-
1
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., and Hemmings, B. A. (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15, 6541-6551
-
(1996)
EMBO J.
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
2
-
-
0032497842
-
The role of PI 3-kinase in insulin action
-
Alessi, D. R., and Downes, C. P. (1998) The role of PI 3-kinase in insulin action. Biochim. Biophys. Acta 1436, 151-164
-
(1998)
Biochim. Biophys. Acta
, vol.1436
, pp. 151-164
-
-
Alessi, D.R.1
Downes, C.P.2
-
3
-
-
0037600600
-
Role of Akt/protein kinase B in metabolism
-
Whiteman, E. L., Cho, H., and Birnbaum, M. J. (2002) Role of Akt/protein kinase B in metabolism. Trends Endocrinol. Metab. 13, 444-451
-
(2002)
Trends Endocrinol. Metab.
, vol.13
, pp. 444-451
-
-
Whiteman, E.L.1
Cho, H.2
Birnbaum, M.J.3
-
4
-
-
34249807012
-
Insulin-induced formation of macromolecular complexes involved in activation of cyclic nucleotide phosphodiesterase 3B (PDE3B) and its interaction with PKB
-
Ahmad, F., Lindh, R., Tang, Y., Weston, M., Degerman, E., and Manganiello, V. C. (2007) Insulin-induced formation of macromolecular complexes involved in activation of cyclic nucleotide phosphodiesterase 3B (PDE3B) and its interaction with PKB. Biochem. J. 404, 257-268
-
(2007)
Biochem. J.
, vol.404
, pp. 257-268
-
-
Ahmad, F.1
Lindh, R.2
Tang, Y.3
Weston, M.4
Degerman, E.5
Manganiello, V.C.6
-
5
-
-
0037151026
-
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain
-
Kane, S., Sano, H., Liu, S. C., Asara, J. M., Lane, W. S., Garner, C. C., and Lienhard, G. E. (2002) A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J. Biol. Chem. 277, 22115-22118
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 22115-22118
-
-
Kane, S.1
Sano, H.2
Liu, S.C.3
Asara, J.M.4
Lane, W.S.5
Garner, C.C.6
Lienhard, G.E.7
-
6
-
-
84871902200
-
The Rab GTPase-activating protein TBC1D4/ AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes
-
Tan, S. X., Ng, Y., Burchfield, J. G., Ramm, G., Lambright, D. G., Stöckli, J., and James, D. E. (2012) The Rab GTPase-activating protein TBC1D4/ AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes. Mol. Cell. Biol. 32, 4946-4959
-
(2012)
Mol. Cell. Biol.
, vol.32
, pp. 4946-4959
-
-
Tan, S.X.1
Ng, Y.2
Burchfield, J.G.3
Ramm, G.4
Lambright, D.G.5
Stöckli, J.6
James, D.E.7
-
7
-
-
77953868236
-
Lipid-induced insulin resistance: Unravelling the mechanism
-
Samuel, V. T., Petersen, K. F., and Shulman, G. I. (2010) Lipid-induced insulin resistance: unravelling the mechanism. Lancet 375, 2267-2277
-
(2010)
Lancet
, vol.375
, pp. 2267-2277
-
-
Samuel, V.T.1
Petersen, K.F.2
Shulman, G.I.3
-
8
-
-
33645074450
-
Etiology of insulin resistance
-
Petersen, K. F., and Shulman, G. I. (2006) Etiology of insulin resistance. Am. J. Med. 119, S10-S16
-
(2006)
Am. J. Med.
