메뉴 건너뛰기




Volumn 62, Issue 5, 2013, Pages 1417-1425

Metabolic signatures of human adipose tissue hypoxia in obesity

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LACTIC ACID; PYRUVIC ACID;

EID: 84876583610     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-1032     Document Type: Article
Times cited : (102)

References (50)
  • 3
    • 77949329629 scopus 로고    scopus 로고
    • Cellular hypoxia and adipose tissue dysfunction in obesity
    • Wood IS, de Heredia FP, Wang B, Trayhurn P. Cellular hypoxia and adipose tissue dysfunction in obesity. Proc Nutr Soc 2009;68:370-377
    • (2009) Proc Nutr Soc , vol.68 , pp. 370-377
    • Wood, I.S.1    De Heredia, F.P.2    Wang, B.3    Trayhurn, P.4
  • 4
    • 35148854599 scopus 로고    scopus 로고
    • Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    • DOI 10.1152/ajpendo.00435.2007
    • Ye J, Gao Z, Yin J, He Q. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 2007;293:E1118-E1128 (Pubitemid 47535846)
    • (2007) American Journal of Physiology - Endocrinology and Metabolism , vol.293 , Issue.4
    • Ye, J.1    Gao, Z.2    Yin, J.3    He, Q.4
  • 5
    • 6944237757 scopus 로고    scopus 로고
    • Adipokines: Inflammation and the pleiotropic role of white adipose tissue
    • DOI 10.1079/BJN20041213
    • Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004;92:347-355 (Pubitemid 40277057)
    • (2004) British Journal of Nutrition , vol.92 , Issue.3 , pp. 347-355
    • Trayhurn, P.1    Wood, I.S.2
  • 6
    • 79960359853 scopus 로고    scopus 로고
    • Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation
    • Goossens GH, Bizzarri A, Venteclef N, et al. Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation. Circulation 2011;124:67-76
    • (2011) Circulation , vol.124 , pp. 67-76
    • Goossens, G.H.1    Bizzarri, A.2    Venteclef, N.3
  • 7
    • 33847054376 scopus 로고    scopus 로고
    • Endocrine role of the renin-angiotensin system in human adipose tissue and muscle: Effect of beta-adrenergic stimulation
    • Goossens GH, Jocken JW, Blaak EE, Schiffers PM, Saris WH, van Baak MA. Endocrine role of the renin-angiotensin system in human adipose tissue and muscle: effect of beta-adrenergic stimulation. Hypertension 2007;49:542-547
    • (2007) Hypertension , vol.49 , pp. 542-547
    • Goossens, G.H.1    Jocken, J.W.2    Blaak, E.E.3    Schiffers, P.M.4    Saris, W.H.5    Van Baak, M.A.6
  • 8
    • 78751534190 scopus 로고    scopus 로고
    • Downregulation of adipose tissue fatty acid traf ficking in obesity: A driver for ectopic fat deposition?
    • McQuaid SE, Hodson L, Neville MJ, et al. Downregulation of adipose tissue fatty acid traf ficking in obesity: a driver for ectopic fat deposition? Diabetes 2011;60:47-55
    • (2011) Diabetes , vol.60 , pp. 47-55
    • McQuaid, S.E.1    Hodson, L.2    Neville, M.J.3
  • 9
    • 18544368076 scopus 로고    scopus 로고
    • Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans
    • Virtanen KA, Lönnroth P, Parkkola R, et al. Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans. J Clin Endocrinol Metab 2002;87:3902- 3910
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3902-3910
    • Virtanen, K.A.1    Lönnroth, P.2    Parkkola, R.3
  • 12
    • 62749167010 scopus 로고    scopus 로고
    • Reduced adipose tissue oxygenation in human obesity: Evidence for rarefaction, macrophage chemotaxis, and in flammation without an angiogenic response
    • Pasarica M, Sereda OR, Redman LM, et al. Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and in flammation without an angiogenic response. Diabetes 2009;58:718-725
    • (2009) Diabetes , vol.58 , pp. 718-725
    • Pasarica, M.1    Sereda, O.R.2    Redman, L.M.3
  • 13
    • 78650882667 scopus 로고    scopus 로고
    • Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: Decreased metabolism and increased immune response
