., Murphy T.L., Sha W.C., et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 1998, 9:745-755.
    • (1998) Immunity , vol.9 , pp. 745-755
    • Ouyang, W.1    Ranganath, S.H.2    Weindel, K.3    Bhattacharya, D.4    Murphy, T.L.5    Sha, W.C.6
  • 34
    • 6344274850 scopus 로고    scopus 로고
    • The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity
    • Artis D., Villarino A., Silverman M., He W., Thornton E.M., Mu S., et al. The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J Immunol 2004, 173:5626-5634.
    • (2004) J Immunol , vol.173 , pp. 5626-5634
    • Artis, D.1    Villarino, A.2    Silverman, M.3    He, W.4    Thornton, E.M.5    Mu, S.6
  • 35
    • 84906535154 scopus 로고    scopus 로고
    • The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing
    • Gaffen S.L., Jain R., Garg A.V., Cua D.J. The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol 2014, 14:585-600.
    • (2014) Nat Rev Immunol , vol.14 , pp. 585-600
    • Gaffen, S.L.1    Jain, R.2    Garg, A.V.3    Cua, D.J.4
  • 36
    • 84933672236 scopus 로고    scopus 로고
    • The IL-23-IL-17 axis in inflammatory arthritis
    • Lubberts E. The IL-23-IL-17 axis in inflammatory arthritis. Nat Rev Rheumatol 2015, 11:415-429.
    • (2015) Nat Rev Rheumatol , vol.11 , pp. 415-429
    • Lubberts, E.1
  • 38
    • 77953023296 scopus 로고    scopus 로고
    • Differential effect of IL-27 on developing versus committed Th17 cells
    • El-behi M., Ciric B., Yu S., Zhang G.X., Fitzgerald D.C., Rostami A. Differential effect of IL-27 on developing versus committed Th17 cells. J Immunol 2009, 183:4957-4967.
    • (2009) J Immunol , vol.183 , pp. 4957-4967
    • El-behi, M.1    Ciric, B.2    Yu, S.3    Zhang, G.X.4    Fitzgerald, D.C.5    Rostami, A.6
  • 39
    • 78951491805 scopus 로고    scopus 로고
    • Interleukin-27 and interferon-gamma are involved in regulation of autoimmune arthritis
    • Rajaiah R., Puttabyatappa M., Polumuri S.K., Moudgil K.D. Interleukin-27 and interferon-gamma are involved in regulation of autoimmune arthritis. J Biol Chem 2011, 286:2817-2825.
    • (2011) J Biol Chem , vol.286 , pp. 2817-2825
    • Rajaiah, R.1    Puttabyatappa, M.2    Polumuri, S.K.3    Moudgil, K.D.4
  • 40
    • 47049114262 scopus 로고    scopus 로고
    • Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t
    • Yang J., Yang M., Htut T.M., Ouyang X., Hanidu A., Li X., et al. Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t. Eur J Immunol 2008, 38:1204-1214.
    • (2008) Eur J Immunol , vol.38 , pp. 1204-1214
    • Yang, J.1    Yang, M.2    Htut, T.M.3    Ouyang, X.4    Hanidu, A.5    Li, X.6
  • 41
    • 33747593830 scopus 로고    scopus 로고
    • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    • Stumhofer J.S., Laurence A., Wilson E.H., Huang E., Tato C.M., Johnson L.M., et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol 2006, 7:937-945.
    • (2006) Nat Immunol , vol.7 , pp. 937-945
    • Stumhofer, J.S.1    Laurence, A.2    Wilson, E.H.3    Huang, E.4    Tato, C.M.5    Johnson, L.M.6
  • 42
    • 33747588291 scopus 로고    scopus 로고
    • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    • Batten M., Li J., Yi S., Kljavin N.M., Danilenko D.M., Lucas S., et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 2006, 7:929-936.
    • (2006) Nat Immunol , vol.7 , pp. 929-936
    • Batten, M.1    Li, J.2    Yi, S.3    Kljavin, N.M.4    Danilenko, D.M.5    Lucas, S.6
  • 43
    • 84865412454 scopus 로고    scopus 로고
    • Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27
    • Young A., Linehan E., Hams E., O'Hara Hall A.C., McClurg A., Johnston J.A., et al. Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27. J Immunol 2012, 189:2079-2083.
    • (2012) J Immunol , vol.189 , pp. 2079-2083
    • Young, A.1    Linehan, E.2    Hams, E.3    O'Hara Hall, A.C.4    McClurg, A.5    Johnston, J.A.6
  • 44
    • 84937635672 scopus 로고    scopus 로고
    • T follicular regulatory cells in the regulation of B cell responses
    • Sage P.T., Sharpe A.H. T follicular regulatory cells in the regulation of B cell responses. Trends Immunol 2015, 36:410-418.
    • (2015) Trends Immunol , vol.36 , pp. 410-418
    • Sage, P.T.1    Sharpe, A.H.2
  • 46
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet A.T., Jin H., Paterson A.M., Mitsdoerffer M., Ho I.C., Sharpe A.H., et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol 2009, 10:167-175.
