-
1
-
-
44949117528
-
Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells
-
18398842
-
Y.Ueno, H.Sakurai, S.Tsunoda, M.K.Choo, M.Matsuo, K.Koizumi, I.Saiki. Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells. Int J Cancer 2008; 123:340-7; PMID:18398842; http://dx.doi.org/10.1002/ijc.23465
-
(2008)
Int J Cancer
, vol.123
, pp. 340-347
-
-
Ueno, Y.1
Sakurai, H.2
Tsunoda, S.3
Choo, M.K.4
Matsuo, M.5
Koizumi, K.6
Saiki, I.7
-
2
-
-
34250870066
-
Peptide vaccines of the HER-2/neu dimerization loop are effective in inhibiting mammary tumor growth in vivo
-
17579068
-
S.D.Allen, J.T.Garrett, S.V.Rawale, A.L.Jones, G.Phillips, G.Forni, J.C.Morris, R.G.Oshima, P.T.Kaumaya. Peptide vaccines of the HER-2/neu dimerization loop are effective in inhibiting mammary tumor growth in vivo. J Immunol 2007; 179:472-82; PMID:17579068; http://dx.doi.org/10.4049/jimmunol.179.1.472
-
(2007)
J Immunol
, vol.179
, pp. 472-482
-
-
Allen, S.D.1
Garrett, J.T.2
Rawale, S.V.3
Jones, A.L.4
Phillips, G.5
Forni, G.6
Morris, J.C.7
Oshima, R.G.8
Kaumaya, P.T.9
-
3
-
-
77950074588
-
The upgraded role of HER3 and HER4 receptors in breast cancer
-
19481955
-
A.K.Koutras, G.Fountzilas, K.T.Kalogeras, I.Starakis, G.Iconomou, H.P.Kalofonos. The upgraded role of HER3 and HER4 receptors in breast cancer. Crit Rev Oncol Hematol 2010; 74:73-8; PMID:19481955; http://dx.doi.org/10.1016/j.critrevonc.2009.04.011
-
(2010)
Crit Rev Oncol Hematol
, vol.74
, pp. 73-78
-
-
Koutras, A.K.1
Fountzilas, G.2
Kalogeras, K.T.3
Starakis, I.4
Iconomou, G.5
Kalofonos, H.P.6
-
4
-
-
84864367360
-
The ERBB network: at last, cancer therapy meets systems biology
-
22785351
-
Y.Yarden, G.Pines. The ERBB network: at last, cancer therapy meets systems biology. Nat Rev Cancer 2012; 12:553-63; PMID:22785351; http://dx.doi.org/10.1038/nrc3309
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 553-563
-
-
Yarden, Y.1
Pines, G.2
-
5
-
-
84890041471
-
The ErbB/HER family of protein-tyrosine kinases and cancer
-
24269963
-
R.Roskoski, Jr. The ErbB/HER family of protein-tyrosine kinases and cancer. Pharmacol Res 2014; 79:34-74; PMID:24269963; http://dx.doi.org/10.1016/j.phrs.2013.11.002
-
(2014)
Pharmacol Res
, vol.79
, pp. 34-74
-
-
Roskoski, R.1
-
6
-
-
84855884072
-
Targeting the EGFR signaling pathway in cancer therapy
-
22239438
-
P.Seshacharyulu, M.P.Ponnusamy, D.Haridas, M.Jain, A.K.Ganti, S.K.Batra. Targeting the EGFR signaling pathway in cancer therapy. Expert Opin Ther Targets 2012; 16:15-31; PMID:22239438; http://dx.doi.org/10.1517/14728222.2011.648617
-
(2012)
Expert Opin Ther Targets
, vol.16
, pp. 15-31
-
-
Seshacharyulu, P.1
Ponnusamy, M.P.2
Haridas, D.3
Jain, M.4
Ganti, A.K.5
Batra, S.K.6
-
7
-
-
65549110881
-
microRNA-205 regulates HER3 in human breast cancer
-
19276373
-
M.V.Iorio, P.Casalini, C.Piovan, G.Di Leva, A.Merlo, T.Triulzi, S.Menard, C.M.Croce, E.Tagliabue. microRNA-205 regulates HER3 in human breast cancer. Cancer Res 2009; 69:2195-200; PMID:19276373; http://dx.doi.org/10.1158/0008-5472.CAN-08-2920
-
(2009)
Cancer Res
, vol.69
, pp. 2195-2200
-
-
Iorio, M.V.1
Casalini, P.2
Piovan, C.3
Di Leva, G.4
Merlo, A.5
Triulzi, T.6
Menard, S.7
Croce, C.M.8
Tagliabue, E.9
-
8
-
-
0037162799
-
Structure of the extracellular region of HER3 reveals an interdomain tether
-
12154198
-
H.S.Cho, D.J.Leahy. Structure of the extracellular region of HER3 reveals an interdomain tether. Science 2002; 297:1330-3; PMID:12154198; http://dx.doi.org/10.1126/science.1074611
-
(2002)
Science
, vol.297
, pp. 1330-1333
-
-
Cho, H.S.1
Leahy, D.J.2
-
9
-
-
1542329005
-
The erbB family: targets for therapeutic development against cancer and therapeutic strategies using monoclonal antibodies and tyrosine kinase inhibitors
-
14746530
-
E.K.Rowinsky. The erbB family: targets for therapeutic development against cancer and therapeutic strategies using monoclonal antibodies and tyrosine kinase inhibitors. Annu Rev Med 2004; 55:433-57; PMID:14746530; http://dx.doi.org/10.1146/annurev.med.55.091902.104433
-
(2004)
Annu Rev Med
, vol.55
, pp. 433-457
-
-
Rowinsky, E.K.1
-
10
-
-
0037429706
-
EGF receptor ligands
-
12648462
-
R.C.Harris, E.Chung, R.J.Coffey. EGF receptor ligands. Exp Cell Res 2003; 284:2-13; PMID:12648462; http://dx.doi.org/10.1016/S0014-4827(02)00105-2
-
(2003)
Exp Cell Res
, vol.284
, pp. 2-13
-
-
Harris, R.C.1
Chung, E.2
Coffey, R.J.3
-
11
-
-
0030973939
-
Biochemical characterization of the protein tyrosine kinase homology domain of the ErbB3 (HER3) receptor protein
-
9148746
-
S.L.Sierke, K.Cheng, H.H.Kim, J.G.Koland. Biochemical characterization of the protein tyrosine kinase homology domain of the ErbB3 (HER3) receptor protein. Biochem J 1997; 322 (Pt 3):757-63; PMID:9148746; http://www.biochemj.org/bj/322/0757/3220757.pdf
-
(1997)
Biochem J
, vol.322
, pp. 757-763
-
-
Sierke, S.L.1
Cheng, K.2
Kim, H.H.3
Koland, J.G.4
-
12
-
-
0028168569
-
Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity
-
8058768
-
