Kinome screen identifies PFKFB3 and glucose metabolism as important regulators of the insulin/insulin-like growth factor (IGF)-1 signaling pathway

Journal of Biological Chemistry

Volumn 290, Issue 43, 2015, Pages 25834-25846

  Trefely, Sophie ^a   Khoo, Poh Sim ^a,b,d   Krycer, James R ^c   Chaudhuri, Rima ^c   Fazakerley, Daniel J ^c   Parker, Benjamin L ^c   Sultani, Ghazal ^a   Lee, James ^b   Stephan, Jean Philippe ^b,e   Torres, Eric ^b   Jung, Kenneth ^b   Kuijl, Coenraad ^b,f   James, David E ^c   Junutula, Jagath R ^b   Stöckli, Jacqueline ^c  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b GENENTECH INC   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

^d Australia   (Australia)

^e INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^f VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; DISEASES; ENZYMES; GLUCOSE; INSULIN; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

AKT PHOSPHORYLATION; BIOLOGICAL PROCESS; GLUCOSE METABOLISM; INSULIN-STIMULATED GLUCOSE; NEGATIVE REGULATORS; PATHWAY ACTIVITIES; PHARMACOLOGICAL INHIBITION; SIGNALING PATHWAYS;

SIGNALING;

GLUCOSE TRANSPORTER 4; INSULIN; LACTIC ACID; PROTEIN KINASE B; PROTEIN PFKFB3; REGULATOR PROTEIN; SMALL INTERFERING RNA; SOMATOMEDIN C; UNCLASSIFIED DRUG; 6 PHOSPHOFRUCTO 2 KINASE; GLUCOSE; PFKFB3 PROTEIN, MOUSE; PROTEIN KINASE; SLC2A4 PROTEIN, HUMAN;

3T3 CELL LINE; ADIPOCYTE; ARTICLE; CANCER CELL; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FEEDBACK SYSTEM; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; HEK293 CELL LINE; HELA CELL LINE; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; ANIMAL; GENETICS; HUMAN; METABOLISM; MOUSE;

3T3-L1 CELLS; ANIMALS; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HELA CELLS; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; MICE; PHOSPHOFRUCTOKINASE-2; PROTEIN KINASES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84944937943     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.658815     Document Type: Article

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