메뉴 건너뛰기




Volumn 84, Issue 2, 2012, Pages 181-199

Cancer chemotherapy: A critical analysis of its 60 years of history

Author keywords

Cancer; Chemotherapy; History

Indexed keywords

ALKYLATING AGENT; ALPHA INTERFERON; AMINOPTERIN; ANTINEOPLASTIC ANTIMETABOLITE; BLEOMYCIN; CARBOPLATIN; CHLORMETHINE; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DACTINOMYCIN; DASATINIB; ERLOTINIB; FLOXURIDINE; FLUOROURACIL; FOLIC ACID ANTAGONIST; FOLINIC ACID; GEFITINIB; IMATINIB; MERCAPTOPURINE; METHOTREXATE; NILOTINIB; PLACEBO; PREDNISONE; PROCARBAZINE; SORAFENIB; THIOTEPA; UNINDEXED DRUG; VINBLASTINE; VINCRISTINE;

EID: 84867843579     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2012.03.002     Document Type: Review
Times cited : (98)

References (216)
  • 1
    • 78651010566 scopus 로고
    • Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid
    • Farber S., Diamond L.K. Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. N Engl J Med 1948, 238:787-793.
    • (1948) N Engl J Med , vol.238 , pp. 787-793
    • Farber, S.1    Diamond, L.K.2
  • 2
    • 80053216633 scopus 로고
    • Therapeutic applications of chemical warfare agents
    • Gilman A. Therapeutic applications of chemical warfare agents. Fed Proc 1946, 5:285-292.
    • (1946) Fed Proc , vol.5 , pp. 285-292
    • Gilman, A.1
  • 3
    • 76949122278 scopus 로고
    • Response of a resistant variant of leukemic cells to an antagonist of pteroylglutamic acid
    • Law L.W. Response of a resistant variant of leukemic cells to an antagonist of pteroylglutamic acid. Proc Soc Exp Biol Med 1951, 77:340-344.
    • (1951) Proc Soc Exp Biol Med , vol.77 , pp. 340-344
    • Law, L.W.1
  • 4
    • 6244287635 scopus 로고
    • Recent contributions to the pharmacology of bis(2-haloethyl) amines and sulfides
    • Philips F.S. Recent contributions to the pharmacology of bis(2-haloethyl) amines and sulfides. J Pharmacol Exp Ther 1950, 99:281-323.
    • (1950) J Pharmacol Exp Ther , vol.99 , pp. 281-323
    • Philips, F.S.1
  • 6
    • 6244298865 scopus 로고
    • Biological action of 'mustard gas' compounds
    • Stevens C.M., Mylorie A., Auerbach C., et al. Biological action of 'mustard gas' compounds. Nature 1950, 166:1019-1021.
    • (1950) Nature , vol.166 , pp. 1019-1021
    • Stevens, C.M.1    Mylorie, A.2    Auerbach, C.3
  • 7
    • 0001347264 scopus 로고
    • Some observations on the effect of folic acid antagonists on acute leukemia and other forms of incurable cancer
    • Farber S. Some observations on the effect of folic acid antagonists on acute leukemia and other forms of incurable cancer. Blood 1949, 4:160-167.
    • (1949) Blood , vol.4 , pp. 160-167
    • Farber, S.1
  • 8
    • 0000204463 scopus 로고
    • Antagonists of nucleic acid derivatives. VI. Purines
    • Elion G.B., Hitchings G.H., Vanderwerff H. Antagonists of nucleic acid derivatives. VI. Purines. J Biol Chem 1951, 192:505-518.
    • (1951) J Biol Chem , vol.192 , pp. 505-518
    • Elion, G.B.1    Hitchings, G.H.2    Vanderwerff, H.3
  • 9
    • 0000284526 scopus 로고
    • Clinical evaluation of a new antimetabolite, 6-mercaptopurine, in the treatment of leukemia and allied diseases
    • Burchenal J.H., Murphy M.L., Ellison R.R., et al. Clinical evaluation of a new antimetabolite, 6-mercaptopurine, in the treatment of leukemia and allied diseases. Blood 1953, 8:965-999.
    • (1953) Blood , vol.8 , pp. 965-999
    • Burchenal, J.H.1    Murphy, M.L.2    Ellison, R.R.3
  • 10
    • 33745464490 scopus 로고
    • Fluorinated pyrimidines, a new class of tumour-inhibitory compounds
    • Heidelberger C., Chaudhuri N.K., Danneberg P., et al. Fluorinated pyrimidines, a new class of tumour-inhibitory compounds. Nature 1957, 179:663-666.
    • (1957) Nature , vol.179 , pp. 663-666
    • Heidelberger, C.1    Chaudhuri, N.K.2    Danneberg, P.3
  • 11
    • 11144234188 scopus 로고
    • Therapy of choriocarcinoma and related trophoblastic tumors with folic acid and purine antagonists
    • Li M.C., Hertz R., Bergenstal D.M. Therapy of choriocarcinoma and related trophoblastic tumors with folic acid and purine antagonists. N Engl J Med 1958, 259:66-74.
    • (1958) N Engl J Med , vol.259 , pp. 66-74
    • Li, M.C.1    Hertz, R.2    Bergenstal, D.M.3
  • 12
    • 11144242211 scopus 로고    scopus 로고
    • Timeline: chemotherapy and the war on cancer
    • Chabner B.A., Roberts T.G. Timeline: chemotherapy and the war on cancer. Nat Rev Cancer 2005, 5:65-72.
    • (2005) Nat Rev Cancer , vol.5 , pp. 65-72
    • Chabner, B.A.1    Roberts, T.G.2
  • 13
    • 78349301150 scopus 로고    scopus 로고
    • Cancer chemotherapy: an annotated history
    • Morrison W.B. Cancer chemotherapy: an annotated history. J Vet Intern Med 2010, 24:1249-1262.
    • (2010) J Vet Intern Med , vol.24 , pp. 1249-1262
    • Morrison, W.B.1
  • 14
    • 0001060019 scopus 로고
    • The biological actions and therapeutic applications of the B-chloroethyl amines and sulfides
    • Gilman A., Philips F.S. The biological actions and therapeutic applications of the B-chloroethyl amines and sulfides. Science 1946, 103:409-415.
    • (1946) Science , vol.103 , pp. 409-415
    • Gilman, A.1    Philips, F.S.2
  • 15
    • 78249277673 scopus 로고
    • Nitrogen mustard therapy; use of methyl-bis (beta-chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders
    • Goodman L.S., Wintrobe M.M., et al. Nitrogen mustard therapy; use of methyl-bis (beta-chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. J Am Med Assoc 1946, 132:126-132.
    • (1946) J Am Med Assoc , vol.132 , pp. 126-132
    • Goodman, L.S.1    Wintrobe, M.M.2
  • 16
    • 0000636701 scopus 로고
    • The initial clinical trial of nitrogen mustard
    • Gilman A. The initial clinical trial of nitrogen mustard. Am J Surg 1963, 105:574-578.
    • (1963) Am J Surg , vol.105 , pp. 574-578
    • Gilman, A.1
  • 17
    • 77049281653 scopus 로고
    • Chlorambucil in treatment of chronic lymphocytic leukemia and certain lymphomas
    • Gellhorn A., Hyman G.A., Ultmann J.E. Chlorambucil in treatment of chronic lymphocytic leukemia and certain lymphomas. J Am Med Assoc 1956, 162:178-183.
    • (1956) J Am Med Assoc , vol.162 , pp. 178-183
    • Gellhorn, A.1    Hyman, G.A.2    Ultmann, J.E.3
  • 18
    • 72949132452 scopus 로고
    • Cyclophosphamide in children with cancer
    • Pinkel D. Cyclophosphamide in children with cancer. Cancer Chemother Rep 1961, 12:187-190.
    • (1961) Cancer Chemother Rep , vol.12 , pp. 187-190
    • Pinkel, D.1
  • 19
    • 0038497542 scopus 로고
    • Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid
    • Watson J.D., Crick F.H. Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. Nature 1953, 171:737-738.
    • (1953) Nature , vol.171 , pp. 737-738
    • Watson, J.D.1    Crick, F.H.2
  • 20
    • 84939100049 scopus 로고
    • Proliferative capacity of hematopoietic stem cells
    • Springer-Verlag, New York, R.J. Fry, M.L. Griem, W.H. Kirsten (Eds.)
    • Lajtha L.G., Schofield R. Proliferative capacity of hematopoietic stem cells. Normal and malignant cell growth 1969, Springer-Verlag, New York. R.J. Fry, M.L. Griem, W.H. Kirsten (Eds.).
    • (1969) Normal and malignant cell growth
    • Lajtha, L.G.1    Schofield, R.2
  • 22
    • 0014028611 scopus 로고
    • A new agent active in the treatment of acute leukemia: cytosine arabinoside
    • Bernard J., Boiron M., Jacquillat C., Weil M., Najean Y. A new agent active in the treatment of acute leukemia: cytosine arabinoside. Presse Med 1966, 74:799-802.
    • (1966) Presse Med , vol.74 , pp. 799-802
    • Bernard, J.1    Boiron, M.2    Jacquillat, C.3    Weil, M.4    Najean, Y.5
  • 24
    • 0001530185 scopus 로고
    • 'Daunomycin', a new antibiotic of the rhodomycin group
    • Dimarco A., Gaetani M., Orezzi P., et al. 'Daunomycin', a new antibiotic of the rhodomycin group. Nature 1964, 201:706-707.
    • (1964) Nature , vol.201 , pp. 706-707
    • Dimarco, A.1    Gaetani, M.2    Orezzi, P.3
  • 25
    • 0013850906 scopus 로고
    • Natulan (Procarbazine) combined with radiotherapy in management of inoperable malignant melanoma
    • Falkson G., de Villiers P.C., Falkson H.C., Fichardt T. Natulan (Procarbazine) combined with radiotherapy in management of inoperable malignant melanoma. Br Med J 1965, 2:1473-1474.
    • (1965) Br Med J , vol.2 , pp. 1473-1474
    • Falkson, G.1    de Villiers, P.C.2    Falkson, H.C.3    Fichardt, T.4
  • 27
    • 73649197013 scopus 로고
    • Trial therapy of Hodgkin's disease and other malignant reticulo-histiocytic diseases by vincaleukoblastin
    • Mathe G., Schweisguth O., Brule G., et al. Trial therapy of Hodgkin's disease and other malignant reticulo-histiocytic diseases by vincaleukoblastin. Presse Med 1962, 70:1349-1352.