P.M.Guy, J.V.Platko, L.C.Cantley, R.A.Cerione, K.L.Carraway, 3rd. Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. Proc Natl Acad Sci U S A 1994; 91:8132-6; PMID:8058768; http://dx.doi.org/10.1073/pnas.91.17.8132
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 8132-8136
-
-
Guy, P.M.1
Platko, J.V.2
Cantley, L.C.3
Cerione, R.A.4
Carraway, K.L.5
-
13
-
-
76049128717
-
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3
-
20007378
-
N.Jura, Y.Shan, X.Cao, D.E.Shaw, J.Kuriyan. Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3. Proc Natl Acad Sci U S A 2009; 106:21608-13; PMID:20007378; http://dx.doi.org/10.1073/pnas.0912101106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 21608-21613
-
-
Jura, N.1
Shan, Y.2
Cao, X.3
Shaw, D.E.4
Kuriyan, J.5
-
14
-
-
0031730476
-
Expression of c-erbB3 protein in primary breast carcinomas
-
9823984
-
R.Naidu, M.Yadav, S.Nair, M.K.Kutty. Expression of c-erbB3 protein in primary breast carcinomas. Br J Cancer 1998; 78:1385-90; PMID:9823984; http://dx.doi.org/10.1038/bjc.1998.689
-
(1998)
Br J Cancer
, vol.78
, pp. 1385-1390
-
-
Naidu, R.1
Yadav, M.2
Nair, S.3
Kutty, M.K.4
-
15
-
-
0028799821
-
Enhanced erbB-3 expression in human pancreatic cancer correlates with tumor progression
-
9815939
-
H.Friess, Y.Yamanaka, M.S.Kobrin, D.A.Do, M.W.Buchler, M.Korc. Enhanced erbB-3 expression in human pancreatic cancer correlates with tumor progression. Clin Cancer Res 1995; 1:1413-20; PMID:9815939; http://clincancerres.aacrjournals.org/content/1/11/1413.full.pdf
-
(1995)
Clin Cancer Res
, vol.1
, pp. 1413-1420
-
-
Friess, H.1
Yamanaka, Y.2
Kobrin, M.S.3
Do, D.A.4
Buchler, M.W.5
Korc, M.6
-
16
-
-
0031928378
-
Increased expression of erbB3 in colorectal cancer is associated with concomitant increase in the level of erbB2
-
9712416
-
C.A.Maurer, H.Friess, B.Kretschmann, A.Zimmermann, A.Stauffer, H.U.Baer, M.Korc, M.W.Buchler. Increased expression of erbB3 in colorectal cancer is associated with concomitant increase in the level of erbB2. Hum Pathol 1998; 29:771-7; PMID:9712416; http://dx.doi.org/10.1016/S0046-8177(98)90444-0
-
(1998)
Hum Pathol
, vol.29
, pp. 771-777
-
-
Maurer, C.A.1
Friess, H.2
Kretschmann, B.3
Zimmermann, A.4
Stauffer, A.5
Baer, H.U.6
Korc, M.7
Buchler, M.W.8
-
17
-
-
48649092620
-
A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy
-
18632642
-
S.T.Lee-Hoeflich, L.Crocker, E.Yao, T.Pham, X.Munroe, K.P.Hoeflich, M.X.Sliwkowski, H.M.Stern. A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy. Cancer Res 2008; 68:5878-87; PMID:18632642; http://dx.doi.org/10.1158/0008-5472.CAN-08-0380
-
(2008)
Cancer Res
, vol.68
, pp. 5878-5887
-
-
Lee-Hoeflich, S.T.1
Crocker, L.2
Yao, E.3
Pham, T.4
Munroe, X.5
Hoeflich, K.P.6
Sliwkowski, M.X.7
Stern, H.M.8
-
18
-
-
0029053716
-
Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas
-
7538656
-
M.Alimandi, A.Romano, M.C.Curia, R.Muraro, P.Fedi, S.A.Aaronson, P.P.Di Fiore, M.H.Kraus. Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. Oncogene 1995; 10:1813-21; PMID:7538656; http://www.ncbi.nlm.nih.gov/pubmed/7538656
-
(1995)
Oncogene
, vol.10
, pp. 1813-1821
-
-
Alimandi, M.1
Romano, A.2
Curia, M.C.3
Muraro, R.4
Fedi, P.5
Aaronson, S.A.6
Di Fiore, P.P.7
Kraus, M.H.8
-
19
-
-
0034782994
-
Expression profiles of ErbB family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder
-
11448910
-
N.H.Chow, S.H.Chan, T.S.Tzai, C.L.Ho, H.S.Liu. Expression profiles of ErbB family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder. Clin Cancer Res 2001; 7:1957-62; PMID:11448910
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1957-1962
-
-
Chow, N.H.1
Chan, S.H.2
Tzai, T.S.3
Ho, C.L.4
Liu, H.S.5
-
20
-
-
34247499539
-
Insights from transgenic mouse models of ERBB2-induced breast cancer
-
17446858
-
J.Ursini-Siegel, B.Schade, R.D.Cardiff, W.J.Muller. Insights from transgenic mouse models of ERBB2-induced breast cancer. Nat Rev Cancer 2007; 7:389-97; PMID:17446858; http://dx.doi.org/10.1038/nrc2127
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 389-397
-
-
Ursini-Siegel, J.1
Schade, B.2
Cardiff, R.D.3
Muller, W.J.4
-
21
-
-
36249003805
-
The HER family and cancer: emerging molecular mechanisms and therapeutic targets
-
17981505
-
N.V.Sergina, M.M.Moasser. The HER family and cancer: emerging molecular mechanisms and therapeutic targets. Trends in molecular medicine 2007; 13:527-34; PMID:17981505; http://dx.doi.org/10.1016/j.molmed.2007.10.002
-
(2007)
Trends in molecular medicine
, vol.13
, pp. 527-534
-
-
Sergina, N.V.1
Moasser, M.M.2
-
22
-
-
73649111355
-
Personalizing HER2-targeted therapy in metastatic breast cancer beyond HER2 status: what we have learned from clinical specimens
-
20300449
-
R.Nahta, S.Shabaya, T.Ozbay, D.L.Rowe. Personalizing HER2-targeted therapy in metastatic breast cancer beyond HER2 status: what we have learned from clinical specimens. Curr Pharmacogenomics Person Med 2009; 7:263-74; PMID:20300449; http://dx.doi.org/10.2174/187569209790112337
-
(2009)
Curr Pharmacogenomics Person Med
, vol.7
, pp. 263-274
