Role of GPR81 in lactate-mediated reduction of adipose lipolysis

Biochemical and Biophysical Research Communications

Volumn 377, Issue 3, 2008, Pages 987-991

  Cai, Tian Quan ^a   Ren, Ning ^a   Jin, Lan ^a   Cheng, Kang ^a   Kash, Shera ^c   Chen, Ruoping ^b   Wright, Samuel D ^a   Taggart, Andrew K P ^a   Waters, M Gerard ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ARENA PHARMACEUTICALS   (United States)

^c Deltagen Inc   (United States)

Author keywords

Exercise; Free fatty acids; Lactic acid; Orphan GPCR; Oxygen deficit

Indexed keywords

FATTY ACID; G PROTEIN COUPLED RECEPTOR; LACTIC ACID; PROTEIN GPR81; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; EXERCISE; HYPOXIA; LIPOLYSIS; MOLECULAR SENSOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADIPOSE TISSUE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; FATTY ACIDS, NONESTERIFIED; HUMANS; LACTIC ACID; LIGANDS; LIPOLYSIS; MICE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NICOTINIC; TRANSFECTION;

EID: 56249083891     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.10.088     Document Type: Article

References (26)

1. Cobb L.A., and Johnson W.P. Hemodynamic relationships of anaerobic metabolism and plasma free fatty acids during prolonged, strenuous exercise in trained and untrained subjects. J. Clin. Invest. 42 (1963) 800-810
2. Havel R.J., Pernow B., and Jones N.L. Uptake and release of free fatty acids and other metabolites in the legs of exercising men. J. Appl. Physiol. 23 (1967) 90-99
3. Pruett E.D. FFA mobilization during and after prolonged severe muscular work in men. J. Appl. Physiol. 29 (1970) 809-815
4. Houghton C.R., Hawkins R.A., Williamson D.H., and Krebs H.A. An explanation for the lowering of blood ketone-body concentrations in starved rats during short-term exercise. Biochem. J. 124 (1971) 56P-57P
5. Gold M., Miller H.I., Issekutz Jr. B., and Spitzer J.J. Effect of exercise and lactic acid infusion on individual free fatty acids of plasma. Am. J. Physiol. 205 (1963) 902-904
6. Boyd III A.E., Giamber S.R., Mager M., and Lebovitz H.E. Lactate inhibition of lipolysis in exercising man. Metabolism 23 (1974) 531-542
7. Bjorntorp P. The effect of lactic acid on adipose tissue metabolism in vitro. Acta Med. Scand. 178 (1965) 253-255
8. De Pergola G., Cignarelli M., Nardelli G., Garruti G., Corso M., Di Paolo S., Cardone F., and Giorgino R. Influence of lactate on isoproterenol-induced lipolysis and β-adrenoceptors distribution in human fat cells. Horm. Metab. Res. 21 (1989) 210-213
9. Wise A., Foord S.M., Fraser N.J., Barnes A.A., Elshourbagy N., Eilert M., Ignar D.M., Murdock P.R., Steplewski K., Green A., Brown A.J., Dowell S.J., Szekeres P.G., Hassall D.G., Marshall F.H., Wilson S., and Pike N.B. Molecular identification of high and low affinity receptors for nicotinic acid. J. Biol. Chem. 278 (2003) 9869-9874
10. Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., and O'Dowd B.F. Discovery and mapping of ten novel G protein-coupled receptor genes. Gene 275 (2001) 83-91
11. Tunaru S., Kero J., Schaub A., Wufka C., Blaukat A., Pfeffer K., and Offermanns S. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat. Med. 9 (2003) 352-355
12. Soga T., Kamohara M., Takasaki J., Matsumoto S., Saito T., Ohishi T., Hiyama H., Matsuo A., Matsushime H., and Furuichi K. Molecular identification of nicotinic acid receptor. Biochem. Biophys. Res. Commun. 303 (2003) 364-369
13. Carlson L.A. Studies on the effect of nicotinic acid on catecholamine stimulated lipolysis in adipose tissue in vitro. Acta Med. Scand. 173 (1973) 719-722
14. Senior B., and Loridan L. Direct regulatory effect of ketones on lipolysis and on glucose concentrations in man. Nature 219 (1968) 83-84
15. Bates M.W., and Linn L.C. Blood D-3-hydroxybutyrate and the regulation of plasma concentrations of free fatty acids in the fasted rat. Metabolism 25 (1976) 685-695
16. Taggart A.K., Kero J., Gan X., Cai T.Q., Cheng K., Ippolito M., Ren N., Kaplan R., Wu K., Wu T.J., Jin L., Liaw C., Chen R., Richman J., Connolly D., Offermanns S., Wright S.D., and Waters M.G. (D)-β-hydroxybutyrate Inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. J. Biol. Chem. 280 (2005) 26649-26652
17. Fukao T., Lopaschuk G.D., and Mitchell G.A. Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Prostaglandins Leukot. Essent. Fatty Acids 70 (2004) 243-251
18. Osnes J.B., and Hermansen L. Acid-base balance after maximal exercise of short duration. J. Appl. Physiol. 32 (1972) 59-63
19. Kreisberg R.A. Lactate homeostasis and lactic acidosis. Ann. Intern. Med. 92 (1980) 227-237
20. Jones N.L., Heigenhauser G.J., Kuksis A., Matsos C.G., Sutton J.R., and Toews C.J. Fat metabolism in heavy exercise. Clin. Sci. (Lond.) 59 (1980) 469-478
21. Wolever T.M., Josse R.G., Leiter L.A., and Chiasson J.L. Time of day and glucose tolerance status affect serum short-chain fatty acid concentrations in humans. Metabolism 46 (1997) 805-811
22. Horowitz J.F. Fatty acid mobilization from adipose tissue during exercise. Trends Endocrinol. Metab. 14 (2003) 386-392
23. DiGirolamo M., Newby F.D., and Lovejoy J. Lactate production in adipose tissue: a regulated function with extra-adipose implications. FASEB J. 6 (1992) 2405-2412
24. Crandall D.L., Fried S.K., Francendese A.A., Nickel M., and DiGirolamo M. Lactate release from isolated rat adipocytes: influence of cell size, glucose concentration, insulin and epinephrine. Horm. Metab. Res. 15 (1983) 326-329
25. Lovejoy J., Mellen B., and Digirolamo M. Lactate generation following glucose ingestion: relation to obesity, carbohydrate tolerance and insulin sensitivity. Int. J. Obes. 14 (1990) 843-855
26. Semple G., Skinner P.J., Cherrier M.C., Webb P.J., Sage C.R., Tamura S.Y., Chen R., Richman J.G., and Connolly D.T. 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. J Med. Chem. 49 (2006) 1227-1230