, vol.119
, pp. S10-S16
-
-
Petersen, K.F.1
Shulman, G.I.2
-
9
-
-
0027280156
-
Insulin stimulates the degradation of IRS-1 in 3T3-L1 adipocytes
-
Rice, K. M., Turnbow, M. A., and Garner, C. W. (1993) Insulin stimulates the degradation of IRS-1 in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 190, 961-967
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.190
, pp. 961-967
-
-
Rice, K.M.1
Turnbow, M.A.2
Garner, C.W.3
-
10
-
-
0030987889
-
Highfat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect
-
Zierath, J. R., Houseknecht, K. L., Gnudi, L., and Kahn, B. B. (1997) Highfat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect. Diabetes 46, 215-223
-
(1997)
Diabetes
, vol.46
, pp. 215-223
-
-
Zierath, J.R.1
Houseknecht, K.L.2
Gnudi, L.3
Kahn, B.B.4
-
11
-
-
0042591261
-
Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases
-
Gao, Z., Zuberi, A., Quon, M. J., Dong, Z., and Ye, J. (2003) Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases. J. Biol. Chem. 278, 24944-24950
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 24944-24950
-
-
Gao, Z.1
Zuberi, A.2
Quon, M.J.3
Dong, Z.4
Ye, J.5
-
12
-
-
0035513703
-
Ceramide mediates insulin resistance by tumor necrosis factor-α in brown adipocytes by maintaining Akt in an inactive dephosphorylated state
-
Teruel, T., Hernandez, R., and Lorenzo, M. (2001) Ceramide mediates insulin resistance by tumor necrosis factor-α in brown adipocytes by maintaining Akt in an inactive dephosphorylated state. Diabetes 50, 2563-2571
-
(2001)
Diabetes
, vol.50
, pp. 2563-2571
-
-
Teruel, T.1
Hernandez, R.2
Lorenzo, M.3
-
13
-
-
0038532298
-
A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
-
Chavez, J. A., Knotts, T. A., Wang, L. P., Li, G., Dobrowsky, R. T., Florant, G. L., and Summers, S. A. (2003) A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J. Biol. Chem. 278, 10297-10303
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 10297-10303
-
-
Chavez, J.A.1
Knotts, T.A.2
Wang, L.P.3
Li, G.4
Dobrowsky, R.T.5
Florant, G.L.6
Summers, S.A.7
-
14
-
-
38649110496
-
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis
-
Biddinger, S. B., Hernandez-Ono, A., Rask-Madsen, C., Haas, J. T., Alemán, J. O., Suzuki, R., Scapa, E. F., Agarwal, C., Carey, M. C., Stephanopoulos, G., Cohen, D. E., King, G. L., Ginsberg, H. N., and Kahn, C. R. (2008) Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab. 7, 125-134
-
(2008)
Cell Metab.
, vol.7
, pp. 125-134
-
-
Biddinger, S.B.1
Hernandez-Ono, A.2
Rask-Madsen, C.3
Haas, J.T.4
Alemán, J.O.5
Suzuki, R.6
Scapa, E.F.7
Agarwal, C.8
Carey, M.C.9
Stephanopoulos, G.10
Cohen, D.E.11
King, G.L.12
Ginsberg, H.N.13
Kahn, C.R.14
-
15
-
-
0033304892
-
Selective insulin resistance in the polycystic ovary syndrome
-
Book, C. B., and Dunaif, A. (1999) Selective insulin resistance in the polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 84, 3110-3116
-
(1999)
J. Clin. Endocrinol. Metab.
, vol.84
, pp. 3110-3116
-
-
Book, C.B.1
Dunaif, A.2
-
16
-
-
84876471343
-
Impaired Akt phosphorylation in insulin-resistant human muscle is accompanied by selective and heterogeneous downstream defects
-
Tonks, K. T., Ng, Y., Miller, S., Coster, A. C., Samocha-Bonet, D., Iseli, T. J., Xu, A., Patrick, E., Yang, J. Y., Junutula, J. R., Modrusan, Z., Kolumam, G., Stöckli, J., Chisholm, D. J., James, D. E., and Greenfield, J. R. (2013) Impaired Akt phosphorylation in insulin-resistant human muscle is accompanied by selective and heterogeneous downstream defects. Diabetologia 56, 875-885
-
(2013)
Diabetologia
, vol.56
, pp. 875-885
-
-
Tonks, K.T.1
Ng, Y.2
Miller, S.3
Coster, A.C.4
Samocha-Bonet, D.5
Iseli, T.J.6
Xu, A.7
Patrick, E.8
Yang, J.Y.9
Junutula, J.R.10
Modrusan, Z.11
Kolumam, G.12
Stöckli, J.13
Chisholm, D.J.14
James, D.E.15
Greenfield, J.R.16
-
17
-
-
79959933430
-
Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor
-
Gonzalez, E., Flier, E., Molle, D., Accili, D., and McGraw, T. E. (2011) Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor. Proc. Natl. Acad. Sci. U.S.A. 108, 10162-10167
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 10162-10167
-
-
Gonzalez, E.1
Flier, E.2
Molle, D.3
Accili, D.4
McGraw, T.E.5
-
18
-
-
0035825643
-
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
-
Abel, E. D., Peroni, O., Kim, J. K., Kim, Y. B., Boss, O., Hadro, E., Minnemann, T., Shulman, G. I., and Kahn, B. B. (2001) Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409, 729-733
-
(2001)
Nature
, vol.409
, pp. 729-733
-
-
Abel, E.D.1
Peroni, O.2
Kim, J.K.3
Kim, Y.B.4
Boss, O.5
Hadro, E.6
Minnemann, T.7
Shulman, G.I.8
Kahn, B.B.9
-
19
-
-
84885859572
-
Analysis of in vitro insulin-resistance models and their physiological relevance to in vivo diet-induced adipose insulin resistance
-
Lo, K. A., Labadorf, A., Kennedy, N. J., Han, M. S., Yap, Y. S., Matthews, B., Xin, X., Sun, L., Davis, R. J., Lodish, H. F., and Fraenkel, E. (2013) Analysis of in vitro insulin-resistance models and their physiological relevance to in vivo diet-induced adipose insulin resistance. Cell Rep. 5, 259-270
-
(2013)
Cell Rep.