-
-
Nahta, R.1
Shabaya, S.2
Ozbay, T.3
Rowe, D.L.4
-
23
-
-
84871229995
-
Trastuzumab: updated mechanisms of action and resistance in breast cancer
-
22720269
-
T.Vu, F.X.Claret. Trastuzumab: updated mechanisms of action and resistance in breast cancer. Front Oncol 2012; 2:62; PMID:22720269; http://dx.doi.org/10.3389/fonc.2012.00062
-
(2012)
Front Oncol
, vol.2
, pp. 62
-
-
Vu, T.1
Claret, F.X.2
-
24
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
17463250
-
J.A.Engelman, K.Zejnullahu, T.Mitsudomi, Y.Song, C.Hyland, J.O.Park, N.Lindeman, C.M.Gale, X.Zhao, J.Christensen, MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007; 316:1039-43; PMID:17463250; http://dx.doi.org/10.1126/science.1141478
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Park, J.O.6
Lindeman, N.7
Gale, C.M.8
Zhao, X.9
Christensen, J.10
-
25
-
-
77955536171
-
HER3 mRNA as a predictive biomarker in anticancer therapy
-
20695834
-
L.C.Amler. HER3 mRNA as a predictive biomarker in anticancer therapy. Expert Opin Biol Ther 2010; 10:1343-55; PMID:20695834; http://dx.doi.org/10.1517/14712598.2010.512003
-
(2010)
Expert Opin Biol Ther
, vol.10
, pp. 1343-1355
-
-
Amler, L.C.1
-
26
-
-
34047274789
-
Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer
-
17203234
-
C.Osipo, K.Meeke, D.Cheng, A.Weichel, A.Bertucci, H.Liu, V.C.Jordan. Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer. Int J Oncol 2007; 30:509-20; PMID:17203234; http://dx.doi.org/10.3892/ijo.30.2.509
-
(2007)
Int J Oncol
, vol.30
, pp. 509-520
-
-
Osipo, C.1
Meeke, K.2
Cheng, D.3
Weichel, A.4
Bertucci, A.5
Liu, H.6
Jordan, V.C.7
-
27
-
-
59449093537
-
Activation of ErbB3, EGFR and Erk is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrant
-
18409071
-
T.Frogne, R.V.Benjaminsen, K.Sonne-Hansen, B.S.Sorensen, E.Nexo, A.V.Laenkholm, L.M.Rasmussen, D.J.Riese, 2nd, P.de Cremoux, J.Stenvang, Activation of ErbB3, EGFR and Erk is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrant. Breast Cancer Res Treat 2009; 114:263-75; PMID:18409071; http://dx.doi.org/10.1007/s10549-008-0011-8
-
(2009)
Breast Cancer Res Treat
, vol.114
, pp. 263-275
-
-
Frogne, T.1
Benjaminsen, R.V.2
Sonne-Hansen, K.3
Sorensen, B.S.4
Nexo, E.5
Laenkholm, A.V.6
Rasmussen, L.M.7
Riese, D.J.8
de Cremoux, P.9
Stenvang, J.10
-
28
-
-
66249119060
-
Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer
-
19435893
-
T.W.Miller, M.Perez-Torres, A.Narasanna, M.Guix, O.Stal, G.Perez-Tenorio, A.M.Gonzalez-Angulo, B.T.Hennessy, G.B.Mills, J.P.Kennedy, Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer. Cancer Res 2009; 69:4192-201; PMID:19435893; http://dx.doi.org/10.1158/0008-5472.CAN-09-0042
-
(2009)
Cancer Res
, vol.69
, pp. 4192-4201
-
-
Miller, T.W.1
Perez-Torres, M.2
Narasanna, A.3
Guix, M.4
Stal, O.5
Perez-Tenorio, G.6
Gonzalez-Angulo, A.M.7
Hennessy, B.T.8
Mills, G.B.9
Kennedy, J.P.10
-
29
-
-
44149128380
-
The role of ErbB3 and its binding partners in breast cancer progression and resistance to hormone and tyrosine kinase directed therapies
-
18425425
-
A.W.Hamburger. The role of ErbB3 and its binding partners in breast cancer progression and resistance to hormone and tyrosine kinase directed therapies. J Mammary Gland Biol Neoplasia 2008; 13:225-33; PMID:18425425; http://dx.doi.org/10.1007/s10911-008-9077-5
-
(2008)
J Mammary Gland Biol Neoplasia
, vol.13
, pp. 225-233
-
-
Hamburger, A.W.1
-
30
-
-
69849115198
-
Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis
-
19567914
-
B.Schoeberl, E.A.Pace, J.B.Fitzgerald, B.D.Harms, L.Xu, L.Nie, B.Linggi, A.Kalra, V.Paragas, R.Bukhalid, Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis. Sci Signal 2009; 2:ra31; PMID:19567914; http://dx.doi.org/10.1126/scisignal.2000352
-
(2009)
Sci Signal
, vol.2
, pp. 31
-
-
Schoeberl, B.1
Pace, E.A.2
Fitzgerald, J.B.3
Harms, B.D.4
Xu, L.5
Nie, L.6
Linggi, B.7
Kalra, A.8
Paragas, V.9
Bukhalid, R.10
-
31
-
-
84886313181
-
Human epidermal growth factor receptor 3 (HER3) blockade with U3-1287/AMG888 enhances the efficacy of radiation therapy in lung and head and neck carcinoma
-
23998444
-
C.Li, T.M.Brand, M.Iida, S.Huang, E.A.Armstrong, A.van der Kogel, D.L.Wheeler. Human epidermal growth factor receptor 3 (HER3) blockade with U3-1287/AMG888 enhances the efficacy of radiation therapy in lung and head and neck carcinoma. Discov Med 2013; 16:79-92; PMID:23998444; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901945/pdf/nihms544643.pdf
-
(2013)
Discov Med
, vol.16
, pp. 79-92
-
-
Li, C.1
Brand, T.M.2
Iida, M.3
Huang, S.4
Armstrong, E.A.5
van der Kogel, A.6
Wheeler, D.L.7
-
32
-
-
84878958728
-
Phase I study of U3-1287, a fully human anti-HER3 monoclonal antibody, in patients with advanced solid tumors
-
23591447
-
P.LoRusso, P.A.Janne, M.Oliveira, N.Rizvi, L.Malburg, V.Keedy, L.Yee, C.Copigneaux, T.Hettmann, C.Y.Wu, Phase I study of U3-1287, a fully human anti-HER3 monoclonal antibody, in patients with advanced solid tumors. Clin Cancer Res 2013; 19:3078-87; PMID:23591447; http://dx.doi.org/10.1158/1078-0432.CCR-12-3051
