-
1
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G, Whyte DB, Martinez R, et al: The protein kinase complement of the human genome. Science 298:1912-1934, 2002
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
-
2
-
-
0034693799
-
The protein tyrosine kinase family of the human genome
-
Robinson DR, Wu YM, Lin SF: The protein tyrosine kinase family of the human genome. Oncogene 19:5548-5557, 2000
-
(2000)
Oncogene
, vol.19
, pp. 5548-5557
-
-
Robinson, D.R.1
Wu, Y.M.2
Lin, S.F.3
-
3
-
-
0010233988
-
Growth stimulation of A431 cells by EGF: Identification of high affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody
-
Kawamoto T, Sato JD, Le A, et al: Growth stimulation of A431 cells by EGF: Identification of high affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody. Proc Natl Acad Sci U S A 80:1337-1341, 1983
-
(1983)
Proc Natl Acad Sci U S A
, vol.80
, pp. 1337-1341
-
-
Kawamoto, T.1
Sato, J.D.2
Le, A.3
-
4
-
-
0020933452
-
Biological effect in vitro of monoclonal antibodies to human EGF receptors
-
Sato JD, Kawamoto T, Le AD, et al: Biological effect in vitro of monoclonal antibodies to human EGF receptors. Mol Biol Med 1:511-529, 1983
-
(1983)
Mol Biol Med
, vol.1
, pp. 511-529
-
-
Sato, J.D.1
Kawamoto, T.2
Le, A.D.3
-
5
-
-
0041629450
-
Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
-
Mendelsohn J, Baselga J: Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol 21:2787-2799, 2003
-
(2003)
J Clin Oncol
, vol.21
, pp. 2787-2799
-
-
Mendelsohn, J.1
Baselga, J.2
-
6
-
-
0028819660
-
Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model
-
Goldstein NI, Prewett M, Zuklys K, et al: Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin Cancer Res 1:1311-1318, 1995
-
(1995)
Clin Cancer Res
, vol.1
, pp. 1311-1318
-
-
Goldstein, N.I.1
Prewett, M.2
Zuklys, K.3
-
7
-
-
0000583326
-
Monoclonal antibody (MoAb) IMC-C225, an anti-epidermal growth factor receptor (EGFR), for patients with EGFR-positive tumors refractory to or in relapse from previous therapeutic regimens
-
abstr 1860
-
Rubin M, Shin D, Pasmantier M, et al: Monoclonal antibody (MoAb) IMC-C225, an anti-epidermal growth factor receptor (EGFR), for patients with EGFR-positive tumors refractory to or in relapse from previous therapeutic regimens. Proc Am Soc Clin Oncol 19:479a, 2000 (abstr 1860)
-
(2000)
Proc Am Soc Clin Oncol
, vol.19
-
-
Rubin, M.1
Shin, D.2
Pasmantier, M.3
-
8
-
-
0036094194
-
Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts
-
Prewett MC, Hooper AT, Bassi R, et al: Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts. Clin Cancer Res 8:994-1003, 2002
-
(2002)
Clin Cancer Res
, vol.8
, pp. 994-1003
-
-
Prewett, M.C.1
Hooper, A.T.2
Bassi, R.3
-
9
-
-
0002823211
-
Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR)
-
abstr 7
-
Saltz L, Rubin M, Hochster H, et al: Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 20:3a, 2001 (abstr 7)
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Saltz, L.1
Rubin, M.2
Hochster, H.3
-
10
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D, Humblet Y, Siena S, et al: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351:337-345, 2004
-
(2004)
N Engl J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
11
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
-
Saltz LB, Meropol NJ, Loehrer PJ, Sr., et al: Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 22:1201-1208, 2004
-
(2004)
J Clin Oncol
, vol.22
, pp. 1201-1208
-
-
Saltz, L.B.1
Meropol, N.J.2
Loehrer Sr., P.J.3
-
12
-
-
6444243519
-
An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing epidermal growth factor receptor (EGFR). Preliminary results
-
abstr 3512
-
Tabernero JM, Van Cutsem E, Sastre J, et al: An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing epidermal growth factor receptor (EGFR). Preliminary results. Proc Am Soc Clin Oncol 23:248, 2004 (abstr 3512)
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 248
-
-
Tabernero, J.M.1
Van Cutsem, E.2
Sastre, J.3
-
13
-
-
6344272498
-
ABX-EGF monotherapy in patients (pts) with metastatic colorectal cancer (mCRC): An updated analysis
-
abstr 3511
-
Hecht JR, Patnaik A, Malik I, et al: ABX-EGF monotherapy in patients (pts) with metastatic colorectal cancer (mCRC): An updated analysis. Proc Am Soc Clin Oncol 23:248, 2004 (abstr 3511)
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 248
-
-
Hecht, J.R.1
Patnaik, A.2
Malik, I.3
-
14
-
-
13844288284
-
Dose-dependent inhibition of the EGFR and signaling pathways with the anti-EGFR monoclonal antibody (MAb) EMD 72000 administered every three weeks (q3w). A phase I pharmacokinetic/ pharmacodynamic (PK/PD) study to define the optimal biological dose (OBD)
-
abstr 2002
-
Salazar R, Tabernero J, Rojo F, et al: Dose-dependent inhibition of the EGFR and signaling pathways with the anti-EGFR monoclonal antibody (MAb) EMD 72000 administered every three weeks (q3w). A phase I pharmacokinetic/ pharmacodynamic (PK/PD) study to define the optimal biological dose (OBD). Proc Am Soc Clin Oncol 23:127, 2004 (abstr 2002)
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 127
-
-
Salazar, R.1
Tabernero, J.2
Rojo, F.3
-
15
-
-
1542344622
-
Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumors that express the epidermal growth factor receptor
-
Vanhoefer U, Tewes M, Rojo F, et al: Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumors that express the epidermal growth factor receptor. J Clin Oncol 22:175-184, 2004
-
(2004)
J Clin Oncol
, vol.22
, pp. 175-184
-
-
Vanhoefer, U.1
Tewes, M.2
Rojo, F.3
-
16
-
-
0034895886
-
Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer
-
Shin DM, Donato NJ, Perez-Soler R, et al: Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer. Clin Cancer Res 7:1204-1213, 2001
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1204-1213
-
-
Shin, D.M.1
Donato, N.J.2
Perez-Soler, R.3
-
17
-
-
0011720039
-
A phase II study of Erbitux (IMC-C225), an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer (NSCLC)
-
abstr 1168
-
Kim ES, Mauer AM, Fossella FV, et al: A phase II study of Erbitux (IMC-C225), an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 21:293a, 2002 (abstr 1168)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Kim, E.S.1
Mauer, A.M.2
Fossella, F.V.3
-
18
-
-
0001407134
-
Cetuximab (C225) plus cisplatin/carboplatin is active in patients (pts) with recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) progressing on a same dose and schedule platinum based agent
-
abstr 900
-
