Model for the complex between the insulin-like growth factor I and its receptor: Towards designing antagonists for the IGF-1 receptor

Protein Engineering, Design and Selection

Volumn 19, Issue 8, 2006, Pages 377-384

  Epa, V Chandana ^a   Ward, Colin W ^a  

^a CSIRO   (Australia)

Author keywords

Antagonist design; Complementarity; IGF 1R; Protein docking

Indexed keywords

COGNITIVE SYSTEMS; GROWTH KINETICS; INSULIN; MACROMOLECULES; MOLECULAR BIOLOGY; MUTAGENESIS; TISSUE; TUMORS;

ANTAGONIST DESIGN; COMPLEMENTARITY; IGF-1R; PROTEIN DOCKING;

BIOMEDICAL ENGINEERING;

DOCKING PROTEIN; INSULIN LIKE GROWTH FACTOR 1 RECEPTOR ANTAGONIST; LIGAND; RECEPTOR BLOCKING AGENT; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

BINDING AFFINITY; CHIMERA; COMPLEX FORMATION; COMPREHENSION; COMPUTER INTERFACE; DRUG DESIGN; MACROMOLECULE; METRIC SYSTEM; MOLECULAR MODEL; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RELIABILITY; REVIEW; THREE DIMENSIONAL IMAGING;

ALGORITHMS; AMINO ACID SEQUENCE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, IGF TYPE 1; SEQUENCE ALIGNMENT;

EID: 33745929892     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzl022     Document Type: Review

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