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3078-3087
-
-
LoRusso, P.1
Janne, P.A.2
Oliveira, M.3
Rizvi, N.4
Malburg, L.5
Keedy, V.6
Yee, L.7
Copigneaux, C.8
Hettmann, T.9
Wu, C.Y.10
-
33
-
-
77950216941
-
An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activation
-
20215504
-
B.Schoeberl, A.C.Faber, D.Li, M.C.Liang, K.Crosby, M.Onsum, O.Burenkova, E.Pace, Z.Walton, L.Nie, An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activation. Cancer Res 2010; 70:2485-94; PMID:20215504; http://dx.doi.org/10.1158/0008-5472.CAN-09-3145
-
(2010)
Cancer Res
, vol.70
, pp. 2485-2494
-
-
Schoeberl, B.1
Faber, A.C.2
Li, D.3
Liang, M.C.4
Crosby, K.5
Onsum, M.6
Burenkova, O.7
Pace, E.8
Walton, Z.9
Nie, L.10
-
34
-
-
11844254414
-
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
-
15637262
-
R.K.Jain. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307:58-62; PMID:15637262; http://dx.doi.org/10.1126/science.1104819
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
35
-
-
28244432561
-
Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
-
16322262
-
R.Nahta, L.X.Yuan, B.Zhang, R.Kobayashi, F.J.Esteva. Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res 2005; 65:11118-28; PMID:16322262; http://dx.doi.org/10.1158/0008-5472.CAN-04-3841
-
(2005)
Cancer Res
, vol.65
, pp. 11118-11128
-
-
Nahta, R.1
Yuan, L.X.2
Zhang, B.3
Kobayashi, R.4
Esteva, F.J.5
-
36
-
-
76249112330
-
Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin
-
20103628
-
X.Huang, L.Gao, S.Wang, J.L.McManaman, A.D.Thor, X.Yang, F.J.Esteva, B.Liu. Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin. Cancer Res 2010; 70:1204-14; PMID:20103628; http://dx.doi.org/10.1158/0008-5472.CAN-09-3321
-
(2010)
Cancer Res
, vol.70
, pp. 1204-1214
-
-
Huang, X.1
Gao, L.2
Wang, S.3
McManaman, J.L.4
Thor, A.D.5
Yang, X.6
Esteva, F.J.7
Liu, B.8
-
37
-
-
77950672269
-
Targeting multiple kinase pathways: a change in paradigm
-
20215532
-
L.Gossage, T.Eisen. Targeting multiple kinase pathways: a change in paradigm. Clin Cancer Res 2010; 16:1973-8; PMID:20215532; http://dx.doi.org/10.1158/1078-0432.CCR-09-3182
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1973-1978
-
-
Gossage, L.1
Eisen, T.2
-
38
-
-
79953207364
-
Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase
-
21385943
-
J.T.Garrett, M.G.Olivares, C.Rinehart, N.D.Granja-Ingram, V.Sanchez, A.Chakrabarty, B.Dave, R.S.Cook, W.Pao, E.McKinely, Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase. Proc Natl Acad Sci U S A 2011; 108:5021-6; PMID:21385943; http://dx.doi.org/10.1073/pnas.1016140108
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 5021-5026
-
-
Garrett, J.T.1
Olivares, M.G.2
Rinehart, C.3
Granja-Ingram, N.D.4
Sanchez, V.5
Chakrabarty, A.6
Dave, B.7
Cook, R.S.8
Pao, W.9
McKinely, E.10
-
39
-
-
84859802154
-
Preclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical dose
-
22203367
-
A.V.Kamath, D.Lu, P.Gupta, D.Jin, H.Xiang, A.Wong, C.Leddy, L.Crocker, G.Schaefer, M.X.Sliwkowski, Preclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical dose. Cancer Chemother Pharmacol 2011; 69(4):1063-9; PMID:22203367; http://dx.doi.org/10.1007/s00280-011-1806-6
-
(2011)
Cancer Chemother Pharmacol
, vol.69
, Issue.4
, pp. 1063-1069
-
-
Kamath, A.V.1
Lu, D.2
Gupta, P.3
Jin, D.4
Xiang, H.5
Wong, A.6
Leddy, C.7
Crocker, L.8
Schaefer, G.9
Sliwkowski, M.X.10
-
40
-
-
80054765331
-
A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies
-
22014573
-
G.Schaefer, L.Haber, L.M.Crocker, S.Shia, L.Shao, D.Dowbenko, K.Totpal, A.Wong, C.V.Lee, S.Stawicki, A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies. Cancer Cell 2011; 20:472-86; PMID:22014573; http://dx.doi.org/10.1016/j.ccr.2011.09.003
-
(2011)
Cancer Cell
, vol.20
, pp. 472-486
-
-
Schaefer, G.1
Haber, L.2
Crocker, L.M.3
Shia, S.4
Shao, L.5
Dowbenko, D.6
Totpal, K.7
Wong, A.8
Lee, C.V.9
Stawicki, S.10
-
41
-
-
84859409756
-
Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3
-
22248472
-
C.F.McDonagh, A.Huhalov, B.D.Harms, S.Adams, V.Paragas, S.Oyama, B.Zhang, L.Luus, R.Overland, S.Nguyen, Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3. Mol Cancer Ther 2012; 11:582-93; PMID:22248472; http://dx.doi.org/10.1158/1535-7163.MCT-11-0820
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 582-593
-
-
McDonagh, C.F.1
Huhalov, A.2
Harms, B.D.3
Adams, S.4
Paragas, V.5
Oyama, S.6
Zhang, B.7
Luus, L.8
Overland, R.9
Nguyen, S.10
-
42
-
-
84885024224
-
An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin
-
23928993
-
A.P.Garner, C.U.Bialucha, E.R.Sprague, J.T.Garrett, Q.Sheng, S.Li, O.Sineshchekova, P.Saxena, C.R.Sutton, D.Chen, An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Cancer Res 2013; 73:6024-35; PMID:23928993; http://dx.doi.org/10.1158/0008-5472.CAN-13-1198
-
(2013)
Cancer Res
, vol.73
, pp. 6024-6035
-
-
Garner, A.P.1
Bialucha, C.U.2
Sprague, E.R.3
Garrett, J.T.4
Sheng, Q.5
Li, S.6
Sineshchekova, O.7
Saxena, P.8
Sutton, C.R.9
Chen, D.10
-
43