Baselga J, Trigo JM, Bourthis J, et al: Cetuximab (C225) plus cisplatin/carboplatin is active in patients (pts) with recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) progressing on a same dose and schedule platinum based agent. Proc Am Soc Clin Oncol 21:226a, 2002 (abstr 900)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Baselga, J.1
Trigo, J.M.2
Bourthis, J.3
-
19
-
-
9744266972
-
Cetuximab monotherapy is active in patients (pts) with platinum-refractory recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN): Results of a phase II study
-
abstr 5502
-
Trigo J, Hitt R, Koralewski P, et al: Cetuximab monotherapy is active in patients (pts) with platinum-refractory recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN): Results of a phase II study. Proc Am Soc Clin Oncol 23:487, 2004 (abstr 5502)
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 487
-
-
Trigo, J.1
Hitt, R.2
Koralewski, P.3
-
20
-
-
3543132150
-
A retrospective analysis of the outcome of patients (pts) with recurrent or metastatic squamous cell carcinoma of the head and neck (R&M SCCHN) who are progressing while on a platinum-based palliative chemotherapy
-
abstr 2022
-
Leon X, Hitt R, Constenla M, et al: A retrospective analysis of the outcome of patients (pts) with recurrent or metastatic squamous cell carcinoma of the head and neck (R&M SCCHN) who are progressing while on a platinum-based palliative chemotherapy. Proc Am Soc Clin Oncol 22:502, 2003 (abstr 2022)
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 502
-
-
Leon, X.1
Hitt, R.2
Constenla, M.3
-
21
-
-
10444220480
-
Cetuximab prolongs survival in patients with locoregionally advanced squamous cell carcinoma of head and neck: A phase III study of high dose radiation therapy with or without cetuximab
-
Bonner JA, Harari PM, Giralt J, et al: Cetuximab prolongs survival in patients with locoregionally advanced squamous cell carcinoma of head and neck: A phase III study of high dose radiation therapy with or without cetuximab. Proc Am Soc Clin Oncol 23: 5507, 2004
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 5507
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
-
22
-
-
2442704412
-
Use of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 in combination with radiotherapy in the treatment of locally advanced head and neck cancer patients
-
Crombet T, Osorio M, Cruz T, et al: Use of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 in combination with radiotherapy in the treatment of locally advanced head and neck cancer patients. J Clin Oncol 22:1646-1654, 2004
-
(2004)
J Clin Oncol
, vol.22
, pp. 1646-1654
-
-
Crombet, T.1
Osorio, M.2
Cruz, T.3
-
23
-
-
4444377694
-
Randomized phase II study of cetuximab in combination with cisplatin (C) and vinorelbine (V) vs. CV alone in the first-line treatment of patients (pts) with epidermal growth factor receptor (EGFR)-expressing advanced non-small-cell lung cancer (NSCLC)
-
abstr 7012
-
Rosell R, Daniel C, Ramlau R, et al: Randomized phase II study of cetuximab in combination with cisplatin (C) and vinorelbine (V) vs. CV alone in the first-line treatment of patients (pts) with epidermal growth factor receptor (EGFR)-expressing advanced non-small-cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 23:618, 2004 (abstr 7012)
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 618
-
-
Rosell, R.1
Daniel, C.2
Ramlau, R.3
-
24
-
-
19044380618
-
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
-
Agus DB, Akita RW, Fox WD, et al: Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell 2:127-137, 2002
-
(2002)
Cancer Cell
, vol.2
, pp. 127-137
-
-
Agus, D.B.1
Akita, R.W.2
Fox, W.D.3
-
25
-
-
20244378677
-
A phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer
-
Agus DB, Gordon MS, Taylor C, et al: A phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer. J Clin Oncol 23:2534-2543, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 2534-2543
-
-
Agus, D.B.1
Gordon, M.S.2
Taylor, C.3
-
26
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
-
Kris MG, Natale RB, Herbst RS, et al: Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial. JAMA 290:2149-2158, 2003
-
(2003)
JAMA
, vol.290
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
-
27
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
-
Fukuoka M, Yano S, Giaccone G, et al: Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol 21:2237-2246, 2003
-
(2003)
J Clin Oncol
, vol.21
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
-
28
-
-
0000329007
-
A phase II trial of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy, in patients (pts) with advanced, EGFR-expressing, non-small cell lung cancer (NSCLC)
-
abstr 1235
-
Perez-Soler R, Chachoua A, Huberman M, et al: A phase II trial of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy, in patients (pts) with advanced, EGFR-expressing, non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 20:310a, 2001 (abstr 1235)
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Perez-Soler, R.1
Chachoua, A.2
Huberman, M.3
-
29
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 1
-
Giaccone G, Herbst RS, Manegold C, et al: Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 1. J Clin Oncol 22:777-784, 2004
-
(2004)
J Clin Oncol
, vol.22
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
-
30
-
-
1542713370
-
Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2
-
Herbst RS, Giaccone G, Schiller JH, et al: Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2. J Clin Oncol 22:785-794, 2004
-
(2004)
J Clin Oncol
, vol.22
, pp. 785-794
-
-
Herbst, R.S.1
Giaccone, G.2
Schiller, J.H.3
-
31
-
-
4444238981
-
TRIBUTE - A phase III trial of erlotinib HCI (OSI-774) combined with carboplatin and paclitaxel (CP) chemotherapy in advanced non-small cell lung cancer (NSCLC)
-
Herbst RS, Prager D, Hermann R, et al: TRIBUTE - A phase III trial of erlotinib HCI (OSI-774) combined with carboplatin and paclitaxel (CP) chemotherapy in advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 23:7011, 2004
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 7011
-
-
Herbst, R.S.1
Prager, D.2
Hermann, R.3
-
32
-
-
4444238981
-
Results of a phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine (GC) chemotherapy in advanced non-small cell lung cancer (NSCLC)
-
abstr 7010
-
Gatzemeier U, Pluzanska A, Szczesna A, et al: Results of a phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine (GC) chemotherapy in advanced non-small cell lung cancer (NSCLC). ASCO Meeting Abstracts 22:617, 2004 (abstr 7010)
-
(2004)
ASCO Meeting Abstracts
, vol.22
, pp. 617
-
-
Gatzemeier, U.1
Pluzanska, A.2
Szczesna, A.3
-
33
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350:2129-2139, 2004
