메뉴 건너뛰기




Volumn 11, Issue 6, 2015, Pages 1368-1386

A paradigm shift: Cancer therapy with peptide-based B-cell epitopes and peptide immunotherapeutics targeting multiple solid tumor types: Emerging concepts and validation of combination immunotherapy

Author keywords

Antibodies; Epitopes; Immunogenicity; Peptide mimics; Resistance; Vaccine candidates

Indexed keywords

CANCER VACCINE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPITOPE; IMMUNOMODULATING AGENT; PERTUZUMAB; SOMATOMEDIN C RECEPTOR; TRASTUZUMAB; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR;

EID: 84944456359     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.1080/21645515.2015.1026495     Document Type: Review
Times cited : (18)

References (188)
  • 1
    • 84865245173 scopus 로고    scopus 로고
    • Peptide vaccines and targeting HER and VEGF proteins may offer a potentially new paradigm in cancer immunotherapy
    • PMID:22894670
    • Kaumaya PT, Foy KC. Peptide vaccines and targeting HER and VEGF proteins may offer a potentially new paradigm in cancer immunotherapy. Future Oncol 2012; 8:961-87; PMID:22894670; http://dx. doi. org/ 10. 2217/fon. 12. 95
    • (2012) Future Oncol , vol.8 , pp. 961-987
    • Kaumaya, P.T.1    Foy, K.C.2
  • 2
    • 84887236342 scopus 로고    scopus 로고
    • Bridging oncology and immunology: Expanding horizons with innovative peptide vaccines and peptidomimetics
    • PMID:24188668
    • Kaumaya PT. Bridging oncology and immunology: expanding horizons with innovative peptide vaccines and peptidomimetics. Immunotherapy 2013; 5:1159-63; PMID:24188668; http://dx. doi. org/ 10. 2217/imt. 13. 128
    • (2013) Immunotherapy , vol.5 , pp. 1159-1163
    • Kaumaya, P.T.1
  • 3
    • 84886315269 scopus 로고    scopus 로고
    • Cancer immunotherapy: Present status, future perspective, and a new paradigm of peptide immunotherapeutics
    • PMID:23545045
    • Miller MJ, Foy KC, Kaumaya PT. Cancer immunotherapy: present status, future perspective, and a new paradigm of peptide immunotherapeutics. Discov Med 2013; 15:166-76; PMID:23545045
    • (2013) Discov Med , vol.15 , pp. 166-176
    • Miller, M.J.1    Foy, K.C.2    Kaumaya, P.T.3
  • 4
    • 79953869885 scopus 로고    scopus 로고
    • Engineered conformation-dependent VEGF peptide mimics are effective in inhibiting VEGF signaling pathways
    • PMID:21321115
    • Vicari D, Foy KC, Liotta EM, Kaumaya PT. Engineered conformation-dependent VEGF peptide mimics are effective in inhibiting VEGF signaling pathways. J Biol Chem 2011; 286:13612-25; PMID:21321115; http://dx. doi. org/10. 1074/jbc. M110. 216812
    • (2011) J Biol Chem , vol.286 , pp. 13612-13625
    • Vicari, D.1    Foy, K.C.2    Liotta, E.M.3    Kaumaya, P.T.4
  • 5
    • 84860876434 scopus 로고    scopus 로고
    • Current advances in humanized mouse models
    • PMID:22327211
    • Ito R, Takahashi T, Katano I, Ito M. Current advances in humanized mouse models. Cell Mol Immunol 2012; 9:208-14; PMID:22327211; http://dx. doi. org/ 10. 1038/cmi. 2012. 2
    • (2012) Cell Mol Immunol , vol.9 , pp. 208-214
    • Ito, R.1    Takahashi, T.2    Katano, I.3    Ito, M.4
  • 6
    • 84939988507 scopus 로고    scopus 로고
    • Immune checkpoint modulation: Rational design of combination strategies
    • PMID:25583297
    • Zamarin D, Postow MA. Immune checkpoint modulation: Rational design of combination strategies. Pharmacol Ther 2015; PMID:25583297
    • (2015) Pharmacol Ther
    • Zamarin, D.1    Postow, M.A.2
  • 7
    • 79953054421 scopus 로고    scopus 로고
    • Strategies to improve radiotherapy with targeted drugs
    • PMID:21430696
    • Begg AC, Stewart FA, Vens C. Strategies to improve radiotherapy with targeted drugs. Nat Rev Cancer 2011; 11:239-53; PMID:21430696; http://dx. doi. org/10. 1038/nrc3007
    • (2011) Nat Rev Cancer , vol.11 , pp. 239-253
    • Begg, A.C.1    Stewart, F.A.2    Vens, C.3
  • 8
    • 84858760109 scopus 로고    scopus 로고
    • Combining immunotherapy and targeted therapies in cancer treatment
    • PMID:22437869
    • Vanneman M, Dranoff G. Combining immunotherapy and targeted therapies in cancer treatment. Nat Rev Cancer 2012; 12:237-51; PMID:22437869; http://dx. doi. org/10. 1038/nrc3237
    • (2012) Nat Rev Cancer , vol.12 , pp. 237-251
    • Vanneman, M.1    Dranoff, G.2
  • 9
    • 84867843579 scopus 로고    scopus 로고
    • Cancer chemotherapy: A critical analysis of its 60 years of history
    • PMID:22542531
    • Galmarini D, Galmarini CM, Galmarini FC. Cancer chemotherapy: a critical analysis of its 60 years of history. Crit Rev Oncol Hematol 2012; 84:181-99; PMID:22542531; http://dx. doi. org/10. 1016/j. critrevonc. 2012. 03. 002
    • (2012) Crit Rev Oncol Hematol , vol.84 , pp. 181-199
    • Galmarini, D.1    Galmarini, C.M.2    Galmarini, F.C.3
  • 10
    • 0035256698 scopus 로고    scopus 로고
    • Untangling the ErbB signalling network
    • PMID:11252954
    • Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2001; 2:127- 37; PMID:11252954; http://dx. doi. org/10. 1038/ 35052073
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 127-137
    • Yarden, Y.1    Sliwkowski, M.X.2
  • 11
    • 0024478054 scopus 로고
    • p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor
    • PMID:2566907
    • Hudziak RM, Lewis GD, Winget M, Fendly BM, Shepard HM, Ullrich A. p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor. Mol Cell Biol 1989; 9:1165-72; PMID:2566907
    • (1989) Mol Cell Biol , vol.9 , pp. 1165-1172
    • Hudziak, R.M.1    Lewis, G.D.2    Winget, M.3    Fendly, B.M.4    Shepard, H.M.5    Ullrich, A.6
  • 13
    • 21244475061 scopus 로고    scopus 로고
    • ZD6474-a novel inhibitor of VEGFR and EGFR tyrosine kinase activity
    • PMID:15928657
    • Ryan AJ, Wedge SR. ZD6474-a novel inhibitor of VEGFR and EGFR tyrosine kinase activity. Br J Cancer 2005; 92 Suppl 1:S6-13; PMID:15928657; http://dx. doi. org/10. 1038/sj. bjc. 6602603
    • (2005) Br J Cancer , vol.92 , pp. S6-13
    • Ryan, A.J.1    Wedge, S.R.2
  • 14
    • 0036281152 scopus 로고    scopus 로고
    • KDR (VEGF receptor 2) is the major mediator for the hypotensive effect of VEGF
    • PMID:12052848
    • Li B, Ogasawara AK, Yang R, Wei W, He GW, Zioncheck TF, Bunting S, de Vos AM, Jin H. KDR (VEGF receptor 2) is the major mediator for the hypotensive effect of VEGF. Hypertension 2002; 39:1095-100; PMID:12052848; http://dx. doi. org/ 10. 1161/01. HYP. 0000018588. 56950. 7A
    • (2002) Hypertension , vol.39 , pp. 1095-1100
    • Li, B.1    Ogasawara, A.K.2    Yang, R.3    Wei, W.4    He, G.W.5    Zioncheck, T.F.6    Bunting, S.7    de Vos, A.M.8    Jin, H.9
  • 15
    • 33845313345 scopus 로고    scopus 로고
    • The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review
    • PMID:17098419
    • Eskens FA, Verweij J. The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review. Eur J Cancer 2006; 42:3127-39; PMID:17098419; http://dx. doi. org/10. 1016/j. ejca. 2006. 09. 015
    • (2006) Eur J Cancer , vol.42 , pp. 3127-3139
    • Eskens, F.A.1    Verweij, J.2
  • 16
    • 34047219240 scopus 로고    scopus 로고
    • Recognizing and managing toxicities of molecular targeted therapies for colorectal cancer
    • PMID:17354514
    • Grothey A. Recognizing and managing toxicities of molecular targeted therapies for colorectal cancer. Oncology (Williston Park) 2006; 20:21-8; PMID:17354514
    • (2006) Oncology (Williston Park) , vol.20 , pp. 21-28
    • Grothey, A.1
  • 18
    • 33645512281 scopus 로고    scopus 로고
    • Her-2/neu Cancer Vaccines: Present Status and Future Prospects
    • Kaumaya P. Her-2/neu Cancer Vaccines: Present Status and Future Prospects. International journal of peptide research and therapeutics 2006; 12:65-77; http:// dx. doi. org/10. 1007/s10989-005-9000-5
    • (2006) International journal of peptide research and therapeutics , vol.12 , pp. 65-77
    • Kaumaya, P.1
  • 19
    • 0022519337 scopus 로고
    • Three-dimensional structure of an antigen-antibody complex at 2. 8 A resolution
    • PMID:2426778
    • Amit AG, Mariuzza RA, Phillips SE, Poljak RJ. Three-dimensional structure of an antigen-antibody complex at 2. 8 A resolution. Science 1986; 233:747- 53; PMID:2426778; http://dx. doi. org/10. 1126/ science. 2426778
    • (1986) Science , vol.233 , pp. 747-753
    • Amit, A.G.1    Mariuzza, R.A.2    Phillips, S.E.3    Poljak, R.J.4
  • 21
    • 84925884639 scopus 로고    scopus 로고
    • Computational prediction of B cell epitopes from antigen sequences
    • PMID:25048126
    • Gao J, Kurgan L. Computational prediction of B cell epitopes from antigen sequences. Methods Mol Biol 2014; 1184:197-215; PMID:25048126; http://dx. doi. org/10. 1007/978-1-4939-1115-8_11
    • (2014) Methods Mol Biol , vol.1184 , pp. 197-215
    • Gao, J.1    Kurgan, L.2
  • 22
    • 84885405356 scopus 로고    scopus 로고
    • The structural basis of antibody-antigen recognition
    • PMID:24115948
    • Sela-Culang I, Kunik V, Ofran Y. The structural basis of antibody-antigen recognition. Front Immunol 2013; 4:302; PMID:24115948; http://dx. doi. org/ 10. 3389/fimmu. 2013. 00302
    • (2013) Front Immunol , vol.4 , pp. 302
    • Sela-Culang, I.1    Kunik, V.2    Ofran, Y.3
  • 23
    • 0026723158 scopus 로고
    • Design and immunological properties of topographic immunogenic determinants of a protein antigen (LDH-C4) as vaccines
    • PMID:1372905
    • Kaumaya PT, VanBuskirk AM, Goldberg E, Pierce SK. Design and immunological properties of topographic immunogenic determinants of a protein antigen (LDH-C4) as vaccines. J Biol Chem 1992; 267:6338-46; PMID:1372905
    • (1992) J Biol Chem , vol.267 , pp. 6338-6346
    • Kaumaya, P.T.1    VanBuskirk, A.M.2    Goldberg, E.3    Pierce, S.K.4
  • 24
    • 0027453468 scopus 로고
    • Engineered topographic determinants with α β, β α β, and β α β α topologies show high affinity binding to native protein antigen (lactate dehydrogenase-C4)
    • PMID:8244959
    • Kobs-Conrad S, Lee H, DiGeorge AM, Kaumaya PT. Engineered topographic determinants with α β, β α β, and β α β α topologies show high affinity binding to native protein antigen (lactate dehydrogenase-C4). J Biol Chem 1993; 268:25285-95; PMID:8244959
    • (1993) J Biol Chem , vol.268 , pp. 25285-25295
    • Kobs-Conrad, S.1    Lee, H.2    DiGeorge, A.M.3    Kaumaya, P.T.4
  • 25
    • 12844271532 scopus 로고    scopus 로고
    • Conformational HER-2/neu B-cell epitope peptide vaccine designed to incorporate two native disulfide bonds enhances tumor cell binding and antitumor activities
    • PMID:15507452
    • Dakappagari NK, LuteKD, Rawale S, Steele JT, Allen SD, Phillips G, Reilly RT, Kaumaya PT. Conformational HER-2/neu B-cell epitope peptide vaccine designed to incorporate two native disulfide bonds enhances tumor cell binding and antitumor activities. J Biol Chem 2005; 280:54-63; PMID:15507452; http://dx. doi. org/10. 1074/jbc. M411020200