, vol.5
, pp. 259-270
-
-
Lo, K.A.1
Labadorf, A.2
Kennedy, N.J.3
Han, M.S.4
Yap, Y.S.5
Matthews, B.6
Xin, X.7
Sun, L.8
Davis, R.J.9
Lodish, H.F.10
Fraenkel, E.11
-
20
-
-
33645860825
-
Reactive oxygen species have a causal role in multiple forms of insulin resistance
-
Houstis, N., Rosen, E. D., and Lander, E. S. (2006) Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440, 944-948
-
(2006)
Nature
, vol.440
, pp. 944-948
-
-
Houstis, N.1
Rosen, E.D.2
Lander, E.S.3
-
21
-
-
84911366985
-
Increased adipose tissue insulin resistance in metabolic syndrome: Relationship to circulating adipokines
-
Adams-Huet, B., Devaraj, S., Siegel, D., and Jialal, I. (2014) Increased adipose tissue insulin resistance in metabolic syndrome: relationship to circulating adipokines. Metab. Syndr. Relat. Disord. 12, 503-507
-
(2014)
Metab. Syndr. Relat. Disord.
, vol.12
, pp. 503-507
-
-
Adams-Huet, B.1
Devaraj, S.2
Siegel, D.3
Jialal, I.4
-
22
-
-
0024237258
-
Rates and tissue sites of non-insulin-and insulin-mediated glucose uptake in humans
-
Baron, A. D., Brechtel, G., Wallace, P., and Edelman, S. V. (1988) Rates and tissue sites of non-insulin-and insulin-mediated glucose uptake in humans. Am. J. Physiol. 255, E769-E774
-
(1988)
Am. J. Physiol.
, vol.255
, pp. E769-E774
-
-
Baron, A.D.1
Brechtel, G.2
Wallace, P.3
Edelman, S.V.4
-
23
-
-
0037341432
-
GLUT4 recycles via a trans-Golgi network (TGN) subdomain enriched in Syntaxins 6 and 16 but not TGN38: Involvement of an acidic targeting motif
-
Shewan, A. M., van Dam, E. M., Martin, S., Luen, T. B., Hong, W., Bryant, N. J., and James, D. E. (2003) GLUT4 recycles via a trans-Golgi network (TGN) subdomain enriched in Syntaxins 6 and 16 but not TGN38: involvement of an acidic targeting motif. Mol. Biol. Cell 14, 973-986
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 973-986
-
-
Shewan, A.M.1
Van Dam, E.M.2
Martin, S.3
Luen, T.B.4
Hong, W.5
Bryant, N.J.6
James, D.E.7
-
24
-
-
42649127400
-
IRS1-independent defects define major nodes of insulin resistance
-
Hoehn, K. L., Hohnen-Behrens, C., Cederberg, A., Wu, L. E., Turner, N., Yuasa, T., Ebina, Y., and James, D. E. (2008) IRS1-independent defects define major nodes of insulin resistance. Cell Metab. 7, 421-433
-
(2008)
Cell Metab.
, vol.7
, pp. 421-433
-
-
Hoehn, K.L.1
Hohnen-Behrens, C.2
Cederberg, A.3
Wu, L.E.4
Turner, N.5
Yuasa, T.6
Ebina, Y.7
James, D.E.8
-
25
-
-
4744373229
-
Noise amidst the silence: Off-target effects of siRNAs?
-
Jackson, A. L., and Linsley, P. S. (2004) Noise amidst the silence: off-target effects of siRNAs? Trends Genet. 20, 521-524
-
(2004)
Trends Genet.