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
34
-
-
0036842170
-
Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types
-
Baselga J, Rischin D, Ranson M, et al: Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types. J Clin Oncol 20:4292-4302, 2002
-
(2002)
J Clin Oncol
, vol.20
, pp. 4292-4302
-
-
Baselga, J.1
Rischin, D.2
Ranson, M.3
-
35
-
-
0035398631
-
Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
-
Hidalgo M, Siu LL, Nemunaitis J, et al: Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J Clin Oncol 19:3267-3279, 2001
-
(2001)
J Clin Oncol
, vol.19
, pp. 3267-3279
-
-
Hidalgo, M.1
Siu, L.L.2
Nemunaitis, J.3
-
36
-
-
17844390172
-
EGFR mutations, small molecule kinase inhibitors, and non-small cell lung cancer: Current knowledge and future directions
-
Pao W, Miller VA: EGFR mutations, small molecule kinase inhibitors, and non-small cell lung cancer: Current knowledge and future directions. J Clin Oncol 23:2556-2568, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 2556-2568
-
-
Pao, W.1
Miller, V.A.2
-
37
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, et al: EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 304:1497-1500, 2004
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
38
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
Pao W, Miller V, Zakowski M, et al: EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 101:13306-13311, 2004
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
-
39
-
-
20244388126
-
Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small cell lung cancer with postoperative recurrence
-
Mitsudomi T, Kosaka T, Endoh H, et al: Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small cell lung cancer with postoperative recurrence. J Clin Oncol 23:2513-2520, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 2513-2520
-
-
Mitsudomi, T.1
Kosaka, T.2
Endoh, H.3
-
40
-
-
0142119289
-
Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis
-
Hirsch FR, Varella-Garcia M, Bunn PA, Jr., et al: Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol 21:3798-3807, 2003
-
(2003)
J Clin Oncol
, vol.21
, pp. 3798-3807
-
-
Hirsch, F.R.1
Varella-Garcia, M.2
Bunn Jr., P.A.3
-
41
-
-
20644465151
-
Improved efficacy of gefitinib therapy in phospho-Akt positive patients with advanced non-small cell lung cancer
-
abstr 3004
-
Cappuzzo F, Magrini E, Bartolini S, et al: Improved efficacy of gefitinib therapy in phospho-Akt positive patients with advanced non-small cell lung cancer. Proc Am Soc Clin Oncol 23:196, 2004 (abstr 3004)
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 196
-
-
Cappuzzo, F.1
Magrini, E.2
Bartolini, S.3
-
42
-
-
0035553174
-
The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo
-
Rusnak DW, Lackey K, Affleck K, et al: The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther 1:85-94, 2001
-
(2001)
Mol Cancer Ther
, vol.1
, pp. 85-94
-
-
Rusnak, D.W.1
Lackey, K.2
Affleck, K.3
-
43
-
-
4644289313
-
A unique structure for epidermal growth factor receptor bound to GW572016 (lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
-
Wood ER, Truesdale AT, McDonald OB, et al: A unique structure for epidermal growth factor receptor bound to GW572016 (lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res 64:6652-6659, 2004
-
(2004)
Cancer Res
, vol.64
, pp. 6652-6659
-
-
Wood, E.R.1
Truesdale, A.T.2
McDonald, O.B.3
-
44
-
-
20244388653
-
A study of the biological effects of lapatinib (GW572016), a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies
-
Spector NL, Xia W, Burris H, III, et al: A study of the biological effects of lapatinib (GW572016), a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies. J Clin Oncol 23:2502-2512, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 2502-2512
-
-
Spector, N.L.1
Xia, W.2
Burris III, H.3
-
45
-
-
4544284509
-
A phase II, open-label, multicenter study of GW572016 in patients with trastuzumab-refractory metastatic breast cancer
-
abstr 3006
-
Blackwell KL, Kaplan EH, Franco SX, et al: A phase II, open-label, multicenter study of GW572016 in patients with trastuzumab-refractory metastatic breast cancer. Proc Am Soc Clin Oncol 23:196, 2004 (abstr 3006)
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 196
-
-
Blackwell, K.L.1
Kaplan, E.H.2
Franco, S.X.3
-
46
-
-
14944343011
-
A phase II, open-label, multicenter study of lapatinib in two cohorts of patients with advanced or metastatic breast cancer who have progressed while receiving trastuzumab-containing regimens
-
abstr 1040; suppl 3
-
Burstein H, Storniolo AM, Franco S, et al: A phase II, open-label, multicenter study of lapatinib in two cohorts of patients with advanced or metastatic breast cancer who have progressed while receiving trastuzumab-containing regimens. Ann Oncol 15:2004 (abstr 1040; suppl 3)
-
(2004)
Ann Oncol
, vol.15
-
-
Burstein, H.1
Storniolo, A.M.2
Franco, S.3
-
47
-
-
3142774878
-
AEE788: A dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity
-
Traxler P, Allegrini PR, Brandt R, et al: AEE788: A dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res 64:4931-4941, 2004
-
(2004)
Cancer Res
, vol.64
, pp. 4931-4941
-
-
Traxler, P.1
Allegrini, P.R.2
Brandt, R.3
-
48
-
-
0037025173
-
Cancer. Addiction to oncogenes - The Achilles heal of cancer
-
Weinstein IB: Cancer. Addiction to oncogenes - The Achilles heal of cancer. Science 297:63-64, 2002
-
(2002)
Science
, vol.297
, pp. 63-64
-
-
Weinstein, I.B.1
-
49
-
-
10844231985
-
Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications
-
Kosaka T, Yatabe Y, Endoh H, et al: Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications. Cancer Res 64:8919-8923, 2004
-
(2004)
Cancer Res
, vol.64
, pp. 8919-8923
-
-
Kosaka, T.1
Yatabe, Y.2
Endoh, H.3
-
50
-
-
1842509828
-
Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to geftinib in advanced non-small-cell lung cancer
-
Miller VA, Kris MG, Shah N, et al: Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to geftinib in advanced non-small-cell lung cancer. J Clin Oncol 22:1103-1109, 2004
-
(2004)
J Clin Oncol
, vol.22
, pp. 1103-1109
-
-
Miller, V.A.1
Kris, M.G.2
Shah, N.3
-
51
-
-
5644303684
-
A randomized placebo-controlled trial of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) following failure of 1st line or 2nd line chemotherapy. A National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial
-
Shepherd FA, Pereira J, Ciuleanu TE, et al: A randomized placebo-controlled trial of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) following failure of 1st line or 2nd line chemotherapy. A National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial. Proc Am Soc Clin Oncol 23:7022, 2004