    • (1962) Presse Med , vol.70 , pp. 1349-1352
    • Mathe, G.1    Schweisguth, O.2    Brule, G.3
  • 29
    • 0016800960 scopus 로고
    • Clinical study of the new podophyllotoxin derivative, 4'-demethylepipodophyllotoxin 9-(4,6-o-ethylidene- beta-d-glucopyranoside) (NSC-141540; VP-16-213), in solid tumors
    • Felix W., Senn H.J. Clinical study of the new podophyllotoxin derivative, 4'-demethylepipodophyllotoxin 9-(4,6-o-ethylidene- beta-d-glucopyranoside) (NSC-141540; VP-16-213), in solid tumors. Cancer Chemother Rep 1975, 59:737-742.
    • (1975) Cancer Chemother Rep , vol.59 , pp. 737-742
    • Felix, W.1    Senn, H.J.2
  • 31
    • 77049171088 scopus 로고
    • The chemical control of cancer
    • Holland J.F. The chemical control of cancer. Public Health Rep 1954, 69:1151-1166.
    • (1954) Public Health Rep , vol.69 , pp. 1151-1166
    • Holland, J.F.1
  • 33
    • 9444230877 scopus 로고
    • A radioautographic study of a human brain and glioblastoma multiforme after the in vivo uptake of tritiated thymidine
    • Johnson H.A., Haymaker W.E., Rubini J.R., et al. A radioautographic study of a human brain and glioblastoma multiforme after the in vivo uptake of tritiated thymidine. Cancer 1960, 13:636-642.
    • (1960) Cancer , vol.13 , pp. 636-642
    • Johnson, H.A.1    Haymaker, W.E.2    Rubini, J.R.3
  • 34
    • 9344221903 scopus 로고
    • Labeling of human tumor cells in vivo by tritiated thymidine
    • Johnson H.A., Rubini J.R., Cronkite E.P., Bond V.P. Labeling of human tumor cells in vivo by tritiated thymidine. Lab Invest 1960, 9:460-465.
    • (1960) Lab Invest , vol.9 , pp. 460-465
    • Johnson, H.A.1    Rubini, J.R.2    Cronkite, E.P.3    Bond, V.P.4
  • 35
    • 73649151185 scopus 로고
    • Cell proliferation in multiple myeloma studied with tritiated thymidine in vivo
    • Killmann S.A., Cronkite E.P., Fliedner T.M., Bond V.P. Cell proliferation in multiple myeloma studied with tritiated thymidine in vivo. Lab Invest 1962, 11:845-853.
    • (1962) Lab Invest , vol.11 , pp. 845-853
    • Killmann, S.A.1    Cronkite, E.P.2    Fliedner, T.M.3    Bond, V.P.4
  • 36
    • 49749212222 scopus 로고
    • Measurement of DNA-synthesis time in myeloid-erythroid precursors
    • Lala P.K., Maloney M.A., Patt H.M. Measurement of DNA-synthesis time in myeloid-erythroid precursors. Exp Cell Res 1965, 38:626-634.
    • (1965) Exp Cell Res , vol.38 , pp. 626-634
    • Lala, P.K.1    Maloney, M.A.2    Patt, H.M.3
  • 37
    • 0000508051 scopus 로고
    • Cell proliferation kinetics in the gastrointestinal tract of man. I. Cell renewal in colon and rectum
    • Lipkin M., Bell B., Sherlock P. Cell proliferation kinetics in the gastrointestinal tract of man. I. Cell renewal in colon and rectum. J Clin Invest 1963, 42:767-776.
    • (1963) J Clin Invest , vol.42 , pp. 767-776
    • Lipkin, M.1    Bell, B.2    Sherlock, P.3
  • 38
    • 0000850597 scopus 로고
    • Kinetics of proliferation of cancer cells in neoplastic effusions in man
    • Clarkson B., Ota K., Ohkita T., O'Connor A. Kinetics of proliferation of cancer cells in neoplastic effusions in man. Cancer 1965, 18:1189-1213.
    • (1965) Cancer , vol.18 , pp. 1189-1213
    • Clarkson, B.1    Ota, K.2    Ohkita, T.3    O'Connor, A.4
  • 39
    • 0014066264 scopus 로고
    • An experimental approach to adjuvant chemotherapy in carcinoma of the rectum and colon
    • McKinna J.A. An experimental approach to adjuvant chemotherapy in carcinoma of the rectum and colon. Proc R Soc Med 1967, 60:212-214.
    • (1967) Proc R Soc Med , vol.60 , pp. 212-214
    • McKinna, J.A.1
  • 41
    • 0014085401 scopus 로고
    • In vivo studies of DNA synthesis in human normal and tumor cells
    • Hoffman J., Post J. In vivo studies of DNA synthesis in human normal and tumor cells. Cancer Res 1967, 27:898-902.
    • (1967) Cancer Res , vol.27 , pp. 898-902
    • Hoffman, J.1    Post, J.2
  • 42
    • 0013807676 scopus 로고
    • The effects of chemotherapy on the kinetics of leukemic cell behavior
    • Skipper H.E. The effects of chemotherapy on the kinetics of leukemic cell behavior. Cancer Res 1965, 25:1544-1550.
    • (1965) Cancer Res , vol.25 , pp. 1544-1550
    • Skipper, H.E.1
  • 43
    • 84867874720 scopus 로고
    • Partial reversal of the antileukemic activity of A-methopterin by cortisone
    • Skipper H.E., Bell M., Thomson J.R. Partial reversal of the antileukemic activity of A-methopterin by cortisone. Cancer Res 1954, 14:86-87.
    • (1954) Cancer Res , vol.14 , pp. 86-87
    • Skipper, H.E.1    Bell, M.2    Thomson, J.R.3
  • 44
    • 78651156947 scopus 로고
    • Experimental evaluation of potential anticancer agents. XIII. On the criteria and kinetics associated with "curability" of experimental leukemia
    • Skipper H.E., Schabel F.M., Wilcox W.S. Experimental evaluation of potential anticancer agents. XIII. On the criteria and kinetics associated with "curability" of experimental leukemia. Cancer Chemother Rep 1964, 35:1-111.
    • (1964) Cancer Chemother Rep , vol.35 , pp. 1-111
    • Skipper, H.E.1    Schabel, F.M.2    Wilcox, W.S.3
  • 45
    • 0013909423 scopus 로고
    • Experimental evaluation of potential anticancer agents XV. On the relative rates of growth and host kill of "single" leukemia cells that survive in vivo cytoxan therapy
    • Wilcox W.S., Schabel F.M., Skipper H.E. Experimental evaluation of potential anticancer agents XV. On the relative rates of growth and host kill of "single" leukemia cells that survive in vivo cytoxan therapy. Cancer Res 1966, 26:1009-1014.
    • (1966) Cancer Res , vol.26 , pp. 1009-1014
    • Wilcox, W.S.1    Schabel, F.M.2    Skipper, H.E.3
  • 46
    • 36949062263 scopus 로고
    • Some biochemical problems of cancer chemotherapy
    • Skipper H.E., Heidelberger C., Welch A.D. Some biochemical problems of cancer chemotherapy. Nature 1957, 179:1159-1162.
    • (1957) Nature , vol.179 , pp. 1159-1162
    • Skipper, H.E.1    Heidelberger, C.2    Welch, A.D.3
  • 47
    • 51349166117 scopus 로고
    • Attempts at dual blocking of biochemical events in cancer chemotherapy
    • Skipper H.E., Thomson J.R., Bell M. Attempts at dual blocking of biochemical events in cancer chemotherapy. Cancer Res 1954, 14:503-507.
    • (1954) Cancer Res , vol.14 , pp. 503-507
    • Skipper, H.E.1    Thomson, J.R.2    Bell, M.3
  • 48
    • 77049255288 scopus 로고
    • The metabolism of P32-labeled ribonucleotides in tissue slices and cell suspensions
    • Leibman K.C., Heidelberger C. The metabolism of P32-labeled ribonucleotides in tissue slices and cell suspensions. J Biol Chem 1955, 216:823-830.
    • (1955) J Biol Chem , vol.216 , pp. 823-830
    • Leibman, K.C.1    Heidelberger, C.2
  • 49
    • 78651048339 scopus 로고
    • Studies in 2-acetylaminofluorene carcinogenesis. III. The utilization of uracil-2-C14 by preneoplastic rat liver and rat hepatoma
    • Rutman R.J., Cantarow A., Paschkis K.E. Studies in 2-acetylaminofluorene carcinogenesis. III. The utilization of uracil-2-C14 by preneoplastic rat liver and rat hepatoma. Cancer Res 1954, 14:119-123.
    • (1954) Cancer Res , vol.14 , pp. 119-123
    • Rutman, R.J.1    Cantarow, A.2    Paschkis, K.E.3
  • 50
    • 0014012919 scopus 로고
    • Extensive histological and cytological survey of patients with acute leukaemia in "complete remission"
    • Mathe G., Schwarzenberg L., Mery A.M., et al. Extensive histological and cytological survey of patients with acute leukaemia in "complete remission." Br Med J 1966, 1:640-642.
    • (1966) Br Med J , vol.1 , pp. 640-642
    • Mathe, G.1    Schwarzenberg, L.2    Mery, A.M.3
  • 51
    • 84867843539 scopus 로고
    • Report to the British Medical Research Council by their Tuberculosis Chemotherapy Trials Committee: Various combinations of isoniazid with streptomycin or with P.A.S. in the treatment of pulmonary tuberculosis
    • Report to the British Medical Research Council by their Tuberculosis Chemotherapy Trials Committee: Various combinations of isoniazid with streptomycin or with P.A.S. in the treatment of pulmonary tuberculosis. Br Med J 1955;1:465-6.
    • (1955) Br Med J , vol.1 , pp. 465-6
  • 52
    • 0001443073 scopus 로고
    • Effects of combined drug therapy on metastatic cancer of the testis
    • Li M.C., Whitmore W.F., Golbey R., Grabstald H. Effects of combined drug therapy on metastatic cancer of the testis. JAMA 1960, 174:1291-1299.
    • (1960) JAMA , vol.174 , pp. 1291-1299
    • Li, M.C.1    Whitmore, W.F.2    Golbey, R.3    Grabstald, H.4
  • 53
    • 0015551581 scopus 로고
    • Therapy of metastatic mammary carcinoma with cyclophosphamide, methotrexate, vincristine and fluorouracil
    • De Lena M., De Palo G.M., Bonadonna G., Beretta G., Bajetta E. Therapy of metastatic mammary carcinoma with cyclophosphamide, methotrexate, vincristine and fluorouracil. Tumori 1973, 59:11-24.