, vol.20
, pp. 521-524
-
-
Jackson, A.L.1
Linsley, P.S.2
-
26
-
-
0024561483
-
Kinetics of insulin action on protein synthesis in isolated adipocytes. Ability of glucose to selectively desensitize the glucose transport system without altering insulin stimulation of protein synthesis
-
Marshall, S. (1989) Kinetics of insulin action on protein synthesis in isolated adipocytes. Ability of glucose to selectively desensitize the glucose transport system without altering insulin stimulation of protein synthesis. J. Biol. Chem. 264, 2029-2036
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 2029-2036
-
-
Marshall, S.1
-
27
-
-
0024502709
-
Amino acid regulation of insulin action in isolated adipocytes. Selective ability of amino acids to enhance both insulin sensitivity and maximal insulin responsiveness of the protein synthesis system
-
Marshall, S., and Monzon, R. (1989) Amino acid regulation of insulin action in isolated adipocytes. Selective ability of amino acids to enhance both insulin sensitivity and maximal insulin responsiveness of the protein synthesis system. J. Biol. Chem. 264, 2037-2042
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 2037-2042
-
-
Marshall, S.1
Monzon, R.2
-
28
-
-
77957832253
-
Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway
-
Choi, S. M., Tucker, D. F., Gross, D. N., Easton, R. M., DiPilato, L. M., Dean, A. S., Monks, B. R., and Birnbaum, M. J. (2010) Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway. Mol. Cell. Biol. 30, 5009-5020
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 5009-5020
-
-
Choi, S.M.1
Tucker, D.F.2
Gross, D.N.3
Easton, R.M.4
Dipilato, L.M.5
Dean, A.S.6
Monks, B.R.7
Birnbaum, M.J.8
-
29
-
-
0013900980
-
Antilipolytic effect of insulin in isolated fat cells of the rat
-
Fain, J. N., Kovacev, V. P., and Scow, R. O. (1966) Antilipolytic effect of insulin in isolated fat cells of the rat. Endocrinology 78, 773-778
-
(1966)
Endocrinology
, vol.78
, pp. 773-778
-
-
Fain, J.N.1
Kovacev, V.P.2
Scow, R.O.3
-
30
-
-
79953186071
-
Next generation Akt inhibitors provide greater specificity-effects on glucose metabolism in adipocytes
-
Tan, S., Ng, Y., and James, D. E. (2011) Next generation Akt inhibitors provide greater specificity-effects on glucose metabolism in adipocytes. Biochem. J. 435, 539-544
-
(2011)
Biochem. J.
, vol.435
, pp. 539-544
-
-
Tan, S.1
Ng, Y.2
James, D.E.3
-
31
-
-
77949321235
-
Dissecting the mechanism of insulin resistance using a novel heterodimerization strategy to activate Akt
-
Ng, Y., Ramm, G., and James, D. E. (2010) Dissecting the mechanism of insulin resistance using a novel heterodimerization strategy to activate Akt. J. Biol. Chem. 285, 5232-5239
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 5232-5239
-
-
Ng, Y.1
Ramm, G.2
James, D.E.3
-
32
-
-
14444286453
-
Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt
-
Wang, D., and Sul, H. S. (1998) Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt. J. Biol. Chem. 273, 25420-25426
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 25420-25426
-
-
Wang, D.1
Sul, H.S.2
-
33
-
-
0037144604
-
Insulin and sterol-regulatory element-binding protein-1c (SREBP-1C) regulation of gene expression in 3T3-L1 adipocytes. Identification of CCAAT/enhancer-binding protein beta as an SREBP-1C target
-
Le Lay, S., Lefrère, I., Trautwein, C., Dugail, I., and Krief, S. (2002) Insulin and sterol-regulatory element-binding protein-1c (SREBP-1C) regulation of gene expression in 3T3-L1 adipocytes. Identification of CCAAT/enhancer-binding protein beta as an SREBP-1C target. J. Biol. Chem. 277, 35625-35634
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35625-35634
-
-
Le Lay, S.1
Lefrère, I.2
Trautwein, C.3
Dugail, I.4
Krief, S.5
-
34
-
-
0028961355
-
High fat diet-induced hyperglycemia: Prevention by low level expression of a glucose transporter (GLUT4) minigene in transgenic mice
-
Ikemoto, S., Thompson, K. S., Takahashi, M., Itakura, H., Lane, M. D., and Ezaki, O. (1995) High fat diet-induced hyperglycemia: prevention by low level expression of a glucose transporter (GLUT4) minigene in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 92, 3096-3099
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 3096-3099
-
-
Ikemoto, S.1
Thompson, K.S.2
Takahashi, M.3
Itakura, H.4
Lane, M.D.5
Ezaki, O.6
-
35
-
-
0028855754
-
High level overexpression of glucose transporter-4 driven by an adiposespecific promoter is maintained in transgenic mice on a high fat diet, but does not prevent impaired glucose tolerance
-
Gnudi, L., Tozzo, E., Shepherd, P. R., Bliss, J. L., and Kahn, B. B. (1995) High level overexpression of glucose transporter-4 driven by an adiposespecific promoter is maintained in transgenic mice on a high fat diet, but does not prevent impaired glucose tolerance. Endocrinology 136, 995-1002
-
(1995)
Endocrinology
, vol.136
, pp. 995-1002
-
-
Gnudi, L.1
Tozzo, E.2
Shepherd, P.R.3
Bliss, J.L.4
Kahn, B.B.5
-
36
-
-
33644672230
-
Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice
-
Park, S. Y., Cho, Y. R., Kim, H. J., Higashimori, T., Danton, C., Lee, M. K., Dey, A., Rothermel, B., Kim, Y. B., Kalinowski, A., Russell, K. S., and Kim, J. K. (2005) Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice. Diabetes 54, 3530-3540
-
(2005)
Diabetes
, vol.54
, pp. 3530-3540
-
-
Park, S.Y.1
Cho, Y.R.2
Kim, H.J.3
Higashimori, T.4
Danton, C.5
Lee, M.K.6
Dey, A.7
Rothermel, B.8
Kim, Y.B.9
Kalinowski, A.10
Russell, K.S.11
Kim, J.K.12
-
37
-
-
0031022434
-
Tumor necrosis factor-α-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction
-
Stephens, J. M., Lee, J., and Pilch, P. F. (1997) Tumor necrosis factor-α-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction. J. Biol. Chem. 272, 971-976
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 971-976
-
-
Stephens, J.M.1
Lee, J.2
Pilch, P.F.3
-
38
-
-
0035316142
-
Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport
-
Carvalho, E., Jansson, P. A., Nagaev, I., Wenthzel, A. M., and Smith, U. (2001) Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport. FASEB J. 15, 1101-1103
-
(2001)
FASEB J.