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 7022
-
-
Shepherd, F.A.1
Pereira, J.2
Ciuleanu, T.E.3
-
52
-
-
15744372810
-
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib and erlotinib
-
Pao W, Wang TY, Riely GJ, et al: KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib and erlotinib. PLoS Med: 57-61, 2005
-
(2005)
PLoS Med
, vol.57-61
-
-
Pao, W.1
Wang, T.Y.2
Riely, G.J.3
-
53
-
-
4143066760
-
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
-
Sordella R, Bell DW, Haber DA, et al: Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 305:1163-1167, 2004
-
(2004)
Science
, vol.305
, pp. 1163-1167
-
-
Sordella, R.1
Bell, D.W.2
Haber, D.A.3
-
54
-
-
0028074316
-
-
Rodriguez-Viciana P, Warne PH, Dhand R, et al: Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370:527-532, 1994
-
Rodriguez-Viciana P, Warne PH, Dhand R, et al: Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370:527-532, 1994
-
-
-
-
55
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A, et al: High frequency of mutations of the PIK3CA gene in human cancers. Science 304:554, 2004
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
56
-
-
7444250290
-
Mutation of the PIK3CA gene in ovarian and breast cancer
-
Campbell IG, Russell SE, Choong DYH, et al: Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 64:7678-7681, 2004
-
(2004)
Cancer Res
, vol.64
, pp. 7678-7681
-
-
Campbell, I.G.1
Russell, S.E.2
Choong, D.Y.H.3
-
57
-
-
16644393213
-
The PIK3CA gene is mutated with high frequency in human breast cancers
-
Bachman K, Argani P, Samuels Y, et al: The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther 3:772-775, 2004
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 772-775
-
-
Bachman, K.1
Argani, P.2
Samuels, Y.3
-
58
-
-
4944232647
-
Lung cancer: Intragenic ERBB2 kinase mutations in tumours
-
Stephens P, Hunter C, Bignell G, et al: Lung cancer: Intragenic ERBB2 kinase mutations in tumours. Nature 431:525-526, 2004
-
(2004)
Nature
, vol.431
, pp. 525-526
-
-
Stephens, P.1
Hunter, C.2
Bignell, G.3
-
59
-
-
19244366949
-
Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin
-
Baselga J, Pfister D, Cooper MR, et al: Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. J Clin Oncol 18:904-914, 2000
-
(2000)
J Clin Oncol
, vol.18
, pp. 904-914
-
-
Baselga, J.1
Pfister, D.2
Cooper, M.R.3
-
60
-
-
0035418622
-
Activated extracellular signal-regulated kinases: Association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments
-
Albanell J, Codony-Servat J, Rojo F, et al: Activated extracellular signal-regulated kinases: Association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments. Cancer Res 61:6500-6510, 2001
-
(2001)
Cancer Res
, vol.61
, pp. 6500-6510
-
-
Albanell, J.1
Codony-Servat, J.2
Rojo, F.3
-
61
-
-
0036139727
-
Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: Histopathologic and molecular consequences of receptor inhibition
-
Albanell J, Rojo F, Averbuch S, et al: Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: Histopathologic and molecular consequences of receptor inhibition. J Clin Oncol 20:110-124, 2002
-
(2002)
J Clin Oncol
, vol.20
, pp. 110-124
-
-
Albanell, J.1
Rojo, F.2
Averbuch, S.3
-
62
-
-
0032546269
-
EGF receptor signaling inhibits keratinocyte apoptosis: Evidence for mediation by Bcl-XL
-
Stoll S, Benedict M, Mitra R, et al: EGF receptor signaling inhibits keratinocyte apoptosis: Evidence for mediation by Bcl-XL. Oncogene 16:1493-1499, 1998
-
(1998)
Oncogene
, vol.16
, pp. 1493-1499
-
-
Stoll, S.1
Benedict, M.2
Mitra, R.3
-
63
-
-
0033762498
-
The EGF receptor - An essential regulator of multiple epidermal functions
-
Jost M, Kari C, Rodeck U: The EGF receptor - An essential regulator of multiple epidermal functions. Eur J Dermatol 10:505-510, 2000
-
(2000)
Eur J Dermatol
, vol.10
, pp. 505-510
-
-
Jost, M.1
Kari, C.2
Rodeck, U.3
-
64
-
-
12444259660
-
Pharmacodynamic evaluation of the epidermal growth factor receptor inhibitor OSI-774 in human epidermis of cancer patients
-
Malik SN, Siu LL, Rowinsky EK, et al: Pharmacodynamic evaluation of the epidermal growth factor receptor inhibitor OSI-774 in human epidermis of cancer patients. Clin Cancer Res 9:2478-2486, 2003
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2478-2486
-
-
Malik, S.N.1
Siu, L.L.2
Rowinsky, E.K.3
-
65
-
-
0005375432
-
A phase I and pharmacological study of intermitent dosing of PKI 166, a novel EGFR tyrosine kinase inhibitor administered orally to patients with advanced cancer
-
Miami, FL
-
Hoeskstra RDH: A phase I and pharmacological study of intermitent dosing of PKI 166, a novel EGFR tyrosine kinase inhibitor administered orally to patients with advanced cancer. AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics, Miami, FL, 2001
-
(2001)
AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics
-
-
Hoeskstra, R.D.H.1
-
66
-
-
84871472431
-
-
Zinner RG, Nemunaitis JJ, Donato NJ, et al: A phase I clinical and biomarker study of the novel pan-erbB tyrosine kinase inhibitor, Cl-1033, in patients with solid tumors. Proceedings AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics, Miami, FL, 2001, pp 566
-
Zinner RG, Nemunaitis JJ, Donato NJ, et al: A phase I clinical and biomarker study of the novel pan-erbB tyrosine kinase inhibitor, Cl-1033, in patients with solid tumors. Proceedings AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics, Miami, FL, 2001, pp 566
-
-
-
-
67
-
-
0041802378
-
Phase II and tumor pharmacodynamic study of gefinitib (ZD1839) in patients with advanced breast cancer
-
abstr 24
-
Baselga J, Albanell A, Ruiz A, et al: Phase II and tumor pharmacodynamic study of gefinitib (ZD1839) in patients with advanced breast cancer. Proc Am Soc Clin Oncol 22:7, 2003 (abstr 24)
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 7
-
-
Baselga, J.1
Albanell, A.2
Ruiz, A.3
-
68
-
-
20244375849
-
A phase I pharmacokinetic and pharmacodynamic study of weekly 1-hour and 24-hour infusion BMS-214662, a farnesyltransferase inhibitor, in patients with advanced solid tumors
-
Tabernero J, Rojo F, Marimón I, et al: A phase I pharmacokinetic and pharmacodynamic study of weekly 1-hour and 24-hour infusion BMS-214662, a farnesyltransferase inhibitor, in patients with advanced solid tumors. J Clin Oncol 23:2521-2533, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 2521-2533
-
-
Tabernero, J.1
Rojo, F.2
Marimón, I.3
-
69
-
-
0345688803
-
Studies of the potential utility of Ki67 as a predictive molecular marker of clinical response in primary breast cancer
-