    • (1973) Tumori , vol.59 , pp. 11-24
    • De Lena, M.1    De Palo, G.M.2    Bonadonna, G.3    Beretta, G.4    Bajetta, E.5
  • 54
    • 0017672542 scopus 로고
    • Cis-diamminedichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer
    • Einhorn L.H., Donohue J. Cis-diamminedichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer. Ann Intern Med 1977, 87:293-298.
    • (1977) Ann Intern Med , vol.87 , pp. 293-298
    • Einhorn, L.H.1    Donohue, J.2
  • 55
    • 0018750149 scopus 로고
    • Combination chemotherapy in disseminated testicular cancer: the Indiana University experience
    • Einhorn L.H., Donohue J.P. Combination chemotherapy in disseminated testicular cancer: the Indiana University experience. Semin Oncol 1979, 6:87-93.
    • (1979) Semin Oncol , vol.6 , pp. 87-93
    • Einhorn, L.H.1    Donohue, J.P.2
  • 56
    • 0013811894 scopus 로고
    • The effectiveness of combinations of antileukemic agents in inducing and maintaining remission in children with acute leukemia
    • Frei E., Karon M., Levin R.H., et al. The effectiveness of combinations of antileukemic agents in inducing and maintaining remission in children with acute leukemia. Blood 1965, 26:642-656.
    • (1965) Blood , vol.26 , pp. 642-656
    • Frei, E.1    Karon, M.2    Levin, R.H.3
  • 57
    • 0014893444 scopus 로고
    • Combination chemotherapy in the treatment of advanced Hodgkin's disease
    • Devita V.T., Serpick A.A., Carbone P.P. Combination chemotherapy in the treatment of advanced Hodgkin's disease. Ann Intern Med 1970, 73:881-895.
    • (1970) Ann Intern Med , vol.73 , pp. 881-895
    • Devita, V.T.1    Serpick, A.A.2    Carbone, P.P.3
  • 58
    • 0016707139 scopus 로고
    • Combination chemotherapy of Hodgkin's disease with adriamycin, bleomycin, vinblastine, and imidazole carboxamide versus MOPP
    • Bonadonna G., Zucali R., Monfardini S., De Lena M., Uslenghi C. Combination chemotherapy of Hodgkin's disease with adriamycin, bleomycin, vinblastine, and imidazole carboxamide versus MOPP. Cancer 1975, 36:252-259.
    • (1975) Cancer , vol.36 , pp. 252-259
    • Bonadonna, G.1    Zucali, R.2    Monfardini, S.3    De Lena, M.4    Uslenghi, C.5
  • 59
    • 0000909726 scopus 로고
    • A comparative study of two regimens of combination chemotherapy in acute leukemia
    • Frei E., Holland J.F., Schneiderman M.A., et al. A comparative study of two regimens of combination chemotherapy in acute leukemia. Blood 1958, 13:1126-1148.
    • (1958) Blood , vol.13 , pp. 1126-1148
    • Frei, E.1    Holland, J.F.2    Schneiderman, M.A.3
  • 60
    • 0018569942 scopus 로고
    • A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate
    • Goldie J.H., Coldman A.J. A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer Treat Rep 1979, 63:1727-1733.
    • (1979) Cancer Treat Rep , vol.63 , pp. 1727-1733
    • Goldie, J.H.1    Coldman, A.J.2
  • 61
    • 70449542594 scopus 로고
    • Current status of cancer chemotherapy
    • Li M.C. Current status of cancer chemotherapy. J Natl Med Assoc 1960, 52:315-320.
    • (1960) J Natl Med Assoc , vol.52 , pp. 315-320
    • Li, M.C.1
  • 62
    • 0014230511 scopus 로고
    • Operational research in anticancer chemotherapy. Chemotherapy and strategy of treatment of cancer
    • Mathe G., Schwarzenberg L., Amiel J.L., et al. Operational research in anticancer chemotherapy. Chemotherapy and strategy of treatment of cancer. Bull Mem Soc Med Hop Paris 1968, 119:133-158.
    • (1968) Bull Mem Soc Med Hop Paris , vol.119 , pp. 133-158
    • Mathe, G.1    Schwarzenberg, L.2    Amiel, J.L.3
  • 63
    • 78651056437 scopus 로고
    • Recurrence in carcinoma of the colon and proximal rectum following resection for carcinoma
    • Cole W.H. Recurrence in carcinoma of the colon and proximal rectum following resection for carcinoma. AMA Arch Surg 1952, 65:264-270.
    • (1952) AMA Arch Surg , vol.65 , pp. 264-270
    • Cole, W.H.1
  • 64
    • 0001229784 scopus 로고
    • The cytologic demonstration and significance of tumor cells in the mesenteric venous blood in patients with colorectal carcinoma
    • Fisher E.R, Turnbull R.B. The cytologic demonstration and significance of tumor cells in the mesenteric venous blood in patients with colorectal carcinoma. Surg Gynecol Obstet 1955, 100:102-108.
    • (1955) Surg Gynecol Obstet , vol.100 , pp. 102-108
    • Fisher, E.R.1    Turnbull, R.B.2
  • 65
    • 0004009176 scopus 로고
    • Relationship of cancer cell in the circulating blood to operation
    • Roberts S., Jonasson O., Long L., Mc G.E., Mc G.R., Cole W.H. Relationship of cancer cell in the circulating blood to operation. Cancer 1962, 15:232-240.
    • (1962) Cancer , vol.15 , pp. 232-240
    • Roberts, S.1    Jonasson, O.2    Long, L.3    Mc, G.E.4    Mc, G.R.5    Cole, W.H.6
  • 66
    • 33644676355 scopus 로고
    • Intraluminal chemotherapy adjuvant (HN2 or 5-FU) to operation for cancer of the colon and rectum. Follow-up report of 83 cases
    • Rousselot L.M., Cole D.R., Slattery J., Grossi C.E., Gonzalez E.M. Intraluminal chemotherapy adjuvant (HN2 or 5-FU) to operation for cancer of the colon and rectum. Follow-up report of 83 cases. Ann Surg 1965, 162:407-415.
    • (1965) Ann Surg , vol.162 , pp. 407-415
    • Rousselot, L.M.1    Cole, D.R.2    Slattery, J.3    Grossi, C.E.4    Gonzalez, E.M.5
  • 68
    • 0014073730 scopus 로고
    • The use of triethylenethiophosphoramide as an adjuvant to the surgical treatment of colorectal carcinoma
    • Holden W.D., Dixon W.J., Kuzma J.W. The use of triethylenethiophosphoramide as an adjuvant to the surgical treatment of colorectal carcinoma. Ann Surg 1967, 165:481-503.
    • (1967) Ann Surg , vol.165 , pp. 481-503
    • Holden, W.D.1    Dixon, W.J.2    Kuzma, J.W.3
  • 69
    • 0016806404 scopus 로고
    • Chemotherapy as an adjuvant to surgery for colorectal cancer
    • Lawrence W., Terz J.J., Horsley S., et al. Chemotherapy as an adjuvant to surgery for colorectal cancer. Ann Surg 1975, 181:616-623.
    • (1975) Ann Surg , vol.181 , pp. 616-623
    • Lawrence, W.1    Terz, J.J.2    Horsley, S.3
  • 70
    • 0023135227 scopus 로고
    • Scientific basis for adjuvant and primary (neoadjuvant) chemotherapy
    • Goldie J.H. Scientific basis for adjuvant and primary (neoadjuvant) chemotherapy. Semin Oncol 1987, 14:1-7.
    • (1987) Semin Oncol , vol.14 , pp. 1-7
    • Goldie, J.H.1
  • 71
    • 0018759652 scopus 로고
    • Growth rates of primary breast cancers
    • Heuser L., Spratt J.S., Polk H.C. Growth rates of primary breast cancers. Cancer 1979, 43:1888-1894.
    • (1979) Cancer , vol.43 , pp. 1888-1894
    • Heuser, L.1    Spratt, J.S.2    Polk, H.C.3
  • 72
    • 0017884087 scopus 로고
    • Growth rate patterns of solid tumors and their relation to responsiveness to therapy: an analytical review
    • Shackney S.E., McCormack G.W., Cuchural G.J. Growth rate patterns of solid tumors and their relation to responsiveness to therapy: an analytical review. Ann Intern Med 1978, 89:107-121.
    • (1978) Ann Intern Med , vol.89 , pp. 107-121
    • Shackney, S.E.1    McCormack, G.W.2    Cuchural, G.J.3
  • 73
    • 0021130051 scopus 로고
    • A stochastic numerical model of breast cancer growth that simulates clinical data
    • Speer J.F., Petrosky V.E., Retsky M.W., Wardwell R.H. A stochastic numerical model of breast cancer growth that simulates clinical data. Cancer Res 1984, 44:4124-4130.
    • (1984) Cancer Res , vol.44 , pp. 4124-4130
    • Speer, J.F.1    Petrosky, V.E.2    Retsky, M.W.3    Wardwell, R.H.4
  • 74
    • 0014334891 scopus 로고
    • Surgical adjuvant chemotherapy in cancer of the breast: results of a decade of cooperative investigation
    • Fisher B., Ravdin R.G., Ausman R.K., Slack N.H., Moore G.E., Noer R.J. Surgical adjuvant chemotherapy in cancer of the breast: results of a decade of cooperative investigation. Ann Surg 1968, 168:337-356.
    • (1968) Ann Surg , vol.168 , pp. 337-356
    • Fisher, B.1    Ravdin, R.G.2    Ausman, R.K.3    Slack, N.H.4    Moore, G.E.5    Noer, R.J.6
  • 75
    • 0016409129 scopus 로고
    • 1-Phenylalanine mustard (L-PAM) in the management of primary breast cancer. A report of early findings
    • Fisher B., Carbone P., Economou S.G., et al. 1-Phenylalanine mustard (L-PAM) in the management of primary breast cancer. A report of early findings. N Engl J Med 1975, 292:117-122.
    • (1975) N Engl J Med , vol.292 , pp. 117-122
    • Fisher, B.1    Carbone, P.2    Economou, S.G.3
  • 76
    • 0017234739 scopus 로고
    • Combination chemotherapy as an adjuvant treatment in operable breast cancer
    • Bonadonna G., Brusamolino E., Valagussa P., et al. Combination chemotherapy as an adjuvant treatment in operable breast cancer. N Engl J Med 1976, 294:405-410.