, vol.15
, pp. 1101-1103
-
-
Carvalho, E.1
Jansson, P.A.2
Nagaev, I.3
Wenthzel, A.M.4
Smith, U.5
-
39
-
-
79953810587
-
Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice
-
Yu, Z., Shao, W., Chiang, Y., Foltz, W., Zhang, Z., Ling, W., Fantus, I. G., and Jin, T. (2011) Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice. Diabetologia 54, 922-934
-
(2011)
Diabetologia
, vol.54
, pp. 922-934
-
-
Yu, Z.1
Shao, W.2
Chiang, Y.3
Foltz, W.4
Zhang, Z.5
Ling, W.6
Fantus, I.G.7
Jin, T.8
-
40
-
-
57349101675
-
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
-
Sabio, G., Das, M., Mora, A., Zhang, Z., Jun, J. Y., Ko, H. J., Barrett, T., Kim, J. K., and Davis, R. J. (2008) A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322, 1539-1543
-
(2008)
Science
, vol.322
, pp. 1539-1543
-
-
Sabio, G.1
Das, M.2
Mora, A.3
Zhang, Z.4
Jun, J.Y.5
Ko, H.J.6
Barrett, T.7
Kim, J.K.8
Davis, R.J.9
-
41
-
-
73549091444
-
Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance
-
Sabio, G., Kennedy, N. J., Cavanagh-Kyros, J., Jung, D. Y., Ko, H. J., Ong, H., Barrett, T., Kim, J. K., and Davis, R. J. (2010) Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Mol. Cell. Biol. 30, 106-115
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 106-115
-
-
Sabio, G.1
Kennedy, N.J.2
Cavanagh-Kyros, J.3
Jung, D.Y.4
Ko, H.J.5
Ong, H.6
Barrett, T.7
Kim, J.K.8
Davis, R.J.9
-
42
-
-
84863127179
-
Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes
-
Tan, S. X., Ng, Y., Meoli, C. C., Kumar, A., Khoo, P. S., Fazakerley, D. J., Junutula, J. R., Vali, S., James, D. E., and Stöckli, J. (2012) Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes. J. Biol. Chem. 287, 6128-6138
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 6128-6138
-
-
Tan, S.X.1
Ng, Y.2
Meoli, C.C.3
Kumar, A.4
Khoo, P.S.5
Fazakerley, D.J.6
Junutula, J.R.7
Vali, S.8
James, D.E.9
Stöckli, J.10
-
43
-
-
0032695529
-
A role for protein kinase Bβ/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes
-
Hill, M. M., Clark, S. F., Tucker, D. F., Birnbaum, M. J., James, D. E., and Macaulay, S. L. (1999) A role for protein kinase Bβ/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes. Mol. Cell. Biol. 19, 7771-7781
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 7771-7781
-
-
Hill, M.M.1
Clark, S.F.2
Tucker, D.F.3
Birnbaum, M.J.4
James, D.E.5
Macaulay, S.L.6
-
44
-
-
84860823513
-
An ATP-site on-off switch that restricts phosphatase accessibility of Akt
-
Lin, K., Lin, J., Wu, W. I., Ballard, J., Lee, B. B., Gloor, S. L., Vigers, G. P., Morales, T. H., Friedman, L. S., Skelton, N., and Brandhuber, B. J. (2012) An ATP-site on-off switch that restricts phosphatase accessibility of Akt. Sci. Signal. 5, ra37
-
(2012)
Sci. Signal.
