Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways

Gastroenterology

Volumn 144, Issue 3, 2013, Pages

  Imbernon, Monica ^a,b   Beiroa, Daniel ^a,b   Vázquez, María J ^a,b   Morgan, Donald A ^c   Veyrat Durebex, Christelle ^d   Porteiro, Begoña ^a,b   Díaz Arteaga, Adenis ^a,b   Senra, Ana ^a,b   Busquets, Silvia ^e   Velásquez, Douglas A ^a,b   Al Massadi, Omar ^b,f   Varela, Luis ^a,b   Gándara, Marina ^a   López Soriano, Francisco Javier ^e   Gallego, Rosalía ^a   Seoane, Luisa M ^b,f   Argiles, Josep M ^e   López, Miguel ^a,b   Davis, Roger J ^g   Sabio, Guadalupe ^h   Rohner Jeanrenaud, Françoise ^d   Rahmouni, Kamal ^c   Dieguez, Carlos ^a,b   Nogueiras, Ruben ^a,b   more..

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c UNIVERSITY OF IOWA   (United States)

^d UNIVERSITY OF GENEVA   (Switzerland)

^e UNIVERSITY OF BARCELONA   (Spain)

^f HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^g UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^h CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

Author keywords

Lipid Metabolism; Liver; MCH; White Adipose Tissue

Indexed keywords

ADENOVIRUS VECTOR; FATTY ACID; JANUS KINASE 1; MELANIN CONCENTRATING HORMONE; MELANIN CONCENTRATING HORMONE RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CELL METABOLISM; CONTROLLED STUDY; ENERGY EXPENDITURE; ENZYME ACTIVITY; FAT MASS; FOOD INTAKE; HYPOTHALAMUS NUCLEUS; LIPID METABOLISM; LIPID STORAGE; LIPID TRANSPORT; LIPOLYSIS; LIVER METABOLISM; LOCOMOTION; MALE; METABOLIC REGULATION; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; PARASYMPATHETIC NERVE; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY QUOTIENT; SIGNAL TRANSDUCTION; VAGOTOMY; WEIGHT GAIN; WESTERN BLOTTING; WHITE ADIPOSE TISSUE;

EID: 84874083651     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.10.051     Document Type: Article

References (56)