    • (2005) J Biol Chem , vol.280 , pp. 54-63
    • Dakappagari, N.K.1    Lute, K.D.2    Rawale, S.3    Steele, J.T.4    Allen, S.D.5    Phillips, G.6    Reilly, R.T.7    Kaumaya, P.T.8
  • 26
    • 34249820537 scopus 로고    scopus 로고
    • Novel engineered trastuzumab conformational epitopes demonstrate in vitro and in vivo antitumor properties against HER-2/neu
    • Garrett JT, Rawale S, Allen SD, Phillips G, Forni G, Morris JC, Kaumaya PT. Novel engineered trastuzumab conformational epitopes demonstrate in vitro and in vivo antitumor properties against HER-2/neu. Journal of immunology 2007; 178:7120-31; http:// dx. doi. org/10. 4049/jimmunol. 178. 11. 7120
    • (2007) Journal of immunology , vol.178 , pp. 7120-7131
    • Garrett, J.T.1    Rawale, S.2    Allen, S.D.3    Phillips, G.4    Forni, G.5    Morris, J.C.6    Kaumaya, P.T.7
  • 28
    • 84875513085 scopus 로고    scopus 로고
    • Identification of relevant conformational epitopes on the HER2 oncoprotein by using Large Fragment Phage Display (LFPD)
    • PMID:23555577
    • Gabrielli F, Salvi R, Garulli C, Kalogris C, Arima S, Tardella L, Monaci P, Pupa SM, Tagliabue E, Montani M, et al. Identification of relevant conformational epitopes on the HER2 oncoprotein by using Large Fragment Phage Display (LFPD). PLoS One 2013; 8: e58358; PMID:23555577; http://dx. doi. org/ 10. 1371/journal. pone. 0058358
    • (2013) PLoS One , vol.8
    • Gabrielli, F.1    Salvi, R.2    Garulli, C.3    Kalogris, C.4    Arima, S.5    Tardella, L.6    Monaci, P.7    Pupa, S.M.8    Tagliabue, E.9    Montani, M.10
  • 29
    • 0027605718 scopus 로고
    • Peptide vaccines incorporating a 'promiscuous' T-cell epitope bypass certain haplotype restricted immune responses and provide broad spectrum immunogenicity
    • PMID:7508238
    • Kaumaya PT, Kobs-Conrad S, Seo YH, Lee H, Van- Buskirk AM, Feng N, Sheridan JF, Stevens V. Peptide vaccines incorporating a 'promiscuous' T-cell epitope bypass certain haplotype restricted immune responses and provide broad spectrum immunogenicity. J Mol Recognit 1993; 6:81-94; PMID:7508238; http://dx. doi. org/10. 1002/jmr. 300060206
    • (1993) J Mol Recognit , vol.6 , pp. 81-94
    • Kaumaya, P.T.1    Kobs-Conrad, S.2    Seo, Y.H.3    Lee, H.4    Van-Buskirk, A.M.5    Feng, N.6    Sheridan, J.F.7    Stevens, V.8
  • 30
    • 84878402196 scopus 로고    scopus 로고
    • Self-adjuvanting synthetic antitumor vaccines from MUC1 glycopeptides conjugated to T-cell epitopes from tetanus toxoid
    • PMID:23616304
    • Cai H, Chen MS, Sun ZY, Zhao YF, Kunz H, Li YM. Self-adjuvanting synthetic antitumor vaccines from MUC1 glycopeptides conjugated to T-cell epitopes from tetanus toxoid. Angew Chem Int Ed Engl 2013; 52:6106-10; PMID:23616304; http://dx. doi. org/ 10. 1002/anie. 201300390
    • (2013) Angew Chem Int Ed Engl , vol.52 , pp. 6106-6110
    • Cai, H.1    Chen, M.S.2    Sun, Z.Y.3    Zhao, Y.F.4    Kunz, H.5    Li, Y.M.6
  • 31
    • 74849113525 scopus 로고    scopus 로고
    • A virosomal formulated Her-2/neu multi-peptide vaccine induces Her-2/neu-specific immune responses in patients with metastatic breast cancer: A phase I study
    • PMID:20092022
    • Wiedermann U, Wiltschke C, Jasinska J, Kundi M, Zurbriggen R, Garner-Spitzer E, Bartsch R, Steger G, Pehamberger H, Scheiner O, et al. A virosomal formulated Her-2/neu multi-peptide vaccine induces Her-2/neu-specific immune responses in patients with metastatic breast cancer: a phase I study. Breast Cancer Res Treat 2010; 119:673-83; PMID:20092022; http://dx. doi. org/10. 1007/s10549-009-0666-9
    • (2010) Breast Cancer Res Treat , vol.119 , pp. 673-683
    • Wiedermann, U.1    Wiltschke, C.2    Jasinska, J.3    Kundi, M.4    Zurbriggen, R.5    Garner-Spitzer, E.6    Bartsch, R.7    Steger, G.8    Pehamberger, H.9    Scheiner, O.10
  • 32
    • 84872473737 scopus 로고    scopus 로고
    • Vaccination for the prevention and treatment of breast cancer with special focus on Her-2/neu peptide vaccines
    • PMID:23340862
    • Wiedermann U, Davis AB, Zielinski CC. Vaccination for the prevention and treatment of breast cancer with special focus on Her-2/neu peptide vaccines. Breast Cancer Res Treat 2013; 138:1-12; PMID:23340862; http://dx. doi. org/10. 1007/s10549-013-2410-8
    • (2013) Breast Cancer Res Treat , vol.138 , pp. 1-12
    • Wiedermann, U.1    Davis, A.B.2    Zielinski, C.C.3
  • 34
    • 27944464948 scopus 로고    scopus 로고
    • Vaccination with cetuximab mimotopes and biological properties of induced antiepidermal growth factor receptor antibodies
    • PMID:16288119
    • Riemer AB, Kurz H, Klinger M, Scheiner O, Zielinski CC, Jensen-Jarolim E. Vaccination with cetuximab mimotopes and biological properties of induced antiepidermal growth factor receptor antibodies. J Natl Cancer Inst 2005; 97:1663-70; PMID:16288119; http://dx. doi. org/10. 1093/jnci/dji373
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1663-1670
    • Riemer, A.B.1    Kurz, H.2    Klinger, M.3    Scheiner, O.4    Zielinski, C.C.5    Jensen-Jarolim, E.6
  • 35
    • 84881240568 scopus 로고    scopus 로고
    • B-cell epitope peptide vaccination targeting dimer interface of epidermal growth factor receptor (EGFR)
    • PMID:23871733
    • Zhu L, Zhao L, Wu M, Chen Z, Li H. B-cell epitope peptide vaccination targeting dimer interface of epidermal growth factor receptor (EGFR). Immunol Lett 2013; 153:33-40; PMID:23871733; http://dx. doi. org/10. 1016/j. imlet. 2013. 07. 003
    • (2013) Immunol Lett , vol.153 , pp. 33-40
    • Zhu, L.1    Zhao, L.2    Wu, M.3    Chen, Z.4    Li, H.5
  • 37
    • 33645512281 scopus 로고    scopus 로고
    • HER-2/neu cancer vaccines: Present status and future prospects
    • Kaumaya PTP. HER-2/neu cancer vaccines: Present status and future prospects. International Journal of Peptide Research and Therapeutics 2006; 12:65-77; http://dx. doi. org/10. 1007/s10989-005-9000-5
    • (2006) International Journal of Peptide Research and Therapeutics , vol.12 , pp. 65-77
    • Kaumaya, P.T.P.1
  • 38
    • 33646174446 scopus 로고    scopus 로고
    • Advances in HTLV-1 peptide vaccines and therapeutics
    • PMID:16611139
    • Lynch MP, Kaumaya PTP. Advances in HTLV-1 peptide vaccines and therapeutics. Current Protein and Peptide Science 2006; 7:137-45; PMID:16611139; http://dx. doi. org/10. 2174/ 138920306776359803
    • (2006) Current Protein and Peptide Science , vol.7 , pp. 137-145
    • Lynch, M.P.1    Kaumaya, P.T.P.2
  • 40
    • 84884932944 scopus 로고    scopus 로고
    • Therapeutic Peptides Targeting HER-2/neu and VEGF Signaling Pathways in Breast Cancer
    • Foy KC, Vicari D, Kaumaya PTP. Therapeutic Peptides Targeting HER-2/neu and VEGF Signaling Pathways in Breast Cancer. Handbook of Biologically Active Peptides, 2013:612-6; http://dx. doi. org/ 10. 1016/B978-0-12-385095-9. 00083-X
    • (2013) Handbook of Biologically Active Peptides , pp. 612-616
    • Foy, K.C.1    Vicari, D.2    Kaumaya, P.T.P.3
  • 41
    • 84886315269 scopus 로고    scopus 로고
    • Cancer immunotherapy: Present status, future perspective, and a new paradigm of peptide immunotherapeutics
    • PMID:23545045
    • Miller MJ, Foy KC, Kaumaya PTP. Cancer immunotherapy: Present status, future perspective, and a new paradigm of peptide immunotherapeutics. Discov Med 2013; 15:166-76; PMID:23545045
    • (2013) Discov Med , vol.15 , pp. 166-176
    • Miller, M.J.1    Foy, K.C.2    Kaumaya, P.T.P.3
  • 42
    • 0025129294 scopus 로고
    • Synthesis and biophysical characterization of engineered topographic immunogenic determinants with α α topology
    • PMID:1691014
    • Kaumaya PT, Berndt KD, Heidorn DB, Trewhella J, Kezdy FJ, Goldberg E. Synthesis and biophysical characterization of engineered topographic immunogenic determinants with α α topology. Biochemistry 1990; 29:13-23; PMID:1691014; http://dx. doi. org/ 10. 1021/bi00453a002
    • (1990) Biochemistry , vol.29 , pp. 13-23
    • Kaumaya, P.T.1    Berndt, K.D.2    Heidorn, D.B.3    Trewhella, J.4    Kezdy, F.J.5    Goldberg, E.6
  • 43
    • 0037446525 scopus 로고    scopus 로고
    • A chimeric multi-human epidermal growth factor receptor-2 B cell epitope peptide vaccine mediates superior antitumor responses
    • Dakappagari NK, Pyles J, Parihar R, Carson WE, Young DC, Kaumaya PT. A chimeric multi-human epidermal growth factor receptor-2 B cell epitope peptide vaccine mediates superior antitumor responses. JImmunol 2003; 170:4242-53; http://dx. doi. org/ 10. 4049/jimmunol. 170. 8. 4242
    • (2003) JImmunol , vol.170 , pp. 4242-4253
    • Dakappagari, N.K.1    Pyles, J.2    Parihar, R.3    Carson, W.E.4    Young, D.C.5    Kaumaya, P.T.6
  • 44
    • 0035400145 scopus 로고    scopus 로고
    • A retro-inverso peptide mimic of CD28 encompassing the MYPPPY motif adopts a polyproline type II helix and inhibits encephalitogenic T cells in vitro
    • Srinivasan M, Wardrop RM, Gienapp IE, Stuckman SS, Whitacre CC, Kaumaya PT. A retro-inverso peptide mimic of CD28 encompassing the MYPPPY motif adopts a polyproline type II helix and inhibits encephalitogenic T cells in vitro. J Immunol 2001; 167:578-85; http://dx. doi. org/10. 4049/ jimmunol. 167. 1. 578
    • (2001) J Immunol , vol.167 , pp. 578-585
    • Srinivasan, M.1    Wardrop, R.M.2    Gienapp, I.E.3    Stuckman, S.S.4    Whitacre, C.C.5    Kaumaya, P.T.6
  • 46
    • 70449727895 scopus 로고    scopus 로고
    • Phase I active immunotherapy with combination of two chimeric, human epidermal growth factor receptor 2, B-cell epitopes fused to a promiscuous T-cell epitope in patients with metastatic and/or recurrent solid tumors
    • PMID:19752336
    • Kaumaya PT, Foy KC, Garrett J, Rawale SV, Vicari D, Thurmond JM, Lamb T, Mani A, Kane Y, Balint CR, et al. Phase I active immunotherapy with combination of two chimeric, human epidermal growth factor receptor 2, B-cell epitopes fused to a promiscuous T-cell epitope in patients with metastatic and/or recurrent solid tumors. J Clin Oncol 2009; 27:5270- 7; PMID:19752336; http://dx. doi. org/10. 1200/ JCO. 2009. 22. 3883
    • (2009) J Clin Oncol , vol.27 , pp. 5270-5277
    • Kaumaya, P.T.1    Foy, K.C.2    Garrett, J.3    Rawale, S.V.4    Vicari, D.5    Thurmond, J.M.6    Lamb, T.7    Mani, A.8    Kane, Y.9    Balint, C.R.10
  • 47
    • 0027520754 scopus 로고
    • Peptides of 23 residues or greater are required to stimulate a high affinity class II-restricted T cell response
    • PMID:8386663