Assersohn L, Salter J, Powles TJ, et al: Studies of the potential utility of Ki67 as a predictive molecular marker of clinical response in primary breast cancer. Breast Cancer Res Treat 82:113-123, 2003
-
(2003)
Breast Cancer Res Treat
, vol.82
, pp. 113-123
-
-
Assersohn, L.1
Salter, J.2
Powles, T.J.3
-
70
-
-
84871465766
-
Short term changes in Ki67 during neoadjuvant treatment of primary breast cancer with anastrozole or tamoxifen alone or combined correlate with recurrence-free survival
-
in press
-
Dowsett M, Smith I, Ebbs SR, et al: Short term changes in Ki67 during neoadjuvant treatment of primary breast cancer with anastrozole or tamoxifen alone or combined correlate with recurrence-free survival. Lancet: in press
-
Lancet
-
-
Dowsett, M.1
Smith, I.2
Ebbs, S.R.3
-
71
-
-
0037157603
-
Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: First results of the ATAC randomised trial
-
Baum M, Buzdar AU, Cuzick J, et al: Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: First results of the ATAC randomised trial. Lancet 359:2131-2139, 2002
-
(2002)
Lancet
, vol.359
, pp. 2131-2139
-
-
Baum, M.1
Buzdar, A.U.2
Cuzick, J.3
-
72
-
-
20244374413
-
Biomarker changes during neoadjuvant anastrozole, tamoxifen or the combination: Influence of hormonal status and HER2 in breast cancer
-
Dowsett M, Smith IE, Ebbs SR, et al: Biomarker changes during neoadjuvant anastrozole, tamoxifen or the combination: Influence of hormonal status and HER2 in breast cancer. J Clin Oncol 23:2477-2492, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 2477-2492
-
-
Dowsett, M.1
Smith, I.E.2
Ebbs, S.R.3
-
73
-
-
10744233578
-
Letrozole inhibits tumor proliferation more effectively than tamoxifen independent of HER1/2 expression
-
Ellis MJ, Coop A, Singh B, et al: Letrozole inhibits tumor proliferation more effectively than tamoxifen independent of HER1/2 expression. Cancer Res 63:6523-6531, 2003
-
(2003)
Cancer Res
, vol.63
, pp. 6523-6531
-
-
Ellis, M.J.1
Coop, A.2
Singh, B.3
-
74
-
-
20244378529
-
Neoadjuvant trastuzumab induces apoptosis in primary breast cancers
-
Mohsin SK, Weiss HL, Gutierrez MC, et al: Neoadjuvant trastuzumab induces apoptosis in primary breast cancers. J Clin Oncol 23:2460-2468, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 2460-2468
-
-
Mohsin, S.K.1
Weiss, H.L.2
Gutierrez, M.C.3
-
75
-
-
84871470531
-
Improved prediction of PSA recurrence through systems pathology
-
abstr 4591
-
Cordon-Cardo C, Kotsianti A, Donovan MJ, et al: Improved prediction of PSA recurrence through systems pathology. Proc Am Soc Clin Oncol 23:403, 2004 (abstr 4591)
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 403
-
-
Cordon-Cardo, C.1
Kotsianti, A.2
Donovan, M.J.3
-
76
-
-
0036852721
-
Automated subcellular localization and quantification of protein expression in tissue microarrays
-
Camp RL, Chung GG, Rimm DL: Automated subcellular localization and quantification of protein expression in tissue microarrays. Nat Med 8:1323-1327, 2002
-
(2002)
Nat Med
, vol.8
, pp. 1323-1327
-
-
Camp, R.L.1
Chung, G.G.2
Rimm, D.L.3
-
77
-
-
5144229336
-
Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): Superiority over single-agent receptor targeting
-
Matar P, Rojo F, Cassia R, et al: Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): Superiority over single-agent receptor targeting. Clin Cancer Res 10:6487-6501, 2004
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6487-6501
-
-
Matar, P.1
Rojo, F.2
Cassia, R.3
-
78
-
-
10744221765
-
Protein microarrays: Meeting analytical challenges for clinical applications
-
Liotta LA, Espina V, Mehta AI, et al: Protein microarrays: Meeting analytical challenges for clinical applications. Cancer Cell 3: 317-325, 2003
-
(2003)
Cancer Cell
, vol.3
, pp. 317-325
-
-
Liotta, L.A.1
Espina, V.2
Mehta, A.I.3
-
79
-
-
0032127350
-
Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts
-
Baselga J, Norton L, Albanell J, et al: Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. Cancer Res 58:2825-2831, 1998
-
(1998)
Cancer Res
, vol.58
, pp. 2825-2831
-
-
Baselga, J.1
Norton, L.2
Albanell, J.3
-
80
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, et al: Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344: 783-792, 2001
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
81
-
-
2942659576
-
Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer
-
Pegram MD, Konecny GE, O'Callaghan C, et al: Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer. J Natl Cancer Inst 96:739-749, 2004
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 739-749
-
-
Pegram, M.D.1
Konecny, G.E.2
O'Callaghan, C.3
-
82
-
-
0041885349
-
Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: Multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm
-
Burstein HJ, Harris LN, Marcom PK, et al: Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: Multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm. J Clin Oncol 21:2889-2895, 2003
-
(2003)
J Clin Oncol
, vol.21
, pp. 2889-2895
-
-
Burstein, H.J.1
Harris, L.N.2
Marcom, P.K.3
-
83
-
-
2942691785
-
Results of two open-label, multicenter phase II studies of docetaxel, platinum salts, and trastuzumab in HER2-positive advanced breast cancer
-
Pegram MD, Pienkowski T, Northfelt DW, et al: Results of two open-label, multicenter phase II studies of docetaxel, platinum salts, and trastuzumab in HER2-positive advanced breast cancer. J Natl Cancer Inst 96:759-769, 2004
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 759-769
-
-
Pegram, M.D.1
Pienkowski, T.2
Northfelt, D.W.3
-
84
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350:2335-2342, 2004
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
85
-
-
0034489914
-
Efficacy of cytotoxic agents against human tumor xenographs is markedly enhanced by coadministration of ZD1839 ('Iressa') an inhibitor of tyrosine kinase
-
Sirotnak FM, Zakowsky MF, Miller VA, et al: Efficacy of cytotoxic agents against human tumor xenographs is markedly enhanced by coadministration of ZD1839 ('Iressa') an inhibitor of tyrosine kinase. Clin Cancer Res 6:4885-4892, 2000
-
(2000)
Clin Cancer Res
, vol.6
, pp. 4885-4892
-
-
Sirotnak, F.M.1
Zakowsky, M.F.2
Miller, V.A.3
-
86
-
-
0034068319
-
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
-
Ciardiello F, Caputo R, Bianco R, et al: Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin Cancer Res 6:2053-2063, 2000
-
(2000)
Clin Cancer Res
, vol.6
, pp. 2053-2063
-
-
Ciardiello, F.1
Caputo, R.2
Bianco, R.3
-
87
-
-
1542503756
-
Combining the anti-EGFR agent gefitinib with chemotherapy in non-small-cell lung cancer: How do we go from INTACT to impact?