    • Klimcáková E, Roussel B, Márquez-Quiñones A, et al. Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: decreased metabolism and increased immune response. J Clin Endocrinol Metab 2011;96:E73-E82
    • (2011) J Clin Endocrinol Metab , vol.96
    • Klimcáková, E.1    Roussel, B.2    Márquez-Quiñones, A.3
  • 14
    • 0002693194 scopus 로고
    • Organ and tissue contribution to metabolic rate
    • Kinney JM, Tucker HN, Eds. New York, Raven Press
    • Elia M. Organ and tissue contribution to metabolic rate. In Energy Metabolism: Tissue Determinants and Cellular Corollaries . Kinney JM, Tucker HN, Eds. New York, Raven Press, 1992, p. 61-79
    • (1992) Energy Metabolism: Tissue Determinants and Cellular Corollaries , pp. 61-79
    • Elia, M.1
  • 15
    • 0010741822 scopus 로고
    • Glucose uptake and gas exchange in human adipose tissue incubated in vitro
    • Pozza G, Ghidoni A, Basilico C. Glucose uptake and gas exchange in human adipose tissue incubated in vitro. Lancet 1963;1:836
    • (1963) Lancet , vol.1 , pp. 836
    • Pozza, G.1    Ghidoni, A.2    Basilico, C.3
  • 16
    • 0001274168 scopus 로고
    • The physiology of adipose tissue
    • Wertheimer E, Shapiro B. The physiology of adipose tissue. Physiol Rev 1948;28:451-464
    • (1948) Physiol Rev , vol.28 , pp. 451-464
    • Wertheimer, E.1    Shapiro, B.2
  • 17
    • 0024551026 scopus 로고
    • Metabolic characteristics of human adipose tissue in vivo
    • Frayn KN, Coppack SW, Humphreys SM, Whyte PL. Metabolic characteristics of human adipose tissue in vivo. Clin Sci (Lond) 1989;76:509-516 (Pubitemid 19116598)
    • (1989) Clinical Science , vol.76 , Issue.5 , pp. 509-516
    • Frayn, K.N.1    Coppack, S.W.2    Humphreys, S.M.3    Whyte, P.L.4
  • 18
    • 0029746036 scopus 로고    scopus 로고
    • Net carbon flux across subcutaneous adipose tissue after a standard meal in normal-weight and insulin-resistant obese subjects
    • Frayn KN, Humphreys SM, Coppack SW. Net carbon flux across subcutaneous adipose tissue after a standard meal in normal-weight and insulinresistant obese subjects. Int J Obes Relat Metab Disord 1996;20:795-800 (Pubitemid 26313100)
    • (1996) International Journal of Obesity , vol.20 , Issue.9 , pp. 795-800
    • Frayn, K.N.1    Humphreys, S.M.2    Coppack, S.W.3
  • 21
    • 0026602489 scopus 로고
    • Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis
    • Hotchkiss RS, Karl IE. Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. JAMA 1992;267:1503-1510
    • (1992) JAMA , vol.267 , pp. 1503-1510
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 22
    • 84856597372 scopus 로고    scopus 로고
    • Metabolic characteristics of human subcutaneous abdominal adipose tissue after overnight fast
    • Frayn KN, Humphreys SM. Metabolic characteristics of human subcutaneous abdominal adipose tissue after overnight fast. Am J Physiol Endocrinol Metab 2012;302:E468-E475
    • (2012) Am J Physiol Endocrinol Metab , vol.302
    • Frayn, K.N.1    Humphreys, S.M.2
  • 23
    • 77951665827 scopus 로고    scopus 로고
    • Development of an arterio-venous difference method to study the metabolic physiology of the femoral adipose tissue depot
    • Silver Spring
    • McQuaid SE, Manolopoulos KN, Dennis AL, Cheeseman J, Karpe F, Frayn KN. Development of an arterio-venous difference method to study the metabolic physiology of the femoral adipose tissue depot. Obesity (Silver Spring) 2010;18:1055-1058
    • (2010) Obesity , vol.18 , pp. 1055-1058
    • McQuaid, S.E.1    Manolopoulos, K.N.2    Dennis, A.L.3    Cheeseman, J.4    Karpe, F.5    Frayn, K.N.6
  • 24
    • 66149116077 scopus 로고    scopus 로고
    • Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage
    • Ruge T, Hodson L, Cheeseman J, et al. Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage. J Clin Endocrinol Metab 2009;94:1781-1788
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1781-1788
    • Ruge, T.1    Hodson, L.2    Cheeseman, J.3
  • 25
    • 48149097201 scopus 로고    scopus 로고
    • Adipose tissue fatty acid metabolism in insulin-resistant men
    • Bickerton AS, Roberts R, Fielding BA, et al. Adipose tissue fatty acid metabolism in insulin-resistant men. Diabetologia 2008;51:1466-1474
    • (2008) Diabetologia , vol.51 , pp. 1466-1474
    • Bickerton, A.S.1    Roberts, R.2    Fielding, B.A.3
  • 26
    • 0026538763 scopus 로고
    • Adipose tissue metabolism in obesity: Lipase action in vivo before and after a mixed meal
    • Coppack SW, Evans RD, Fisher RM, et al. Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal. Metabolism 1992;41:264-272
    • (1992) Metabolism , vol.41 , pp. 264-272
    • Coppack, S.W.1    Evans, R.D.2    Fisher, R.M.3
  • 28
    • 31444436445 scopus 로고    scopus 로고
    • The in vivo effects of the Pro12Ala PPARgamma2 polymorphism on adipose tissue NEFA metabolism: The first use of the Oxford Biobank
    • DOI 10.1007/s00125-005-0044-z
    • Tan GD, Neville MJ, Liverani E, et al. The in vivo effects of the Pro12Ala PPARgamma2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank. Diabetologia 2006;49:158-168 (Pubitemid 43151627)
    • (2006) Diabetologia , vol.49 , Issue.1 , pp. 158-168
    • Tan, G.D.1    Neville, M.J.2    Liverani, E.3    Humphreys, S.M.4    Currie, J.M.5    Dennis, L.6    Fielding, B.A.7    Karpe, F.8
  • 31
    • 0027455528 scopus 로고
    • Local forearm and whole-body respiratory quotient in humans after an oral glucose load: Methodological problems
    • Simonsen L, Bülow J, Madsen J, Hermansen F, Astrup A. Local forearm and whole-body respiratory quotient in humans after an oral glucose load: methodological problems. Acta Physiol Scand 1993;147:69-75 (Pubitemid 23035586)
    • (1993) Acta Physiologica Scandinavica , vol.147 , Issue.1 , pp. 69-75
    • Simonsen, L.1    Bulow, J.2    Madsen, J.3    Hermansen, F.4    Astrup, A.5
  • 32
    • 33847074643 scopus 로고    scopus 로고
    • Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period
    • Bickerton AS, Roberts R, Fielding BA, et al. Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period. Diabetes 2007;56:168 -176
    • (2007) Diabetes , vol.56 , pp. 168-176
    • Bickerton, A.S.1    Roberts, R.2    Fielding, B.A.3
  • 33
    • 0027440295 scopus 로고
    • Interpretation of oxygen and carbon dioxide exchange across tissue beds in vivo
    • Frayn KN, Lund P, Walker M. Interpretation of oxygen and carbon dioxide exchange across tissue beds in vivo. Clin Sci (Lond) 1993;85:373-384 (Pubitemid 23308447)
    • (1993) Clinical Science , vol.85 , Issue.4 , pp. 373-384
    • Frayn, K.N.1    Lund, P.2    Walker, M.3
  • 34
    • 0033976814 scopus 로고    scopus 로고
    • Evolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholamine-treated septic shock
    • Levy B, Sadoune LO, Gelot AM, Bollaert PE, Nabet P, Larcan A. Evolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholamine-treated septic shock. Crit Care Med 2000;28:114-119 (Pubitemid 30091039)
    • (2000) Critical Care Medicine , vol.28 , Issue.1 , pp. 114-119
    • Levy, B.1    Sadoune, L.-O.2    Gelot, A.-M.3    Bollaert, P.-E.4    Nabet, P.5    Larcan, A.6
  • 36
    • 0019637510 scopus 로고
    • Massive weight loss will improve arterial oxygenation in selected patients
    • Sugerman HJ, Fairman RP. Massive weight loss will improve arterial oxygenation in selected patients. Anesthesiology 1981;55:604-605
    • (1981) Anesthesiology , vol.55 , pp. 604-605
    • Sugerman, H.J.1    Fairman, R.P.2
  • 37
    • 0028985547 scopus 로고