    • Srinivasan M, Domanico SZ, Kaumaya PT, Pierce SK. Peptides of 23 residues or greater are required to stimulate a high affinity class II-restricted T cell response. Eur J Immunol 1993; 23:1011-6; PMID:8386663; http://dx. doi. org/10. 1002/ eji. 1830230504
    • (1993) Eur J Immunol , vol.23 , pp. 1011-1016
    • Srinivasan, M.1    Domanico, S.Z.2    Kaumaya, P.T.3    Pierce, S.K.4
  • 48
    • 0034660850 scopus 로고    scopus 로고
    • Prevention of mammary tumors with a chimeric HER-2 B-cell epitope peptide vaccine
    • PMID:10919651
    • Dakappagari NK, Douglas DB, Triozzi PL, Stevens VC, Kaumaya PT. Prevention of mammary tumors with a chimeric HER-2 B-cell epitope peptide vaccine. Cancer Res 2000; 60:3782-9; PMID:10919651
    • (2000) Cancer Res , vol.60 , pp. 3782-3789
    • Dakappagari, N.K.1    Douglas, D.B.2    Triozzi, P.L.3    Stevens, V.C.4    Kaumaya, P.T.5
  • 49
    • 84865209205 scopus 로고    scopus 로고
    • Immunotherapy with HER-2 and VEGF peptide mimics plus metronomic paclitaxel causes superior antineoplastic effects in transplantable and transgenic mouse models of human breast cancer
    • PMID:23170249
    • Foy KC, Miller MJ, Moldovan N, Bozanovic T, Carson Iii WE, Kaumaya PT. Immunotherapy with HER-2 and VEGF peptide mimics plus metronomic paclitaxel causes superior antineoplastic effects in transplantable and transgenic mouse models of human breast cancer. Oncoimmunology 2012; 1:1004-16; PMID:23170249; http://dx. doi. org/10. 4161/ onci. 21057
    • (2012) Oncoimmunology , vol.1 , pp. 1004-1016
    • Foy, K.C.1    Miller, M.J.2    Moldovan, N.3    Bozanovic, T.4    Carson Iii, W.E.5    Kaumaya, P.T.6
  • 50
    • 0025284352 scopus 로고
    • Characteristics of peptides which compete for presented antigen-binding sites on antigen-presenting cells
    • PMID:2162778
    • Smolenski LA, Kaumaya P, Atassi MZ, Pierce SK. Characteristics of peptides which compete for presented antigen-binding sites on antigen-presenting cells. Eur J Immunol 1990; 20:953-60; PMID:2162778; http://dx. doi. org/10. 1002/ eji. 1830200502
    • (1990) Eur J Immunol , vol.20 , pp. 953-960
    • Smolenski, L.A.1    Kaumaya, P.2    Atassi, M.Z.3    Pierce, S.K.4
  • 51
    • 0034992588 scopus 로고    scopus 로고
    • Peptides as receptor ligand drugs and their relationship to G-coupled signal transduction
    • PMID:11772235
    • Mizejewski GJ. Peptides as receptor ligand drugs and their relationship to G-coupled signal transduction. Exp Opin Investig Drugs 2001; 10:1063-73; PMID:11772235; http://dx. doi. org/10. 1517/ 13543784. 10. 6. 1063
    • (2001) Exp Opin Investig Drugs , vol.10 , pp. 1063-1073
    • Mizejewski, G.J.1
  • 52
    • 74149094591 scopus 로고    scopus 로고
    • Synthetic therapeutic peptides: Science and market
    • PMID:19879957
    • Vlieghe P, Lisowski V, Martinez J, Khrestchatisky M. Synthetic therapeutic peptides: science and market. Drug Discov Today 2010; 15:40-56; PMID:19879957; http://dx. doi. org/10. 1016/j. drudis. 2009. 10. 009
    • (2010) Drug Discov Today , vol.15 , pp. 40-56
    • Vlieghe, P.1    Lisowski, V.2    Martinez, J.3    Khrestchatisky, M.4
  • 54
    • 0141988798 scopus 로고    scopus 로고
    • The design, synthesis and application of stereochemical and directional peptide isomers: A critical review
    • PMID:14529528
    • Fischer PM. The design, synthesis and application of stereochemical and directional peptide isomers: a critical review. Curr Protein Pept Sci 2003; 4:339-56; PMID:14529528; http://dx. doi. org/10. 2174/ 1389203033487054
    • (2003) Curr Protein Pept Sci , vol.4 , pp. 339-356
    • Fischer, P.M.1
  • 55
    • 0027626855 scopus 로고
    • Conformational and topographical considerations in the design of biologically active peptides
    • PMID:8102072
    • Hruby VJ. Conformational and topographical considerations in the design of biologically active peptides. Biopolymers 1993; 33:1073-82; PMID:8102072; http://dx. doi. org/10. 1002/bip. 360330709
    • (1993) Biopolymers , vol.33 , pp. 1073-1082
    • Hruby, V.J.1
  • 56
    • 0011822184 scopus 로고    scopus 로고
    • Partially Modified Retro-Inverso Peptides: Development, Synthesis, and Conformational Behavior
    • PMID:11848914
    • Fletcher MD, Campbell MM. Partially Modified Retro-Inverso Peptides: Development, Synthesis, and Conformational Behavior. Chem Rev 1998; 98:763- 96; PMID:11848914; http://dx. doi. org/10. 1021/ cr970468t
    • (1998) Chem Rev , vol.98 , pp. 763-796
    • Fletcher, M.D.1    Campbell, M.M.2
  • 57
    • 0033820739 scopus 로고    scopus 로고
    • Retro-inverso prosaptide peptides retain bioactivity, are stable In vivo, and are blood-brain barrier permeable
    • PMID:10991978
    • Taylor EM, Otero DA, Banks WA, O'Brien JS. Retro-inverso prosaptide peptides retain bioactivity, are stable In vivo, and are blood-brain barrier permeable. J Pharmacol Exp Ther 2000; 295:190-4; PMID:10991978
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 190-194
    • Taylor, E.M.1    Otero, D.A.2    Banks, W.A.3    O'Brien, J.S.4
  • 58
    • 84882284393 scopus 로고    scopus 로고
    • Prospects of combinatorial synthetic peptide vaccine-based immunotherapy against cancer
    • PMID:23706598
    • Arens R, van Hall T, van der Burg SH, Ossendorp F, Melief CJ. Prospects of combinatorial synthetic peptide vaccine-based immunotherapy against cancer. Semin Immunol 2013; 25:182-90; PMID:23706598; http://dx. doi. org/10. 1016/j. smim. 2013. 04. 008
    • (2013) Semin Immunol , vol.25 , pp. 182-190
    • Arens, R.1    van Hall, T.2    van der Burg, S.H.3    Ossendorp, F.4    Melief, C.J.5
  • 59
    • 34247891741 scopus 로고    scopus 로고
    • More than one reason to rethink the use of peptides in vaccine design
    • PMID:17473845
    • Purcell AW, McCluskey J, Rossjohn J. More than one reason to rethink the use of peptides in vaccine design. Nat Rev Drug Discov 2007; 6:404-14; PMID:17473845; http://dx. doi. org/10. 1038/ nrd2224
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 404-414
    • Purcell, A.W.1    McCluskey, J.2    Rossjohn, J.3
  • 60
    • 79951918591 scopus 로고    scopus 로고
    • Peptidomimetics: Modifying peptides in the pursuit of better vaccines
    • PMID:21332270
    • Croft NP, Purcell AW. Peptidomimetics: modifying peptides in the pursuit of better vaccines. Exp Rev Vaccines 2011; 10:211-26; PMID:21332270; http:// dx. doi. org/10. 1586/erv. 10. 161
    • (2011) Exp Rev Vaccines , vol.10 , pp. 211-226
    • Croft, N.P.1    Purcell, A.W.2
  • 61
    • 84904702429 scopus 로고    scopus 로고
    • Peptides and peptidomimetics as immunomodulators
    • PMID:25186605
    • Gokhale AS, Satyanarayanajois S. Peptides and peptidomimetics as immunomodulators. Immunotherapy 2014; 6:755-74; PMID:25186605; http://dx. doi. org/ 10. 2217/imt. 14. 37
    • (2014) Immunotherapy , vol.6 , pp. 755-774
    • Gokhale, A.S.1    Satyanarayanajois, S.2
  • 62
    • 84864367360 scopus 로고    scopus 로고
    • The ERBB network: At last, cancer therapy meets systems biology
    • PMID:22785351
    • Yarden Y, Pines G. The ERBB network: at last, cancer therapy meets systems biology. Nat Rev Cancer 2012; 12:553-63; PMID:22785351; http://dx. doi. org/ 10. 1038/nrc3309
    • (2012) Nat Rev Cancer , vol.12 , pp. 553-563
    • Yarden, Y.1    Pines, G.2
  • 63
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • PMID:11057895
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000; 103:211-25; PMID:11057895; http://dx. doi. org/10. 1016/S0092-8674(00)00114-8
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 64
    • 77952338791 scopus 로고    scopus 로고
    • ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation
    • PMID:20351256
    • Shi F, Telesco SE, Liu Y, Radhakrishnan R, Lemmon MA. ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation. Proc Natl Acad Sci U S A 2010; 107:7692-7; PMID:20351256; http://dx. doi. org/10. 1073/ pnas. 1002753107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 7692-7697
    • Shi, F.1    Telesco, S.E.2    Liu, Y.3    Radhakrishnan, R.4    Lemmon, M.A.5
  • 65
    • 17844372539 scopus 로고    scopus 로고
    • Critical update and emerging trends in epidermal growth factor receptor targeting in cancer
    • PMID:15753456
    • Baselga J, Arteaga CL. Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J Clin Oncol 2005; 23:2445-59; PMID:15753456; http://dx. doi. org/10. 1200/ JCO. 2005. 11. 890
    • (2005) J Clin Oncol , vol.23 , pp. 2445-2459
    • Baselga, J.1    Arteaga, C.L.2
  • 66
    • 33744493376 scopus 로고    scopus 로고
    • Targeting tyrosine kinases in cancer: The second wave
    • PMID:16728632
    • Baselga J. Targeting tyrosine kinases in cancer: the second wave. Science 2006; 312:1175-8; PMID:16728632; http://dx. doi. org/10. 1126/ science. 1125951
    • (2006) Science , vol.312 , pp. 1175-1178
    • Baselga, J.1
  • 67
    • 30944446883 scopus 로고    scopus 로고
    • Lessons from phase III clinical trials on anti-VEGF therapy for cancer
    • PMID:16407877
    • Jain RK, Duda DG, Clark JW, Loeffler JS. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 2006; 3:24-40; PMID:16407877; http://dx. doi. org/10. 1038/ ncponc0403
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3    Loeffler, J.S.4
  • 68
    • 0026395163 scopus 로고
    • The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA
    • PMID:1791831
    • Houck KA, Ferrara N, Winer J, Cachianes G, Li B, Leung DW. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 1991; 5:1806-14; PMID:1791831; http://dx. doi. org/10. 1210/mend-5-12-1806
    • (1991) Mol Endocrinol , vol.5 , pp. 1806-1814
    • Houck, K.A.1    Ferrara, N.2    Winer, J.3    Cachianes, G.4    Li, B.5    Leung, D.W.6
  • 69
    • 0242468884 scopus 로고    scopus 로고
    • A phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer
    • PMID:14613032
    • Cobleigh MA, Langmuir VK, Sledge GW, Miller KD, Haney L, Novotny WF, Reimann JD, Vassel A. A phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer. Semin Oncol 2003; 30:117-24; PMID:14613032; http://dx. doi. org/10. 1053/j. seminoncol. 2003. 08. 013
    • (2003) Semin Oncol , vol.30 , pp. 117-124
    • Cobleigh, M.A.1    Langmuir, V.K.2    Sledge, G.W.3    Miller, K.D.4    Haney, L.5    Novotny, W.F.6    Reimann, J.D.7    Vassel, A.8
  • 70
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • PMID:15864276
    • Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 2005; 5:341-54; PMID:15864276; http://dx. doi. org/ 10. 1038/nrc1609
    • (2005) Nat Rev Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 72
    • 0033396950 scopus 로고    scopus 로고
    • Inhibition of tumor growth and metastasis by targeting tumor-associated angiogenesis with antagonists to the receptors of vascular endothelial growth factor
    • PMID:10665474