    • (1976) N Engl J Med , vol.294 , pp. 405-410
    • Bonadonna, G.1    Brusamolino, E.2    Valagussa, P.3
  • 77
    • 0016242550 scopus 로고
    • Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma
    • Jaffe N., Frei E., Traggis D., Bishop Y. Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma. N Engl J Med 1974, 291:994-997.
    • (1974) N Engl J Med , vol.291 , pp. 994-997
    • Jaffe, N.1    Frei, E.2    Traggis, D.3    Bishop, Y.4
  • 78
    • 0017200032 scopus 로고
    • Predicting the course of Gompertzian growth
    • Norton L., Simon R., Brereton H.D., Bogden A.E. Predicting the course of Gompertzian growth. Nature 1976, 264:542-545.
    • (1976) Nature , vol.264 , pp. 542-545
    • Norton, L.1    Simon, R.2    Brereton, H.D.3    Bogden, A.E.4
  • 79
    • 0014649428 scopus 로고
    • The inheritance of growth and form in the mouse. II. The Gompertz growth equation
    • Kidwell J.F., Howard A., Laird A.K. The inheritance of growth and form in the mouse. II. The Gompertz growth equation. Growth 1969, 33:339-352.
    • (1969) Growth , vol.33 , pp. 339-352
    • Kidwell, J.F.1    Howard, A.2    Laird, A.K.3
  • 80
    • 0016725288 scopus 로고
    • The therapeutic response of three human tumor lines maintained in immune-suppressed mice
    • Kopper L., Steel G.G. The therapeutic response of three human tumor lines maintained in immune-suppressed mice. Cancer Res 1975, 35:2704-2713.
    • (1975) Cancer Res , vol.35 , pp. 2704-2713
    • Kopper, L.1    Steel, G.G.2
  • 81
    • 0014506406 scopus 로고
    • Dynamics of growth in tumors and in normal organisms
    • Laird A.K. Dynamics of growth in tumors and in normal organisms. Natl Cancer Inst Monogr 1969, 30:15-28.
    • (1969) Natl Cancer Inst Monogr , vol.30 , pp. 15-28
    • Laird, A.K.1
  • 82
    • 0013980608 scopus 로고
    • Analysis of the cell population kinetics of transplanted tumours of widely-differing growth rate
    • Steel G.G., Adams K., Barrett J.C. Analysis of the cell population kinetics of transplanted tumours of widely-differing growth rate. Br J Cancer 1966, 20:784-800.
    • (1966) Br J Cancer , vol.20 , pp. 784-800
    • Steel, G.G.1    Adams, K.2    Barrett, J.C.3
  • 83
    • 0015302808 scopus 로고
    • Age-specific changes in the proliferation of Ehrlich ascites tumor cells grown as solid tumors
    • Lala P.K. Age-specific changes in the proliferation of Ehrlich ascites tumor cells grown as solid tumors. Cancer Res 1972, 32:628-636.
    • (1972) Cancer Res , vol.32 , pp. 628-636
    • Lala, P.K.1
  • 84
    • 84982635765 scopus 로고
    • The cell proliferation kinetics of the EMT6/M/AC mouse tumour at four volumes during unperturbed growth in vivo
    • Watson J.V. The cell proliferation kinetics of the EMT6/M/AC mouse tumour at four volumes during unperturbed growth in vivo. Cell Tissue Kinet 1976, 9:147-156.
    • (1976) Cell Tissue Kinet , vol.9 , pp. 147-156
    • Watson, J.V.1
  • 85
    • 0022360120 scopus 로고
    • Implications of kinetic heterogeneity in clinical oncology
    • Norton L. Implications of kinetic heterogeneity in clinical oncology. Semin Oncol 1985, 12:231-249.
    • (1985) Semin Oncol , vol.12 , pp. 231-249
    • Norton, L.1
  • 86
    • 22244440256 scopus 로고    scopus 로고
    • Conceptual and practical implications of breast tissue geometry: toward a more effective, less toxic therapy
    • Norton L. Conceptual and practical implications of breast tissue geometry: toward a more effective, less toxic therapy. Oncologist 2005, 10:370-381.
    • (2005) Oncologist , vol.10 , pp. 370-381
    • Norton, L.1
  • 87
    • 84863896575 scopus 로고    scopus 로고
    • Systematic review of efficacy of dose-dense versus non-dose-dense chemotherapy in breast cancer, non-Hodgkin lymphoma, and non-small cell lung cancer
    • Lyman G.H., Barron R.L., Natoli J.L., Miller R.M. Systematic review of efficacy of dose-dense versus non-dose-dense chemotherapy in breast cancer, non-Hodgkin lymphoma, and non-small cell lung cancer. Crit Rev Oncol Hematol 2011.
    • (2011) Crit Rev Oncol Hematol
    • Lyman, G.H.1    Barron, R.L.2    Natoli, J.L.3    Miller, R.M.4
  • 88
    • 0021346853 scopus 로고
    • Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
    • Groffen J., Stephenson J.R., Heisterkamp N., de Klein A., Bartram C.R., Grosveld G. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 1984, 36:93-99.
    • (1984) Cell , vol.36 , pp. 93-99
    • Groffen, J.1    Stephenson, J.R.2    Heisterkamp, N.3    de Klein, A.4    Bartram, C.R.5    Grosveld, G.6
  • 89
    • 0020972979 scopus 로고
    • Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia
    • Heisterkamp N., Stephenson J.R., Groffen J., et al. Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia. Nature 1983, 306:239-242.
    • (1983) Nature , vol.306 , pp. 239-242
    • Heisterkamp, N.1    Stephenson, J.R.2    Groffen, J.3
  • 90
    • 0025348013 scopus 로고
    • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products
    • Lugo T.G., Pendergast A.M., Muller A.J., Witte O.N. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science 1990, 247:1079-1082.
    • (1990) Science , vol.247 , pp. 1079-1082
    • Lugo, T.G.1    Pendergast, A.M.2    Muller, A.J.3    Witte, O.N.4
  • 91
    • 34547687734 scopus 로고    scopus 로고
    • Discovery of the Philadelphia chromosome: a personal perspective
    • Nowell P.C. Discovery of the Philadelphia chromosome: a personal perspective. J Clin Invest 2007, 117:2033-2035.
    • (2007) J Clin Invest , vol.117 , pp. 2033-2035
    • Nowell, P.C.1
  • 92
    • 0036463948 scopus 로고    scopus 로고
    • Perspectives on the development of a molecularly targeted agent
    • Druker B.J. Perspectives on the development of a molecularly targeted agent. Cancer Cell 2002, 1:31-36.
    • (2002) Cancer Cell , vol.1 , pp. 31-36
    • Druker, B.J.1
  • 93
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker B.J., Guilhot F., O'Brien S.G., et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006, 355:2408-2417.
    • (2006) N Engl J Med , vol.355 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'Brien, S.G.3
  • 94
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien S.G., Guilhot F., Larson R.A., et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003, 348:994-1004.
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 95
    • 39149123549 scopus 로고    scopus 로고
    • Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT
    • Blanke C.D., Demetri G.D., von Mehren M., et al. Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT. J Clin Oncol 2008, 26:620-625.
    • (2008) J Clin Oncol , vol.26 , pp. 620-625
    • Blanke, C.D.1    Demetri, G.D.2    von Mehren, M.3
  • 96
    • 39149127634 scopus 로고    scopus 로고
    • Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033
    • Blanke C.D., Rankin C., Demetri G.D., et al. Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033. J Clin Oncol 2008, 26:626-632.
    • (2008) J Clin Oncol , vol.26 , pp. 626-632
    • Blanke, C.D.1    Rankin, C.2    Demetri, G.D.3
  • 97
    • 22044442973 scopus 로고    scopus 로고
    • Tyrosine kinases as targets for cancer therapy
    • Krause D.S., Van Etten R.A. Tyrosine kinases as targets for cancer therapy. N Engl J Med 2005, 353:172-187.
    • (2005) N Engl J Med , vol.353 , pp. 172-187
    • Krause, D.S.1    Van Etten, R.A.2
  • 98
    • 20844433223 scopus 로고    scopus 로고
    • Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial
    • Verweij J., Casali P.G., Zalcberg J., et al. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet 2004, 364:1127-1134.
    • (2004) Lancet , vol.364 , pp. 1127-1134
    • Verweij, J.1    Casali, P.G.2    Zalcberg, J.3
  • 99
    • 9144230676 scopus 로고    scopus 로고
    • Phase II study of imatinib in patients with small cell lung cancer
    • Johnson B.E., Fischer T., Fischer B., et al. Phase II study of imatinib in patients with small cell lung cancer. Clin Cancer Res 2003, 9:5880-5887.
    • (2003) Clin Cancer Res , vol.9 , pp. 5880-5887
    • Johnson, B.E.1    Fischer, T.2    Fischer, B.3
  • 100
    • 2342518106 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib in adult patients with c-kit-positive acute myeloid leukemia
    • Kindler T., Breitenbuecher F., Marx A., et al. Efficacy and safety of imatinib in adult patients with c-kit-positive acute myeloid leukemia. Blood 2004, 103:3644-3654.
    • (2004) Blood , vol.103 , pp. 3644-3654
    • Kindler, T.1    Breitenbuecher, F.2    Marx, A.3
  • 101
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker B.J., Tamura S., Buchdunger E., et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996, 2:561-566.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 102
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B., Eisen T., Stadler W.M., et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007, 356:125-134.
    • (2007) N Engl J Med , vol.356 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 103
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • Kantarjian H., Giles F., Wunderle L., et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006, 354:2542-2551.
    • (2006) N Engl J Med , vol.354 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3
  • 104
    • 77953725855 scopus 로고    scopus 로고
    • Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia
    • Kantarjian H., Shah N.P., Hochhaus A., et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2010, 362:2260-2270.
    • (2010) N Engl J Med , vol.362 , pp. 2260-2270
    • Kantarjian, H.1    Shah, N.P.2    Hochhaus, A.3
  • 105
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet J.M., Ricci S., Mazzaferro V., et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008, 359:378-390.
    • (2008) N Engl J Med , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 106
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz M., Shah N.P., Kantarjian H., et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006, 354:2531-2541.
    • (2006) N Engl J Med , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 107
    • 77953691179 scopus 로고    scopus 로고
    • Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia
    • Saglio G., Kim D.W., Issaragrisil S., et al. Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med 2010, 362:2251-2259.
    • (2010) N Engl J Med , vol.362 , pp. 2251-2259
    • Saglio, G.1    Kim, D.W.2    Issaragrisil, S.3
  • 108
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial
    • Kris M.G., Natale R.B., Herbst R.S., et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 2003, 290:2149-2158.