, vol.5
, pp. ra37
-
-
Lin, K.1
Lin, J.2
Wu, W.I.3
Ballard, J.4
Lee, B.B.5
Gloor, S.L.6
Vigers, G.P.7
Morales, T.H.8
Friedman, L.S.9
Skelton, N.10
Brandhuber, B.J.11
-
45
-
-
84878871217
-
Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
-
Turner, N., Kowalski, G. M., Leslie, S. J., Risis, S., Yang, C., Lee-Young, R. S., Babb, J. R., Meikle, P. J., Lancaster, G. I., Henstridge, D. C., White, P. J., Kraegen, E. W., Marette, A., Cooney, G. J., Febbraio, M. A., and Bruce, C. R. (2013) Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding. Diabetologia 56, 1638-1648
-
(2013)
Diabetologia
, vol.56
, pp. 1638-1648
-
-
Turner, N.1
Kowalski, G.M.2
Leslie, S.J.3
Risis, S.4
Yang, C.5
Lee-Young, R.S.6
Babb, J.R.7
Meikle, P.J.8
Lancaster, G.I.9
Henstridge, D.C.10
White, P.J.11
Kraegen, E.W.12
Marette, A.13
Cooney, G.J.14
Febbraio, M.A.15
Bruce, C.R.16
-
46
-
-
4344601004
-
Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts
-
Mazumder, P. K., O'Neill, B. T., Roberts, M. W., Buchanan, J., Yun, U. J., Cooksey, R. C., Boudina, S., and Abel, E. D. (2004) Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. Diabetes 53, 2366-2374
-
(2004)
Diabetes
, vol.53
, pp. 2366-2374
-
-
Mazumder, P.K.1
O'neill, B.T.2
Roberts, M.W.3
Buchanan, J.4
Yun, U.J.5
Cooksey, R.C.6
Boudina, S.7
Abel, E.D.8
-
47
-
-
0019084534
-
Age-dependent development of insulin resistance of soleus muscle in genetically obese (ob/ob) mice
-
Grundleger, M. L., Godbole, V. Y., and Thenen, S. W. (1980) Age-dependent development of insulin resistance of soleus muscle in genetically obese (ob/ob) mice. Am. J. Physiol. 239, E363-E371
-
(1980)
Am. J. Physiol.
, vol.239
, pp. E363-E371
-
-
Grundleger, M.L.1
Godbole, V.Y.2
Thenen, S.W.3
-
48
-
-
0019068765
-
Early development of lipogenesis in genetically obese (ob/ob) mice
-
Godbole, V. Y., Grundleger, M. L., and Thenen, S. W. (1980) Early development of lipogenesis in genetically obese (ob/ob) mice. Am. J. Physiol. 239, E265-E268
-
(1980)
Am. J. Physiol.
, vol.239
, pp. E265-E268
-
-
Godbole, V.Y.1
Grundleger, M.L.2
Thenen, S.W.3
-
49
-
-
77649264504
-
Bifurcation of insulin signaling pathway in rat liver: MTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
-
Li, S., Brown, M. S., and Goldstein, J. L. (2010) Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc. Natl. Acad. Sci. U.S.A. 107, 3441-3446
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 3441-3446
-
-
Li, S.1
Brown, M.S.2
Goldstein, J.L.3
-
50
-
-
84916898719
-
Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects
-
Yore, M. M., Syed, I., Moraes-Vieira, P. M., Zhang, T., Herman, M. A., Homan, E. A., Patel, R. T., Lee, J., Chen, S., Peroni, O. D., Dhaneshwar, A. S., Hammarstedt, A., Smith, U., McGraw, T. E., Saghatelian, A., and Kahn, B. B. (2014) Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell 159, 318-332
-
(2014)
Cell
, vol.159
, pp. 318-332
-
-
Yore, M.M.1
Syed, I.2
Moraes-Vieira, P.M.3
Zhang, T.4
Herman, M.A.5
Homan, E.A.6
Patel, R.T.7
Lee, J.8
Chen, S.9
Peroni, O.D.10
Dhaneshwar, A.S.11
Hammarstedt, A.12
Smith, U.13
McGraw, T.E.14
Saghatelian, A.15
Kahn, B.B.16
-
51
-
-
0034635408
-
Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance
-
Clark, S. F., Molero, J. C., and James, D. E. (2000) Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance. J. Biol. Chem. 275, 3819-3826
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 3819-3826
-
-
Clark, S.F.1
Molero, J.C.2
James, D.E.3
-
52
-
-
0018237942
-
Insulin resistance, insulin insensitivity, and insulin unresponsiveness: A necessary distinction
-
Kahn, C. R. (1978) Insulin resistance, insulin insensitivity, and insulin unresponsiveness: a necessary distinction. Metabolism 27, 1893-1902
-
(1978)
Metabolism
, vol.27
, pp. 1893-1902
-
-
Kahn, C.R.1
-
53
-
-
0019435550
-
Normal valine disposal in obese subjects with impaired glucose disposal: Evidence for selective insulin resistance
-
Glass, A. R., Bongiovanni, R., Smith, C. E., and Boehm, T. M. (1981) Normal valine disposal in obese subjects with impaired glucose disposal: evidence for selective insulin resistance. Metabolism 30, 578-582
-
(1981)
Metabolism
, vol.30
, pp. 578-582
-
-
Glass, A.R.1
Bongiovanni, R.2
Smith, C.E.3
Boehm, T.M.4
-
54
-
-
67749088181
-
Direct effect of glucocorticoids on lipolysis in adipocytes
-
Xu, C., He, J., Jiang, H., Zu, L., Zhai, W., Pu, S., and Xu, G. (2009) Direct effect of glucocorticoids on lipolysis in adipocytes. Mol. Endocrinol. 23, 1161-1170
-
(2009)
Mol. Endocrinol.