    • Zhu Z, Witte L. Inhibition of tumor growth and metastasis by targeting tumor-associated angiogenesis with antagonists to the receptors of vascular endothelial growth factor. Invest New Drugs 1999; 17:195- 212; PMID:10665474; http://dx. doi. org/10. 1023/ A:1006314501634
    • (1999) Invest New Drugs , vol.17 , pp. 195-212
    • Zhu, Z.1    Witte, L.2
  • 74
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • PMID:4938153
    • Folkman J. Tumor angiogenesis: therapeutic implications. NEng J Med 1971; 285:1182-6; PMID:4938153; http://dx. doi. org/10. 1056/ NEJM197108122850711
    • (1971) NEng J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 75
    • 67649472398 scopus 로고    scopus 로고
    • Novel anticancer targets: Revisiting ERBB2 and discovering ERBB3
    • PMID:19536107
    • Baselga J, Swain SM. Novel anticancer targets: revisiting ERBB2 and discovering ERBB3. Nat Rev Cancer 2009; 9:463-75; PMID:19536107; http://dx. doi. org/ 10. 1038/nrc2656
    • (2009) Nat Rev Cancer , vol.9 , pp. 463-475
    • Baselga, J.1    Swain, S.M.2
  • 76
    • 3042781558 scopus 로고    scopus 로고
    • Insulin- like growth factors and neoplasia
    • PMID:15229476
    • Pollak MN, Schernhammer ES, Hankinson SE. Insulin- like growth factors and neoplasia. Nat Rev Cancer 2004; 4:505-18; PMID:15229476; http://dx. doi. org/ 10. 1038/nrc1387
    • (2004) Nat Rev Cancer , vol.4 , pp. 505-518
    • Pollak, M.N.1    Schernhammer, E.S.2    Hankinson, S.E.3
  • 77
    • 16544395386 scopus 로고    scopus 로고
    • Insulin-like growth factors and neoplasia
    • discussion -107, 265-8
    • Pollak MN. Insulin-like growth factors and neoplasia. Novartis Found Symp 2004; 262:84-98; discussion -107, 265-8
    • (2004) Novartis Found Symp , vol.262 , pp. 84-98
    • Pollak, M.N.1
  • 78
    • 0030242225 scopus 로고    scopus 로고
    • Fighting cancer by attacking its blood supply
    • PMID:8701285
    • Folkman J. Fighting cancer by attacking its blood supply. Scientific American 1996; 275:150-4; PMID:8701285; http://dx. doi. org/10. 1038/ scientificamerican0996-150
    • (1996) Scientific American , vol.275 , pp. 150-154
    • Folkman, J.1
  • 79
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • PMID:16355214
    • Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005; 438:967-74; PMID:16355214; http://dx. doi. org/10. 1038/nature04483
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 80
    • 22544461679 scopus 로고    scopus 로고
    • The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models
    • PMID:15886048
    • Yakar S, Leroith D, Brodt P. The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models. Cytokine Growth Factor Rev 2005; 16:407-20; PMID:15886048; http://dx. doi. org/10. 1016/j. cytogfr. 2005. 01. 010
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 407-420
    • Yakar, S.1    Leroith, D.2    Brodt, P.3
  • 81
    • 0029096782 scopus 로고
    • Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor I receptors
    • PMID:7641185
    • Resnicoff M, Burgaud JL, Rotman HL, Abraham D, Baserga R. Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor I receptors. Cancer Res 1995; 55:3739-41; PMID:7641185
    • (1995) Cancer Res , vol.55 , pp. 3739-3741
    • Resnicoff, M.1    Burgaud, J.L.2    Rotman, H.L.3    Abraham, D.4    Baserga, R.5
  • 83
    • 0030629622 scopus 로고    scopus 로고
    • The role of the IGF-I receptor in apoptosis
    • PMID:9197178
    • Baserga R, Resnicoff M, D'Ambrosio C, Valentinis B. The role of the IGF-I receptor in apoptosis. Vitam Horm 1997; 53:65-98; PMID:9197178; http://dx. doi. org/10. 1016/S0083-6729(08)60704-9
    • (1997) Vitam Horm , vol.53 , pp. 65-98
    • Baserga, R.1    Resnicoff, M.2    D'Ambrosio, C.3    Valentinis, B.4
  • 84
    • 84858785688 scopus 로고    scopus 로고
    • Antibody therapy of cancer
    • PMID:22437872
    • Scott AM, Wolchok JD, Old LJ. Antibody therapy of cancer. Nat Rev Cancer 2012; 12:278-87; PMID:22437872; http://dx. doi. org/10. 1038/ nrc3236
    • (2012) Nat Rev Cancer , vol.12 , pp. 278-287
    • Scott, A.M.1    Wolchok, J.D.2    Old, L.J.3
  • 85
    • 77951614830 scopus 로고    scopus 로고
    • Monoclonal antibodies: Versatile platforms for cancer immunotherapy
    • PMID:20414205
    • Weiner LM, Surana R, Wang S. Monoclonal antibodies: versatile platforms for cancer immunotherapy. Nat Rev Immunol 2010; 10:317-27; PMID:20414205; http://dx. doi. org/10. 1038/nri2744
    • (2010) Nat Rev Immunol , vol.10 , pp. 317-327
    • Weiner, L.M.1    Surana, R.2    Wang, S.3
  • 86
    • 0013110937 scopus 로고    scopus 로고
    • Monoclonal antibody therapy for cancer
    • PMID:12525678
    • von Mehren M, Adams GP, Weiner LM. Monoclonal antibody therapy for cancer. Annu Rev Med 2003; 54:343-69; PMID:12525678; http://dx. doi. org/ 10. 1146/annurev. med. 54. 101601. 152442
    • (2003) Annu Rev Med , vol.54 , pp. 343-369
    • von Mehren, M.1    Adams, G.P.2    Weiner, L.M.3
  • 87
    • 84857139331 scopus 로고    scopus 로고
    • Monoclonal antibodies for the treatment of cancer
    • PMID:22245472
    • Shuptrine CW, Surana R, Weiner LM. Monoclonal antibodies for the treatment of cancer. Semin Cancer Biol 2012; 22:3-13; PMID:22245472; http://dx. doi. org/10. 1016/j. semcancer. 2011. 12. 009
    • (2012) Semin Cancer Biol , vol.22 , pp. 3-13
    • Shuptrine, C.W.1    Surana, R.2    Weiner, L.M.3
  • 88
    • 84858416256 scopus 로고    scopus 로고
    • Antibodybased immunotherapy of cancer
    • PMID:22424219
    • Weiner LM, Murray JC, Shuptrine CW. Antibodybased immunotherapy of cancer. Cell 2012; 148:1081-4; PMID:22424219; http://dx. doi. org/ 10. 1016/j. cell. 2012. 02. 034
    • (2012) Cell , vol.148 , pp. 1081-1084
    • Weiner, L.M.1    Murray, J.C.2    Shuptrine, C.W.3
  • 89
    • 70149086034 scopus 로고    scopus 로고
    • Engineered therapeutic antibodies with improved effector functions
    • PMID:19538497
    • Kubota T, Niwa R, Satoh M, Akinaga S, Shitara K, Hanai N. Engineered therapeutic antibodies with improved effector functions. Cancer Sci 2009; 100:1566-72; PMID:19538497; http://dx. doi. org/ 10. 1111/j. 1349-7006. 2009. 01222. x
    • (2009) Cancer Sci , vol.100 , pp. 1566-1572
    • Kubota, T.1    Niwa, R.2    Satoh, M.3    Akinaga, S.4    Shitara, K.5    Hanai, N.6
  • 90
    • 33646712747 scopus 로고    scopus 로고
    • Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
    • PMID:16683005
    • Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 2006; 3:269-80; PMID:16683005; http://dx. doi. org/10. 1038/ ncponc0509
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 269-280
    • Nahta, R.1    Yu, D.2    Hung, M.C.3    Hortobagyi, G.N.4    Esteva, F.J.5
  • 92
    • 1942474587 scopus 로고    scopus 로고
    • The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells
    • PMID:15059883
    • Nahta R, Hung MC, Esteva FJ. The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Res 2004; 64:2343-6; PMID:15059883; http://dx. doi. org/10. 1158/0008- 5472. CAN-03-3856
    • (2004) Cancer Res , vol.64 , pp. 2343-2346
    • Nahta, R.1    Hung, M.C.2    Esteva, F.J.3
  • 94
    • 33645651433 scopus 로고    scopus 로고
    • A phase II trial with trastuzumab and pertuzumab in patients with HER2-overexpressed locally advanced and metastatic breast cancer
    • PMID:16595039
    • Walshe JM, Denduluri N, Berman AW, Rosing DR, Swain SM. A phase II trial with trastuzumab and pertuzumab in patients with HER2-overexpressed locally advanced and metastatic breast cancer. Clin Breast Cancer 2006; 6:535-9; PMID:16595039; http://dx. doi. org/10. 3816/CBC. 2006. n. 009
    • (2006) Clin Breast Cancer , vol.6 , pp. 535-539
    • Walshe, J.M.1    Denduluri, N.2    Berman, A.W.3    Rosing, D.R.4    Swain, S.M.5
  • 95
    • 20544455330 scopus 로고    scopus 로고
    • Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy
    • PMID:15961063
    • Ferrara N, Hillan KJ, Novotny W. Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy. Biochem Biophys Res Commun 2005; 333:328-35; PMID:15961063; http://dx. doi. org/10. 1016/j. bbrc. 2005. 05. 132
    • (2005) Biochem Biophys Res Commun , vol.333 , pp. 328-335
    • Ferrara, N.1    Hillan, K.J.2    Novotny, W.3
  • 96
    • 33745325007 scopus 로고    scopus 로고
    • Mechanisms of drug inhibition of signalling molecules
    • PMID:16724058
    • Sebolt-Leopold JS, English JM. Mechanisms of drug inhibition of signalling molecules. Nature 2006; 441:457-62; PMID:16724058; http://dx. doi. org/ 10. 1038/nature04874
    • (2006) Nature , vol.441 , pp. 457-462
    • Sebolt-Leopold, J.S.1    English, J.M.2
  • 97
    • 33746622984 scopus 로고    scopus 로고
    • Strategies for optimizing combinations of molecularly targeted anticancer agents
    • PMID:16883303
    • Dancey JE, Chen HX. Strategies for optimizing combinations of molecularly targeted anticancer agents. Nat Rev Drug discov 2006; 5:649-59; PMID:16883303; http://dx. doi. org/10. 1038/ nrd2089
    • (2006) Nat Rev Drug discov , vol.5 , pp. 649-659
    • Dancey, J.E.1    Chen, H.X.2
  • 98
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • PMID:12778165
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9:669-76; PMID:12778165; http://dx. doi. org/10. 1038/ nm0603-669
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 99
    • 0033533508 scopus 로고    scopus 로고
    • Characterization of the VEGF binding site on the Flt-1 receptor
    • PMID:10471394
    • Herley MT, Yu Y, Whitney RG, Sato JD. Characterization of the VEGF binding site on the Flt-1 receptor. Biochem Biophys Res Commun 1999; 262:731-8; PMID:10471394; http://dx. doi. org/10. 1006/ bbrc. 1999. 1282
    • (1999) Biochem Biophys Res Commun , vol.262 , pp. 731-738
    • Herley, M.T.1    Yu, Y.2    Whitney, R.G.3    Sato, J.D.4
  • 100
    • 0034690028 scopus 로고    scopus 로고
    • Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells
    • PMID:10815805
    • Kanno S, Oda N, Abe M, Terai Y, Ito M, Shitara K, Tabayashi K, Shibuya M, Sato Y. Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells. Oncogene 2000; 19:2138-46; PMID:10815805; http://dx. doi. org/10. 1038/sj. onc. 1203533
    • (2000) Oncogene , vol.19 , pp. 2138-2146
    • Kanno, S.1    Oda, N.2    Abe, M.3    Terai, Y.4    Ito, M.5    Shitara, K.6    Tabayashi, K.7    Shibuya, M.8    Sato, Y.9
  • 101
    • 0029920944 scopus 로고    scopus 로고
    • Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis
    • PMID:8621427
    • Keyt BA, Nguyen HV, Berleau LT, Duarte CM, Park J, Chen H, Ferrara N. Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis. J Biol Chem 1996; 271:5638-46; PMID:8621427; http:// dx. doi. org/10. 1074/jbc. 271. 10. 5638
    • (1996) J Biol Chem , vol.271 , pp. 5638-5646
    • Keyt, B.A.1    Nguyen, H.V.2    Berleau, L.T.3    Duarte, C.M.4    Park, J.5    Chen, H.6    Ferrara, N.7