-
Baselga J: Combining the anti-EGFR agent gefitinib with chemotherapy in non-small-cell lung cancer: How do we go from INTACT to impact? J Clin Oncol 22:759-761, 2004
-
(2004)
J Clin Oncol
, vol.22
, pp. 759-761
-
-
Baselga, J.1
-
88
-
-
0003203826
-
Adjuvant chemohormonal therapy for primary breast cancer should be sequential instead of concurrent: Initial results from intergroup trial 0100 (SWOG-8814)
-
abstr 143
-
Albain KS, Green SJ, Ravdin PM, et al: Adjuvant chemohormonal therapy for primary breast cancer should be sequential instead of concurrent: initial results from intergroup trial 0100 (SWOG-8814). Proc Am Soc Clin Oncol 21:37a, 2002 (abstr 143)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Albain, K.S.1
Green, S.J.2
Ravdin, P.M.3
-
89
-
-
0035883542
-
Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung
-
Ahrendt SA, Decker PA, Alawi EA, et al: Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung. Cancer 92:1525-1530, 2001
-
(2001)
Cancer
, vol.92
, pp. 1525-1530
-
-
Ahrendt, S.A.1
Decker, P.A.2
Alawi, E.A.3
-
90
-
-
0033561522
-
Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck
-
Huang SM, Bock JM, Harari PM: Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res 59:1935-1940, 1999
-
(1999)
Cancer Res
, vol.59
, pp. 1935-1940
-
-
Huang, S.M.1
Bock, J.M.2
Harari, P.M.3
-
91
-
-
0035254521
-
Head and neck cancer as a clinical model for molecular targeting of therapy: Combining EGFR blockade with radiation
-
Harari PM, Huang SM: Head and neck cancer as a clinical model for molecular targeting of therapy: Combining EGFR blockade with radiation. Int J Radiat Oncol Biol Phys 49:427-433, 2001
-
(2001)
Int J Radiat Oncol Biol Phys
, vol.49
, pp. 427-433
-
-
Harari, P.M.1
Huang, S.M.2
-
92
-
-
0027428571
-
Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts
-
Fan Z, Baselga J, Masui H, et al: Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts. Cancer Res 53:4637-4642, 1993
-
(1993)
Cancer Res
, vol.53
, pp. 4637-4642
-
-
Fan, Z.1
Baselga, J.2
Masui, H.3
-
93
-
-
0037137519
-
A gene-expression signature as a predictor of survival in breast cancer
-
van de Vijver MJ, He YD, van 't Veer LJ, et al: A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 347: 1999-2009, 2002
-
(2002)
N Engl J Med
, vol.347
, pp. 1999-2009
-
-
van de Vijver, M.J.1
He, Y.D.2
van 't Veer, L.J.3
-
94
-
-
0041301731
-
Emerging science: Prospective validation of gene expression profiling-based prediction of complete pathologic response to neoadjuvant paclitaxel/FAC chemotherapy in breast cancer
-
abstr 1
-
Pusztai L, Ayers M, Simmans FW, et al: Emerging science: Prospective validation of gene expression profiling-based prediction of complete pathologic response to neoadjuvant paclitaxel/FAC chemotherapy in breast cancer. Proc Am Soc Clin Oncol 22:1, 2003 (abstr 1)
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 1
-
-
Pusztai, L.1
Ayers, M.2
Simmans, F.W.3
-
95
-
-
0347615106
-
A phase I PK and serial tumor and skin pharmacodynamic (PD) study of weekly (q1w), every 2-week (q2w) or every 3-week (q3w) 1-hour (h) infusion EMD72000, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients (pt) with advanced tumors
-
abstr 770
-
Tabernero J, Rojo F, Jimenez E, et al: A phase I PK and serial tumor and skin pharmacodynamic (PD) study of weekly (q1w), every 2-week (q2w) or every 3-week (q3w) 1-hour (h) infusion EMD72000, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients (pt) with advanced tumors. Proc Am Soc Clin Oncol 22:192, 2003 (abstr 770)
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 192
-
-
Tabernero, J.1
Rojo, F.2
Jimenez, E.3
-
96
-
-
33645086838
-
Pharmacogenomic approaches for identifying markers predictive of tumor response to Cetuximab (Erbitux)
-
abstr 2032
-
Khambata Ford S, Perkins N-A, Yoganathan S, et al: Pharmacogenomic approaches for identifying markers predictive of tumor response to Cetuximab (Erbitux). Proc Am Assoc Cancer Res 45:2004 (abstr 2032)
-
(2004)
Proc Am Assoc Cancer Res
, vol.45
-
-
Khambata Ford, S.1
Perkins, N.-A.2
Yoganathan, S.3
-
97
-
-
0347910287
-
Quantitative gene expression in non-small cell lung cancer from paraffin-embedded tissue specimens: Predicting response to gefitinib, an EGFR kinase inhibitor
-
abstr 763
-
Natale RB, Shak S, Aronson N, et al: Quantitative gene expression in non-small cell lung cancer from paraffin-embedded tissue specimens: Predicting response to gefitinib, an EGFR kinase inhibitor. Proc Am Soc Clin Oncol 22:190, 2003 (abstr 763)
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 190
-
-
Natale, R.B.1
Shak, S.2
Aronson, N.3
-
98
-
-
0042675500
-
Open-label, phase II, multicenter trial of ZD1839 (Iressa) in patients with advanced breast cancer
-
abstr 20; suppl 1
-
Albain K, Elledge R, Gradishar WJ, et al: Open-label, phase II, multicenter trial of ZD1839 (Iressa) in patients with advanced breast cancer. Breast Cancer Res Treat 76:S33, 2002 (abstr 20; suppl 1)
-
(2002)
Breast Cancer Res Treat
, vol.76
-
-
Albain, K.1
Elledge, R.2
Gradishar, W.J.3
-
99
-
-
0042804495
-
Gefitinib (ZD1839) is active in acquired tamoxifen (TAM)-resistant estrogen receptor (ER)-positive and ER-negative breast cancer: Results from a phase II study
-
abstr 23
-
Robertson JFR, Gutteridge E, Cheung KL, et al: Gefitinib (ZD1839) is active in acquired tamoxifen (TAM)-resistant estrogen receptor (ER)-positive and ER-negative breast cancer: Results from a phase II study. Proc Am Soc Clin Oncol 22:7, 2003 (abstr 23)
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 7
-
-
Robertson, J.F.R.1
Gutteridge, E.2
Cheung, K.L.3
-
100
-
-
4143149763
-
Evaluation of biologic end points and pharmacokinetics in patients with metastatic breast cancer after treatment with erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor
-
Tan AR, Yang X, Hewitt SM, et al: Evaluation of biologic end points and pharmacokinetics in patients with metastatic breast cancer after treatment with erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor. J Clin Oncol 22:3080-3090, 2004
-
(2004)
J Clin Oncol
, vol.22
, pp. 3080-3090
-
-
Tan, A.R.1
Yang, X.2
Hewitt, S.M.3
-
101
-
-
9144251561
-
Nonendocrine pathways and endocrine resistance: Observations with antiestrogens and signal transduction inhibitors in combination
-