    • (2003) JAMA , vol.290 , pp. 2149-2158
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3
  • 109
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok T.S., Wu Y.L., Thongprasert S., et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009, 361:947-957.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 110
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd F.A., Rodrigues Pereira J., Ciuleanu T., et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005, 353:123-132.
    • (2005) N Engl J Med , vol.353 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2    Ciuleanu, T.3
  • 111
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman P.B., Hauschild A., Robert C., et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011, 364:2507-2516.
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 112
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak E.L., Bang Y.J., Camidge D.R., et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010, 363:1693-1703.
    • (2010) N Engl J Med , vol.363 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 113
    • 84875810019 scopus 로고    scopus 로고
    • Early detection, prevention and management of cutaneous adverse events due to sorafenib: Recommendations from the Sorafenib Working Group
    • Bracarda S., Ruggeri E.M., Monti M., et al. Early detection, prevention and management of cutaneous adverse events due to sorafenib: Recommendations from the Sorafenib Working Group. Crit Rev Oncol Hematol 2011.
    • (2011) Crit Rev Oncol Hematol
    • Bracarda, S.1    Ruggeri, E.M.2    Monti, M.3
  • 114
    • 43549112555 scopus 로고    scopus 로고
    • Commentary: novel therapies for cancer: why dirty might be better
    • Fojo T. Commentary: novel therapies for cancer: why dirty might be better. Oncologist 2008, 13:277-283.
    • (2008) Oncologist , vol.13 , pp. 277-283
    • Fojo, T.1
  • 115
    • 0006658203 scopus 로고
    • Cancer chemotherapy
    • WB Saunders Co, Philadelphia, London, Toronto, L.L.H. Smith (Ed.)
    • Cline M.J. Cancer chemotherapy. Major series in internal medicine 1971, 1-11. WB Saunders Co, Philadelphia, London, Toronto. L.L.H. Smith (Ed.).
    • (1971) Major series in internal medicine , pp. 1-11
    • Cline, M.J.1
  • 116
    • 85055220378 scopus 로고
    • Principi di chemioterapia antitumorale
    • Masson Italia Editori, Milano, G. Bonadonna (Ed.)
    • Bonadonna G. Principi di chemioterapia antitumorale. Manuale di Oncología Medica 1983, 201-210. Masson Italia Editori, Milano. 2nd ed. G. Bonadonna (Ed.).
    • (1983) Manuale di Oncología Medica , pp. 201-210
    • Bonadonna, G.1
  • 117
    • 0008023938 scopus 로고    scopus 로고
    • Principles of medical oncology
    • People's Medical Publishing House, Shelton, Connecticut, W.K. Hong, R.C. Bast, W.N. Hait, D.W. Kufe, R.E. Pollock, R.R. Weichselbaum, J.F. Holland, E. Frei (Eds.)
    • Hait W.N., Holland J.F., Frei E., Kufe D.W., Bast R.C., Hong W.K. Principles of medical oncology. Cancer medicine 2010, People's Medical Publishing House, Shelton, Connecticut. 8th ed. W.K. Hong, R.C. Bast, W.N. Hait, D.W. Kufe, R.E. Pollock, R.R. Weichselbaum, J.F. Holland, E. Frei (Eds.).
    • (2010) Cancer medicine
    • Hait, W.N.1    Holland, J.F.2    Frei, E.3    Kufe, D.W.4    Bast, R.C.5    Hong, W.K.6
  • 118
    • 0034994444 scopus 로고    scopus 로고
    • Nucleoside analogues: mechanisms of drug resistance and reversal strategies
    • Galmarini C.M., Mackey J.R., Dumontet C. Nucleoside analogues: mechanisms of drug resistance and reversal strategies. Leukemia 2001, 15:875-890.
    • (2001) Leukemia , vol.15 , pp. 875-890
    • Galmarini, C.M.1    Mackey, J.R.2    Dumontet, C.3
  • 119
    • 0022355121 scopus 로고
    • Genetic instability in the development of drug resistance
    • Goldie J.H., Coldman A.J. Genetic instability in the development of drug resistance. Semin Oncol 1985, 12:222-230.
    • (1985) Semin Oncol , vol.12 , pp. 222-230
    • Goldie, J.H.1    Coldman, A.J.2
  • 120
    • 0141888537 scopus 로고    scopus 로고
    • The role of ABC transporters in clinical practice
    • Leonard G.D., Fojo T., Bates S.E. The role of ABC transporters in clinical practice. Oncologist 2003, 8:411-424.
    • (2003) Oncologist , vol.8 , pp. 411-424
    • Leonard, G.D.1    Fojo, T.2    Bates, S.E.3
  • 121
    • 0027944206 scopus 로고
    • P53 status and the efficacy of cancer therapy in vivo
    • Lowe S.W., Bodis S., McClatchey A., et al. p53 status and the efficacy of cancer therapy in vivo. Science 1994, 266:807-810.
    • (1994) Science , vol.266 , pp. 807-810
    • Lowe, S.W.1    Bodis, S.2    McClatchey, A.3
  • 122
    • 0031747280 scopus 로고    scopus 로고
    • The next frontier of molecular medicine: delivery of therapeutics
    • Jain R.K. The next frontier of molecular medicine: delivery of therapeutics. Nat Med 1998, 4:655-657.
    • (1998) Nat Med , vol.4 , pp. 655-657
    • Jain, R.K.1
  • 123
    • 1642518617 scopus 로고    scopus 로고
    • Multidrug resistance in cancer therapy: role of the microenvironment
    • Galmarini C.M., Galmarini F.C. Multidrug resistance in cancer therapy: role of the microenvironment. Curr Opin Investig Drugs 2003, 4:1416-1421.
    • (2003) Curr Opin Investig Drugs , vol.4 , pp. 1416-1421
    • Galmarini, C.M.1    Galmarini, F.C.2
  • 125
    • 0034564933 scopus 로고    scopus 로고
    • Heterogeneous distribution of tumor blood supply affects the response to chemotherapy in patients with head and neck cancer
    • Galmarini F.C., Galmarini C.M., Sarchi M.I., Abulafia J., Galmarini D. Heterogeneous distribution of tumor blood supply affects the response to chemotherapy in patients with head and neck cancer. Microcirculation 2000, 7:405-410.
    • (2000) Microcirculation , vol.7 , pp. 405-410
    • Galmarini, F.C.1    Galmarini, C.M.2    Sarchi, M.I.3    Abulafia, J.4    Galmarini, D.5
  • 126
    • 0023909330 scopus 로고
    • Determinants of tumor blood flow: a review
    • Jain R.K. Determinants of tumor blood flow: a review. Cancer Res 1988, 48:2641-2658.
    • (1988) Cancer Res , vol.48 , pp. 2641-2658
    • Jain, R.K.1
  • 127
    • 0028470454 scopus 로고
    • Barriers to drug delivery in solid tumors
    • Jain R.K. Barriers to drug delivery in solid tumors. Sci Am 1994, 271:58-65.
    • (1994) Sci Am , vol.271 , pp. 58-65
    • Jain, R.K.1
  • 128
    • 0032053823 scopus 로고    scopus 로고
    • The unique physiology of solid tumors: opportunities (and problems) for cancer therapy
    • Brown J.M., Giaccia A.J. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res 1998, 58:1408-1416.
    • (1998) Cancer Res , vol.58 , pp. 1408-1416
    • Brown, J.M.1    Giaccia, A.J.2
  • 129
    • 0031090132 scopus 로고    scopus 로고
    • Geometric resistance and microvascular network architecture of human colorectal carcinoma
    • Less J.R., Posner M.C., Skalak T.C., Wolmark N., Jain R.K. Geometric resistance and microvascular network architecture of human colorectal carcinoma. Microcirculation 1997, 4:25-33.
    • (1997) Microcirculation , vol.4 , pp. 25-33
    • Less, J.R.1    Posner, M.C.2    Skalak, T.C.3    Wolmark, N.4    Jain, R.K.5
  • 130
    • 0024409952 scopus 로고
    • Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity
    • Sevick E.M., Jain R.K. Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity. Cancer Res 1989, 49:3513-3519.
    • (1989) Cancer Res , vol.49 , pp. 3513-3519
    • Sevick, E.M.1    Jain, R.K.2
  • 131
    • 0025769296 scopus 로고
    • Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia
    • Sevick E.M., Jain R.K. Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia. Cancer Res 1991, 51:2727-2730.
    • (1991) Cancer Res , vol.51 , pp. 2727-2730
    • Sevick, E.M.1    Jain, R.K.2
  • 132
    • 0026611970 scopus 로고
    • 2H-nuclear magnetic resonance imaging of tumor blood flow: spatial and temporal heterogeneity in a tissue-isolated mammary adenocarcinoma
    • Eskey C.J., Koretsky A.P., Domach M.M., Jain R.K. 2H-nuclear magnetic resonance imaging of tumor blood flow: spatial and temporal heterogeneity in a tissue-isolated mammary adenocarcinoma. Cancer Res 1992, 52:6010-6019.
    • (1992) Cancer Res , vol.52 , pp. 6010-6019
    • Eskey, C.J.1    Koretsky, A.P.2    Domach, M.M.3    Jain, R.K.4
  • 133
    • 0028105089 scopus 로고
    • Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution
    • Hamberg L.M., Kristjansen P.E., Hunter G.J., Wolf G.L., Jain R.K. Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution. Cancer Res 1994, 54:6032-6036.
    • (1994) Cancer Res , vol.54 , pp. 6032-6036
    • Hamberg, L.M.1    Kristjansen, P.E.2    Hunter, G.J.3    Wolf, G.L.4    Jain, R.K.5
  • 134
    • 0024584819 scopus 로고
    • Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection
    • Baxter L.T., Jain R.K. Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection. Microvasc Res 1989, 37:77-104.
    • (1989) Microvasc Res , vol.37 , pp. 77-104
    • Baxter, L.T.1    Jain, R.K.2
  • 135
    • 0023481357 scopus 로고
    • Transport of molecules across tumor vasculature
    • Jain R.K. Transport of molecules across tumor vasculature. Cancer Metastasis Rev 1987, 6:559-593.
    • (1987) Cancer Metastasis Rev , vol.6 , pp. 559-593
    • Jain, R.K.1
  • 136
    • 0025334830 scopus 로고
    • Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy
    • Boucher Y., Baxter L.T., Jain R.K. Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy. Cancer Res 1990, 50:4478-4484.