  • 102
    • 0036941125 scopus 로고    scopus 로고
    • A monoclonal antibody that blocks VEGF binding to VEGFR2 (KDR/Flk-1) inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast cancer model
    • PMID:12549858
    • Zhang W, Ran S, Sambade M, Huang X, Thorpe PE. A monoclonal antibody that blocks VEGF binding to VEGFR2 (KDR/Flk-1) inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast cancer model. Angiogenesis 2002; 5:35-44; PMID:12549858; http://dx. doi. org/10. 1023/ A:1021540120521
    • (2002) Angiogenesis , vol.5 , pp. 35-44
    • Zhang, W.1    Ran, S.2    Sambade, M.3    Huang, X.4    Thorpe, P.E.5
  • 103
    • 0242353266 scopus 로고    scopus 로고
    • Tailoring in vitro selection for a picomolar affinity human antibody directed against vascular endothelial growth factor receptor 2 for enhanced neutralizing activity
    • PMID:12917408
    • Lu D, Shen J, Vil MD, Zhang H, Jimenez X, Bohlen P, Witte L, Zhu Z. Tailoring in vitro selection for a picomolar affinity human antibody directed against vascular endothelial growth factor receptor 2 for enhanced neutralizing activity. J Biol Chem 2003; 278:43496-507; PMID:12917408; http://dx. doi. org/ 10. 1074/jbc. M307742200
    • (2003) J Biol Chem , vol.278 , pp. 43496-43507
    • Lu, D.1    Shen, J.2    Vil, M.D.3    Zhang, H.4    Jimenez, X.5    Bohlen, P.6    Witte, L.7    Zhu, Z.8
  • 104
    • 0035182022 scopus 로고    scopus 로고
    • Anti-VEGFR-2 scFvs for cell isolation. Singlechain antibodies recognizing the human vascular endothelial growth factor receptor-2 (VEGFR-2/flk- 1) on the surface of primary endothelial cells and preselected CD34+ cells from cord blood
    • PMID:11209088
    • Boldicke T, Tesar M, Griesel C, Rohde M, Grone HJ, Waltenberger J, Kollet O, Lapidot T, Yayon A, Weich H. Anti-VEGFR-2 scFvs for cell isolation. Singlechain antibodies recognizing the human vascular endothelial growth factor receptor-2 (VEGFR-2/flk- 1) on the surface of primary endothelial cells and preselected CD34+ cells from cord blood. Stem cells 2001; 19:24-36; PMID:11209088; http://dx. doi. org/ 10. 1634/stemcells. 19-1-24
    • (2001) Stem cells , vol.19 , pp. 24-36
    • Boldicke, T.1    Tesar, M.2    Griesel, C.3    Rohde, M.4    Grone, H.J.5    Waltenberger, J.6    Kollet, O.7    Lapidot, T.8    Yayon, A.9    Weich, H.10
  • 106
    • 33745743631 scopus 로고    scopus 로고
    • Angiogenesis inhibitors: Perspectives for medical, surgical and radiation oncology
    • PMID:16842162
    • Verhoef C, de Wilt JH, Verheul HM. Angiogenesis inhibitors: perspectives for medical, surgical and radiation oncology. Current pharmaceutical design 2006; 12:2623-30; PMID:16842162; http://dx. doi. org/ 10. 2174/138161206777698756
    • (2006) Current pharmaceutical design , vol.12 , pp. 2623-2630
    • Verhoef, C.1    de Wilt, J.H.2    Verheul, H.M.3
  • 107
    • 77951709259 scopus 로고    scopus 로고
    • Targeting the insulin-like growth factor receptor-1R pathway for cancer therapy
    • PMID:20388853
    • Zha J, Lackner MR. Targeting the insulin-like growth factor receptor-1R pathway for cancer therapy. Clin Cancer Res 2010; 16:2512-7; PMID:20388853; http://dx. doi. org/10. 1158/1078-0432. CCR-09-2232
    • (2010) Clin Cancer Res , vol.16 , pp. 2512-2517
    • Zha, J.1    Lackner, M.R.2
  • 108
    • 84886313817 scopus 로고    scopus 로고
    • Combined vaccination with HER-2 peptide followed by therapy with VEGF peptide mimics exerts effective anti-tumor and anti-angiogenic effects in vitro and in vivo
    • PMID:23170253
    • Foy KC, Miller MJ, Moldovan N, Carson Iii WE, Kaumaya PT. Combined vaccination with HER-2 peptide followed by therapy with VEGF peptide mimics exerts effective anti-tumor and anti-angiogenic effects in vitro and in vivo. Oncoimmunology 2012; 1:1048-60; PMID:23170253; http://dx. doi. org/ 10. 4161/onci. 20708
    • (2012) Oncoimmunology , vol.1 , pp. 1048-1060
    • Foy, K.C.1    Miller, M.J.2    Moldovan, N.3    Carson Iii, W.E.4    Kaumaya, P.T.5
  • 109
    • 0025359146 scopus 로고
    • Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues
    • PMID:1973830
    • Press MF, Cordon-Cardo C, Slamon DJ. Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues. Oncogene 1990; 5:953-62; PMID:1973830
    • (1990) Oncogene , vol.5 , pp. 953-962
    • Press, M.F.1    Cordon-Cardo, C.2    Slamon, D.J.3
  • 110
    • 0025177290 scopus 로고
    • Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: Prognostic significance of erbB-2 protein overexpression in primary breast cancer
    • PMID:1967301
    • Paik S, Hazan R, Fisher ER, Sass RE, Fisher B, Redmond C, Schlessinger J, Lippman ME, King CR. Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer. J Clin Oncol 1990; 8:103-12; PMID:1967301
    • (1990) J Clin Oncol , vol.8 , pp. 103-112
    • Paik, S.1    Hazan, R.2    Fisher, E.R.3    Sass, R.E.4    Fisher, B.5    Redmond, C.6    Schlessinger, J.7    Lippman, M.E.8    King, C.R.9
  • 111
    • 0027283498 scopus 로고
    • Stability of HER-2/neu expression over time and at multiple metastatic sites
    • PMID:8101229
    • Niehans GA, Singleton TP, Dykoski D, Kiang DT. Stability of HER-2/neu expression over time and at multiple metastatic sites. J Natl Cancer Inst 1993; 85:1230-5; PMID:8101229; http://dx. doi. org/ 10. 1093/jnci/85. 15. 1230
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1230-1235
    • Niehans, G.A.1    Singleton, T.P.2    Dykoski, D.3    Kiang, D.T.4
  • 112
    • 14744269680 scopus 로고    scopus 로고
    • Intracellular delivery of a novel multiepitope peptide vaccine by an amphipathic peptide carrier enhances cytotoxic T-cell responses in HLA-A*201 mice
    • PMID:15705163
    • Dakappagari NK, Sundaram R, Rawale S, Liner A, Galloway DR, Kaumaya PT. Intracellular delivery of a novel multiepitope peptide vaccine by an amphipathic peptide carrier enhances cytotoxic T-cell responses in HLA-A*201 mice. J Pept Res 2005; 65:189-99; PMID:15705163; http://dx. doi. org/ 10. 1111/j. 1399-3011. 2005. 00212. x
    • (2005) J Pept Res , vol.65 , pp. 189-199
    • Dakappagari, N.K.1    Sundaram, R.2    Rawale, S.3    Liner, A.4    Galloway, D.R.5    Kaumaya, P.T.6
  • 113
    • 0037434791 scopus 로고    scopus 로고
    • Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
    • PMID:12610629
    • Cho HS, Mason K, Ramyar KX, Stanley AM, Gabelli SB, Denney DW, Jr., Leahy DJ. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 2003; 421:756-60; PMID:12610629; http://dx. doi. org/10. 1038/ nature01392
    • (2003) Nature , vol.421 , pp. 756-760
    • Cho, H.S.1    Mason, K.2    Ramyar, K.X.3    Stanley, A.M.4    Gabelli, S.B.5    Denney, D.W.6    Leahy, D.J.7
  • 114
    • 0037291226 scopus 로고    scopus 로고
    • The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors
    • PMID:12620236
    • Garrett TP, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Kofler M, Jorissen RN, Nice EC, Burgess AW, et al. The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors. Mol Cell 2003; 11:495-505; PMID:12620236; http://dx. doi. org/10. 1016/S1097-2765(03)00048-0
    • (2003) Mol Cell , vol.11 , pp. 495-505
    • Garrett, T.P.1    McKern, N.M.2    Lou, M.3    Elleman, T.C.4    Adams, T.E.5    Lovrecz, G.O.6    Kofler, M.7    Jorissen, R.N.8    Nice, E.C.9    Burgess, A.W.10
  • 115
    • 1842605531 scopus 로고    scopus 로고
    • Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
    • PMID:15093539
    • Franklin MC, Carey KD, Vajdos FF, Leahy DJ, de Vos AM, Sliwkowski MX. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer cell 2004; 5:317-28; PMID:15093539; http://dx. doi. org/10. 1016/S1535-6108(04)00083-2
    • (2004) Cancer cell , vol.5 , pp. 317-328
    • Franklin, M.C.1    Carey, K.D.2    Vajdos, F.F.3    Leahy, D.J.4    de Vos, A.M.5    Sliwkowski, M.X.6
  • 116
    • 2942590261 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as a target for anticancer therapy
    • PMID:15178810
    • Ferrara N. Vascular endothelial growth factor as a target for anticancer therapy. The oncologist 2004; 9 Suppl 1:2-10; PMID:15178810; http://dx. doi. org/ 10. 1634/theoncologist. 9-suppl_1-2
    • (2004) The oncologist , vol.9 , pp. 2-10
    • Ferrara, N.1
  • 117
    • 0031738664 scopus 로고    scopus 로고
    • Relationship between the expression of vascular endothelial growth factor and the density of dendritic cells in gastric adenocarcinoma tissue
    • PMID:9862566
    • Saito H, Tsujitani S, Ikeguchi M, Maeta M, Kaibara N. Relationship between the expression of vascular endothelial growth factor and the density of dendritic cells in gastric adenocarcinoma tissue. British journal of cancer 1998; 78:1573-7; PMID:9862566; http:// dx. doi. org/10. 1038/bjc. 1998. 725
    • (1998) British journal of cancer , vol.78 , pp. 1573-1577
    • Saito, H.1    Tsujitani, S.2    Ikeguchi, M.3    Maeta, M.4    Kaibara, N.5
  • 118
    • 0025999033 scopus 로고
    • The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
    • PMID:1711045
    • Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, Abraham JA. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 1991; 266:11947-54; PMID:1711045
    • (1991) J Biol Chem , vol.266 , pp. 11947-11954
    • Tischer, E.1    Mitchell, R.2    Hartman, T.3    Silva, M.4    Gospodarowicz, D.5    Fiddes, J.C.6    Abraham, J.A.7
  • 119
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • PMID:2735925
    • Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989; 161:851-8; PMID:2735925; http://dx. doi. org/10. 1016/0006- 291X(89)92678-8
    • (1989) Biochem Biophys Res Commun , vol.161 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 120
    • 0037441869 scopus 로고    scopus 로고
    • Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt1 receptor
    • PMID:12406876
    • Casella I, Feccia T, Chelucci C, Samoggia P, Castelli G, Guerriero R, Parolini I, Petrucci E, Pelosi E, Morsilli O, et al. Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt1 receptor. Blood 2003; 101:1316-23; PMID:12406876; http://dx. doi. org/10. 1182/blood- 2002-07-2184
    • (2003) Blood , vol.101 , pp. 1316-1323
    • Casella, I.1    Feccia, T.2    Chelucci, C.3    Samoggia, P.4    Castelli, G.5    Guerriero, R.6    Parolini, I.7    Petrucci, E.8    Pelosi, E.9    Morsilli, O.10
  • 121
    • 2242469358 scopus 로고    scopus 로고
    • Exploiting the differential production of angiogenic factors within the tumor microenvironment in the design of a novel vascular-targeted gene therapybased approach to the treatment of cancer
    • PMID:12459373