    • (2009) Nat Immunol , vol.10 , pp. 167-175
    • Bauquet, A.T.1    Jin, H.2    Paterson, A.M.3    Mitsdoerffer, M.4    Ho, I.C.5    Sharpe, A.H.6
  • 47
    • 78650357814 scopus 로고    scopus 로고
    • IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
    • Batten M., Ramamoorthi N., Kljavin N.M., Ma C.S., Cox J.H., Dengler H.S., et al. IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. J Exp Med 2010, 207:2895-2906.
    • (2010) J Exp Med , vol.207 , pp. 2895-2906
    • Batten, M.1    Ramamoorthi, N.2    Kljavin, N.M.3    Ma, C.S.4    Cox, J.H.5    Dengler, H.S.6
  • 48
    • 84921900452 scopus 로고    scopus 로고
    • Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production
    • Gringhuis S.I., Kaptein T.M., Wevers B.A., van der Vlist M., Klaver E.J., van Die I., et al. Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production. Nat Commun 2014, 5:5074.
    • (2014) Nat Commun , vol.5 , pp. 5074
    • Gringhuis, S.I.1    Kaptein, T.M.2    Wevers, B.A.3    van der Vlist, M.4    Klaver, E.J.5    van Die, I.6
  • 49
    • 81155160952 scopus 로고    scopus 로고
    • Type 1 regulatory T cells (Tr1) in autoimmunity
    • Pot C., Apetoh L., Kuchroo V.K. Type 1 regulatory T cells (Tr1) in autoimmunity. Semin Immunol 2011, 23:202-208.
    • (2011) Semin Immunol , vol.23 , pp. 202-208
    • Pot, C.1    Apetoh, L.2    Kuchroo, V.K.3
  • 50
    • 36248970701 scopus 로고    scopus 로고
    • A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
    • Awasthi A., Carrier Y., Peron J.P., Bettelli E., Kamanaka M., Flavell R.A., et al. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol 2007, 8:1380-1389.
    • (2007) Nat Immunol , vol.8 , pp. 1380-1389
    • Awasthi, A.1    Carrier, Y.2    Peron, J.P.3    Bettelli, E.4    Kamanaka, M.5    Flavell, R.A.6
  • 51
    • 84880275285 scopus 로고    scopus 로고
    • Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
    • Gagliani N., Magnani C.F., Huber S., Gianolini M.E., Pala M., Licona-Limon P., et al. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat Med 2013, 19:739-746.
    • (2013) Nat Med , vol.19 , pp. 739-746
    • Gagliani, N.1    Magnani, C.F.2    Huber, S.3    Gianolini, M.E.4    Pala, M.5    Licona-Limon, P.6
  • 52
    • 77955903212 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    • Apetoh L., Quintana F.J., Pot C., Joller N., Xiao S., Kumar D., et al. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol 2010, 11:854-861.
    • (2010) Nat Immunol , vol.11 , pp. 854-861
    • Apetoh, L.1    Quintana, F.J.2    Pot, C.3    Joller, N.4    Xiao, S.5    Kumar, D.6
  • 53
    • 84877321163 scopus 로고    scopus 로고
    • Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation
    • Wu C., Pot C., Apetoh L., Thalhamer T., Zhu B., Murugaiyan G., et al. Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation. Proc Natl Acad Sci U S A 2013, 110:7802-7807.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 7802-7807
    • Wu, C.1    Pot, C.2    Apetoh, L.3    Thalhamer, T.4    Zhu, B.5    Murugaiyan, G.6
  • 55
    • 84897941063 scopus 로고    scopus 로고
    • TTregs, pTregs, and iTregs: similarities and differences
    • Shevach E.M., Thornton A.M. tTregs, pTregs, and iTregs: similarities and differences. Immunol Rev 2014, 259:88-102.
    • (2014) Immunol Rev , vol.259 , pp. 88-102
    • Shevach, E.M.1    Thornton, A.M.2
  • 56
    • 34447567140 scopus 로고    scopus 로고
    • IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1
    • Neufert C., Becker C., Wirtz S., Fantini M.C., Weigmann B., Galle P.R., et al. IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1. Eur J Immunol 2007, 37:1809-1816.
    • (2007) Eur J Immunol , vol.37 , pp. 1809-1816
    • Neufert, C.1    Becker, C.2    Wirtz, S.3    Fantini, M.C.4    Weigmann, B.5    Galle, P.R.6
  • 58
    • 84866483591 scopus 로고    scopus 로고
    • The cytokines interleukin 27 and interferon-gamma promote distinct Treg cell populations required to limit infection-induced pathology
    • Hall A.O., Beiting D.P., Tato C., John B., Oldenhove G., Lombana C.G., et al. The cytokines interleukin 27 and interferon-gamma promote distinct Treg cell populations required to limit infection-induced pathology. Immunity 2012, 37:511-523.