    • (1990) Cancer Res , vol.50 , pp. 4478-4484
    • Boucher, Y.1    Baxter, L.T.2    Jain, R.K.3
  • 137
    • 0023219734 scopus 로고
    • Transport of molecules in the tumor interstitium: a review
    • Jain R.K. Transport of molecules in the tumor interstitium: a review. Cancer Res 1987, 47:3039-3051.
    • (1987) Cancer Res , vol.47 , pp. 3039-3051
    • Jain, R.K.1
  • 138
    • 0036307898 scopus 로고    scopus 로고
    • Limited penetration of anticancer drugs through tumor tissue: a potential cause of resistance of solid tumors to chemotherapy
    • Tannock I.F., Lee C.M., Tunggal J.K., Cowan D.S., Egorin M.J. Limited penetration of anticancer drugs through tumor tissue: a potential cause of resistance of solid tumors to chemotherapy. Clin Cancer Res 2002, 8:878-884.
    • (2002) Clin Cancer Res , vol.8 , pp. 878-884
    • Tannock, I.F.1    Lee, C.M.2    Tunggal, J.K.3    Cowan, D.S.4    Egorin, M.J.5
  • 139
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review
    • Vaupel P., Kallinowski F., Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989, 49:6449-6465.
    • (1989) Cancer Res , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 140
    • 21744437791 scopus 로고    scopus 로고
    • Repopulation of cancer cells during therapy: an important cause of treatment failure
    • Kim J.J., Tannock I.F. Repopulation of cancer cells during therapy: an important cause of treatment failure. Nat Rev Cancer 2005, 5:516-525.
    • (2005) Nat Rev Cancer , vol.5 , pp. 516-525
    • Kim, J.J.1    Tannock, I.F.2
  • 142
  • 144
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J. What is the evidence that tumors are angiogenesis dependent?. J Natl Cancer Inst 1990, 82:4-6.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 4-6
    • Folkman, J.1
  • 145
    • 0029944122 scopus 로고    scopus 로고
    • Angiostatin induces and sustains dormancy of human primary tumors in mice
    • O'Reilly M.S., Holmgren L., Chen C., Folkman J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med 1996, 2:689-692.
    • (1996) Nat Med , vol.2 , pp. 689-692
    • O'Reilly, M.S.1    Holmgren, L.2    Chen, C.3    Folkman, J.4
  • 146
    • 0027970092 scopus 로고
    • Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
    • O'Reilly M.S., Holmgren L., Shing Y., et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994, 79:315-328.
    • (1994) Cell , vol.79 , pp. 315-328
    • O'Reilly, M.S.1    Holmgren, L.2    Shing, Y.3
  • 147
    • 14344264034 scopus 로고    scopus 로고
    • Does surgery unfavourably perturb the "natural history" of early breast cancer by accelerating the appearance of distant metastases?
    • Baum M., Demicheli R., Hrushesky W., Retsky M. Does surgery unfavourably perturb the "natural history" of early breast cancer by accelerating the appearance of distant metastases?. Eur J Cancer 2005, 41:508-515.
    • (2005) Eur J Cancer , vol.41 , pp. 508-515
    • Baum, M.1    Demicheli, R.2    Hrushesky, W.3    Retsky, M.4
  • 148
    • 24044520722 scopus 로고    scopus 로고
    • Breast cancer recurrence dynamics following adjuvant CMF is consistent with tumor dormancy and mastectomy-driven acceleration of the metastatic process
    • Demicheli R., Miceli R., Moliterni A., et al. Breast cancer recurrence dynamics following adjuvant CMF is consistent with tumor dormancy and mastectomy-driven acceleration of the metastatic process. Ann Oncol 2005, 16:1449-1457.
    • (2005) Ann Oncol , vol.16 , pp. 1449-1457
    • Demicheli, R.1    Miceli, R.2    Moliterni, A.3
  • 149
    • 0029947991 scopus 로고    scopus 로고
    • Duration and reintroduction of adjuvant chemotherapy for node-positive premenopausal breast cancer patients
    • International Breast Cancer Study Group
    • Duration and reintroduction of adjuvant chemotherapy for node-positive premenopausal breast cancer patients. J Clin Oncol 1996, 14:1885-1894. International Breast Cancer Study Group.
    • (1996) J Clin Oncol , vol.14 , pp. 1885-1894
  • 150
    • 0031415404 scopus 로고    scopus 로고
    • Retreating recurrent breast cancer with the same CMF-containing regimen used as adjuvant therapy. The International Breast Cancer Study Group
    • Castiglione-Gertsch M., Tattersall M., Hacking A., et al. Retreating recurrent breast cancer with the same CMF-containing regimen used as adjuvant therapy. The International Breast Cancer Study Group. Eur J Cancer 1997, 33:2321-2325.
    • (1997) Eur J Cancer , vol.33 , pp. 2321-2325
    • Castiglione-Gertsch, M.1    Tattersall, M.2    Hacking, A.3
  • 152
    • 0027940245 scopus 로고
    • Recent insights on DNA repair. The mechanism of damaged nucleotide excision in eukaryotes and its relationship to other cellular processes
    • Bardwell A.J., Bardwell L., Wang Z., et al. Recent insights on DNA repair. The mechanism of damaged nucleotide excision in eukaryotes and its relationship to other cellular processes. Ann N Y Acad Sci 1994, 726:281-291.
    • (1994) Ann N Y Acad Sci , vol.726 , pp. 281-291
    • Bardwell, A.J.1    Bardwell, L.2    Wang, Z.3
  • 153
    • 0023553574 scopus 로고
    • ATP-binding properties of P glycoprotein from multidrug-resistant KB cells
    • Cornwell M.M., Tsuruo T., Gottesman M.M., Pastan I. ATP-binding properties of P glycoprotein from multidrug-resistant KB cells. FASEB J 1987, 1:51-54.
    • (1987) FASEB J , vol.1 , pp. 51-54
    • Cornwell, M.M.1    Tsuruo, T.2    Gottesman, M.M.3    Pastan, I.4
  • 154
    • 0029048485 scopus 로고
    • The drug resistance-related protein LRP is the human major vault protein
    • Scheffer G.L., Wijngaard P.L., Flens M.J., et al. The drug resistance-related protein LRP is the human major vault protein. Nat Med 1995, 1:578-582.
    • (1995) Nat Med , vol.1 , pp. 578-582
    • Scheffer, G.L.1    Wijngaard, P.L.2    Flens, M.J.3
  • 156
    • 79952171625 scopus 로고    scopus 로고
    • Probing the links between in vitro potency, ADMET and physicochemical parameters
    • Gleeson M.P., Hersey A., Montanari D., Overington J. Probing the links between in vitro potency, ADMET and physicochemical parameters. Nat Rev Drug Discov 2011, 10:197-208.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 197-208
    • Gleeson, M.P.1    Hersey, A.2    Montanari, D.3    Overington, J.4
  • 157
    • 33749011163 scopus 로고    scopus 로고
    • The NCI60 human tumour cell line anticancer drug screen
    • Shoemaker R.H. The NCI60 human tumour cell line anticancer drug screen. Nat Rev Cancer 2006, 6:813-823.
    • (2006) Nat Rev Cancer , vol.6 , pp. 813-823
    • Shoemaker, R.H.1
  • 158
    • 0027313188 scopus 로고
    • Changes in glycosylation of L1210 cells after exposure to various antimetabolites
    • De Graaf T.W., Slot S.S., Peters G.J., Van Dijk W. Changes in glycosylation of L1210 cells after exposure to various antimetabolites. Eur J Cancer 1993, 29A:1760-1765.
    • (1993) Eur J Cancer , vol.29 A , pp. 1760-1765
    • De Graaf, T.W.1    Slot, S.S.2    Peters, G.J.3    Van Dijk, W.4
  • 159
    • 0024838332 scopus 로고
    • Incorporation of 5-fluorouracil into nucleotide sugars and the effect on glycoconjugates in rat hepatoma cells and hepatocytes
    • Pels Rijcken W.R., Telleman F., Peters G.J., Ferwerda W. Incorporation of 5-fluorouracil into nucleotide sugars and the effect on glycoconjugates in rat hepatoma cells and hepatocytes. Adv Exp Med Biol 1989, 253B:313-320.
    • (1989) Adv Exp Med Biol , vol.253 B , pp. 313-320
    • Pels Rijcken, W.R.1    Telleman, F.2    Peters, G.J.3    Ferwerda, W.4
  • 161
    • 4043134677 scopus 로고    scopus 로고
    • Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects
    • Borg C., Terme M., Taieb J., et al. Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects. J Clin Invest 2004, 114:379-388.
    • (2004) J Clin Invest , vol.114 , pp. 379-388
    • Borg, C.1    Terme, M.2    Taieb, J.3
  • 162
    • 65949085379 scopus 로고    scopus 로고
    • Natural killer cell IFN-gamma levels predict long-term survival with imatinib mesylate therapy in gastrointestinal stromal tumor-bearing patients
    • Menard C., Blay J.Y., Borg C., et al. Natural killer cell IFN-gamma levels predict long-term survival with imatinib mesylate therapy in gastrointestinal stromal tumor-bearing patients. Cancer Res 2009, 69:3563-3569.
    • (2009) Cancer Res , vol.69 , pp. 3563-3569
    • Menard, C.1    Blay, J.Y.2    Borg, C.3
  • 163
    • 69049092008 scopus 로고    scopus 로고
    • Exploiting the promiscuity of imatinib
    • Lee S.J., Wang J.Y. Exploiting the promiscuity of imatinib. J Biol 2009, 8:30.
    • (2009) J Biol , vol.8 , pp. 30
    • Lee, S.J.1    Wang, J.Y.2
  • 164
    • 33746232407 scopus 로고    scopus 로고
    • Multitargeted therapy: can promiscuity be praised in an era of political correctness?
    • Jimeno A., Hidalgo M. Multitargeted therapy: can promiscuity be praised in an era of political correctness?. Crit Rev Oncol Hematol 2006, 59:150-158.
    • (2006) Crit Rev Oncol Hematol , vol.59 , pp. 150-158
    • Jimeno, A.1    Hidalgo, M.2
  • 165
    • 33750711391 scopus 로고    scopus 로고
    • Kinase inhibitors in the treatment of renal cell carcinoma
    • Larkin J.M., Eisen T. Kinase inhibitors in the treatment of renal cell carcinoma. Crit Rev Oncol Hematol 2006, 60:216-226.
    • (2006) Crit Rev Oncol Hematol , vol.60 , pp. 216-226
    • Larkin, J.M.1    Eisen, T.2
  • 166
    • 0023902287 scopus 로고
    • Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity
    • Diasio R.B., Beavers T.L., Carpenter J.T. Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity. J Clin Invest 1988, 81:47-51.