    • Carpenito C, Davis PD, Dougherty ST, Dougherty GJ. Exploiting the differential production of angiogenic factors within the tumor microenvironment in the design of a novel vascular-targeted gene therapybased approach to the treatment of cancer. Int J Radiat Oncol, Biol, Phys 2002; 54:1473-8; PMID:12459373; http://dx. doi. org/10. 1016/S0360- 3016(02)03921-4
    • (2002) Int J Radiat Oncol, Biol, Phys , vol.54 , pp. 1473-1478
    • Carpenito, C.1    Davis, P.D.2    Dougherty, S.T.3    Dougherty, G.J.4
  • 122
    • 0036554830 scopus 로고    scopus 로고
    • Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: Mammary fat pad versus cranial tumors
    • PMID:11948107
    • Monsky WL, Mouta Carreira C, Tsuzuki Y, Gohongi T, Fukumura D, Jain RK. Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors. Clin Cancer Res 2002; 8:1008- 13; PMID:11948107
    • (2002) Clin Cancer Res , vol.8 , pp. 1008-1013
    • Monsky, W.L.1    Mouta Carreira, C.2    Tsuzuki, Y.3    Gohongi, T.4    Fukumura, D.5    Jain, R.K.6
  • 123
    • 79953859123 scopus 로고    scopus 로고
    • Combination Treatment with HER-2 and VEGF Peptide Mimics Induces Potent Anti-tumor and Antiangiogenic Responses in Vitro and in Vivo
    • PMID:21325276
    • Foy KC, Liu Z, Phillips G, Miller M, Kaumaya PT. Combination Treatment with HER-2 and VEGF Peptide Mimics Induces Potent Anti-tumor and Antiangiogenic Responses in Vitro and in Vivo. J Biol Chem 2011; 286:13626-37; PMID:21325276; http://dx. doi. org/10. 1074/jbc. M110. 216820
    • (2011) J Biol Chem , vol.286 , pp. 13626-13637
    • Foy, K.C.1    Liu, Z.2    Phillips, G.3    Miller, M.4    Kaumaya, P.T.5
  • 124
    • 84879614294 scopus 로고    scopus 로고
    • Peptide vaccines and peptidomimetics of EGFR (HER-1) ligand binding domain inhibit cancer cell growth in vitro and in vivo
    • Foy KC, Wygle RM, Miller MJ, Overholser JP, Bekaii-Saab T, Kaumaya PTP. Peptide vaccines and peptidomimetics of EGFR (HER-1) ligand binding domain inhibit cancer cell growth in vitro and in vivo. J Immunol 2013; 191:217-27; http://dx. doi. org/ 10. 4049/jimmunol. 1300231
    • (2013) J Immunol , vol.191 , pp. 217-227
    • Foy, K.C.1    Wygle, R.M.2    Miller, M.J.3    Overholser, J.P.4    Bekaii-Saab, T.5    Kaumaya, P.T.P.6
  • 125
    • 48649092620 scopus 로고    scopus 로고
    • A central role for HER3 in HER2-amplified breast cancer: Implications for targeted therapy
    • PMID:18632642
    • Lee-Hoeflich ST, Crocker L, Yao E, Pham T, Munroe X, Hoeflich KP, Sliwkowski MX, Stern HM. A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy. Cancer Res 2008; 68:5878-87; PMID:18632642; http://dx. doi. org/ 10. 1158/0008-5472. CAN-08-0380
    • (2008) Cancer Res , vol.68 , pp. 5878-5887
    • Lee-Hoeflich, S.T.1    Crocker, L.2    Yao, E.3    Pham, T.4    Munroe, X.5    Hoeflich, K.P.6    Sliwkowski, M.X.7    Stern, H.M.8
  • 126
  • 127
  • 128
    • 0042307325 scopus 로고    scopus 로고
    • The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation
    • PMID:12853564
    • Holbro T, Beerli RR, Maurer F, Koziczak M, Barbas CF, 3rd, Hynes NE. The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci U S A 2003; 100:8933-8; PMID:12853564; http://dx. doi. org/10. 1073/ pnas. 1537685100
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8933-8938
    • Holbro, T.1    Beerli, R.R.2    Maurer, F.3    Koziczak, M.4    Barbas, C.F.5    Hynes, N.E.6
  • 129
    • 44949141721 scopus 로고    scopus 로고
    • The ERBB3 receptor in cancer and cancer gene therapy
    • PMID:18404164
    • Sithanandam G, Anderson LM. The ERBB3 receptor in cancer and cancer gene therapy. Cancer Gene Ther 2008; 15:413-48; PMID:18404164; http://dx. doi. org/10. 1038/cgt. 2008. 15
    • (2008) Cancer Gene Ther , vol.15 , pp. 413-448
    • Sithanandam, G.1    Anderson, L.M.2
  • 130
    • 0029814271 scopus 로고    scopus 로고
    • A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor
    • PMID:8816440
    • Tzahar E, Waterman H, Chen X, Levkowitz G, Karunagaran D, Lavi S, Ratzkin BJ, Yarden Y. A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol Cell Biol 1996; 16:5276-87; PMID:8816440
    • (1996) Mol Cell Biol , vol.16 , pp. 5276-5287
    • Tzahar, E.1    Waterman, H.2    Chen, X.3    Levkowitz, G.4    Karunagaran, D.5    Lavi, S.6    Ratzkin, B.J.7    Yarden, Y.8
  • 131
    • 36249003805 scopus 로고    scopus 로고
    • The HER family and cancer: Emerging molecular mechanisms and therapeutic targets
    • PMID:17981505
    • Sergina NV, Moasser MM. The HER family and cancer: emerging molecular mechanisms and therapeutic targets. Trends in molecular medicine 2007; 13:527- 34; PMID:17981505; http://dx. doi. org/10. 1016/j. molmed. 2007. 10. 002
    • (2007) Trends in molecular medicine , vol.13 , pp. 527-534
    • Sergina, N.V.1    Moasser, M.M.2
  • 133
    • 77955536171 scopus 로고    scopus 로고
    • HER3 mRNA as a predictive biomarker in anticancer therapy
    • PMID:20695834
    • Amler LC. HER3 mRNA as a predictive biomarker in anticancer therapy. Exp Opin Biol Ther 2010; 10:1343-55; PMID:20695834; http://dx. doi. org/ 10. 1517/14712598. 2010. 512003
    • (2010) Exp Opin Biol Ther , vol.10 , pp. 1343-1355
    • Amler, L.C.1
  • 136
    • 66249119060 scopus 로고    scopus 로고
    • Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer
    • PMID:19435893
    • Miller TW, Perez-Torres M, Narasanna A, Guix M, Stal O, Perez-Tenorio G, Gonzalez-Angulo AM, Hennessy BT, Mills GB, Kennedy JP, et al. Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer. Cancer Res 2009; 69:4192-201; PMID:19435893; http://dx. doi. org/ 10. 1158/0008-5472. CAN-09-0042
    • (2009) Cancer Res , vol.69 , pp. 4192-4201
    • Miller, T.W.1    Perez-Torres, M.2    Narasanna, A.3    Guix, M.4    Stal, O.5    Perez-Tenorio, G.6    Gonzalez-Angulo, A.M.7    Hennessy, B.T.8    Mills, G.B.9    Kennedy, J.P.10
  • 137
    • 44149128380 scopus 로고    scopus 로고
    • The role of ErbB3 and its binding partners in breast cancer progression and resistance to hormone and tyrosine kinase directed therapies
    • PMID:18425425
    • Hamburger AW. The role of ErbB3 and its binding partners in breast cancer progression and resistance to hormone and tyrosine kinase directed therapies. J Mammary Gland Biol Neoplasia 2008; 13:225-33; PMID:18425425; http://dx. doi. org/10. 1007/s10911- 008-9077-5
    • (2008) J Mammary Gland Biol Neoplasia , vol.13 , pp. 225-233
    • Hamburger, A.W.1
  • 138
    • 84938630138 scopus 로고    scopus 로고
    • HER-3 peptide vaccines/mimics: Combined therapy with IGF-1R, HER-2, and HER-1 peptides induces synergistic antitumor effects against breast and pancreatic cancer cells
    • Miller MJ, Foy KC, Overholser JP, Nahta R, Kaumaya PTP. HER-3 peptide vaccines/mimics: Combined therapy with IGF-1R, HER-2, and HER-1 peptides induces synergistic antitumor effects against breast and pancreatic cancer cells. OncoImmunology 2014; 3:e956012; http://dx. doi. org/10. 4161/ 21624011. 2014. 956012
    • (2014) OncoImmunology , vol.3
    • Miller, M.J.1    Foy, K.C.2    Overholser, J.P.3    Nahta, R.4    Kaumaya, P.T.P.5
  • 139
    • 0033906634 scopus 로고    scopus 로고
    • Structure and function of the type 1 insulin-like growth factor receptor
    • PMID:10961344
    • Adams TE, Epa VC, Garrett TP, Ward CW. Structure and function of the type 1 insulin-like growth factor receptor. Cell Mol Life Sci 2000; 57:1050-93; PMID:10961344; http://dx. doi. org/10. 1007/ PL00000744
    • (2000) Cell Mol Life Sci , vol.57 , pp. 1050-1093
    • Adams, T.E.1    Epa, V.C.2    Garrett, T.P.3    Ward, C.W.4
  • 140
    • 0033585421 scopus 로고    scopus 로고
    • Plasma levels of insulin-like growth factor-I and lung cancer risk: A case-control analysis
    • PMID:9923856
    • Yu H, Spitz MR, Mistry J, Gu J, Hong WK, Wu X. Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis. J Natl Cancer Inst 1999; 91:151-6; PMID:9923856; http://dx. doi. org/ 10. 1093/jnci/91. 2. 151
    • (1999) J Natl Cancer Inst , vol.91 , pp. 151-156
    • Yu, H.1    Spitz, M.R.2    Mistry, J.3    Gu, J.4    Hong, W.K.5    Wu, X.6
  • 142
    • 0028997487 scopus 로고
    • Insulin-like growth factor I overexpression in human pancreatic cancer: Evidence for autocrine and paracrine roles
    • PMID:7743492
    • Bergmann U, Funatomi H, Yokoyama M, Beger HG, Korc M. Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles. Cancer Res 1995; 55:2007-11; PMID:7743492
    • (1995) Cancer Res , vol.55 , pp. 2007-2011
    • Bergmann, U.1    Funatomi, H.2    Yokoyama, M.3    Beger, H.G.4    Korc, M.5
  • 143
    • 0033531765 scopus 로고    scopus 로고
    • Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
    • PMID:10203281
    • Ma J, Pollak MN, Giovannucci E, Chan JM, Tao Y, Hennekens CH, Stampfer MJ. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst 1999; 91:620-5; PMID:10203281; http://dx. doi. org/10. 1093/jnci/ 91. 7. 620
    • (1999) J Natl Cancer Inst , vol.91 , pp. 620-625
    • Ma, J.1    Pollak, M.N.2    Giovannucci, E.3    Chan, J.M.4    Tao, Y.5    Hennekens, C.H.6    Stampfer, M.J.7
  • 144
    • 0032559272 scopus 로고    scopus 로고
    • Plasma insulin-like growth factor-I and prostate cancer risk: A prospective study
    • PMID:9438850
    • Chan JM, Stampfer MJ, Giovannucci E, Gann PH, Ma J, Wilkinson P, Hennekens CH, Pollak M. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 1998; 279:563- 6; PMID:9438850; http://dx. doi. org/10. 1126/ science. 279. 5350. 563
    • (1998) Science , vol.279 , pp. 563-566
    • Chan, J.M.1    Stampfer, M.J.2    Giovannucci, E.3    Gann, P.H.4    Ma, J.5    Wilkinson, P.6    Hennekens, C.H.7    Pollak, M.8
  • 145
    • 3042673048 scopus 로고    scopus 로고
    • Serum levels of insulin growth factor (IGF-I) and IGF-binding protein predict risk of second primary tumors in patients with head and neck cancer
    • PMID:15217929
    • Wu X, Zhao H, Do KA, Johnson MM, Dong Q, Hong WK, Spitz MR. Serum levels of insulin growth factor (IGF-I) and IGF-binding protein predict risk of second primary tumors in patients with head and neck cancer. Clin Cancer Res 2004; 10:3988-95; PMID:15217929; http://dx. doi. org/10. 1158/1078- 0432. CCR-03-0762
    • (2004) Clin Cancer Res , vol.10 , pp. 3988-3995
    • Wu, X.1    Zhao, H.2    Do, K.A.3    Johnson, M.M.4    Dong, Q.5    Hong, W.K.6    Spitz, M.R.7
  • 146
    • 33750571170 scopus 로고    scopus 로고
    • Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib
    • PMID:17047074
    • Morgillo F, Woo JK, Kim ES, Hong WK, Lee HY. Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib. Cancer research 2006; 66:10100- 11; PMID:17047074; http://dx. doi. org/10. 1158/ 0008-5472. CAN-06-1684
    • (2006) Cancer research , vol.66 , pp. 10100-10111
    • Morgillo, F.1    Woo, J.K.2    Kim, E.S.3    Hong, W.K.4    Lee, H.Y.5
  • 147
    • 9244220090 scopus 로고    scopus 로고