-
-
84882679616
-
RG7116, a therapeutic antibody that binds the inactive HER3 receptor and is optimized for immune effector activation
-
23780344
-
C.Mirschberger, C.B.Schiller, M.Schraml, N.Dimoudis, T.Friess, C.A.Gerdes, U.Reiff, V.Lifke, G.Hoelzlwimmer, I.Kolm, RG7116, a therapeutic antibody that binds the inactive HER3 receptor and is optimized for immune effector activation. Cancer Res 2013; 73:5183-94; PMID:23780344; http://dx.doi.org/10.1158/0008-5472.CAN-13-0099
-
(2013)
Cancer Res
, vol.73
, pp. 5183-5194
-
-
Mirschberger, C.1
Schiller, C.B.2
Schraml, M.3
Dimoudis, N.4
Friess, T.5
Gerdes, C.A.6
Reiff, U.7
Lifke, V.8
Hoelzlwimmer, G.9
Kolm, I.10
-
45
-
-
0027605718
-
Peptide vaccines incorporating a 'promiscuous' T-cell epitope bypass certain haplotype restricted immune responses and provide broad spectrum immunogenicity
-
7508238
-
P.T.Kaumaya, S.Kobs-Conrad, Y.H.Seo, H.Lee, A.M.VanBuskirk, N.Feng, J.F.Sheridan, V.Stevens. Peptide vaccines incorporating a 'promiscuous' T-cell epitope bypass certain haplotype restricted immune responses and provide broad spectrum immunogenicity. J Mol Recognit 1993; 6:81-94; PMID:7508238; http://dx.doi.org/10.1002/jmr.300060206
-
(1993)
J Mol Recognit
, vol.6
, pp. 81-94
-
-
Kaumaya, P.T.1
Kobs-Conrad, S.2
Seo, Y.H.3
Lee, H.4
VanBuskirk, A.M.5
Feng, N.6
Sheridan, J.F.7
Stevens, V.8
-
46
-
-
57149142362
-
Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer
-
Q.Jin, F.J.Esteva. Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer. J Mammary Gland Biol 2008; 13:485-98; http://dx.doi.org/10.1007/s10911-008-9107-3
-
(2008)
J Mammary Gland Biol
, vol.13
, pp. 485-498
-
-
Jin, Q.1
Esteva, F.J.2
-
47
-
-
84867281628
-
HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-driven tumour cells
-
22853430
-
D.N.Amin, N.Sergina, L.Lim, A.Goga, M.M.Moasser. HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-driven tumour cells. Biochem J 2012; 447:417-25; PMID:22853430; http://dx.doi.org/10.1042/BJ20120724
-
(2012)
Biochem J
, vol.447
, pp. 417-425
-
-
Amin, D.N.1
Sergina, N.2
Lim, L.3
Goga, A.4
Moasser, M.M.5
-
48
-
-
70749084657
-
HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells
-
19878579
-
Y.Zhang, L.Opresko, H.Shankaran, W.B.Chrisler, H.S.Wiley, H.Resat. HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells. BMC Cell Biol 2009; 10:78; PMID:19878579; http://dx.doi.org/10.1186/1471-2121-10-78
-
(2009)
BMC Cell Biol
, vol.10
, pp. 78
-
-
Zhang, Y.1
Opresko, L.2
Shankaran, H.3
Chrisler, W.B.4
Wiley, H.S.5
Resat, H.6
-
49
-
-
23844510061
-
Anti-erbB-2 antibody trastuzumab in the treatment of HER2-amplified breast cancer
-
16133791
-
C.H.Yeon, M.D.Pegram. Anti-erbB-2 antibody trastuzumab in the treatment of HER2-amplified breast cancer. Invest New Drugs 2005; 23:391-409; PMID:16133791; http://dx.doi.org/10.1007/s10637-005-2899-8
-
(2005)
Invest New Drugs
, vol.23
, pp. 391-409
-
-
Yeon, C.H.1
Pegram, M.D.2
-
50
-
-
46249087766
-
Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members
-
18297114
-
D.L.Wheeler, S.Huang, T.J.Kruser, M.M.Nechrebecki, E.A.Armstrong, S.Benavente, V.Gondi, K.T.Hsu, P.M.Harari. Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members. Oncogene 2008; 27:3944-56; PMID:18297114; http://dx.doi.org/10.1038/onc.2008.19
-
(2008)
Oncogene
, vol.27
, pp. 3944-3956
-
-
Wheeler, D.L.1
Huang, S.2
Kruser, T.J.3
Nechrebecki, M.M.4
Armstrong, E.A.5
Benavente, S.6
Gondi, V.7
Hsu, K.T.8
Harari, P.M.9
-
51
-
-
80054747872
-
Resistance to EGFR-targeted therapy: a family affair
-
22014569
-
G.Vlacich, R.J.Coffey. Resistance to EGFR-targeted therapy: a family affair. Cancer Cell 2011; 20:423-5; PMID:22014569; http://dx.doi.org/10.1016/j.ccr.2011.10.006
-
(2011)
Cancer Cell
, vol.20
, pp. 423-425
-
-
Vlacich, G.1
Coffey, R.J.2
-
52
-
-
33846552656
-
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
-
17206155
-
N.V.Sergina, M.Rausch, D.Wang, J.Blair, B.Hann, K.M.Shokat, M.M.Moasser. Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 2007; 445:437-41; PMID:17206155; http://dx.doi.org/10.1038/nature05474
-
(2007)
Nature
, vol.445
, pp. 437-441
-
-
Sergina, N.V.1
Rausch, M.2
Wang, D.3
Blair, J.4
Hann, B.5
Shokat, K.M.6
Moasser, M.M.7
-
53
-
-
84883316085
-
Advances in targeting HER3 as an anticancer therapy
-
23198146
-
N.Jiang, N.F.Saba, Z.G.Chen. Advances in targeting HER3 as an anticancer therapy. Chemother Res Pract 2012; 2012:817304; PMID:23198146; http://dx.doi.org/10.1155/2012/817304
-
(2012)
Chemother Res Pract
, vol.2012
, pp. 817304
-
-
Jiang, N.1
Saba, N.F.2
Chen, Z.G.3
-
54
-
-
33751344602
-
HER2 therapy: molecular mechanisms of trastuzumab resistance
-
17096862
-
R.Nahta, F.J.Esteva. HER2 therapy: molecular mechanisms of trastuzumab resistance. Breast Cancer Res 2006; 8:215; PMID:17096862; http://dx.doi.org/10.1186/bcr1612
-
(2006)
Breast Cancer Res
, vol.8
, pp. 215
-
-
Nahta, R.1
Esteva, F.J.2
-
55
-
-
33646712747
-
Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer
-
16683005
-
