Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation

Journal of Translational Medicine

Volumn 10, Issue 1, 2012, Pages

  Telang, Sucheta ^a,c   Clem, Brian F ^a   Klarer, Alden C ^a   Clem, Amy L ^a   Trent, John O ^a   Bucala, Richard ^b   Chesney, Jason ^a,c  

^a University of Louisville School of Medicine   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

6 bisphosphate; 6 Phosphofructo 2 kinase fructose 2, 6 bisphosphatase; Fructose 2; Glycolysis; T cell

Indexed keywords

3 (3 PYRIDINYL) 1 (4 PYRIDINYL) 2 PROPEN 1 ONE; 6 PHOSPHOFRUCTO 2 KINASE; DEOXYGLUCOSE; ENZYME INHIBITOR; FRUCTOSE 2,6 BISPHOSPHATASE; IMIQUIMOD; IMMUNOSUPPRESSIVE AGENT; LACTIC ACID; PLACEBO; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD3+ T LYMPHOCYTE; CELL AGGREGATION; CELLULAR IMMUNITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DELAYED HYPERSENSITIVITY; DRUG POTENCY; DRUG TARGETING; ENZYME INHIBITION; EXPERIMENTAL MOUSE; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PSORIASIS; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD; ENZYME-LINKED IMMUNOSORBENT ASSAY; HYPERSENSITIVITY, DELAYED; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; PHOSPHOFRUCTOKINASE-2; REAL-TIME POLYMERASE CHAIN REACTION; SMALL MOLECULE LIBRARIES; T-LYMPHOCYTES;

EID: 84861005700     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-10-95     Document Type: Article

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