    • Beta-adrenergic stimulation and abdominal subcutaneous fat blood flow in lean, obese, and reduced-obese subjects
    • Blaak EE, van Baak MA, Kemerink GJ, Pakbiers MT, Heidendal GA, Saris WH. Beta-adrenergic stimulation and abdominal subcutaneous fat blood flow in lean, obese, and reduced-obese subjects. Metabolism 1995;44:183-187
    • (1995) Metabolism , vol.44 , pp. 183-187
    • Blaak, E.E.1    Van Baak, M.A.2    Kemerink, G.J.3    Pakbiers, M.T.4    Heidendal, G.A.5    Saris, W.H.6
  • 38
    • 0027958360 scopus 로고
    • Adipose tissue density, estimated adipose lipid fraction and whole body adiposity in male cadavers
    • Martin AD, Daniel MZ, Drinkwater DT, Clarys JP. Adipose tissue density, estimated adipose lipid fraction and whole body adiposity in male cadavers. Int J Obes Relat Metab Disord 1994;18:79-83 (Pubitemid 24056310)
    • (1994) International Journal of Obesity , vol.18 , Issue.2 , pp. 79-83
    • Martin, A.D.1    Daniel, M.Z.2    Drinkwater, D.T.3    Clarys, J.P.4
  • 39
    • 0015256850 scopus 로고
    • Estimation of arterial PO2, PCO2, pH, and lactate from arterialized venous blood
    • Forster HV, Dempsey JA, Thomson J, Vidruk E, DoPico GA. Estimation of arterial PO2, PCO2, pH, and lactate from arterialized venous blood. J Appl Physiol 1972;32:134-137
    • (1972) J Appl Physiol , vol.32 , pp. 134-137
    • Forster, H.V.1    Dempsey, J.A.2    Thomson, J.3    Vidruk, E.4    DoPico, G.A.5
  • 40
    • 0000044662 scopus 로고
    • The quantitatively minor role of carbohydrate in oxidative metabolism by skeletal muscle in intact man in the basal state; measurements of oxygen and glucose uptake and carbon dioxide and lactate production in the forearm
    • Andres R, Cader G, Zierler KL. The quantitatively minor role of carbohydrate in oxidative metabolism by skeletal muscle in intact man in the basal state; measurements of oxygen and glucose uptake and carbon dioxide and lactate production in the forearm. J Clin Invest 1956;35:671-682
    • (1956) J Clin Invest , vol.35 , pp. 671-682
    • Andres, R.1    Cader, G.2    Zierler, K.L.3
  • 44
    • 80051806800 scopus 로고    scopus 로고
    • De novo lipogenesis in the differentiating human adipocyte can provide all fatty acids necessary for maturation
    • Collins JM, Neville MJ, Pinnick KE, et al. De novo lipogenesis in the differentiating human adipocyte can provide all fatty acids necessary for maturation. J Lipid Res 2011;52:1683-1692
    • (2011) J Lipid Res , vol.52 , pp. 1683-1692
    • Collins, J.M.1    Neville, M.J.2    Pinnick, K.E.3
  • 45
    • 64149103134 scopus 로고    scopus 로고
    • Markers of de novo lipogenesis in adipose tissue: Associations with small adipocytes and insulin sensitivity in humans
    • Roberts R, Hodson L, Dennis AL, et al. Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans. Diabetologia 2009;52:882-890
    • (2009) Diabetologia , vol.52 , pp. 882-890
    • Roberts, R.1    Hodson, L.2    Dennis, A.L.3
  • 47
    • 77049114953 scopus 로고    scopus 로고
    • Stranger in a strange land: Roles of glycogen turnover in adipose tissue metabolism
    • Markan KR, Jurczak MJ, Brady MJ. Stranger in a strange land: roles of glycogen turnover in adipose tissue metabolism. Mol Cell Endocrinol 2010;318:54-60
    • (2010) Mol Cell Endocrinol , vol.318 , pp. 54-60
    • Markan, K.R.1    Jurczak, M.J.2    Brady, M.J.3
  • 50
    • 0014317833 scopus 로고
    • Blood pyruvate and plasma glucose levels during oral and intravenous glucose tolerance tests in obese and nonobese women
    • Doar JW, Wynn V, Cramp DG. Blood pyruvate and plasma glucose levels during oral and intravenous glucose tolerance tests in obese and nonobese women. Metabolism 1968;17:690-701
    • (1968) Metabolism , vol.17 , pp. 690-701
    • Doar, J.W.1    Wynn, V.2    Cramp, D.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.