    • (2012) Immunity , vol.37 , pp. 511-523
    • Hall, A.O.1    Beiting, D.P.2    Tato, C.3    John, B.4    Oldenhove, G.5    Lombana, C.G.6
  • 59
    • 84873543730 scopus 로고    scopus 로고
    • A novel role for IL-27 in mediating the survival of activated mouse CD4 T lymphocytes
    • Kim G., Shinnakasu R., Saris C.J., Cheroutre H., Kronenberg M. A novel role for IL-27 in mediating the survival of activated mouse CD4 T lymphocytes. J Immunol 2013, 190:1510-1518.
    • (2013) J Immunol , vol.190 , pp. 1510-1518
    • Kim, G.1    Shinnakasu, R.2    Saris, C.J.3    Cheroutre, H.4    Kronenberg, M.5
  • 60
    • 84892421982 scopus 로고    scopus 로고
    • In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis
    • Moon S.J., Park J.S., Heo Y.J., Kang C.M., Kim E.K., Lim M.A., et al. In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis. Exp Mol Med 2013, 45:e46.
    • (2013) Exp Mol Med , vol.45 , pp. e46
    • Moon, S.J.1    Park, J.S.2    Heo, Y.J.3    Kang, C.M.4    Kim, E.K.5    Lim, M.A.6
  • 61
    • 84945491341 scopus 로고    scopus 로고
    • An IL-27/Lag3 axis enhances Foxp3 regulatory T cell-suppressive function and therapeutic efficacy
    • [Epub ahead of print]
    • Do J.S., Visperas A., Sanogo Y.O., Bechtel J.J., Dvorina N., Kim S., et al. An IL-27/Lag3 axis enhances Foxp3 regulatory T cell-suppressive function and therapeutic efficacy. Mucosal Immunol May 27 2015, [Epub ahead of print].
    • (2015) Mucosal Immunol
    • Do, J.S.1    Visperas, A.2    Sanogo, Y.O.3    Bechtel, J.J.4    Dvorina, N.5    Kim, S.6
  • 62
    • 78650338317 scopus 로고    scopus 로고
    • IL-27 increases the proliferation and effector functions of human naive CD8+ T lymphocytes and promotes their development into Tc1 cells
    • Schneider R., Yaneva T., Beauseigle D., El-Khoury L., Arbour N. IL-27 increases the proliferation and effector functions of human naive CD8+ T lymphocytes and promotes their development into Tc1 cells. Eur J Immunol 2011, 41:47-59.
    • (2011) Eur J Immunol , vol.41 , pp. 47-59
    • Schneider, R.1    Yaneva, T.2    Beauseigle, D.3    El-Khoury, L.4    Arbour, N.5
  • 63
    • 22544433708 scopus 로고    scopus 로고
    • Augmentation of effector CD8+ T cell generation with enhanced granzyme B expression by IL-27
    • Morishima N., Owaki T., Asakawa M., Kamiya S., Mizuguchi J., Yoshimoto T. Augmentation of effector CD8+ T cell generation with enhanced granzyme B expression by IL-27. J Immunol 2005, 175:1686-1693.
    • (2005) J Immunol , vol.175 , pp. 1686-1693
    • Morishima, N.1    Owaki, T.2    Asakawa, M.3    Kamiya, S.4    Mizuguchi, J.5    Yoshimoto, T.6
  • 66
    • 55849095891 scopus 로고    scopus 로고
    • Evidence that cytokines play a role in rheumatoid arthritis
    • Brennan F.M., McInnes I.B. Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest 2008, 118:3537-3545.
    • (2008) J Clin Invest , vol.118 , pp. 3537-3545
    • Brennan, F.M.1    McInnes, I.B.2
  • 67
    • 25444508411 scopus 로고    scopus 로고
    • Pathogenesis of rheumatoid arthritis: targeting cytokines
    • Zwerina J., Redlich K., Schett G., Smolen J.S. Pathogenesis of rheumatoid arthritis: targeting cytokines. Ann N Y Acad Sci 2005, 1051:716-729.
    • (2005) Ann N Y Acad Sci , vol.1051 , pp. 716-729
    • Zwerina, J.1    Redlich, K.2    Schett, G.3    Smolen, J.S.4
  • 69
    • 75749091859 scopus 로고    scopus 로고
    • Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling
    • Kalliolias G.D., Zhao B., Triantafyllopoulou A., Park-Min K.H., Ivashkiv L.B. Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling. Arthritis Rheum 2010, 62:402-413.
    • (2010) Arthritis Rheum , vol.62 , pp. 402-413
    • Kalliolias, G.D.1    Zhao, B.2    Triantafyllopoulou, A.3    Park-Min, K.H.4    Ivashkiv, L.B.5
  • 71
    • 79959547499 scopus 로고    scopus 로고
    • IL-27-producing CD14(+) cells infiltrate inflamed joints of rheumatoid arthritis and regulate inflammation and chemotactic migration
    • Tanida S., Yoshitomi H., Ishikawa M., Kasahara T., Murata K., Shibuya H., et al. IL-27-producing CD14(+) cells infiltrate inflamed joints of rheumatoid arthritis and regulate inflammation and chemotactic migration. Cytokine 2011, 55:237-244.