    • (1988) J Clin Invest , vol.81 , pp. 47-51
    • Diasio, R.B.1    Beavers, T.L.2    Carpenter, J.T.3
  • 167
    • 0021714459 scopus 로고
    • Pharmacokinetics and dosage reduction of cis-diammine(1,1-cyclobutanedicarboxylato)platinum in patients with impaired renal function
    • Egorin M.J., Van Echo D.A., Tipping S.J., et al. Pharmacokinetics and dosage reduction of cis-diammine(1,1-cyclobutanedicarboxylato)platinum in patients with impaired renal function. Cancer Res 1984, 44:5432-5438.
    • (1984) Cancer Res , vol.44 , pp. 5432-5438
    • Egorin, M.J.1    Van Echo, D.A.2    Tipping, S.J.3
  • 168
    • 0034892379 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)
    • Mathijssen R.H., van Alphen R.J., Verweij J., et al. Clinical pharmacokinetics and metabolism of irinotecan (CPT-11). Clin Cancer Res 2001, 7:2182-2194.
    • (2001) Clin Cancer Res , vol.7 , pp. 2182-2194
    • Mathijssen, R.H.1    van Alphen, R.J.2    Verweij, J.3
  • 169
    • 34250304874 scopus 로고    scopus 로고
    • Clinical pharmacogenomics of thiopurine S-methyltransferase
    • Zhou S. Clinical pharmacogenomics of thiopurine S-methyltransferase. Curr Clin Pharmacol 2006, 1:119-128.
    • (2006) Curr Clin Pharmacol , vol.1 , pp. 119-128
    • Zhou, S.1
  • 170
    • 84984537308 scopus 로고    scopus 로고
    • Dosing modifications of targeted cancer therapies in patients with special needs: evidence and controversies
    • Ng T., Chan A. Dosing modifications of targeted cancer therapies in patients with special needs: evidence and controversies. Crit Rev Oncol Hematol 2012, 81:58-74.
    • (2012) Crit Rev Oncol Hematol , vol.81 , pp. 58-74
    • Ng, T.1    Chan, A.2
  • 171
    • 33750735723 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic relationships of imatinib and its main metabolite in patients with advanced gastrointestinal stromal tumors
    • Delbaldo C., Chatelut E., Re M., et al. Pharmacokinetic-pharmacodynamic relationships of imatinib and its main metabolite in patients with advanced gastrointestinal stromal tumors. Clin Cancer Res 2006, 12:6073-6078.
    • (2006) Clin Cancer Res , vol.12 , pp. 6073-6078
    • Delbaldo, C.1    Chatelut, E.2    Re, M.3
  • 172
    • 0042305479 scopus 로고    scopus 로고
    • Alpha1 acid glycoprotein binds to imatinib (STI571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients
    • Gambacorti-Passerini C., Zucchetti M., Russo D., et al. Alpha1 acid glycoprotein binds to imatinib (STI571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients. Clin Cancer Res 2003, 9:625-632.
    • (2003) Clin Cancer Res , vol.9 , pp. 625-632
    • Gambacorti-Passerini, C.1    Zucchetti, M.2    Russo, D.3
  • 173
    • 33746881712 scopus 로고    scopus 로고
    • Population pharmacokinetics of imatinib and the role of alpha-acid glycoprotein
    • Widmer N., Decosterd L.A., Csajka C., et al. Population pharmacokinetics of imatinib and the role of alpha-acid glycoprotein. Br J Clin Pharmacol 2006, 62:97-112.
    • (2006) Br J Clin Pharmacol , vol.62 , pp. 97-112
    • Widmer, N.1    Decosterd, L.A.2    Csajka, C.3
  • 174
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch T.J., Bell D.W., Sordella R., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004, 350:2129-2139.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 175
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]
    • Fukuoka M., Yano S., Giaccone G., et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]. J Clin Oncol 2003, 21:2237-2246.
    • (2003) J Clin Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 176
    • 1542503746 scopus 로고    scopus 로고
    • Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 1
    • Giaccone G., Herbst R.S., Manegold C., et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 1. J Clin Oncol 2004, 22:777-784.
    • (2004) J Clin Oncol , vol.22 , pp. 777-784
    • Giaccone, G.1    Herbst, R.S.2    Manegold, C.3
  • 177
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 2
    • Herbst R.S., Giaccone G., Schiller J.H., et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 2. J Clin Oncol 2004, 22:785-794.
    • (2004) J Clin Oncol , vol.22 , pp. 785-794
    • Herbst, R.S.1    Giaccone, G.2    Schiller, J.H.3
  • 178
    • 0036139727 scopus 로고    scopus 로고
    • Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: histopathologic and molecular consequences of receptor inhibition
    • Albanell J., Rojo F., Averbuch S., et al. Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: histopathologic and molecular consequences of receptor inhibition. J Clin Oncol 2002, 20:110-124.
    • (2002) J Clin Oncol , vol.20 , pp. 110-124
    • Albanell, J.1    Rojo, F.2    Averbuch, S.3
  • 179
    • 79953704023 scopus 로고    scopus 로고
    • Predicting harms and benefits in translational trials: ethics, evidence, and uncertainty
    • Kimmelman J., London A.J. Predicting harms and benefits in translational trials: ethics, evidence, and uncertainty. PLoS Med 2011, 8:e1001010.
    • (2011) PLoS Med , vol.8
    • Kimmelman, J.1    London, A.J.2
  • 180
    • 66849099602 scopus 로고    scopus 로고
    • XIII International Charles Heidelberger Symposium and 50 years of fluoropyrimidines in cancer therapy held on September 6 to 8, 2007 at New York University Cancer Institute, Smilow Conference Center
    • Muggia F.M., Peters G.J., Landolph J.R. XIII International Charles Heidelberger Symposium and 50 years of fluoropyrimidines in cancer therapy held on September 6 to 8, 2007 at New York University Cancer Institute, Smilow Conference Center. Mol Cancer Ther 2009, 8:992-999.
    • (2009) Mol Cancer Ther , vol.8 , pp. 992-999
    • Muggia, F.M.1    Peters, G.J.2    Landolph, J.R.3
  • 181
    • 0042893255 scopus 로고
    • 5-Fluorouracil (Nsc-19893) treatment of advanced cancer in ambulatory patients
    • Field J.B. 5-Fluorouracil (Nsc-19893) treatment of advanced cancer in ambulatory patients. Cancer Chemother Rep 1963, 33:45-49.
    • (1963) Cancer Chemother Rep , vol.33 , pp. 45-49
    • Field, J.B.1
  • 182
    • 78651120156 scopus 로고
    • 5-Fluorouracil in the treatment of inoperable carcinoma of the colon and rectum
    • Sharp G.S., Benefiel W.W. 5-Fluorouracil in the treatment of inoperable carcinoma of the colon and rectum. Cancer Chemother Rep 1962, 20:97-101.
    • (1962) Cancer Chemother Rep , vol.20 , pp. 97-101
    • Sharp, G.S.1    Benefiel, W.W.2
  • 183
    • 0024595925 scopus 로고
    • Clinical pharmacology of 5-fluorouracil
    • Diasio R.B., Harris B.E. Clinical pharmacology of 5-fluorouracil. Clin Pharmacokinet 1989, 16:215-237.
    • (1989) Clin Pharmacokinet , vol.16 , pp. 215-237
    • Diasio, R.B.1    Harris, B.E.2
  • 184
    • 0018095703 scopus 로고
    • Fluorouracil therapy in patients with carcinoma of the large bowel: a pharmacokinetic comparison of various rates and routes of administration
    • Chirstophidis N., Vajda F.J., Lucas I., Drummer O., Moon W.J., Louis W.J. Fluorouracil therapy in patients with carcinoma of the large bowel: a pharmacokinetic comparison of various rates and routes of administration. Clin Pharmacokinet 1978, 3:330-336.
    • (1978) Clin Pharmacokinet , vol.3 , pp. 330-336
    • Chirstophidis, N.1    Vajda, F.J.2    Lucas, I.3    Drummer, O.4    Moon, W.J.5    Louis, W.J.6
  • 185
    • 0014574598 scopus 로고
    • Comparative study of monthly courses versus weekly doses of 5-fluorouracil (NSC-19893)
    • Ramirez G., Korbitz B.C., Davis H.L., Ansfield F.J. Comparative study of monthly courses versus weekly doses of 5-fluorouracil (NSC-19893). Cancer Chemother Rep 1969, 53:243-247.
    • (1969) Cancer Chemother Rep , vol.53 , pp. 243-247
    • Ramirez, G.1    Korbitz, B.C.2    Davis, H.L.3    Ansfield, F.J.4
  • 186
    • 0344109583 scopus 로고    scopus 로고
    • Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer
    • Meta-analysis Group In Cancer
    • Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol 1998, 16:301-308. Meta-analysis Group In Cancer.
    • (1998) J Clin Oncol , vol.16 , pp. 301-308
  • 187
    • 0025058867 scopus 로고
    • Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion
    • Harris B.E., Song R., Soong S.J., Diasio R.B. Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion. Cancer Res 1990, 50:197-201.
    • (1990) Cancer Res , vol.50 , pp. 197-201
    • Harris, B.E.1    Song, R.2    Soong, S.J.3    Diasio, R.B.4
  • 188
    • 0016768026 scopus 로고
    • Comparison of continuously infused 5-fluorouracil with bolus injection in treatment of patients with colorectal adenocarcinoma
    • Seifert P., Baker L.H., Reed M.L., Vaitkevicius V.K. Comparison of continuously infused 5-fluorouracil with bolus injection in treatment of patients with colorectal adenocarcinoma. Cancer 1975, 36:123-128.
    • (1975) Cancer , vol.36 , pp. 123-128
    • Seifert, P.1    Baker, L.H.2    Reed, M.L.3    Vaitkevicius, V.K.4
  • 189
    • 0021927568 scopus 로고
    • 5-FU infusion in advanced colorectal cancer: a comparison of three dose schedules
    • Shah A., MacDonald W., Goldie J., Gudauskas G., Brisebois B. 5-FU infusion in advanced colorectal cancer: a comparison of three dose schedules. Cancer Treat Rep 1985, 69:739-742.
