메뉴 건너뛰기




Volumn 16, Issue 9, 2010, Pages 2512-2517

Targeting the insulin-like growth factor receptor-1R pathway for cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR BLOCKING AGENT; SOMATOMEDIN RECEPTOR; SOMATOMEDIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

EID: 77951709259     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-09-2232     Document Type: Review
Times cited : (122)

References (58)
  • 1
    • 43349088787 scopus 로고    scopus 로고
    • Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer
    • DOI 10.1517/14728222.12.5.589
    • Yuen JS, Macaulay VM. Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer. Expert Opin Ther Targets 2008;12:589-603. (Pubitemid 351699478)
    • (2008) Expert Opinion on Therapeutic Targets , vol.12 , Issue.5 , pp. 589-603
    • Yuen, J.S.P.1    Macaulay, V.M.2
  • 2
    • 0036111682 scopus 로고    scopus 로고
    • Insulin-like growth factors and cancer
    • Furstenberger G, Senn HJ. Insulin-like growth factors and cancer. Lancet Oncol 2002;3:298-302.
    • (2002) Lancet Oncol , vol.3 , pp. 298-302
    • Furstenberger, G.1    Senn, H.J.2
  • 3
    • 0032930759 scopus 로고    scopus 로고
    • Type-2 IGF receptor: A multi-ligand binding protein
    • Braulke T. Type-2 IGF receptor: a multi-ligand binding protein. Horm Metab Res 1999;31:242-246 (Pubitemid 29169502)
    • (1999) Hormone and Metabolic Research , vol.31 , Issue.2-3 , pp. 242-246
    • Braulke, T.1
  • 4
    • 33750453743 scopus 로고    scopus 로고
    • Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells
    • DOI 10.1038/sj.bjc.6603354, PII 6603354
    • Byron SA, Horwitz KB, Richer JK, Lange CA, Zhang X, Yee D. Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells. Br J Cancer 2006;95:1220-1228 (Pubitemid 44658486)
    • (2006) British Journal of Cancer , vol.95 , Issue.9 , pp. 1220-1228
    • Byron, S.A.1    Horwitz, K.B.2    Richer, J.K.3    Lange, C.A.4    Zhang, X.5    Yee, D.6
  • 5
    • 23144467910 scopus 로고    scopus 로고
    • An expanding role for mTOR in cancer
    • Guertin DA, Sabatini DM. An expanding role for mTOR in cancer. Trends Mol Med 2005;11:353-361
    • (2005) Trends Mol Med , vol.11 , pp. 353-361
    • Guertin, D.A.1    Sabatini, D.M.2
  • 6
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev 1999;13:2905-2927
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 7
    • 77951723307 scopus 로고    scopus 로고
    • mTOR and cancer: Many loops in one pathway
    • Epub 2009 Nov 27
    • Efeyan A, Sabatini DM. mTOR and cancer: many loops in one pathway. Curr Opin Cell Biol 2009, Epub 2009 Nov 27.
    • (2009) Curr Opin Cell Biol
    • Efeyan, A.1    Sabatini, D.M.2
  • 8
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 2008;8:915-928
    • (2008) Nat Rev Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 9
    • 0037191919 scopus 로고    scopus 로고
    • In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform a
    • Sciacca L, Mineo R, Pandini G, Murabito A, Vigneri R, Belfiore A. In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A. Oncogene 2002;21:8240-8250
    • (2002) Oncogene , vol.21 , pp. 8240-8250
    • Sciacca, L.1    Mineo, R.2    Pandini, G.3    Murabito, A.4    Vigneri, R.5    Belfiore, A.6
  • 10
    • 0032800850 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: Evidence for a second mechanism of IGF-I signaling
    • Pandini G, Vigneri R, Costantino A, et al. Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling. Clin Cancer Res 1999;5:1935-1944.
    • (1999) Clin Cancer Res , vol.5 , pp. 1935-1944
    • Pandini, G.1    Vigneri, R.2    Costantino, A.3
  • 13
    • 33846859096 scopus 로고    scopus 로고
    • IGF1R signalling and its inhibition
    • Riedemann J, Macaulay VM. IGF1R signalling and its inhibition. Endocr Relat Cancer 2006;13 [Suppl 1]:S33-43.