, vol.23
, pp. 1161-1170
-
-
Xu, C.1
He, J.2
Jiang, H.3
Zu, L.4
Zhai, W.5
Pu, S.6
Xu, G.7
-
55
-
-
77449115115
-
Cluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membrane
-
Ng, Y., Ramm, G., Burchfield, J. G., Coster, A. C., Stöckli, J., and James, D. E. (2010) Cluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membrane. J. Biol. Chem. 285, 2245-2257
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 2245-2257
-
-
Ng, Y.1
Ramm, G.2
Burchfield, J.G.3
Coster, A.C.4
Stöckli, J.5
James, D.E.6
-
56
-
-
0020576117
-
In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus
-
Kashiwagi, A., Verso, M. A., Andrews, J., Vasquez, B., Reaven, G., and Foley, J. E. (1983) In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus. J. Clin. Invest. 72, 1246-1254
-
(1983)
J. Clin. Invest.
, vol.72
, pp. 1246-1254
-
-
Kashiwagi, A.1
Verso, M.A.2
Andrews, J.3
Vasquez, B.4
Reaven, G.5
Foley, J.E.6
-
57
-
-
0023683874
-
An in vitro human muscle preparation suitable for metabolic studies: Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects
-
Dohm, G. L., Tapscott, E. B., Pories, W. J., Dabbs, D. J., Flickinger, E. G., Meelheim, D., Fushiki, T., Atkinson, S. M., Elton, C. W., and Caro, J. F. (1988) An in vitro human muscle preparation suitable for metabolic studies: decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects. J. Clin. Invest. 82, 486-494
-
(1988)
J. Clin. Invest.
, vol.82
, pp. 486-494
-
-
Dohm, G.L.1
Tapscott, E.B.2
Pories, W.J.3
Dabbs, D.J.4
Flickinger, E.G.5
Meelheim, D.6
Fushiki, T.7
Atkinson, S.M.8
Elton, C.W.9
Caro, J.F.10
-
58
-
-
0021329432
-
Influence of hyperglycemia on insulin's in vivo effects in type II diabetes
-
Revers, R. R., Fink, R., Griffin, J., Olefsky, J. M., and Kolterman, O. G. (1984) Influence of hyperglycemia on insulin's in vivo effects in type II diabetes. J. Clin. Invest. 73, 664-672
-
(1984)
J. Clin. Invest.
, vol.73
, pp. 664-672
-
-
Revers, R.R.1
Fink, R.2
Griffin, J.3
Olefsky, J.M.4
Kolterman, O.G.5
-
59
-
-
33646148946
-
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta
-
Taniguchi, C. M., Kondo, T., Sajan, M., Luo, J., Bronson, R., Asano, T., Farese, R., Cantley, L. C., and Kahn, C. R. (2006) Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab. 3, 343-353
-
(2006)
Cell Metab.
, vol.3
, pp. 343-353
-
-
Taniguchi, C.M.1
Kondo, T.2
Sajan, M.3
Luo, J.4
Bronson, R.5
Asano, T.6
Farese, R.7
Cantley, L.C.8
Kahn, C.R.9
-
60
-
-
0043127453
-
Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation
-
Schubert, M., Brazil, D. P., Burks, D. J., Kushner, J. A., Ye, J., Flint, C. L., Farhang-Fallah, J., Dikkes, P., Warot, X. M., Rio, C., Corfas, G., and White, M. F. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J. Neurosci. 23, 7084-7092
-
(2003)
J. Neurosci.
, vol.23
, pp. 7084-7092
-
-
Schubert, M.1
Brazil, D.P.2
Burks, D.J.3
Kushner, J.A.4
Ye, J.5
Flint, C.L.6
Farhang-Fallah, J.7
Dikkes, P.8
Warot, X.M.9
Rio, C.10
Corfas, G.11
White, M.F.12
-
61
-
-
0034078910
-
Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous GLUT4 knockout mice
-
Li, J., Houseknecht, K. L., Stenbit, A. E., Katz, E. B., and Charron, M. J. (2000) Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous GLUT4 knockout mice. FASEB J. 14, 1117-1125
-
(2000)
FASEB J.