R.Nahta, D.Yu, M.C.Hung, G.N.Hortobagyi, F.J.Esteva. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 2006; 3:269-80; PMID:16683005; http://dx.doi.org/10.1038/ncponc0509
-
(2006)
Nat Clin Pract Oncol
, vol.3
, pp. 269-280
-
-
Nahta, R.1
Yu, D.2
Hung, M.C.3
Hortobagyi, G.N.4
Esteva, F.J.5
-
56
-
-
71249091175
-
Current trends in the clinical development of peptide therapeutics
-
19943221
-
P.M.Saladin, B.D.Zhang, J.M.Reichert. Current trends in the clinical development of peptide therapeutics. IDrugs 2009; 12:779-84; PMID:19943221; http://www.ncbi.nlm.nih.gov/pubmed/19943221
-
(2009)
IDrugs
, vol.12
, pp. 779-784
-
-
Saladin, P.M.1
Zhang, B.D.2
Reichert, J.M.3
-
57
-
-
84938610530
-
Development trends for peptide therapeutics
-
Tufts University, Peptide Therapeutics Foundation, San Diego CA 92121
-
J.Reichert. Development trends for peptide therapeutics. Tufts Center for the Study of Drug Development Tufts University, 2008. Peptide Therapeutics Foundation, San Diego CA 92121; http://www.peptidetherapeutics.org/PTF_report_summary_2010.pdf
-
(2008)
Tufts Center for the Study of Drug Development
-
-
Reichert, J.1
-
58
-
-
79953859123
-
Combination treatment with HER-2 and VEGF peptide mimics induces potent anti-tumor and anti-angiogenic responses in vitro and in vivo
-
21325276
-
K.C.Foy, Z.Liu, G.Phillips, M.Miller, P.T.Kaumaya. Combination treatment with HER-2 and VEGF peptide mimics induces potent anti-tumor and anti-angiogenic responses in vitro and in vivo. J Biol Chem 2011; 286:13626-37; PMID:21325276; http://dx.doi.org/10.1074/jbc.M110.216820
-
(2011)
J Biol Chem
, vol.286
, pp. 13626-13637
-
-
Foy, K.C.1
Liu, Z.2
Phillips, G.3
Miller, M.4
Kaumaya, P.T.5
-
59
-
-
84886313817
-
Combined vaccination with HER-2 peptide followed by therapy with VEGF peptide mimics exerts effective anti-tumor and anti-angiogenic effects in vitro and in vivo
-
23170253
-
K.C.Foy, M.J.Miller, N.Moldovan, W.E.Carson Iii, P.T.Kaumaya. Combined vaccination with HER-2 peptide followed by therapy with VEGF peptide mimics exerts effective anti-tumor and anti-angiogenic effects in vitro and in vivo. Oncoimmunology 2012; 1:1048-60; PMID:23170253; http://dx.doi.org/10.4161/onci.20708
-
(2012)
Oncoimmunology
, vol.1
, pp. 1048-1060
-
-
Foy, K.C.1
Miller, M.J.2
Moldovan, N.3
Carson Iii, W.E.4
Kaumaya, P.T.5
-
60
-
-
84893276441
-
Basics and recent advances in peptide and protein drug delivery
-
24228993
-
B.J.Bruno, G.D.Miller, C.S.Lim. Basics and recent advances in peptide and protein drug delivery. Ther Deliv 2013; 4:1443-67; PMID:24228993; http://dx.doi.org/10.4155/tde.13.104
-
(2013)
Ther Deliv
, vol.4
, pp. 1443-1467
-
-
Bruno, B.J.1
Miller, G.D.2
Lim, C.S.3
-
61
-
-
84886315269
-
Cancer immunotherapy: present status, future perspective, and a new paradigm of peptide immunotherapeutics
-
23545045
-
M.J.Miller, K.C.Foy, P.T.Kaumaya. Cancer immunotherapy: present status, future perspective, and a new paradigm of peptide immunotherapeutics. Discov Med 2013; 15:166-76; PMID:23545045; http://www.discoverymedicine.com/Megan-Jo-Miller/2013/03/28/cancer-immunotherapy-present-status-future-perspective-and-a-new-paradigm-of-peptide-immunotherapeutics/
-
(2013)
Discov Med
, vol.15
, pp. 166-176
-
-
Miller, M.J.1
Foy, K.C.2
Kaumaya, P.T.3
-
62
-
-
0037103157
-
Suppression of experimental autoimmune encephalomyelitis using peptide mimics of CD28
-
12165548
-
M.Srinivasan, I.E.Gienapp, S.S.Stuckman, C.J.Rogers, S.D.Jewell, P.T.Kaumaya, C.C.Whitacre. Suppression of experimental autoimmune encephalomyelitis using peptide mimics of CD28. J Immunol 2002; 169:2180-8; PMID:12165548; http://dx.doi.org/10.4049/jimmunol.169.4.2180
-
(2002)
J Immunol
, vol.169
, pp. 2180-2188
-
-
Srinivasan, M.1
Gienapp, I.E.2
Stuckman, S.S.3
Rogers, C.J.4
Jewell, S.D.5
Kaumaya, P.T.6
Whitacre, C.C.7
-
63
-
-
0035400145
-
A retro-inverso peptide mimic of CD28 encompassing the MYPPPY motif adopts a polyproline type II helix and inhibits encephalitogenic T cells in vitro
-
11418697
-
M.Srinivasan, R.M.Wardrop, I.E.Gienapp, S.S.Stuckman, C.C.Whitacre, P.T.Kaumaya. A retro-inverso peptide mimic of CD28 encompassing the MYPPPY motif adopts a polyproline type II helix and inhibits encephalitogenic T cells in vitro. J Immunol 2001; 167:578-85; PMID:11418697; http://dx.doi.org/10.4049/jimmunol.167.1.578
-
(2001)
J Immunol
, vol.167
, pp. 578-585
-
-
Srinivasan, M.1
Wardrop, R.M.2
Gienapp, I.E.3
Stuckman, S.S.4
Whitacre, C.C.5
Kaumaya, P.T.6
-
64
-
-
20144384609
-
Therapeutic peptidomimetic strategies for autoimmune diseases: costimulation blockade
-
15885118
-
S.D.Allen, S.V.Rawale, C.C.Whitacre, P.T.Kaumaya. Therapeutic peptidomimetic strategies for autoimmune diseases: costimulation blockade. J Pept Res 2005; 65:591-604; PMID:15885118; http://dx.doi.org/10.1111/j.1399-3011.2005.00256.x
-
(2005)
J Pept Res
, vol.65
, pp. 591-604
-
-
Allen, S.D.1
Rawale, S.V.2
Whitacre, C.C.3
Kaumaya, P.T.4
-
65
-
-
0034660850
-
Prevention of mammary tumors with a chimeric HER-2 B-cell epitope peptide vaccine