    • (2006) Endocr Relat Cancer , vol.13 , Issue.SUPPL. 1
    • Riedemann, J.1    Macaulay, V.M.2
  • 14
    • 37549006702 scopus 로고    scopus 로고
    • Integrated profiling of basal and luminal breast cancers
    • Adelaide J, Finetti P, Bekhouche I, et al. Integrated profiling of basal and luminal breast cancers. Cancer Res 2007;67:11565-11575
    • (2007) Cancer Res , vol.67 , pp. 11565-11575
    • Adelaide, J.1    Finetti, P.2    Bekhouche, I.3
  • 16
    • 0036022345 scopus 로고    scopus 로고
    • IGF1 receptor expression protects against microenvironmental stress found in the solid tumor
    • Peretz S, Kim C, Rockwell S, Baserga R, Glazer PM. IGF1 receptor expression protects against microenvironmental stress found in the solid tumor. Radiat Res 2002;158:174-180 (Pubitemid 34851812)
    • (2002) Radiation Research , vol.158 , Issue.2 , pp. 174-180
    • Peretz, S.1    Kim, C.2    Rockwell, S.3    Baserga, R.4    Glazer, P.M.5
  • 17
    • 0029027521 scopus 로고
    • The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo
    • Resnicoff M, Abraham D, Yutanawiboonchai W, et al. The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo. Cancer Res 1995;55:2463-2469
    • (1995) Cancer Res , vol.55 , pp. 2463-2469
    • Resnicoff, M.1    Abraham, D.2    Yutanawiboonchai, W.3
  • 18
    • 0036559535 scopus 로고    scopus 로고
    • Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis
    • DOI 10.1016/S1535-6108(02)00055-7
    • Lopez T, Hanahan D. Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 2002;1:339-353 (Pubitemid 41039136)
    • (2002) Cancer Cell , vol.1 , Issue.4 , pp. 339-353
    • Lopez, T.1    Hanahan, D.2
  • 19
    • 0031770813 scopus 로고    scopus 로고
    • Frequent loss of imprinting of the H19 and IGF-II genes in ovarian tumors
    • DOI 10.1002/(SICI)1096-8628(19981204)80:4<391::AID-AJMG16>3.0.CO;2- H
    • Kim HT, Choi BH, Niikawa N, Lee TS, Chang SI. Frequent loss of imprinting of the H19 and IGF-II genes in ovarian tumors. Am J Med Genet 1998;80:391-395 (Pubitemid 28541605)
    • (1998) American Journal of Medical Genetics , vol.80 , Issue.4 , pp. 391-395
    • Kirn, H.T.1    Choi, B.H.2    Niikawa, N.3    Lee Sung, T.4    Chang, S.I.5
  • 21
    • 0032127906 scopus 로고    scopus 로고
    • Insulin-like growth factor II (IGF-II)
    • O'Dell SD, Day IN. Insulin-like growth factor II (IGF-II). Int J Biochem Cell Biol 1998;30:767-771
    • (1998) Int J Biochem Cell Biol , vol.30 , pp. 767-771
    • O'Dell, S.D.1    Day, I.N.2
  • 22
    • 0033059976 scopus 로고    scopus 로고
    • Enhancement of susceptibility to diverse skin tumor promoters by activation of the insulin-like growth factor-1 receptor in the epidermis of transgenic mice
    • DOI 10.1002/(SICI)1098-2744(199906)25:2<122::AID-MC7>3.0.CO;2-8
    • Wilker E, Bol D, Kiguchi K, Rupp T, Beltran L, DiGiovanni J. Enhancement of susceptibility to diverse skin tumor promoters by activation of the insulin-like growth factor-1 receptor in the epidermis of transgenic mice. Mol Carcinog 1999;25:122-131 (Pubitemid 29275025)
    • (1999) Molecular Carcinogenesis , vol.25 , Issue.2 , pp. 122-131
    • Wilker, E.1    Bol, D.2    Kiguchi, K.3    Rupp, T.4    Beltran, L.5    Digiovanni, J.6
  • 23
    • 0032079677 scopus 로고    scopus 로고
    • Metastasizing mammary carcinomas in H19 enhancers-Igf2 transgenic mice
    • Pravtcheva DD, Wise TL. Metastasizing mammary carcinomas in H19 enhancers-Igf2 transgenic mice. J Exp Zool 1998;281:43-57.