    • (2011) Cytokine , vol.55 , pp. 237-244
    • Tanida, S.1    Yoshitomi, H.2    Ishikawa, M.3    Kasahara, T.4    Murata, K.5    Shibuya, H.6
  • 72
    • 79957694768 scopus 로고    scopus 로고
    • IL-27 suppresses RANKL expression in CD4+ T cells in part through STAT3
    • Kamiya S., Okumura M., Chiba Y., Fukawa T., Nakamura C., Nimura N., et al. IL-27 suppresses RANKL expression in CD4+ T cells in part through STAT3. Immunol Lett 2011, 138:47-53.
    • (2011) Immunol Lett , vol.138 , pp. 47-53
    • Kamiya, S.1    Okumura, M.2    Chiba, Y.3    Fukawa, T.4    Nakamura, C.5    Nimura, N.6
  • 73
    • 84869838745 scopus 로고    scopus 로고
    • Interleukin-27 suppresses osteoclastogenesis via induction of interferon-gamma
    • Park J.S., Jung Y.O., Oh H.J., Park S.J., Heo Y.J., Kang C.M., et al. Interleukin-27 suppresses osteoclastogenesis via induction of interferon-gamma. Immunology 2012, 137:326-335.
    • (2012) Immunology , vol.137 , pp. 326-335
    • Park, J.S.1    Jung, Y.O.2    Oh, H.J.3    Park, S.J.4    Heo, Y.J.5    Kang, C.M.6
  • 75
    • 33751521013 scopus 로고    scopus 로고
    • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    • Sato K., Suematsu A., Okamoto K., Yamaguchi A., Morishita Y., Kadono Y., et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med 2006, 203:2673-2682.
    • (2006) J Exp Med , vol.203 , pp. 2673-2682
    • Sato, K.1    Suematsu, A.2    Okamoto, K.3    Yamaguchi, A.4    Morishita, Y.5    Kadono, Y.6
  • 76
    • 77954198190 scopus 로고    scopus 로고
    • Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis
    • Wong C.K., Chen da P., Tam L.S., Li E.K., Yin Y.B., Lam C.W. Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther 2010, 12:R129.
    • (2010) Arthritis Res Ther , vol.12 , pp. R129
    • Wong, C.K.1    Chen da, P.2    Tam, L.S.3    Li, E.K.4    Yin, Y.B.5    Lam, C.W.6
  • 78
    • 3142719733 scopus 로고    scopus 로고
    • Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27
    • Goldberg R., Wildbaum G., Zohar Y., Maor G., Karin N. Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27. J Immunol 2004, 173:1171-1178.
    • (2004) J Immunol , vol.173 , pp. 1171-1178
    • Goldberg, R.1    Wildbaum, G.2    Zohar, Y.3    Maor, G.4    Karin, N.5
  • 79
    • 40449100736 scopus 로고    scopus 로고
    • IL-27 induces a Th1 immune response and susceptibility to experimental arthritis
    • Cao Y., Doodes P.D., Glant T.T., Finnegan A. IL-27 induces a Th1 immune response and susceptibility to experimental arthritis. J Immunol 2008, 180:922-930.
    • (2008) J Immunol , vol.180 , pp. 922-930
    • Cao, Y.1    Doodes, P.D.2    Glant, T.T.3    Finnegan, A.4
  • 80
    • 84884907926 scopus 로고    scopus 로고
    • Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination
    • Rostami A., Ciric B. Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination. J Neurol Sci 2013, 333:76-87.
    • (2013) J Neurol Sci , vol.333 , pp. 76-87
    • Rostami, A.1    Ciric, B.2
  • 81
  • 82
    • 84920940028 scopus 로고    scopus 로고
    • Decreased expression of IL-27 and its correlation with Th1 and Th17 cells in progressive multiple sclerosis
    • Tang S.C., Fan X.H., Pan Q.M., Sun Q.S., Liu Y. Decreased expression of IL-27 and its correlation with Th1 and Th17 cells in progressive multiple sclerosis. J Neurol Sci 2015, 348:174-180.
    • (2015) J Neurol Sci , vol.348 , pp. 174-180
    • Tang, S.C.1    Fan, X.H.2    Pan, Q.M.3    Sun, Q.S.4    Liu, Y.5
  • 85
  • 86
    • 35648988381 scopus 로고    scopus 로고
    • Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis
    • Fitzgerald D.C., Ciric B., Touil T., Harle H., Grammatikopolou J., Das Sarma J., et al. Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J Immunol 2007, 179:3268-3275.
    • (2007) J Immunol , vol.179 , pp. 3268-3275
    • Fitzgerald, D.C.1    Ciric, B.2    Touil, T.3    Harle, H.4    Grammatikopolou, J.5    Das Sarma, J.6
  • 87
    • 84899106289 scopus 로고    scopus 로고
    • IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses
    • Chong W.P., Horai R., Mattapallil M.J., Silver P.B., Chen J., Zhou R., et al. IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses. J Autoimmun 2014, 50:12-22.
