Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle

Journal of Physiology

Volumn 529, Issue 2, 2000, Pages 285-293

  Manning Fox, J E ^a   Meredith, D ^a   Halestrap, A P ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,7 BIS(CARBOXYETHYL) 6 CARBOXYFLUORESCEIN; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 5 NITRO 2 (3 PHENYLPROPYLAMINO)BENZOIC ACID; ALPHA CYANO 4 HYDROXYCINNAMIC ACID; CARBON 14; CARRIER PROTEIN; CHLOROMERCURIBENZENESULFONIC ACID; ISOBUTYLMETHYLXANTHINE; ISOPROTEIN; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER 4; PHLORETIN; PYRUVIC ACID; UNCLASSIFIED DRUG; 2',7' BIS(CARBOXYETHYL) 5 (6)CARBOXYFLUORESCEIN; 6 CARBOXYFLUORESCEIN;

ACIDIFICATION; ARTICLE; CELL MEMBRANE TRANSPORT; CELL PH; CONTROLLED STUDY; CYTOSOL; DIFFUSION; FAST MUSCLE; GLYCOLYSIS; KINETICS; MEMBRANE VESICLE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN TARGETING; SARCOLEMMA; SKELETAL MUSCLE; TECHNIQUE; TUMOR CELL; XENOPUS; ANIMAL CELL; BIOACCUMULATION; FEMALE; PH MEASUREMENT; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SENSITIVITY ANALYSIS; TRANSPORT KINETICS;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; CELLS, CULTURED; FLUORESCEINS; FLUORESCENT DYES; HUMANS; KINETICS; LACTIC ACID; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE PROTEINS; MUSCLE, SKELETAL; OOCYTES; PROTEIN ISOFORMS; SUBSTRATE SPECIFICITY; XENOPUS;

EID: 0034525940     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2000.00285.x     Document Type: Article

References (30)

1. Lactate transport and lactate transporters in skeletal muscle
2. Abundance and subcellular distribution of MCT1 and MCT4 in heart and fast-twitch skeletal muscles
3. Characterisation of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes
4. Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes - Expression of two different monocarboxylate transporters in astroglial cells and neurons
5. Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH
6. The kinetics, substrate and inhibitor specificity of the lactate transporter of Ehrlich-Lettre tumour cells studied with the intracellular pH indicator BCECF
7. Influence of organic acids on intracellular pH
8. Regulation of pyruvate metabolism in mammalian tissues
9. cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1
10. The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
11. The kinetics, substrate, and inhibitor specificity of the monocarboxylate (lactate) transporter of rat liver cells determined using the fluorescent intracellular pH indicator, 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein
12. Lactate-proton cotransport in skeletal muscle
13. Lactate transport in skeletal muscle - Role and regulation of the monocarboxylate transporter
14. Human monocarboxylate transport 2 (MCT2) is a high affinity pyruvate transporter
15. Role of the lactate transporter (MCT1) in skeletal muscles
16. Chronic electrical stimulation increases MCT1 and lactate uptake in red and white skeletal muscle
17. Both K290 and K413 are essential for DIDS covalent modification of the rat proton-linked monocarboxylate (lactate) transporter MCT1 expressed in Xenopus laevis oocytes
18. Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE
19. + transport in rat skeletal muscle
20. + transport capacity in human skeletal muscle
21. + transporter isoforms MCT1 and MCT4 in human skeletal muscle
22. Transport of lactate and other monocarboxylates across mammalian plasma membranes
23. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past
24. Regulation mechanisms of intracellular pH of Xenopus laevis oocyte
25. Monocarboxylic acid permeation through lipid bilayer membranes
26. Substrate and inhibitor specificities of the monocarboxylate transporters of single rat heart cells
27. Kinetics of the sarcolemmal lactate carrier in single heart cells using BCECF to measure pH(i)
28. Colocalization of immunoglobulin superfamily member CD147 with a monocarboxylate transporter (MCT1)
29. Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3
30. Identification of a unique monocarboxylate transporter (MCT3) in retinal pigment epithelium