    • (1998) J Exp Zool , vol.281 , pp. 43-57
    • Pravtcheva, D.D.1    Wise, T.L.2
  • 25
    • 3543026281 scopus 로고    scopus 로고
    • EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
    • DOI 10.1128/MCB.24.16.7275-7283.2004
    • Prieur A, Tirode F, Cohen P, Delattre O. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol 2004;24:7275-7283 (Pubitemid 39014452)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.16 , pp. 7275-7283
    • Prieur, A.1    Tirode, F.2    Cohen, P.3    Delattre, O.4
  • 26
    • 36348970313 scopus 로고    scopus 로고
    • Targeted therapies in Ewing's sarcoma
    • Scotlandi K. Targeted therapies in Ewing's sarcoma. Adv Exp Med Biol 2006;587:13-22.
    • (2006) Adv Exp Med Biol , vol.587 , pp. 13-22
    • Scotlandi, K.1
  • 28
    • 57149093206 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma
    • Friedrichs N, Kuchler J, Endl E, et al. Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma. J Pathol 2008;216:428-439
    • (2008) J Pathol , vol.216 , pp. 428-439
    • Friedrichs, N.1    Kuchler, J.2    Endl, E.3
  • 29
    • 0036141447 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
    • Chakravarti A, Loeffler JS, Dyson NJ. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res 2002;62:200-207 (Pubitemid 34074005)
    • (2002) Cancer Research , vol.62 , Issue.1 , pp. 200-207
    • Chakravarti, A.1    Loeffler, J.S.2    Dyson, N.J.3
  • 30
    • 54249117292 scopus 로고    scopus 로고
    • Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors
    • Buck E, Eyzaguirre A, Rosenfeld-Franklin M, et al. Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors. Cancer Res 2008;68:8322-8332
    • (2008) Cancer Res , vol.68 , pp. 8322-8332
    • Buck, E.1    Eyzaguirre, A.2    Rosenfeld-Franklin, M.3
  • 31
    • 58249101005 scopus 로고    scopus 로고
    • The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors
    • Huang F, Greer A, Hurlburt W, et al. The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors. Cancer Res 2009;69:161-170
    • (2009) Cancer Res , vol.69 , pp. 161-170
    • Huang, F.1    Greer, A.2    Hurlburt, W.3
  • 32
    • 0035915421 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
    • Lu Y, Zi X, Zhao Y, Mascarenhas D, Pollak M. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst 2001;93:1852-1857.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1852-1857
    • Lu, Y.1    Zi, X.2    Zhao, Y.3    Mascarenhas, D.4    Pollak, M.5
  • 33
    • 0346154748 scopus 로고    scopus 로고
    • Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (herceptin) on SKBR3 breast cancer cells
    • DOI 10.1002/ijc.11445
    • Lu Y, Zi X, Pollak M. Molecular mechanisms underlying IGFI-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells. Int J Cancer 2004;108:334-341 (Pubitemid 37549597)
    • (2004) International Journal of Cancer , vol.108 , Issue.3 , pp. 334-341
    • Lu, Y.1    Zi, X.2    Pollak, M.3
  • 34
    • 28244468422 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor (IGF-1R) expression does not predict for resistance to trastuzumab-based treatment in patients with Her-2/neu overexpressing metastatic breast cancer
    • DOI 10.1007/s00432-005-0038-8
    • Kostler WJ, Hudelist G, Rabitsch W, et al. Insulin-like growth factor-1 receptor (IGF-1R) expression does not predict for resistance to trastuzumab-based treatment in patients with Her-2/neu overexpressing metastatic breast cancer. J Cancer Res Clin Oncol 2006;132:9-18. (Pubitemid 41712801)
    • (2006) Journal of Cancer Research and Clinical Oncology , vol.132 , Issue.1 , pp. 9-18
    • Kostler, W.J.1    Hudelist, G.2    Rabitsch, W.3    Czerwenka, K.4    Muller, R.5    Singer, C.F.6    Zielinski, C.C.7
  • 35
    • 42649104659 scopus 로고    scopus 로고
    • The type I insulin-like growth factor receptor pathway: A key player in cancer therapeutic resistance
    • DOI 10.2741/2925
    • Casa AJ, Dearth RK, Litzenburger BC, Lee AV, Cui X. The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance. Front Biosci 2008;13:3273-3287 (Pubitemid 351594682)
    • (2008) Frontiers in Bioscience , vol.13 , Issue.9 , pp. 3273-3287