    • Evidence that basal activity, but not transactivation, of the epidermal growth factor receptor tyrosine kinase is required for insulin-like growth factor I-induced activation of extracellular signal-regulated kinase in oral carcinoma cells
    • PMID:15271882
    • Kuribayashi A, Kataoka K, Kurabayashi T, Miura M. Evidence that basal activity, but not transactivation, of the epidermal growth factor receptor tyrosine kinase is required for insulin-like growth factor I-induced activation of extracellular signal-regulated kinase in oral carcinoma cells. Endocrinology 2004; 145:4976-84; PMID:15271882; http://dx. doi. org/10. 1210/ en. 2004-0713
    • (2004) Endocrinology , vol.145 , pp. 4976-4984
    • Kuribayashi, A.1    Kataoka, K.2    Kurabayashi, T.3    Miura, M.4
  • 148
    • 33745929892 scopus 로고    scopus 로고
    • Model for the complex between the insulin-like growth factor I and its receptor: Towards designing antagonists for the IGF-1 receptor
    • PMID:16772308
    • Epa VC, Ward CW. Model for the complex between the insulin-like growth factor I and its receptor: towards designing antagonists for the IGF-1 receptor. Protein Eng Des Sel 2006; 19:377-84; PMID:16772308; http://dx. doi. org/10. 1093/protein/ gzl022
    • (2006) Protein Eng Des Sel , vol.19 , pp. 377-384
    • Epa, V.C.1    Ward, C.W.2
  • 149
    • 84938631417 scopus 로고    scopus 로고
    • IGF-1R peptide vaccines/ mimics inhibit the growth of BxPC3 and JIMT-1 cancer cells and exhibit synergistic antitumor effects with HER-1 and HER-2 peptides
    • Foy KC, Miller MJ, Overholser J, Donnelly SM, Nahta R, Kaumaya PTP. IGF-1R peptide vaccines/ mimics inhibit the growth of BxPC3 and JIMT-1 cancer cells and exhibit synergistic antitumor effects with HER-1 and HER-2 peptides. OncoImmunology 2014; 3:e956005; http://dx. doi. org/10. 4161/ 21624011. 2014. 956005
    • (2014) OncoImmunology , vol.3
    • Foy, K.C.1    Miller, M.J.2    Overholser, J.3    Donnelly, S.M.4    Nahta, R.5    Kaumaya, P.T.P.6
  • 150
    • 0035804218 scopus 로고    scopus 로고
    • Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells
    • PMID:11244498
    • Balana ME, Labriola L, Salatino M, Movsichoff F, Peters G, Charreau EH, Elizalde PV. Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells. Oncogene 2001; 20:34-47; PMID:11244498; http://dx. doi. org/10. 1038/sj. onc. 1204050
    • (2001) Oncogene , vol.20 , pp. 34-47
    • Balana, M.E.1    Labriola, L.2    Salatino, M.3    Movsichoff, F.4    Peters, G.5    Charreau, E.H.6    Elizalde, P.V.7
  • 151
    • 0036963448 scopus 로고    scopus 로고
    • Co-targeting HER2/ ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cells
    • Camirand A, Lu Y, Pollak M. Co-targeting HER2/ ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cells. Med Sci Monit 2002; 8: BR521-6
    • (2002) Med Sci Monit , vol.8 , pp. BR521-BR526
    • Camirand, A.1    Lu, Y.2    Pollak, M.3
  • 152
    • 28244432561 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
    • PMID:16322262
    • Nahta R, Yuan LX, Zhang B, Kobayashi R, Esteva FJ. Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res 2005; 65:11118-28; PMID:16322262; http://dx. doi. org/10. 1158/0008- 5472. CAN-04-3841
    • (2005) Cancer Res , vol.65 , pp. 11118-11128
    • Nahta, R.1    Yuan, L.X.2    Zhang, B.3    Kobayashi, R.4    Esteva, F.J.5
  • 153
    • 33644615750 scopus 로고    scopus 로고
    • IGF-1 induced vascular endothelial growth factor secretion in head and neck squamous cell carcinoma
    • PMID:16499871
    • Slomiany MG, Black LA, Kibbey MM, Day TA, Rosenzweig SA. IGF-1 induced vascular endothelial growth factor secretion in head and neck squamous cell carcinoma. Biochem Biophys Res Commun 2006; 342:851-8; PMID:16499871; http://dx. doi. org/10. 1016/j. bbrc. 2006. 02. 043
    • (2006) Biochem Biophys Res Commun , vol.342 , pp. 851-858
    • Slomiany, M.G.1    Black, L.A.2    Kibbey, M.M.3    Day, T.A.4    Rosenzweig, S.A.5
  • 154
    • 33947202858 scopus 로고    scopus 로고
    • Downregulation of erbB3 abrogates erbB2-mediated tamoxifen resistance in breast cancer cells
    • PMID:17266042
    • Liu B, Ordonez-Ercan D, Fan Z, Edgerton SM, Yang X, Thor AD. Downregulation of erbB3 abrogates erbB2-mediated tamoxifen resistance in breast cancer cells. Int J Cancer 2007; 120:1874-82; PMID:17266042; http://dx. doi. org/10. 1002/ ijc. 22423
    • (2007) Int J Cancer , vol.120 , pp. 1874-1882
    • Liu, B.1    Ordonez-Ercan, D.2    Fan, Z.3    Edgerton, S.M.4    Yang, X.5    Thor, A.D.6
  • 155
    • 33846552656 scopus 로고    scopus 로고
    • Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
    • PMID:17206155
    • Sergina NV, Rausch M, Wang D, Blair J, Hann B, Shokat KM, Moasser MM. Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 2007; 445:437-41; PMID:17206155; http://dx. doi. org/10. 1038/ nature05474
    • (2007) Nature , vol.445 , pp. 437-441
    • Sergina, N.V.1    Rausch, M.2    Wang, D.3    Blair, J.4    Hann, B.5    Shokat, K.M.6    Moasser, M.M.7
  • 156
    • 0346154748 scopus 로고    scopus 로고
    • Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells
    • PMID:14648698
    • Lu Y, Zi X, Pollak M. Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells. Int J Cancer 2004; 108:334-41; PMID:14648698; http://dx. doi. org/10. 1002/ ijc. 11445
    • (2004) Int J Cancer , vol.108 , pp. 334-341
    • Lu, Y.1    Zi, X.2    Pollak, M.3
  • 157
    • 54049086648 scopus 로고    scopus 로고
    • HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924
    • PMID:18765823
    • Haluska P, Carboni JM, TenEyck C, Attar RM, Hou X, Yu C, Sagar M, Wong TW, Gottardis MM, Erlichman C. HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924. Mol Cancer Ther 2008; 7:2589-98; PMID:18765823; http://dx. doi. org/10. 1158/1535- 7163. MCT-08-0493
    • (2008) Mol Cancer Ther , vol.7 , pp. 2589-2598
    • Haluska, P.1    Carboni, J.M.2    TenEyck, C.3    Attar, R.M.4    Hou, X.5    Yu, C.6    Sagar, M.7    Wong, T.W.8    Gottardis, M.M.9    Erlichman, C.10
  • 158
    • 84919714378 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor signaling increases the invasive potential of HER2-overexpressing breast cancer cells via Src-FAK and FoxM1
    • PMID:25391374
    • Sanabria-Figueroa E, Donnelly S, Foy K, Buss M, Castellino RC, Paplomata E, Taliaferro-Smith L, Kaumaya P, Nahta R. Insulin-like growth factor-1 receptor signaling increases the invasive potential of HER2-overexpressing breast cancer cells via Src-FAK and FoxM1. Mol Pharmacol 2014; 87(2):150-61; PMID:25391374
    • (2014) Mol Pharmacol , vol.87 , Issue.2 , pp. 150-161
    • Sanabria-Figueroa, E.1    Donnelly, S.2    Foy, K.3    Buss, M.4    Castellino, R.C.5    Paplomata, E.6    Taliaferro-Smith, L.7    Kaumaya, P.8    Nahta, R.9
  • 159
    • 46749156706 scopus 로고    scopus 로고
    • Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins
    • PMID:18568074
    • Guix M, Faber AC, Wang SE, Olivares MG, Song Y, Qu S, Rinehart C, Seidel B, Yee D, Arteaga CL, et al. Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. J Clin Invest 2008; 118:2609-19; PMID:18568074
    • (2008) J Clin Invest , vol.118 , pp. 2609-2619
    • Guix, M.1    Faber, A.C.2    Wang, S.E.3    Olivares, M.G.4    Song, Y.5    Qu, S.6    Rinehart, C.7    Seidel, B.8    Yee, D.9    Arteaga, C.L.10
  • 160
    • 77955635233 scopus 로고    scopus 로고
    • Cancer statistics, 2010
    • PMID:20610543
    • Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010; 60:277-300; PMID:20610543; http://dx. doi. org/10. 3322/ caac. 20073
    • (2010) CA Cancer J Clin , vol.60 , pp. 277-300
    • Jemal, A.1    Siegel, R.2    Xu, J.3    Ward, E.4
  • 161
    • 55249085150 scopus 로고    scopus 로고
    • Cancer of the pancreas: Are we making progress? A review of studies in the US Oncology Research Network
    • PMID:18813198
    • Cartwright T, Richards DA, Boehm KA. Cancer of the pancreas: are we making progress? A review of studies in the US Oncology Research Network. Cancer Control 2008; 15:308-13; PMID:18813198
    • (2008) Cancer Control , vol.15 , pp. 308-313
    • Cartwright, T.1    Richards, D.A.2    Boehm, K.A.3
  • 162
    • 84863319601 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma
    • PMID:22086503
    • Valsecchi ME, McDonald M, Brody JR, Hyslop T, Freydin B, Yeo CJ, Solomides C, Peiper SC, Witkiewicz AK. Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma. Cancer 2012; 118:3484-93; PMID:22086503; http://dx. doi. org/10. 1002/cncr. 26661
    • (2012) Cancer , vol.118 , pp. 3484-3493
    • Valsecchi, M.E.1    McDonald, M.2    Brody, J.R.3    Hyslop, T.4    Freydin, B.5    Yeo, C.J.6    Solomides, C.7    Peiper, S.C.8    Witkiewicz, A.K.9
  • 163
    • 0032423809 scopus 로고    scopus 로고
    • Epidermal growth factor and its receptor as prognostic indicators in Chinese patients with pancreatic cancer
    • PMID:9891528
    • Dong M, Nio Y, Guo KJ, Tamura K, Tian YL, Dong YT. Epidermal growth factor and its receptor as prognostic indicators in Chinese patients with pancreatic cancer. Anticancer Res 1998; 18:4613-9; PMID:9891528
    • (1998) Anticancer Res , vol.18 , pp. 4613-4619
    • Dong, M.1    Nio, Y.2    Guo, K.J.3    Tamura, K.4    Tian, Y.L.5    Dong, Y.T.6
  • 164
    • 0031937611 scopus 로고    scopus 로고
    • Epidermal growth factor receptor activation in androgen-independent but not androgen-stimulated growth of human prostatic carcinoma cells
    • PMID:9528825
    • Sherwood ER, Van Dongen JL, Wood CG, Liao S, Kozlowski JM, Lee C. Epidermal growth factor receptor activation in androgen-independent but not androgen-stimulated growth of human prostatic carcinoma cells. Br J Cancer 1998; 77:855-61; PMID:9528825; http://dx. doi. org/10. 1038/ bjc. 1998. 142
    • (1998) Br J Cancer , vol.77 , pp. 855-861
    • Sherwood, E.R.1    Van Dongen, J.L.2    Wood, C.G.3    Liao, S.4    Kozlowski, J.M.5    Lee, C.6
  • 165
    • 0042926509 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer
    • PMID:12937141
    • Stoeltzing O, Liu W, Reinmuth N, Fan F, Parikh AA, Bucana CD, Evans DB, Semenza GL, Ellis LM. Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. A J Pathol 2003; 163:1001-11; PMID:12937141; http://dx. doi. org/ 10. 1016/S0002-9440(10)63460-8
    • (2003) A J Pathol , vol.163 , pp. 1001-1011
    • Stoeltzing, O.1    Liu, W.2    Reinmuth, N.3    Fan, F.4    Parikh, A.A.5    Bucana, C.D.6    Evans, D.B.7    Semenza, G.L.8    Ellis, L.M.9
  • 166
    • 0030816910 scopus 로고    scopus 로고
    • Altered expression of insulin-like growth factor II receptor in human pancreatic cancer
    • PMID:9361090