    • (2014) J Autoimmun , vol.50 , pp. 12-22
    • Chong, W.P.1    Horai, R.2    Mattapallil, M.J.3    Silver, P.B.4    Chen, J.5    Zhou, R.6
  • 88
    • 84882860516 scopus 로고    scopus 로고
    • The suppressive effect of IL-27 on encephalitogenic Th17 cells induced by multiwalled carbon nanotubes reduces the severity of experimental autoimmune encephalomyelitis
    • Moraes A.S., Paula R.F., Pradella F., Santos M.P., Oliveira E.C., von Glehn F., et al. The suppressive effect of IL-27 on encephalitogenic Th17 cells induced by multiwalled carbon nanotubes reduces the severity of experimental autoimmune encephalomyelitis. CNS Neurosci Ther 2013, 19:682-687.
    • (2013) CNS Neurosci Ther , vol.19 , pp. 682-687
    • Moraes, A.S.1    Paula, R.F.2    Pradella, F.3    Santos, M.P.4    Oliveira, E.C.5    von Glehn, F.6
  • 89
    • 84883739704 scopus 로고    scopus 로고
    • Defining and scoring response to IFN-beta in multiple sclerosis
    • Sormani M.P., De Stefano N. Defining and scoring response to IFN-beta in multiple sclerosis. Nat Rev 2013, 9:504-512.
    • (2013) Nat Rev , vol.9 , pp. 504-512
    • Sormani, M.P.1    De Stefano, N.2
  • 90
    • 79960219135 scopus 로고    scopus 로고
    • IL-27 mediates the response to IFN-beta therapy in multiple sclerosis patients by inhibiting Th17 cells
    • Sweeney C.M., Lonergan R., Basdeo S.A., Kinsella K., Dungan L.S., Higgins S.C., et al. IL-27 mediates the response to IFN-beta therapy in multiple sclerosis patients by inhibiting Th17 cells. Brain Behav Immun 2011, 25:1170-1181.
    • (2011) Brain Behav Immun , vol.25 , pp. 1170-1181
    • Sweeney, C.M.1    Lonergan, R.2    Basdeo, S.A.3    Kinsella, K.4    Dungan, L.S.5    Higgins, S.C.6
  • 91
    • 84875447284 scopus 로고    scopus 로고
    • Independent and interdependent immunoregulatory effects of IL-27, IFN-beta, and IL-10 in the suppression of human Th17 cells and murine experimental autoimmune encephalomyelitis
    • Fitzgerald D.C., Fonseca-Kelly Z., Cullimore M.L., Safabakhsh P., Saris C.J., Zhang G.X., et al. Independent and interdependent immunoregulatory effects of IL-27, IFN-beta, and IL-10 in the suppression of human Th17 cells and murine experimental autoimmune encephalomyelitis. J Immunol 2013, 190:3225-3234.
    • (2013) J Immunol , vol.190 , pp. 3225-3234
    • Fitzgerald, D.C.1    Fonseca-Kelly, Z.2    Cullimore, M.L.3    Safabakhsh, P.4    Saris, C.J.5    Zhang, G.X.6
  • 92
    • 84886728752 scopus 로고    scopus 로고
    • IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39
    • Mascanfroni I.D., Yeste A., Vieira S.M., Burns E.J., Patel B., Sloma I., et al. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat Immunol 2013, 14:1054-1063.
    • (2013) Nat Immunol , vol.14 , pp. 1054-1063
    • Mascanfroni, I.D.1    Yeste, A.2    Vieira, S.M.3    Burns, E.J.4    Patel, B.5    Sloma, I.6
  • 93
    • 8444235333 scopus 로고    scopus 로고
    • Suppression of ongoing experimental autoimmune encephalomyelitis by neutralizing the function of the p28 subunit of IL-27
    • Goldberg R., Zohar Y., Wildbaum G., Geron Y., Maor G., Karin N. Suppression of ongoing experimental autoimmune encephalomyelitis by neutralizing the function of the p28 subunit of IL-27. J Immunol 2004, 173:6465-6471.
    • (2004) J Immunol , vol.173 , pp. 6465-6471
    • Goldberg, R.1    Zohar, Y.2    Wildbaum, G.3    Geron, Y.4    Maor, G.5    Karin, N.6
  • 95
    • 84873691650 scopus 로고    scopus 로고
    • The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin
    • Weaver C.T., Elson C.O., Fouser L.A., Kolls J.K. The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin. Annu Rev Pathol 2013, 8:477-512.
    • (2013) Annu Rev Pathol , vol.8 , pp. 477-512
    • Weaver, C.T.1    Elson, C.O.2    Fouser, L.A.3    Kolls, J.K.4
  • 96
    • 13944281011 scopus 로고    scopus 로고
    • Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis
    • Schmidt C., Giese T., Ludwig B., Mueller-Molaian I., Marth T., Zeuzem S., et al. Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis. Inflamm Bowel Dis 2005, 11:16-23.