    • Casa, A.J.1    Dearth, R.K.2    Litzenburger, B.C.3    Lee, A.V.4    Cui, X.5
  • 36
    • 69449097339 scopus 로고    scopus 로고
    • Emerging role of insulin-like growth factor receptor inhibitors in oncology: Early clinical trial results and future directions
    • Gualberto A, Pollak M. Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions. Oncogene 2009;28:3009-3021
    • (2009) Oncogene , vol.28 , pp. 3009-3021
    • Gualberto, A.1    Pollak, M.2
  • 37
    • 54049108939 scopus 로고    scopus 로고
    • Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: Lessons from the first clinical trials
    • Rodon J, DeSantos V, Ferry RJ Jr., Kurzrock R. Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials. Mol Cancer Ther 2008;7:2575-2588
    • (2008) Mol Cancer Ther , vol.7 , pp. 2575-2588
    • Rodon, J.1    DeSantos, V.2    Ferry Jr., R.J.3    Kurzrock, R.4
  • 38
    • 70349443573 scopus 로고    scopus 로고
    • Development of the monoclonal antibody figitumumab, targeting the insulin-like growth factor-1 receptor, for the treatment of patients with non-small-cell lung cancer
    • Gualberto A, Karp DD. Development of the monoclonal antibody figitumumab, targeting the insulin-like growth factor-1 receptor, for the treatment of patients with non-small-cell lung cancer. Clin Lung Cancer 2009;10:273-280
    • (2009) Clin Lung Cancer , vol.10 , pp. 273-280
    • Gualberto, A.1    Karp, D.D.2
  • 39
    • 54049118086 scopus 로고    scopus 로고
    • Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake
    • Shang Y, Mao Y, Batson J, et al. Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake. Mol Cancer Ther 2008;7:2599-2608
    • (2008) Mol Cancer Ther , vol.7 , pp. 2599-2608
    • Shang, Y.1    Mao, Y.2    Batson, J.3
  • 40
    • 0345098557 scopus 로고    scopus 로고
    • Monoclonal antibodies in human cancer
    • Barc
    • Mellstedt H. Monoclonal antibodies in human cancer. Drugs Today (Barc) 2003;39 [Suppl C]:1-16.
    • (2003) Drugs Today , vol.39 , Issue.SUPPL. C , pp. 1-16
    • Mellstedt, H.1
  • 42
    • 73349099049 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
    • Tolcher AW, Sarantopoulos J, Patnaik A, et al. Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J Clin Oncol 2009;27:5800-5807
    • (2009) J Clin Oncol , vol.27 , pp. 5800-5807
    • Tolcher, A.W.1    Sarantopoulos, J.2    Patnaik, A.3
  • 43
    • 34047174592 scopus 로고    scopus 로고
    • The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer
    • DOI 10.2174/138161207780249173
    • Belfiore A. The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer. Curr Pharm Des 2007;13:671-686 (Pubitemid 46510744)
    • (2007) Current Pharmaceutical Design , vol.13 , Issue.7 , pp. 671-686
    • Belfiore, A.1
  • 45
    • 56149086171 scopus 로고    scopus 로고
    • A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor-1 receptor (IGF1R) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors
    • Atzori F, Tabernero J, Cervantes A, et al. A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor-1 receptor (IGF1R) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors. J Clin Oncol 2008;26:157s.
    • (2008) J Clin Oncol , vol.26
    • Atzori, F.1    Tabernero, J.2    Cervantes, A.3
  • 46
    • 57149124243 scopus 로고    scopus 로고
    • A phase I study of MK-0646, a humanized monoclonal antibody against the insulin-like growth factor receptor type 1 (IGF1R) in advanced solid tumor patients in a q2 wk schedule
    • Hidalgo M, Gomez MT, Lewis N, et al. A phase I study of MK-0646, a humanized monoclonal antibody against the insulin-like growth factor receptor type 1 (IGF1R) in advanced solid tumor patients in a q2 wk schedule. J Clin Oncol 2008;26:158s.
    • (2008) J Clin Oncol , vol.26
    • Hidalgo, M.1    Gomez, M.T.2    Lewis, N.3
  • 47
    • 77951759381 scopus 로고    scopus 로고
    • Pfizer discontinues a phase 3 trial of figitumumab in non-small cell lung cancer (NSCLC) for futility
    • Businesswire
    • Businesswire. Pfizer discontinues a phase 3 trial of figitumumab in non-small cell lung cancer (NSCLC) for futility. The Wall Street Journal 2009.