, vol.14
, pp. 1117-1125
-
-
Li, J.1
Houseknecht, K.L.2
Stenbit, A.E.3
Katz, E.B.4
Charron, M.J.5
-
62
-
-
24144479967
-
Acute bidirectional manipulation of muscle glucose uptake by in vivo electrotransfer of constructs targeting glucose transporter genes
-
Cleasby, M. E., Davey, J. R., Reinten, T. A., Graham, M. W., James, D. E., Kraegen, E. W., and Cooney, G. J. (2005) Acute bidirectional manipulation of muscle glucose uptake by in vivo electrotransfer of constructs targeting glucose transporter genes. Diabetes 54, 2702-2711
-
(2005)
Diabetes
, vol.54
, pp. 2702-2711
-
-
Cleasby, M.E.1
Davey, J.R.2
Reinten, T.A.3
Graham, M.W.4
James, D.E.5
Kraegen, E.W.6
Cooney, G.J.7
-
63
-
-
0025910841
-
Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity
-
Garvey, W. T., Maianu, L., Huecksteadt, T. P., Birnbaum, M. J., Molina, J. M., and Ciaraldi, T. P. (1991) Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity. J. Clin. Invest. 87, 1072-1081
-
(1991)
J. Clin. Invest.
, vol.87
, pp. 1072-1081
-
-
Garvey, W.T.1
Maianu, L.2
Huecksteadt, T.P.3
Birnbaum, M.J.4
Molina, J.M.5
Ciaraldi, T.P.6
-
64
-
-
0026723385
-
Gene expression of GLUT4 in skeletal muscle from insulinresistant patients with obesity, IGT, GDM, and NIDDM
-
Garvey, W. T., Maianu, L., Hancock, J. A., Golichowski, A. M., and Baron, A. (1992) Gene expression of GLUT4 in skeletal muscle from insulinresistant patients with obesity, IGT, GDM, and NIDDM. Diabetes 41, 465-475
-
(1992)
Diabetes
, vol.41
, pp. 465-475
-
-
Garvey, W.T.1
Maianu, L.2
Hancock, J.A.3
Golichowski, A.M.4
Baron, A.5
-
65
-
-
84873461338
-
Novel systems for dynamically assessing insulin action in live cells reveals heterogeneity in the insulin response
-
Burchfield, J. G., Lu, J., Fazakerley, D. J., Tan, S. X., Ng, Y., Mele, K., Buckley, M. J., Han, W., Hughes, W. E., and James, D. E. (2013) Novel systems for dynamically assessing insulin action in live cells reveals heterogeneity in the insulin response. Traffic 14, 259-273
-
(2013)
Traffic
, vol.14
, pp. 259-273
-
-
Burchfield, J.G.1
Lu, J.2
Fazakerley, D.J.3
Tan, S.X.4
Ng, Y.5
Mele, K.6
Buckley, M.J.7
Han, W.8
Hughes, W.E.9
James, D.E.10
-
66
-
-
84858796367
-
A two-way street: Reciprocal regulation of metabolism and signalling
-
Wellen, K. E., and Thompson, C. B. (2012) A two-way street: reciprocal regulation of metabolism and signalling. Nat. Rev. Mol. Cell Biol. 13, 270-276
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 270-276
-
-
Wellen, K.E.1
Thompson, C.B.2
-
67
-
-
0032719024
-
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
-
Jiang, Z. Y., Lin, Y. W., Clemont, A., Feener, E. P., Hein, K. D., Igarashi, M., Yamauchi, T., White, M. F., and King, G. L. (1999) Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J. Clin. Invest. 104, 447-457
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 447-457
-
-
Jiang, Z.Y.1
Lin, Y.W.2
Clemont, A.3
Feener, E.P.4
Hein, K.D.5
Igarashi, M.6
Yamauchi, T.7
White, M.F.8
King, G.L.9
-
68
-
-
79251541212
-
The extending network of FOXO transcriptional target genes
-
van der Vos, K. E., and Coffer, P. J. (2011) The extending network ofFOXO transcriptional target genes. Antioxid. Redox Signal. 14, 579-592
-
(2011)
Antioxid. Redox Signal.
, vol.14
, pp. 579-592
-
-
Van Der Vos, K.E.1
Coffer, P.J.2
|