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 16-23
    • Schmidt, C.1    Giese, T.2    Ludwig, B.3    Mueller-Molaian, I.4    Marth, T.5    Zeuzem, S.6
  • 98
    • 79955064497 scopus 로고    scopus 로고
    • Treatment with IL-27 attenuates experimental colitis through the suppression of the development of IL-17-producing T helper cells
    • Sasaoka T., Ito M., Yamashita J., Nakajima K., Tanaka I., Narita M., et al. Treatment with IL-27 attenuates experimental colitis through the suppression of the development of IL-17-producing T helper cells. Am J Physiol Gastrointest Liver Physiol 2011, 300:G568-G576.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300 , pp. G568-G576
    • Sasaoka, T.1    Ito, M.2    Yamashita, J.3    Nakajima, K.4    Tanaka, I.5    Narita, M.6
  • 99
    • 27944495565 scopus 로고    scopus 로고
    • T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis
    • Honda K., Nakamura K., Matsui N., Takahashi M., Kitamura Y., Mizutani T., et al. T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis. Inflamm Bowel Dis 2005, 11:1044-1052.
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 1044-1052
    • Honda, K.1    Nakamura, K.2    Matsui, N.3    Takahashi, M.4    Kitamura, Y.5    Mizutani, T.6
  • 100
    • 84890608517 scopus 로고    scopus 로고
    • Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice
    • [e13]
    • Hanson M.L., Hixon J.A., Li W., Felber B.K., Anver M.R., Stewart C.A., et al. Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice. Gastroenterology 2014, 146:210-221. [e13].
    • (2014) Gastroenterology , vol.146 , pp. 210-221
    • Hanson, M.L.1    Hixon, J.A.2    Li, W.3    Felber, B.K.4    Anver, M.R.5    Stewart, C.A.6
  • 102
    • 84899495625 scopus 로고    scopus 로고
    • IL-27, targeting antigen-presenting cells, promotes Th17 differentiation and colitis in mice
    • Visperas A., Do J.S., Bulek K., Li X., Min B. IL-27, targeting antigen-presenting cells, promotes Th17 differentiation and colitis in mice. Mucosal Immunol 2014, 7:625-633.
    • (2014) Mucosal Immunol , vol.7 , pp. 625-633
    • Visperas, A.1    Do, J.S.2    Bulek, K.3    Li, X.4    Min, B.5
  • 104
    • 84943819103 scopus 로고    scopus 로고
    • The role of serum IL-17 and IL-6 as biomarkers of disease activity and predictors of remission in patients with lupus nephritis
    • [Epub ahead of print]
    • Abdel Galil S.M., Ezzeldin N., El-Boshy M.E. The role of serum IL-17 and IL-6 as biomarkers of disease activity and predictors of remission in patients with lupus nephritis. Cytokine June 11 2015, [Epub ahead of print].
    • (2015) Cytokine
    • Abdel Galil, S.M.1    Ezzeldin, N.2    El-Boshy, M.E.3
  • 105
    • 77951117432 scopus 로고    scopus 로고
    • Low level of serum interleukin 27 in patients with systemic lupus erythematosus
    • Li T.T., Zhang T., Chen G.M., Zhu Q.Q., Tao J.H., Pan H.F., et al. Low level of serum interleukin 27 in patients with systemic lupus erythematosus. J Investig Med 2010, 58:737-739.
    • (2010) J Investig Med , vol.58 , pp. 737-739
    • Li, T.T.1    Zhang, T.2    Chen, G.M.3    Zhu, Q.Q.4    Tao, J.H.5    Pan, H.F.6
  • 106
    • 84882940099 scopus 로고    scopus 로고
    • Glucocorticoid downregulates expression of IL-12 family cytokines in systemic lupus erythematosus patients
    • Qiu F., Song L., Yang N., Li X. Glucocorticoid downregulates expression of IL-12 family cytokines in systemic lupus erythematosus patients. Lupus 2013, 22:1011-1016.
    • (2013) Lupus , vol.22 , pp. 1011-1016
    • Qiu, F.1    Song, L.2    Yang, N.3    Li, X.4
  • 107
    • 84929260469 scopus 로고    scopus 로고
    • Interleukin-27 and interleukin-23 in patients with systemic lupus erythematosus: possible role in lupus nephritis
    • Xia L.P., Li B.F., Shen H., Lu J. Interleukin-27 and interleukin-23 in patients with systemic lupus erythematosus: possible role in lupus nephritis. Scand J Rheumatol 2015, 44:200-205.
    • (2015) Scand J Rheumatol , vol.44 , pp. 200-205
    • Xia, L.P.1    Li, B.F.2    Shen, H.3    Lu, J.4
  • 108
    • 75649142843 scopus 로고    scopus 로고
    • The gene expression of type 17T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus
    • Kwan B.C., Tam L.S., Lai K.B., Lai F.M., Li E.K., Wang G., et al. The gene expression of type 17T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus. Rheumatology (Oxford) 2009, 48:1491-1497.