-
10919651
-
N.K.Dakappagari, D.B.Douglas, P.L.Triozzi, V.C.Stevens, P.T.Kaumaya. Prevention of mammary tumors with a chimeric HER-2 B-cell epitope peptide vaccine. Cancer Res 2000; 60:3782-9; PMID:10919651; http://cancerres.aacrjournals.org/content/60/14/3782.full.pdf+html
-
(2000)
Cancer Res
, vol.60
, pp. 3782-3789
-
-
Dakappagari, N.K.1
Douglas, D.B.2
Triozzi, P.L.3
Stevens, V.C.4
Kaumaya, P.T.5
-
66
-
-
0037446525
-
A chimeric multi-human epidermal growth factor receptor-2 B cell epitope peptide vaccine mediates superior antitumor responses
-
12682258
-
N.K.Dakappagari, J.Pyles, R.Parihar, W.E.Carson, D.C.Young, P.T.Kaumaya. A chimeric multi-human epidermal growth factor receptor-2 B cell epitope peptide vaccine mediates superior antitumor responses. J Immunol 2003; 170:4242-53; PMID:12682258; http://dx.doi.org/10.4049/jimmunol.170.8.4242
-
(2003)
J Immunol
, vol.170
, pp. 4242-4253
-
-
Dakappagari, N.K.1
Pyles, J.2
Parihar, R.3
Carson, W.E.4
Young, D.C.5
Kaumaya, P.T.6
-
67
-
-
14744269680
-
Intracellular delivery of a novel multiepitope peptide vaccine by an amphipathic peptide carrier enhances cytotoxic T-cell responses in HLA-A*201 mice
-
15705163
-
N.K.Dakappagari, R.Sundaram, S.Rawale, A.Liner, D.R.Galloway, P.T.Kaumaya. Intracellular delivery of a novel multiepitope peptide vaccine by an amphipathic peptide carrier enhances cytotoxic T-cell responses in HLA-A*201 mice. J Pept Res 2005; 65:189-99; PMID:15705163; http://dx.doi.org/10.1111/j.1399-3011.2005.00212.x
-
(2005)
J Pept Res
, vol.65
, pp. 189-199
-
-
Dakappagari, N.K.1
Sundaram, R.2
Rawale, S.3
Liner, A.4
Galloway, D.R.5
Kaumaya, P.T.6
-
68
-
-
12844271532
-
Conformational HER-2/neu B-cell epitope peptide vaccine designed to incorporate two native disulfide bonds enhances tumor cell binding and antitumor activities
-
15507452
-
N.K.Dakappagari, K.D.Lute, S.Rawale, J.T.Steele, S.D.Allen, G.Phillips, R.T.Reilly, P.T.Kaumaya. Conformational HER-2/neu B-cell epitope peptide vaccine designed to incorporate two native disulfide bonds enhances tumor cell binding and antitumor activities. J Biol Chem 2005; 280:54-63; PMID:15507452; http://dx.doi.org/10.1074/jbc.M411020200
-
(2005)
J Biol Chem
, vol.280
, pp. 54-63
-
-
Dakappagari, N.K.1
Lute, K.D.2
Rawale, S.3
Steele, J.T.4
Allen, S.D.5
Phillips, G.6
Reilly, R.T.7
Kaumaya, P.T.8
-
69
-
-
70449727895
-
Phase I active immunotherapy with combination of two chimeric, human epidermal growth factor receptor 2, B-cell epitopes fused to a promiscuous T-cell epitope in patients with metastatic and/or recurrent solid tumors
-
19752336
-
P.T.Kaumaya, K.C.Foy, J.Garrett, S.V.Rawale, D.Vicari, J.M.Thurmond, T.Lamb, A.Mani, Y.Kane, C.R.Balint, Phase I active immunotherapy with combination of two chimeric, human epidermal growth factor receptor 2, B-cell epitopes fused to a promiscuous T-cell epitope in patients with metastatic and/or recurrent solid tumors. J Clin Oncol 2009; 27:5270-7; PMID:19752336; http://dx.doi.org/10.1200/JCO.2009.22.3883
-
(2009)
J Clin Oncol
, vol.27
, pp. 5270-5277
-
-
Kaumaya, P.T.1
Foy, K.C.2
Garrett, J.3
Rawale, S.V.4
Vicari, D.5
Thurmond, J.M.6
Lamb, T.7
Mani, A.8
Kane, Y.9
Balint, C.R.10
-
70
-
-
0346154748
-
Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells
-
14648698
-
Y.Lu, X.Zi, M.Pollak. Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells. Int J Cancer 2004; 108:334-41; PMID:14648698; http://dx.doi.org/10.1002/ijc.11445
-
(2004)
Int J Cancer
, vol.108
, pp. 334-341
-
-
Lu, Y.1
Zi, X.2
Pollak, M.3
-
71
-
-
54049086648
-
HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924
-
18765823
-
P.Haluska, J.M.Carboni, C.TenEyck, R.M.Attar, X.Hou, C.Yu, M.Sagar, T.W.Wong, M.M.Gottardis, C.Erlichman. HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924. Mol Cancer Ther 2008; 7:2589-98; PMID:18765823; http://dx.doi.org/10.1158/1535-7163.MCT-08-0493
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2589-2598
-
-
Haluska, P.1
Carboni, J.M.2
TenEyck, C.3
Attar, R.M.4
Hou, X.5
Yu, C.6
Sagar, M.7
Wong, T.W.8
Gottardis, M.M.9
Erlichman, C.10
-
72
-
-
55249104916
-
Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro
-
18841159
-
M.K.Robinson, K.M.Hodge, E.Horak, A.L.Sundberg, M.Russeva, C.C.Shaller, M.von Mehren, I.Shchaveleva, H.H.Simmons, J.D.Marks, Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro. Br J Cancer 2008; 99:1415-25; PMID:18841159; http://dx.doi.org/10.1038/sj.bjc.6604700
-
(2008)
Br J Cancer
, vol.99
, pp. 1415-1425
-
-
Robinson, M.K.1
Hodge, K.M.2
Horak, E.3
Sundberg, A.L.4
Russeva, M.5
Shaller, C.C.6
von Mehren, M.7
Shchaveleva, I.8
Simmons, H.H.9
Marks, J.D.10
-
73
-
-
84858013723
-
In pancreatic carcinoma, dual EGFR/HER2 targeting with cetuximab/trastuzumab is more effective than treatment with trastuzumab/erlotinib or lapatinib alone: implication of receptors' downregulation and dimers' disruption
-
22431920
-
