Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors: Generation of receptor-selective VEGF variants by site-directed mutagenesis

Journal of Biological Chemistry

Volumn 271, Issue 10, 1996, Pages 5638-5646

  Keyt, Bruce A ^a   Nguyen, Hung V ^a   Berleau, Lea T ^a   Duarte, Carlos M ^a   Park, Jeanie ^a   Chen, Helen ^a   Ferrara, Napoleone ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CATTLE; CELL PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; VASCULAR ENDOTHELIUM;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; KINETICS; LIVER; LYMPHOKINES; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PLATELET-DERIVED GROWTH FACTOR; POINT MUTATION; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION; VARIATION (GENETICS); VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ANIMALIA; BOS TAURUS;

EID: 0029920944     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.10.5638     Document Type: Article

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