    • (2009) Rheumatology (Oxford) , vol.48 , pp. 1491-1497
    • Kwan, B.C.1    Tam, L.S.2    Lai, K.B.3    Lai, F.M.4    Li, E.K.5    Wang, G.6
  • 109
    • 28244474156 scopus 로고    scopus 로고
    • Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1)
    • Shimizu S., Sugiyama N., Masutani K., Sadanaga A., Miyazaki Y., Inoue Y., et al. Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1). J Immunol 2005, 175:7185-7192.
    • (2005) J Immunol , vol.175 , pp. 7185-7192
    • Shimizu, S.1    Sugiyama, N.2    Masutani, K.3    Sadanaga, A.4    Miyazaki, Y.5    Inoue, Y.6
  • 110
    • 33947278280 scopus 로고    scopus 로고
    • T cell TRAIL promotes murine lupus by sustaining effector CD4 Th cell numbers and by inhibiting CD8 CTL activity
    • Rus V., Nguyen V., Puliaev R., Puliaeva I., Zernetkina V., Luzina I., et al. T cell TRAIL promotes murine lupus by sustaining effector CD4 Th cell numbers and by inhibiting CD8 CTL activity. J Immunol 2007, 178:3962-3972.
    • (2007) J Immunol , vol.178 , pp. 3962-3972
    • Rus, V.1    Nguyen, V.2    Puliaev, R.3    Puliaeva, I.4    Zernetkina, V.5    Luzina, I.6
  • 111
    • 60149106103 scopus 로고    scopus 로고
    • Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis
    • Igawa T., Nakashima H., Sadanaga A., Masutani K., Miyake K., Shimizu S., et al. Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis. Mod Rheumatol 2009, 19:33-41.
    • (2009) Mod Rheumatol , vol.19 , pp. 33-41
    • Igawa, T.1    Nakashima, H.2    Sadanaga, A.3    Masutani, K.4    Miyake, K.5    Shimizu, S.6
  • 112
    • 53149133918 scopus 로고    scopus 로고
    • Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1)
    • Sugiyama N., Nakashima H., Yoshimura T., Sadanaga A., Shimizu S., Masutani K., et al. Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1). Ann Rheum Dis 2008, 67:1461-1467.
    • (2008) Ann Rheum Dis , vol.67 , pp. 1461-1467
    • Sugiyama, N.1    Nakashima, H.2    Yoshimura, T.3    Sadanaga, A.4    Shimizu, S.5    Masutani, K.6
  • 113
    • 77951141454 scopus 로고    scopus 로고
    • Therapeutic potential of IL-27 in systemic lupus erythematosus
    • Pan H.F., Tao J.H., Ye D.Q. Therapeutic potential of IL-27 in systemic lupus erythematosus. Expert Opin Ther Targets 2010, 14:479-484.
    • (2010) Expert Opin Ther Targets , vol.14 , pp. 479-484
    • Pan, H.F.1    Tao, J.H.2    Ye, D.Q.3
  • 114
    • 79957596746 scopus 로고    scopus 로고
    • T cell-specific overexpression of interleukin-27 receptor alpha subunit (WSX-1) prevents spontaneous skin inflammation in MRL/lpr mice
    • Kido M., Takeuchi S., Sugiyama N., Esaki H., Nakashima H., Yoshida H., et al. T cell-specific overexpression of interleukin-27 receptor alpha subunit (WSX-1) prevents spontaneous skin inflammation in MRL/lpr mice. Br J Dermatol 2011, 164:1214-1220.
    • (2011) Br J Dermatol , vol.164 , pp. 1214-1220
    • Kido, M.1    Takeuchi, S.2    Sugiyama, N.3    Esaki, H.4    Nakashima, H.5    Yoshida, H.6
  • 115
    • 84945435728 scopus 로고    scopus 로고
    • Psoriasis
    • [Epub ahead of print]
    • Boehncke W.H., Schon M.P. Psoriasis. Lancet May 26 2015, [Epub ahead of print].
    • (2015) Lancet
    • Boehncke, W.H.1    Schon, M.P.2
  • 117
    • 84866642459 scopus 로고    scopus 로고
    • Systemic lupus erythematosus accompanied by psoriasis induces IL-27-producing cells in both affected areas of the skin
    • Tojo G., Fujimura T., Kambayashi Y., Aiba S. Systemic lupus erythematosus accompanied by psoriasis induces IL-27-producing cells in both affected areas of the skin. Case reports in dermatology 2012, 4:181-185.
    • (2012) Case reports in dermatology , vol.4 , pp. 181-185
    • Tojo, G.1    Fujimura, T.2    Kambayashi, Y.3    Aiba, S.4
  • 119
    • 83555175993 scopus 로고    scopus 로고
    • Interleukin (IL)-17 versus IL-27: opposite effects on tumor necrosis factor-alpha-mediated chemokine production in human keratinocytes
    • Fujiwara S., Nagai H., Oniki S., Yoshimoto T., Nishigori C. Interleukin (IL)-17 versus IL-27: opposite effects on tumor necrosis factor-alpha-mediated chemokine production in human keratinocytes. Exp Dermatol 2012, 21:70-72.