    • (2009) The Wall Street Journal
  • 48
    • 75449117196 scopus 로고    scopus 로고
    • A SARC global collaborative phase II trial of R1507, a recombinant human monoclonal antibody to the insulin-like growth factor-1 receptor in patients with recurrent or refractory sarcomas
    • Patel S, Pappo A, Crowley J, et al. A SARC global collaborative phase II trial of R1507, a recombinant human monoclonal antibody to the insulin-like growth factor-1 receptor in patients with recurrent or refractory sarcomas. J Clin Oncol 2009;27:15s.
    • (2009) J Clin Oncol , vol.27
    • Patel, S.1    Pappo, A.2    Crowley, J.3
  • 49
    • 68849086676 scopus 로고    scopus 로고
    • Preliminary activity in adrenocortical tumor (ACC) in phase I dose escalation study of intermittent oral dosing of OSI-906, a small-molecule insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase inhibitor in patients with advanced solid tumors
    • Carden CP, Frentzas S, Langham M, et al. Preliminary activity in adrenocortical tumor (ACC) in phase I dose escalation study of intermittent oral dosing of OSI-906, a small-molecule insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase inhibitor in patients with advanced solid tumors. J Clin Oncol 2009;27:3544s.
    • (2009) J Clin Oncol , vol.27
    • Carden, C.P.1    Frentzas, S.2    Langham, M.3
  • 50
    • 68849085354 scopus 로고    scopus 로고
    • Predictive biomarkers for targeting insulin-like growth factor-I (IGF-I) receptor
    • Carden CP, Molife LR, De Bono JS. Predictive biomarkers for targeting insulin-like growth factor-I (IGF-I) receptor. Mol Cancer Ther 2009;8:2077-2078
    • (2009) Mol Cancer Ther , vol.8 , pp. 2077-2078
    • Carden, C.P.1    Molife, L.R.2    De Bono, J.S.3
  • 51
    • 54249157471 scopus 로고    scopus 로고
    • Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody
    • Cao L, Yu Y, Darko I, et al. Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody. Cancer Res 2008;68:8039-8048
    • (2008) Cancer Res , vol.68 , pp. 8039-8048
    • Cao, L.1    Yu, Y.2    Darko, I.3
  • 52
    • 70349476392 scopus 로고    scopus 로고
    • Molecular bases for sensitivity to figitumumab (CP-751,871) in NSCLC
    • Gualberto A, Dolled-Filhart MP, Hixon ML, et al. Molecular bases for sensitivity to figitumumab (CP-751,871) in NSCLC. J Clin Oncol 2009;27:15s.
    • (2009) J Clin Oncol , vol.27
    • Gualberto, A.1    Dolled-Filhart, M.P.2    Hixon, M.L.3
  • 53
    • 67649628084 scopus 로고    scopus 로고
    • Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression
    • Mukohara T, Shimada H, Ogasawara N, et al. Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression. Cancer Lett 2009;282:14-24.
    • (2009) Cancer Lett , vol.282 , pp. 14-24
    • Mukohara, T.1    Shimada, H.2    Ogasawara, N.3
  • 54
    • 68849128275 scopus 로고    scopus 로고
    • Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer
    • Zha J, O'Brien C, Savage H, et al. Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer. Mol Cancer Ther 2009;8:2110-2121
    • (2009) Mol Cancer Ther , vol.8 , pp. 2110-2121
    • Zha, J.1    O'Brien, C.2    Savage, H.3
  • 55
    • 8544284095 scopus 로고    scopus 로고
    • Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer
    • Surmacz E, Bartucci M. Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer. J Exp Clin Cancer Res 2004;23:385-394 (Pubitemid 39490622)
    • (2004) Journal of Experimental and Clinical Cancer Research , vol.23 , Issue.3 , pp. 385-394
    • Surmacz, E.1    Bartucci, M.2
  • 57
    • 68049085887 scopus 로고    scopus 로고
    • In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models
    • Hoeflich KP, O'Brien C, Boyd Z, et al. In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models. Clin Cancer Res 2009;15:4649-4664
    • (2009) Clin Cancer Res , vol.15 , pp. 4649-4664
    • Hoeflich, K.P.1    O'Brien, C.2    Boyd, Z.3
  • 58
    • 58349091262 scopus 로고    scopus 로고
    • Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition
    • Mirzoeva OK, Das D, Heiser LM, et al. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res 2009;69:565-572
    • (2009) Cancer Res , vol.69 , pp. 565-572
    • Mirzoeva, O.K.1    Das, D.2    Heiser, L.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.