Nicholson RI, Hutcheson IR, Knowlden JM, et al: Nonendocrine pathways and endocrine resistance: observations with antiestrogens and signal transduction inhibitors in combination. Clin Cancer Res 10:346S-354S, 2004
-
(2004)
Clin Cancer Res
, vol.10
-
-
Nicholson, R.I.1
Hutcheson, I.R.2
Knowlden, J.M.3
-
102
-
-
0034790009
-
Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer
-
Nicholson R, Hutcheson I, Harper M, et al: Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer. Endocr Relat Cancer 8:175-182, 2001
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 175-182
-
-
Nicholson, R.1
Hutcheson, I.2
Harper, M.3
-
103
-
-
0042675505
-
Targeting the epidermal growth factor receptor pathway improves the anti-tumor effect of tamoxifen and delays acquired resistance in a xenograft model of breast cancer
-
abstr 18; suppl 1
-
Massarweh S, Shou J, Dipietro M, et al: Targeting the epidermal growth factor receptor pathway improves the anti-tumor effect of tamoxifen and delays acquired resistance in a xenograft model of breast cancer. Breast Cancer Res Treat 76:S33, 2002 (abstr 18; suppl 1)
-
(2002)
Breast Cancer Res Treat
, vol.76
-
-
Massarweh, S.1
Shou, J.2
Dipietro, M.3
-
104
-
-
0037420192
-
Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer
-
Osborne CK, Bardou V, Hopp TA, et al: Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer. J Natl Cancer Inst 95:353-361, 2003
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 353-361
-
-
Osborne, C.K.1
Bardou, V.2
Hopp, T.A.3
-
105
-
-
2942652871
-
Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/ HER2-positive breast cancer
-
Shou J, Massarweh S, Osborne CK, et al: Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/ HER2-positive breast cancer. J Natl Cancer Inst 96:926-935, 2004
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 926-935
-
-
Shou, J.1
Massarweh, S.2
Osborne, C.K.3
-
106
-
-
2342591455
-
The discovery of receptor tyrosine kinases: Targets for cancer therapy
-
Gschwind A, Fischer OM, Ullrich A: The discovery of receptor tyrosine kinases: Targets for cancer therapy. Nat Rev Cancer 4:361-370, 2004
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 361-370
-
-
Gschwind, A.1
Fischer, O.M.2
Ullrich, A.3
-
107
-
-
0030030072
-
ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: Implications for breast cancer
-
Karunagaran D, Tzahar E, Beerli RR, et al: ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J 15:254-264, 1996
-
(1996)
EMBO J
, vol.15
, pp. 254-264
-
-
Karunagaran, D.1
Tzahar, E.2
Beerli, R.R.3
-
108
-
-
10144255098
-
Synergistic interaction of the neu proto-oncogene product and transforming growth factor α in the mammary epithelium of transgenic mice
-
Muller W, Arteaga C, Muthuswamy S, et al: Synergistic interaction of the neu proto-oncogene product and transforming growth factor α in the mammary epithelium of transgenic mice. Mol Cell Biol 16:5726-5736, 1996
-
(1996)
Mol Cell Biol
, vol.16
, pp. 5726-5736
-
-
Muller, W.1
Arteaga, C.2
Muthuswamy, S.3
-
109
-
-
0033372557
-
Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members
-
Xia W, Lau Y-K, Zhang H-Z, et al: Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members. Clin Cancer Res 5:4164-4174, 1999
-
(1999)
Clin Cancer Res
, vol.5
, pp. 4164-4174
-
-
Xia, W.1
Lau, Y.-K.2
Zhang, H.-Z.3
-
110
-
-
0028136407
-
Prognostic influence of the co-expression of epidermal growth factor receptor and c-erbB-2 protein in human lung adenocarcinoma
-
Tateishi M, Ishida T, Kohdono S, et al: Prognostic influence of the co-expression of epidermal growth factor receptor and c-erbB-2 protein in human lung adenocarcinoma. Surg Oncol 3:109-113, 1994
-
(1994)
Surg Oncol
, vol.3
, pp. 109-113
-
-
Tateishi, M.1
Ishida, T.2
Kohdono, S.3
-
111
-
-
0028205406
-
Kinase-deficient neu proteins suppress epidermal growth factor receptor function and abolish cell transformation
-
Qian X, Dougall WC, Hellman ME, et al: Kinase-deficient neu proteins suppress epidermal growth factor receptor function and abolish cell transformation. Oncogene 9:1507-1514, 1994
-
(1994)
Oncogene
, vol.9
, pp. 1507-1514
-
-
Qian, X.1
Dougall, W.C.2
Hellman, M.E.3
-
112
-
-
0028893444
-
Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling
-
Graus-Porta D, Beerli RR, Hynes NE: Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling. Mol Cell Biol 15:1182-1191, 1995
-
(1995)
Mol Cell Biol
, vol.15
, pp. 1182-1191
-
-
Graus-Porta, D.1
Beerli, R.R.2
Hynes, N.E.3
-
113
-
-
0035679211
-
High levels of HER-2 expression alter the ability of epidermal growth factor receptor (EGFR) family tyrosine kinase inhibitors to inhibit EGFR phosphorylation in vivo
-
Christensen JG, Schreck RE, Chan E, et al: High levels of HER-2 expression alter the ability of epidermal growth factor receptor (EGFR) family tyrosine kinase inhibitors to inhibit EGFR phosphorylation in vivo. Clin Cancer Res 7:4230-4238, 2001
-
(2001)
Clin Cancer Res
, vol.7
, pp. 4230-4238
-
-
Christensen, J.G.1
Schreck, R.E.2
Chan, E.3
-
114
-
-
0036606779
-
The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides
-
Motoyama AB, Hynes NE, Lane HA: The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides. Cancer Res 62:3151-3158, 2002
-
(2002)
Cancer Res
, vol.62
, pp. 3151-3158
-
-
Motoyama, A.B.1
Hynes, N.E.2
Lane, H.A.3
-
115
-
-
0033590602
-
Augmentation of a humanized anti-HER2 mAb 4D5 induced growth inhibition by a human-mouse chimeric anti-EGF receptor mAb C225
-
Ye D, Mendelsohn J, Fan Z: Augmentation of a humanized anti-HER2 mAb 4D5 induced growth inhibition by a human-mouse chimeric anti-EGF receptor mAb C225. Oncogene 18:731-738, 1999
-
(1999)
Oncogene
, vol.18
, pp. 731-738
-
-
Ye, D.1
Mendelsohn, J.2
Fan, Z.3
-
116
-
-
0035476803
-
The tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells
-
Moasser MM, Basso A, Averbuch SD, et al: The tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res 61:7184-7188, 2001
-
(2001)
Cancer Res
, vol.61
, pp. 7184-7188
-
-
Moasser, M.M.1
Basso, A.2
Averbuch, S.D.3
-
117
-
-
0035893560
-
Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/Neu (erb-2)- overexpressing breast cancer cells in vitro and in vivo
-
Moulder SL, Yakes M, Muthuswamy SK, et al: Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/Neu (erb-2)- overexpressing breast cancer cells in vitro and in vivo. Cancer Res 61:8887-8895, 2001
-
(2001)
Cancer Res
, vol.61
, pp. 8887-8895
-
-
Moulder, S.L.1
Yakes, M.2
Muthuswamy, S.K.3