    • (2012) Exp Dermatol , vol.21 , pp. 70-72
    • Fujiwara, S.1    Nagai, H.2    Oniki, S.3    Yoshimoto, T.4    Nishigori, C.5
  • 121
    • 84872600320 scopus 로고    scopus 로고
    • IL-27 activates Th1-mediated responses in imiquimod-induced psoriasis-like skin lesions
    • Shibata S., Tada Y., Asano Y., Yanaba K., Sugaya M., Kadono T., et al. IL-27 activates Th1-mediated responses in imiquimod-induced psoriasis-like skin lesions. J Invest Dermatol 2013, 133:479-488.
    • (2013) J Invest Dermatol , vol.133 , pp. 479-488
    • Shibata, S.1    Tada, Y.2    Asano, Y.3    Yanaba, K.4    Sugaya, M.5    Kadono, T.6
  • 122
    • 56249095154 scopus 로고    scopus 로고
    • Pancreatic pathology in type 1 diabetes in human
    • [discussion 13-8, 122-9, 202-3]
    • Foulis A.K. Pancreatic pathology in type 1 diabetes in human. Novartis Found Symp 2008, 292:2-13. [discussion 13-8, 122-9, 202-3].
    • (2008) Novartis Found Symp , vol.292 , pp. 2-13
    • Foulis, A.K.1
  • 124
    • 80055003184 scopus 로고    scopus 로고
    • IL-27 inhibits hyperglycemia and pancreatic islet inflammation induced by streptozotocin in mice
    • Fujimoto H., Hirase T., Miyazaki Y., Hara H., Ide-Iwata N., Nishimoto-Hazuku A., et al. IL-27 inhibits hyperglycemia and pancreatic islet inflammation induced by streptozotocin in mice. Am J Pathol 2011, 179:2327-2336.
    • (2011) Am J Pathol , vol.179 , pp. 2327-2336
    • Fujimoto, H.1    Hirase, T.2    Miyazaki, Y.3    Hara, H.4    Ide-Iwata, N.5    Nishimoto-Hazuku, A.6
  • 125
    • 57349116921 scopus 로고    scopus 로고
    • The pathogenic role of interleukin-27 in autoimmune diabetes
    • Wang R., Han G., Wang J., Chen G., Xu R., Wang L., et al. The pathogenic role of interleukin-27 in autoimmune diabetes. Cell Mol Life Sci 2008, 65:3851-3860.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3851-3860
    • Wang, R.1    Han, G.2    Wang, J.3    Chen, G.4    Xu, R.5    Wang, L.6
  • 126
    • 13044311376 scopus 로고    scopus 로고
    • Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: a phase I/II clinical trial
    • Nussenblatt R.B., Fortin E., Schiffman R., Rizzo L., Smith J., Van Veldhuisen P., et al. Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: a phase I/II clinical trial. Proc Natl Acad Sci U S A 1999, 96:7462-7466.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7462-7466
    • Nussenblatt, R.B.1    Fortin, E.2    Schiffman, R.3    Rizzo, L.4    Smith, J.5    Van Veldhuisen, P.6
  • 127
    • 34250005444 scopus 로고    scopus 로고
    • TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
    • Amadi-Obi A., Yu C.R., Liu X., Mahdi R.M., Clarke G.L., Nussenblatt R.B., et al. TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med 2007, 13:711-718.
    • (2007) Nat Med , vol.13 , pp. 711-718
    • Amadi-Obi, A.1    Yu, C.R.2    Liu, X.3    Mahdi, R.M.4    Clarke, G.L.5    Nussenblatt, R.B.6
  • 128
    • 84896993161 scopus 로고    scopus 로고
    • Understanding autoimmunity in the eye: from animal models to novel therapies
    • Caspi R.R. Understanding autoimmunity in the eye: from animal models to novel therapies. Discov Med 2014, 17:155-162.
    • (2014) Discov Med , vol.17 , pp. 155-162
    • Caspi, R.R.1
  • 129
  • 130
  • 131
    • 84867755894 scopus 로고    scopus 로고
    • Novel IL27p28/IL12p40 cytokine suppressed experimental autoimmune uveitis by inhibiting autoreactive Th1/Th17 cells and promoting expansion of regulatory T cells
    • Wang R.X., Yu C.R., Mahdi R.M., Egwuagu C.E. Novel IL27p28/IL12p40 cytokine suppressed experimental autoimmune uveitis by inhibiting autoreactive Th1/Th17 cells and promoting expansion of regulatory T cells. J Biol Chem 2012, 287:36012-36021.
    • (2012) J Biol Chem , vol.287 , pp. 36012-36021
    • Wang, R.X.1    Yu, C.R.2    Mahdi, R.M.3    Egwuagu, C.E.4
  • 132
    • 79952527975 scopus 로고    scopus 로고
    • Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10
    • Lee Y.S., Amadi-Obi A., Yu C.R., Egwuagu C.E. Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10. Immunology 2011, 132:492-502.
    • (2011) Immunology , vol.132 , pp. 492-502
    • Lee, Y.S.1    Amadi-Obi, A.2    Yu, C.R.3    Egwuagu, C.E.4


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