    • (1985) Cancer Treat Rep , vol.69 , pp. 739-742
    • Shah, A.1    MacDonald, W.2    Goldie, J.3    Gudauskas, G.4    Brisebois, B.5
  • 190
    • 0024227210 scopus 로고
    • Enhancement of fluorinated pyrimidine-induced cytotoxicity by leucovorin in human colorectal carcinoma cell lines
    • Park J.G., Collins J.M., Gazdar A.F., et al. Enhancement of fluorinated pyrimidine-induced cytotoxicity by leucovorin in human colorectal carcinoma cell lines. J Natl Cancer Inst 1988, 80:1560-1564.
    • (1988) J Natl Cancer Inst , vol.80 , pp. 1560-1564
    • Park, J.G.1    Collins, J.M.2    Gazdar, A.F.3
  • 191
    • 0026721532 scopus 로고
    • Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate
    • Advanced Colorectal Cancer Meta-Analysis Project
    • Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. J Clin Oncol 1992, 10:896-903. Advanced Colorectal Cancer Meta-Analysis Project.
    • (1992) J Clin Oncol , vol.10 , pp. 896-903
  • 192
    • 2542615200 scopus 로고    scopus 로고
    • Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
    • Andre T., Boni C., Mounedji-Boudiaf L., et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 2004, 350:2343-2351.
    • (2004) N Engl J Med , vol.350 , pp. 2343-2351
    • Andre, T.1    Boni, C.2    Mounedji-Boudiaf, L.3
  • 193
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial
    • Douillard J.Y., Cunningham D., Roth A.D., et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 2000, 355:1041-1047.
    • (2000) Lancet , vol.355 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3
  • 194
    • 24644432555 scopus 로고    scopus 로고
    • Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of Cancer Gastrointestinal Group Study 40986
    • Kohne C.H., van Cutsem E., Wils J., et al. Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of Cancer Gastrointestinal Group Study 40986. J Clin Oncol 2005, 23:4856-4865.
    • (2005) J Clin Oncol , vol.23 , pp. 4856-4865
    • Kohne, C.H.1    van Cutsem, E.2    Wils, J.3
  • 195
    • 34250210799 scopus 로고    scopus 로고
    • Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07
    • Kuebler J.P., Wieand H.S., O'Connell M.J., et al. Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07. J Clin Oncol 2007, 25:2198-2204.
    • (2007) J Clin Oncol , vol.25 , pp. 2198-2204
    • Kuebler, J.P.1    Wieand, H.S.2    O'Connell, M.J.3
  • 196
    • 77949681150 scopus 로고    scopus 로고
    • Recurrence and mortality dynamics for breast cancer patients undergoing mastectomy according to estrogen receptor status: different mortality but similar recurrence
    • Demicheli R., Biganzoli E., Ardoino I., et al. Recurrence and mortality dynamics for breast cancer patients undergoing mastectomy according to estrogen receptor status: different mortality but similar recurrence. Cancer Sci 2010, 101:826-830.
    • (2010) Cancer Sci , vol.101 , pp. 826-830
    • Demicheli, R.1    Biganzoli, E.2    Ardoino, I.3
  • 197
    • 36549069842 scopus 로고    scopus 로고
    • Tumor dormancy and surgery-driven interruption of dormancy in breast cancer: learning from failures
    • Demicheli R., Retsky M.W., Hrushesky W.J., Baum M. Tumor dormancy and surgery-driven interruption of dormancy in breast cancer: learning from failures. Nat Clin Pract Oncol 2007, 4:699-710.
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 699-710
    • Demicheli, R.1    Retsky, M.W.2    Hrushesky, W.J.3    Baum, M.4
  • 198
    • 55049137067 scopus 로고    scopus 로고
    • Tumor growth rates derived from data for patients in a clinical trial correlate strongly with patient survival: a novel strategy for evaluation of clinical trial data
    • Stein W.D., Figg W.D., Dahut W., et al. Tumor growth rates derived from data for patients in a clinical trial correlate strongly with patient survival: a novel strategy for evaluation of clinical trial data. Oncologist 2008, 13:1046-1054.
    • (2008) Oncologist , vol.13 , pp. 1046-1054
    • Stein, W.D.1    Figg, W.D.2    Dahut, W.3
  • 199
    • 79951826832 scopus 로고    scopus 로고
    • Tumor regression and growth rates determined in five intramural NCI prostate cancer trials: the growth rate constant as an indicator of therapeutic efficacy
    • Stein W.D., Gulley J.L., Schlom J., et al. Tumor regression and growth rates determined in five intramural NCI prostate cancer trials: the growth rate constant as an indicator of therapeutic efficacy. Clin Cancer Res 2011, 17:907-917.
    • (2011) Clin Cancer Res , vol.17 , pp. 907-917
    • Stein, W.D.1    Gulley, J.L.2    Schlom, J.3
  • 200
    • 55049109179 scopus 로고    scopus 로고
    • Bevacizumab reduces the growth rate constants of renal carcinomas: a novel algorithm suggests early discontinuation of bevacizumab resulted in a lack of survival advantage
    • Stein W.D., Yang J., Bates S.E., Fojo T. Bevacizumab reduces the growth rate constants of renal carcinomas: a novel algorithm suggests early discontinuation of bevacizumab resulted in a lack of survival advantage. Oncologist 2008, 13:1055-1062.
    • (2008) Oncologist , vol.13 , pp. 1055-1062
    • Stein, W.D.1    Yang, J.2    Bates, S.E.3    Fojo, T.4
  • 201
    • 0018931869 scopus 로고
    • Dose: a critical factor in cancer chemotherapy
    • Frei E., Canellos G.P. Dose: a critical factor in cancer chemotherapy. Am J Med 1980, 69:585-594.
    • (1980) Am J Med , vol.69 , pp. 585-594
    • Frei, E.1    Canellos, G.P.2
  • 202
    • 0024266208 scopus 로고
    • More is better
    • Hryniuk W.M. More is better. J Clin Oncol 1988, 6:1365-1367.
    • (1988) J Clin Oncol , vol.6 , pp. 1365-1367
    • Hryniuk, W.M.1
  • 203
    • 77955172181 scopus 로고    scopus 로고
    • Metronomic chemotherapy: new rationale for new directions
    • Pasquier E., Kavallaris M., Andre N. Metronomic chemotherapy: new rationale for new directions. Nat Rev Clin Oncol 2010, 7:455-465.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 455-465
    • Pasquier, E.1    Kavallaris, M.2    Andre, N.3
  • 205
    • 84867852516 scopus 로고    scopus 로고
    • Cyclophosphamide-based metronomic chemotherapy: after 10 years of experience, where do we stand and where are we going?
    • Penel N., Adenis A., Bocci G. Cyclophosphamide-based metronomic chemotherapy: after 10 years of experience, where do we stand and where are we going?. Crit Rev Oncol Hematol 2011.
    • (2011) Crit Rev Oncol Hematol
    • Penel, N.1    Adenis, A.2    Bocci, G.3
  • 206
    • 78651320045 scopus 로고    scopus 로고
    • When are "positive" clinical trials in oncology truly positive?
    • Ocana A., Tannock I.F. When are "positive" clinical trials in oncology truly positive?. J Natl Cancer Inst 2011, 103:16-20.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 16-20
    • Ocana, A.1    Tannock, I.F.2
  • 207
    • 0028835864 scopus 로고
    • Meta-analysis: statistical alchemy for the 21st century
    • Feinstein A.R. Meta-analysis: statistical alchemy for the 21st century. J Clin Epidemiol 1995, 48:71-79.
    • (1995) J Clin Epidemiol , vol.48 , pp. 71-79
    • Feinstein, A.R.1
  • 208
    • 78650382003 scopus 로고    scopus 로고
    • Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much?
    • Fojo T., Parkinson D.R. Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much?. Clin Cancer Res 2010, 16:5972-5980.
    • (2010) Clin Cancer Res , vol.16 , pp. 5972-5980
    • Fojo, T.1    Parkinson, D.R.2
  • 209
    • 78650408868 scopus 로고    scopus 로고
    • Evaluating patient-centered outcomes in the randomized controlled trial and beyond: informing the future with lessons from the past
    • Booth C.M. Evaluating patient-centered outcomes in the randomized controlled trial and beyond: informing the future with lessons from the past. Clin Cancer Res 2010, 16:5963-5971.
    • (2010) Clin Cancer Res , vol.16 , pp. 5963-5971
    • Booth, C.M.1
  • 210
    • 77954254832 scopus 로고    scopus 로고
    • Absolute benefits of medical therapies in phase III clinical trials for breast and colorectal cancer
    • Seruga B., Hertz P.C., Wang L., et al. Absolute benefits of medical therapies in phase III clinical trials for breast and colorectal cancer. Ann Oncol 2010, 21:1411-1418.
    • (2010) Ann Oncol , vol.21 , pp. 1411-1418
    • Seruga, B.1    Hertz, P.C.2    Wang, L.3
  • 211
    • 80054745457 scopus 로고    scopus 로고
    • Gene regulatory networks: a new conceptual framework to analyse breast cancer behaviour
    • Demicheli R., Coradini D. Gene regulatory networks: a new conceptual framework to analyse breast cancer behaviour. Ann Oncol 2010.
    • (2010) Ann Oncol
    • Demicheli, R.1    Coradini, D.2
  • 212
    • 78649467513 scopus 로고    scopus 로고
    • Does tumour dormancy offer a therapeutic target?
    • Goss P.E., Chambers A.F. Does tumour dormancy offer a therapeutic target?. Nat Rev Cancer 2010, 10:871-877.
    • (2010) Nat Rev Cancer , vol.10 , pp. 871-877
    • Goss, P.E.1    Chambers, A.F.2
  • 213
    • 0028913573 scopus 로고
    • Shifting the cancer paradigm: must we kill to cure?
    • Schipper H., Goh C.R., Wang T.L. Shifting the cancer paradigm: must we kill to cure?. J Clin Oncol 1995, 13:801-807.
    • (1995) J Clin Oncol , vol.13 , pp. 801-807
    • Schipper, H.1    Goh, C.R.2    Wang, T.L.3
  • 215
    • 79952594233 scopus 로고    scopus 로고
    • Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors
    • Diop-Frimpong B., Chauhan V.P., Krane S., Boucher Y., Jain R.K. Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proc Natl Acad Sci U S A 2011, 108:2909-2914.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 2909-2914
    • Diop-Frimpong, B.1    Chauhan, V.P.2    Krane, S.3    Boucher, Y.4    Jain, R.K.5
  • 216
    • 78049452610 scopus 로고    scopus 로고
    • Delivering nanomedicine to solid tumors
    • Jain R.K., Stylianopoulos T. Delivering nanomedicine to solid tumors. Nat Rev Clin Oncol 2010, 7:653-664.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 653-664
    • Jain, R.K.1    Stylianopoulos, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.