C.Larbouret, N.Gaborit, T.Chardes, M.Coelho, E.Campigna, C.Bascoul-Mollevi, J.P.Mach, D.Azria, B.Robert, A.Pelegrin. In pancreatic carcinoma, dual EGFR/HER2 targeting with cetuximab/trastuzumab is more effective than treatment with trastuzumab/erlotinib or lapatinib alone: implication of receptors' downregulation and dimers' disruption. Neoplasia 2012; 14:121-30; PMID:22431920
-
(2012)
Neoplasia
, vol.14
, pp. 121-130
-
-
Larbouret, C.1
Gaborit, N.2
Chardes, T.3
Coelho, M.4
Campigna, E.5
Bascoul-Mollevi, C.6
Mach, J.P.7
Azria, D.8
Robert, B.9
Pelegrin, A.10
-
74
-
-
84872525097
-
Dual targeting of EGFR and HER3 with MEHD7945A overcomes acquired resistance to EGFR inhibitors and radiation
-
23172311
-
S.Huang, C.Li, E.A.Armstrong, C.R.Peet, J.Saker, L.C.Amler, M.X.Sliwkowski, P.M.Harari. Dual targeting of EGFR and HER3 with MEHD7945A overcomes acquired resistance to EGFR inhibitors and radiation. Cancer Res 2013; 73:824-33; PMID:23172311; http://dx.doi.org/10.1158/0008-5472.CAN-12-1611
-
(2013)
Cancer Res
, vol.73
, pp. 824-833
-
-
Huang, S.1
Li, C.2
Armstrong, E.A.3
Peet, C.R.4
Saker, J.5
Amler, L.C.6
Sliwkowski, M.X.7
Harari, P.M.8
-
75
-
-
84873045081
-
Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells
-
23367880
-
N.Ioannou, A.M.Seddon, A.Dalgleish, D.Mackintosh, H.Modjtahedi. Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells. BMC Cancer 2013; 13:41; PMID:23367880; http://dx.doi.org/10.1186/1471-2407-13-41
-
(2013)
BMC Cancer
, vol.13
, pp. 41
-
-
Ioannou, N.1
Seddon, A.M.2
Dalgleish, A.3
Mackintosh, D.4
Modjtahedi, H.5
-
76
-
-
79955675632
-
A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity
-
21393993
-
J.Dong, A.Sereno, D.Aivazian, E.Langley, B.R.Miller, W.B.Snyder, E.Chan, M.Cantele, R.Morena, I.B.Joseph, A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity. MAbs 2011; 3:273-88; PMID:21393993; http://dx.doi.org/10.4161/mabs.3.3.15188
-
(2011)
MAbs
, vol.3
, pp. 273-288
-
-
Dong, J.1
Sereno, A.2
Aivazian, D.3
Langley, E.4
Miller, B.R.5
Snyder, W.B.6
Chan, E.7
Cantele, M.8
Morena, R.9
Joseph, I.B.10
-
77
-
-
79953016709
-
Stable IgG-like bispecific antibodies directed toward the type I insulin-like growth factor receptor demonstrate enhanced ligand blockade and anti-tumor activity
-
21123183
-
J.Dong, A.Sereno, W.B.Snyder, B.R.Miller, S.Tamraz, A.Doern, M.Favis, X.Wu, H.Tran, E.Langley, Stable IgG-like bispecific antibodies directed toward the type I insulin-like growth factor receptor demonstrate enhanced ligand blockade and anti-tumor activity. J Biol Chem 2011; 286:4703-17; PMID:21123183; http://dx.doi.org/10.1074/jbc.M110.184317
-
(2011)
J Biol Chem
, vol.286
, pp. 4703-4717
-
-
Dong, J.1
Sereno, A.2
Snyder, W.B.3
Miller, B.R.4
Tamraz, S.5
Doern, A.6
Favis, M.7
Wu, X.8
Tran, H.9
Langley, E.10
-
78
-
-
84894145210
-
MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors
-
24282274
-
J.B.Fitzgerald, B.W.Johnson, J.Baum, S.Adams, S.Iadevaia, J.Tang, V.Rimkunas, L.Xu, N.Kohli, R.Rennard, MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors. Mol Cancer Ther 2014; 13:410-25; PMID:24282274; http://dx.doi.org/10.1158/1535-7163.MCT-13-0255
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 410-425
-
-
Fitzgerald, J.B.1
Johnson, B.W.2
Baum, J.3
Adams, S.4
Iadevaia, S.5
Tang, J.6
Rimkunas, V.7
Xu, L.8
Kohli, N.9
Rennard, R.10
-
79
-
-
84892598423
-
Superior antitumor activity of a novel bispecific antibody cotargeting human epidermal growth factor receptor 2 and type I insulin-like growth factor receptor
-
24227890
-
C.Chen, Y.Zhang, J.Li, S.W.Tsao, M.Y.Zhang. Superior antitumor activity of a novel bispecific antibody cotargeting human epidermal growth factor receptor 2 and type I insulin-like growth factor receptor. Mol Cancer Ther 2014; 13:90-100; PMID:24227890; http://dx.doi.org/10.1158/1535-7163.MCT-13-0558
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 90-100
-
-
Chen, C.1
Zhang, Y.2
Li, J.3
Tsao, S.W.4
Zhang, M.Y.5
-
80
-
-
34249820537
-
Novel engineered trastuzumab conformational epitopes demonstrate in vitro and in vivo antitumor properties against HER-2/neu
-
17513761
-
J.T.Garrett, S.Rawale, S.D.Allen, G.Phillips, G.Forni, J.C.Morris, P.T.Kaumaya. Novel engineered trastuzumab conformational epitopes demonstrate in vitro and in vivo antitumor properties against HER-2/neu. J Immunol 2007; 178:7120-31; PMID:17513761; http://dx.doi.org/10.4049/jimmunol.178.11.7120
-
(2007)
J Immunol
, vol.178
, pp. 7120-7131
-
-
Garrett, J.T.1
Rawale, S.2
Allen, S.D.3
Phillips, G.4
Forni, G.5
Morris, J.C.6
Kaumaya, P.T.7
-
81
-
-
84879614294
-
-
23698748
-
K.C.Foy, R.M.Wygle, M.J.Miller, J.P.Overholser, T.Bekaii-Saab, P.T.Kaumaya. Peptide vaccines and peptidomimetics of EGFR (HER-1) ligand binding domain inhibit cancer cell growth in vitro and in vivo. J Immunol; 191:217-27; PMID:23698748; http://dx.doi.org/10.4049/jimmunol.1300231
-
Peptide vaccines and peptidomimetics of EGFR (HER-1) ligand binding domain inhibit cancer cell growth in vitro and in vivo
, vol.191
, pp. 217-227
-
-
Foy, K.C.1
Wygle, R.M.2
Miller, M.J.3
Overholser, J.P.4
Bekaii-Saab, T.5
Kaumaya, P.T.6
|