    • Ishiwata T, Bergmann U, Kornmann M, Lopez M, Beger HG, Korc M. Altered expression of insulin-like growth factor II receptor in human pancreatic cancer. Pancreas 1997; 15:367-73; PMID:9361090; http:// dx. doi. org/10. 1097/00006676-199711000-00006
    • (1997) Pancreas , vol.15 , pp. 367-373
    • Ishiwata, T.1    Bergmann, U.2    Kornmann, M.3    Lopez, M.4    Beger, H.G.5    Korc, M.6
  • 167
    • 84879055684 scopus 로고    scopus 로고
    • Co-inhibition of epidermal growth factor receptor and insulin-like growth factor receptor 1 enhances radiosensitivity in human breast cancer cells
    • PMID:23777562
    • Li P, Veldwijk MR, Zhang Q, Li ZB, Xu WC, Fu S. Co-inhibition of epidermal growth factor receptor and insulin-like growth factor receptor 1 enhances radiosensitivity in human breast cancer cells. BMC Cancer 2013; 13:297; PMID:23777562; http://dx. doi. org/10. 1186/1471-2407-13-297
    • (2013) BMC Cancer , vol.13 , pp. 297
    • Li, P.1    Veldwijk, M.R.2    Zhang, Q.3    Li, Z.B.4    Xu, W.C.5    Fu, S.6
  • 168
    • 77649095719 scopus 로고    scopus 로고
    • HER3 comes of age: New insights into its functions and role in signaling, tumor biology, and cancer therapy
    • PMID:20179223
    • Campbell MR, Amin D, Moasser MM. HER3 comes of age: new insights into its functions and role in signaling, tumor biology, and cancer therapy. Clin Cancer Res 2010; 16:1373-83; PMID:20179223; http:// dx. doi. org/10. 1158/1078-0432. CCR-09-1218
    • (2010) Clin Cancer Res , vol.16 , pp. 1373-1383
    • Campbell, M.R.1    Amin, D.2    Moasser, M.M.3
  • 169
    • 33746905531 scopus 로고    scopus 로고
    • Phosphotyrosine interactome of the ErbB-receptor kinase family
    • PMID:16729043
    • Schulze WX, Deng L, Mann M. Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol 2005; 1:2005 0008; PMID:16729043; http://dx. doi. org/10. 1038/msb4100012
    • (2005) Mol Syst Biol , vol.1
    • Schulze, W.X.1    Deng, L.2    Mann, M.3
  • 170
    • 0141731299 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling
    • PMID:14522909
    • Tai YT, Podar K, Catley L, Tseng YH, Akiyama M, Shringarpure R, Burger R, Hideshima T, Chauhan D, Mitsiades N, et al. Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling. Cancer Res 2003; 63:5850-8; PMID:14522909
    • (2003) Cancer Res , vol.63 , pp. 5850-5858
    • Tai, Y.T.1    Podar, K.2    Catley, L.3    Tseng, Y.H.4    Akiyama, M.5    Shringarpure, R.6    Burger, R.7    Hideshima, T.8    Chauhan, D.9    Mitsiades, N.10
  • 171
    • 0034974302 scopus 로고    scopus 로고
    • IGF-I receptor signalling in transformation and differentiation
    • PMID:11376123
    • Valentinis B, Baserga R. IGF-I receptor signalling in transformation and differentiation. Mol Pathol 2001; 54:133-7; PMID:11376123; http://dx. doi. org/ 10. 1136/mp. 54. 3. 133
    • (2001) Mol Pathol , vol.54 , pp. 133-137
    • Valentinis, B.1    Baserga, R.2
  • 172
    • 0034630763 scopus 로고    scopus 로고
    • Neuregulin induces the rapid association of focal adhesion kinase with the erbB2-erbB3 receptor complex in schwann cells
    • PMID:10799311
    • Vartanian T, Goodearl A, Lefebvre S, Park SK, Fischbach G. Neuregulin induces the rapid association of focal adhesion kinase with the erbB2-erbB3 receptor complex in schwann cells. Biochem Biophys Res Commun 2000; 271:414-7; PMID:10799311; http://dx. doi. org/10. 1006/bbrc. 2000. 2624
    • (2000) Biochem Biophys Res Commun , vol.271 , pp. 414-417
    • Vartanian, T.1    Goodearl, A.2    Lefebvre, S.3    Park, S.K.4    Fischbach, G.5
  • 173
    • 77950257304 scopus 로고    scopus 로고
    • Disruption of laminin-integrin-CD151- focal adhesion kinase axis sensitizes breast cancer cells to ErbB2 antagonists
    • PMID:20197472
    • Yang XH, Flores LM, Li Q, Zhou P, Xu F, Krop IE, Hemler ME. Disruption of laminin-integrin-CD151- focal adhesion kinase axis sensitizes breast cancer cells to ErbB2 antagonists. Cancer Res 2010; 70:2256-63; PMID:20197472; http://dx. doi. org/10. 1158/0008- 5472. CAN-09-4032
    • (2010) Cancer Res , vol.70 , pp. 2256-2263
    • Yang, X.H.1    Flores, L.M.2    Li, Q.3    Zhou, P.4    Xu, F.5    Krop, I.E.6    Hemler, M.E.7
  • 174
    • 33646896769 scopus 로고    scopus 로고
    • Focal adhesion kinase controls cellular levels of p27/Kip1 and p21/ Cip1 through Skp2-dependent and -independent mechanisms
    • PMID:16705171
    • Bryant P, Zheng Q, Pumiglia K. Focal adhesion kinase controls cellular levels of p27/Kip1 and p21/ Cip1 through Skp2-dependent and -independent mechanisms. Mol Cell Biol 2006; 26:4201-13; PMID:16705171; http://dx. doi. org/10. 1128/ MCB. 01612-05
    • (2006) Mol Cell Biol , vol.26 , pp. 4201-4213
    • Bryant, P.1    Zheng, Q.2    Pumiglia, K.3
  • 175
    • 51849111524 scopus 로고    scopus 로고
    • NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
    • PMID:18829560
    • Serra V, Markman B, Scaltriti M, Eichhorn PJ, Valero V, Guzman M, Botero ML, Llonch E, Atzori F, Di Cosimo S, et al. NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res 2008; 68:8022-30; PMID:18829560; http://dx. doi. org/10. 1158/0008-5472. CAN-08-1385
    • (2008) Cancer Res , vol.68 , pp. 8022-8030
    • Serra, V.1    Markman, B.2    Scaltriti, M.3    Eichhorn, P.J.4    Valero, V.5    Guzman, M.6    Botero, M.L.7    Llonch, E.8    Atzori, F.9    Di Cosimo, S.10
  • 176
    • 52449092107 scopus 로고    scopus 로고
    • Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling
    • PMID:18725974
    • She QB, Chandarlapaty S, Ye Q, Lobo J, Haskell KM, Leander KR, DeFeo-Jones D, Huber HE, Rosen N. Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. PLoS One 2008; 3:e3065; PMID:18725974; http:// dx. doi. org/10. 1371/journal. pone. 0003065
    • (2008) PLoS One , vol.3
    • She, Q.B.1    Chandarlapaty, S.2    Ye, Q.3    Lobo, J.4    Haskell, K.M.5    Leander, K.R.6    DeFeo-Jones, D.7    Huber, H.E.8    Rosen, N.9
  • 177
    • 33751168744 scopus 로고    scopus 로고
    • Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor
    • PMID:16887935
    • Tseng PH, Wang YC, Weng SC, Weng JR, Chen CS, Brueggemeier RW, Shapiro CL, Chen CY, Dunn SE, Pollak M. Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor. Mol Pharmacol 2006; 70:1534- 41; PMID:16887935; http://dx. doi. org/10. 1124/ mol. 106. 023911
    • (2006) Mol Pharmacol , vol.70 , pp. 1534-1541
    • Tseng, P.H.1    Wang, Y.C.2    Weng, S.C.3    Weng, J.R.4    Chen, C.S.5    Brueggemeier, R.W.6    Shapiro, C.L.7    Chen, C.Y.8    Dunn, S.E.9    Pollak, M.10
  • 178
    • 57149142362 scopus 로고    scopus 로고
    • Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer
    • PMID:19034632
    • Jin Q, Esteva FJ. Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer. J Mammary Gland Biol Neoplasia 2008; 13:485-98; PMID:19034632; http://dx. doi. org/10. 1007/s10911- 008-9107-3
    • (2008) J Mammary Gland Biol Neoplasia , vol.13 , pp. 485-498
    • Jin, Q.1    Esteva, F.J.2
  • 180
    • 84859802154 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical dose
    • PMID:22203367
    • Kamath AV, Lu D, Gupta P, Jin D, Xiang H, Wong A, Leddy C, Crocker L, Schaefer G, Sliwkowski MX, et al. Preclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical dose. Cancer Chemother Pharmacol 2012; 69 (4):1063-69; PMID:22203367; http://dx. doi. org/ 10:1007/s00280-011-1806-6
    • (2012) Cancer Chemother Pharmacol , vol.69 , Issue.4 , pp. 1063-1069
    • Kamath, A.V.1    Lu, D.2    Gupta, P.3    Jin, D.4    Xiang, H.5    Wong, A.6    Leddy, C.7    Crocker, L.8    Schaefer, G.9    Sliwkowski, M.X.10
  • 181
    • 80054765331 scopus 로고    scopus 로고
    • A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies
    • PMID:22014573
    • Schaefer G, Haber L, Crocker LM, Shia S, Shao L, Dowbenko D, Totpal K, Wong A, Lee CV, Stawicki S, et al. A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies. Cancer Cell 2011; 20:472- 86; PMID:22014573; http://dx. doi. org/10. 1016/j. ccr. 2011. 09. 003
    • (2011) Cancer Cell , vol.20 , pp. 472-486
    • Schaefer, G.1    Haber, L.2    Crocker, L.M.3    Shia, S.4    Shao, L.5    Dowbenko, D.6    Totpal, K.7    Wong, A.8    Lee, C.V.9    Stawicki, S.10
  • 183
    • 0029739588 scopus 로고    scopus 로고
    • c-erbB3 protein expression in ovarian cancer
    • PMID:16696074
    • Rajkumar T, Stamp GW, Hughes CM, Gullick WJ. c-erbB3 protein expression in ovarian cancer. Clin Mol Pathol 1996; 49:M199-202; PMID:16696074; http://dx. doi. org/10. 1136/mp. 49. 4. M199
    • (1996) Clin Mol Pathol , vol.49 , pp. M199-M202
    • Rajkumar, T.1    Stamp, G.W.2    Hughes, C.M.3    Gullick, W.J.4
  • 184
    • 84891596003 scopus 로고    scopus 로고
    • Preclinical HER-2 Vaccines: From Rodent to Human HER-2
    • PMID:23772419
    • Lollini PL, De Giovanni C, Nanni P. Preclinical HER-2 Vaccines: From Rodent to Human HER-2. Front Oncol 2013; 3:151; PMID:23772419; http:// dx. doi. org/10. 3389/fonc. 2013. 00151
    • (2013) Front Oncol , vol.3 , pp. 151
    • Lollini, P.L.1    De Giovanni, C.2    Nanni, P.3
  • 185
    • 44449107609 scopus 로고    scopus 로고
    • Basic concept of development and practical application of animal models for human diseases
    • PMID:18481450
    • Nomura T, Tamaoki N, Takakura A, Suemizu H. Basic concept of development and practical application of animal models for human diseases. Curr Top Microbiol Immunol 2008; 324:1-24; PMID:18481450
    • (2008) Curr Top Microbiol Immunol , vol.324 , pp. 1-24
    • Nomura, T.1    Tamaoki, N.2    Takakura, A.3    Suemizu, H.4
  • 186
    • 18344410760 scopus 로고    scopus 로고
    • NOD/SCID/gamma(c)(null) mouse: An excellent recipient mouse model for engraftment of human cells
    • PMID:12384415
    • Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K, Ueyama Y, Koyanagi Y, Sugamura K, Tsuji K, et al. NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 2002; 100:3175- 82; PMID:12384415; http://dx. doi. org/10. 1182/ blood-2001-12-0207
    • (2002) Blood , vol.100 , pp. 3175-3182
    • Ito, M.1    Hiramatsu, H.2    Kobayashi, K.3    Suzue, K.4    Kawahata, M.5    Hioki, K.6    Ueyama, Y.7    Koyanagi, Y.8    Sugamura, K.9    Tsuji, K.10
  • 188
    • 1842588698 scopus 로고    scopus 로고
    • Development of a human adaptive immune system in cord blood celltransplanted mice
    • PMID:15064419
    • Traggiai E, Chicha L, Mazzucchelli L, Bronz L, Piffaretti JC, Lanzavecchia A, Manz MG. Development of a human adaptive immune system in cord blood celltransplanted mice. Science 2004; 304:104-7; PMID:15064419; http://dx. doi. org/10. 1126/ science. 1093933
    • (2004) Science , vol.304 , pp. 104-107
    • Traggiai, E.1    Chicha, L.2    Mazzucchelli, L.3    Bronz, L.4    Piffaretti, J.C.5    Lanzavecchia, A.6    Manz, M.G.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.