-
118
-
-
0036225446
-
Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth
-
Normanno N, Campiglio M, De Luca A, et al: Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth. Ann Oncol 13:65-72, 2002
-
(2002)
Ann Oncol
, vol.13
, pp. 65-72
-
-
Normanno, N.1
Campiglio, M.2
De Luca, A.3
-
119
-
-
21044436219
-
ECOG1100: A phase I-II study of combined blockade of the erbB receptor network with trastuzmab and gefitinib (Iressa) in patients (pts) with HER2-overexpressing metastatic breast cancer (met br ca)
-
San Antonio, TX, December, abstr 24
-
Arteaga CL, O'Neil A, Moulder SL, et al: ECOG1100: A phase I-II study of combined blockade of the erbB receptor network with trastuzmab and gefitinib (Iressa) in patients (pts) with HER2-overexpressing metastatic breast cancer (met br ca). 27th San Antonio Breast Cancer Symposium, San Antonio, TX, December 2004 (abstr 24)
-
(2004)
27th San Antonio Breast Cancer Symposium
-
-
Arteaga, C.L.1
O'Neil, A.2
Moulder, S.L.3
-
120
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
Vogel CL, Cobleigh MA, Tripathy D, et al: Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 20:719-726, 2002
-
(2002)
J Clin Oncol
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
-
121
-
-
17144371333
-
-
Baselga J, Carbonell X, Castaneda-Soto N-J, et al: Efficacy, safety and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule: A phase II study. J Clin Oncol 23: in press
-
Baselga J, Carbonell X, Castaneda-Soto N-J, et al: Efficacy, safety and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule: A phase II study. J Clin Oncol 23: in press
-
-
-
-
122
-
-
0036141447
-
Insulin-like growth factor receptor I mediates resistance to anti-EGFR therapy in primary human glioblastoma cells trough continued activation of phosphoinositide 3-kinase signaling
-
Chakravarti A, Loeffler JS, Dyson NJ: Insulin-like growth factor receptor I mediates resistance to anti-EGFR therapy in primary human glioblastoma cells trough continued activation of phosphoinositide 3-kinase signaling. Cancer Res 62:200-207, 2002
-
(2002)
Cancer Res
, vol.62
, pp. 200-207
-
-
Chakravarti, A.1
Loeffler, J.S.2
Dyson, N.J.3
-
123
-
-
0035915421
-
Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
-
Lu Y, Zi X, Zhao Y, et al: Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst 93:1852-1857, 2001
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1852-1857
-
-
Lu, Y.1
Zi, X.2
Zhao, Y.3
-
124
-
-
12144285705
-
In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase
-
Garcia-Echeverria C, Pearson MA, Marti A, et al: In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell 5:231-239, 2004
-
(2004)
Cancer Cell
, vol.5
, pp. 231-239
-
-
Garcia-Echeverria, C.1
Pearson, M.A.2
Marti, A.3
-
125
-
-
0037616593
-
Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors
-
Bianco R, Shin I, Ritter CA, et al: Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. Oncogene 22:2812-2822, 2003
-
(2003)
Oncogene
, vol.22
, pp. 2812-2822
-
-
Bianco, R.1
Shin, I.2
Ritter, C.A.3
-
126
-
-
8344257124
-
Schedule-dependent effects of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib in combination with the mammalian target of rapamycin (mTOR) inhibitor everolimus (RAD001)
-
abstr 3074
-
Di Cosimo S, Matar P, Rojo F, et al: Schedule-dependent effects of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib in combination with the mammalian target of rapamycin (mTOR) inhibitor everolimus (RAD001). Proc Am Soc Clin Oncol 23:213b, 2004 (abstr 3074)
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
-
-
Di Cosimo, S.1
Matar, P.2
Rojo, F.3
-
127
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg R: The hallmarks of cancer. Cell 100:57-70, 2000
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.2
-
128
-
-
0001223491
-
Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
-
Petit AM, Rak J, Hung MC, et al: Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol 151:1523-1530, 1997
-
(1997)
Am J Pathol
, vol.151
, pp. 1523-1530
-
-
Petit, A.M.1
Rak, J.2
Hung, M.C.3
-
129
-
-
0034896362
-
Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor
-
Ciardiello F, Caputo R, Bianco R, et al: Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clin Cancer Res 7: 1459-1465, 2001
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1459-1465
-
-
Ciardiello, F.1
Caputo, R.2
Bianco, R.3
-
130
-
-
0035394833
-
Acquired resistance to the antitumor effect of EGFR-blocking antibodies in vivo: A role for altered tumor angiogenesis
-
Viloria-Petit A, Crombet T, Jothy S, et al: Acquired resistance to the antitumor effect of EGFR-blocking antibodies in vivo: A role for altered tumor angiogenesis. Cancer Res 61: 5090-5101, 2001
-
(2001)
Cancer Res
, vol.61
, pp. 5090-5101
-
-
Viloria-Petit, A.1
Crombet, T.2
Jothy, S.3
-
131
-
-
20244381389
-
Phase I/II trial evaluating the anti-vascular endothelial growth factor receptor monoclonal antibody, bevacizumab, in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib, for patients with recurrent non-small cell lung cancer
-
Herbst RS, Johnson DH, Mininberg E, et al: Phase I/II trial evaluating the anti-vascular endothelial growth factor receptor monoclonal antibody, bevacizumab, in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib, for patients with recurrent non-small cell lung cancer. J Clin Oncol 23:2544-2555, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 2544-2555
-
-
Herbst, R.S.1
Johnson, D.H.2
Mininberg, E.3
-
132
-
-
21044443432
-
Phase I combined biological therapy of breast cancer using two humanized monoclonal antibodies directed against HER2 proto-oncogene and vascular endothelial growth factor (VEGF)
-
San Antonio, TX, December, abstr 3039
-
Pegram MD, Yeon C, Ku NC, et al: Phase I combined biological therapy of breast cancer using two humanized monoclonal antibodies directed against HER2 proto-oncogene and vascular endothelial growth factor (VEGF). 27th San Antonio Breast Cancer Symposium, San Antonio, TX, December 2004 (abstr 3039)
-
(2004)
27th San Antonio Breast Cancer Symposium
-
-
Pegram, M.D.1
Yeon, C.2
Ku, N.C.3
-
133
-
-
0037102369
-
ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
-
Wedge SR, Ogilvie DJ, Dukes M, et al: ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 62: 4645-4655, 2002
-
(2002)
Cancer Res
, vol.62
, pp. 4645-4655
-
-
Wedge, S.R.1
Ogilvie, D.J.2
Dukes, M.3
|