1. C. Broberger, L. De Lecea, J.G. Sutcliffe Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems J Comp Neurol 402 1998 460 474
2. D. Qu, D.S. Ludwig, S. Gammeltoft A role for melanin-concentrating hormone in the central regulation of feeding behaviour Nature 380 1996 243 247
3. H.J. Grill, A.B. Ginsberg, R.J. Seeley Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight J Neurosci 18 1998 10128 10135
4. M. Shimada, N.A. Tritos, B.B. Lowell Mice lacking melanin-concentrating hormone are hypophagic and lean Nature 396 1998 670 674
5. C.L. Chaffer, M.J. Morris The feeding response to melanin-concentrating hormone is attenuated by antagonism of the NPY Y(1)-receptor in the rat Endocrinology 143 2002 191 197
6. J.Y. Jeon, R.L. Bradley, E.G. Kokkotou MCH-/- mice are resistant to aging-associated increases in body weight and insulin resistance Diabetes 55 2006 428 434
7. E. Kokkotou, J.Y. Jeon, X. Wang Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms Am J Physiol Regul Integr Comp Physiol 289 2005 R117 R124
8. Y. Wang, D.C. Ziogas, S. Biddinger You deserve what you eat: lessons learned from the study of the melanin-concentrating hormone (MCH)-deficient mice Gut 59 2010 1625 1634
9. D.S. Ludwig, N.A. Tritos, J.W. Mastaitis Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance J Clin Invest 107 2001 379 386
10. G. Segal-Lieberman, R.L. Bradley, E. Kokkotou Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype Proc Natl Acad Sci U S A 100 2003 10085 10090
11. T. Alon, J.M. Friedman Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons J Neurosci 26 2006 389 397
12. T.J. Bartness, C.K. Song Thematic review series: adipocyte biology Sympathetic and sensory innervation of white adipose tissue J Lipid Res 48 2007 1655 1672
13. C. Buettner, E.D. Muse, A. Cheng Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms Nat Med 14 2008 667 675
14. L. Koch, F.T. Wunderlich, J. Seibler Central insulin action regulates peripheral glucose and fat metabolism in mice J Clin Invest 118 2008 2132 2147
15. T. Scherer, J. O'Hare, K. Diggs-Andrews Brain insulin controls adipose tissue lipolysis and lipogenesis Cell Metab 13 2011 183 194
16. C. Theander-Carrillo, P. Wiedmer, P. Cettour-Rose Ghrelin action in the brain controls adipocyte metabolism J Clin Invest 116 2006 1983 1993
17. N. Zarjevski, I. Cusin, R. Vettor Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity Endocrinology 133 1993 1753 1758
18. R. Nogueiras, P. Wiedmer, D. Perez-Tilve The central melanocortin system directly controls peripheral lipid metabolism J Clin Invest 117 2007 3475 3488
19. R. Nogueiras, D. Perez-Tilve, C. Veyrat-Durebex Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity J Neurosci 29 2009 5916 5925
20. C.A. Perez, S.A. Stanley, R.W. Wysocki Molecular annotation of integrative feeding neural circuits Cell Metab 13 2011 222 232
21. S. Stanley, S. Pinto, J. Segal Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically Proc Natl Acad Sci U S A 107 2010 7024 7029
22. P. Mohan, S. Bloom Lipolysis is an important determinant of isoproterenol-induced myocardial necrosis Cardiovasc Pathol 8 1999 255 261
23. E.A. Nordstrom, M. Ryden, E.C. Backlund A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity Diabetes 54 2005 1726 1734
24. G. Sabio, J. Cavanagh-Kyros, H.J. Ko Prevention of steatosis by hepatic JNK1 Cell Metab 10 2009 491 498
25. J. Kluwe, J.P. Pradere, G.Y. Gwak Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition Gastroenterology 138 2010 347 359
26. O. Della-Zuana, F. Presse, C. Ortola Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats Int J Obes Relat Metab Disord 26 2002 1289 1295
27. S. Mashiko, A. Ishihara, A. Gomori Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice Endocrinology 146 2005 3080 3086
28. M.E. Cleasby, N. Dzamko, B.D. Hegarty Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms Diabetes 53 2004 3258 3266
29. H. Kaneto, Y. Nakatani, T. Miyatsuka Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide Nat Med 10 2004 1128 1132
30. J. Hirosumi, G. Tuncman, L. Chang A central role for JNK in obesity and insulin resistance Nature 420 2002 333 336
31. Y. Nakatani, H. Kaneto, D. Kawamori Modulation of the JNK pathway in liver affects insulin resistance status J Biol Chem 279 2004 45803 45809
32. G. Sabio, M. Das, A. Mora A stress signaling pathway in adipose tissue regulates hepatic insulin resistance Science 322 2008 1539 1543
33. E. Pardina, J.A. Baena-Fustegueras, R. Llamas Lipoprotein lipase expression in livers of morbidly obese patients could be responsible for liver steatosis Obes Surg 19 2009 608 616
34. A. Kalsbeek, E. Bruinstroop, C.X. Yi Hypothalamic control of energy metabolism via the autonomic nervous system Ann N Y Acad Sci 1212 2010 114 129
35. T.K. Lam, G.J. Schwartz, L. Rossetti Hypothalamic sensing of fatty acids Nat Neurosci 8 2005 579 584
36. G. Sabio, N.J. Kennedy, J. Cavanagh-Kyros Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance Mol Cell Biol 30 2010 106 115
37. T.J. Bartness, Y.B. Shrestha, C.H. Vaughan Sensory and sympathetic nervous system control of white adipose tissue lipolysis Mol Cell Endocrinol 318 2010 34 43
38. Z. Zhou, S. Yon Toh, Z. Chen Cidea-deficient mice have lean phenotype and are resistant to obesity Nat Genet 35 2003 49 56
39. R.J. Davis Signal transduction by the JNK group of MAP kinases Cell 103 2000 239 252
40. G.J. Hervieu, J.E. Cluderay, D. Harrison The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene, slc-1, in the central nervous system of the rat Eur J Neurosci 12 2000 1194 1216
41. M. Bamshad, V.T. Aoki, M.G. Adkison Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue Am J Physiol 275 1998 R291 R299
42. R.A. Dampney Arcuate nucleus-a gateway for insulin's action on sympathetic activity J Physiol 589 2011 2109 2110
43. C. Jiang, R. Fogel, X. Zhang Lateral hypothalamus modulates gut-sensitive neurons in the dorsal vagal complex Brain Res 980 2003 31 47
44. J. Kluwe, J.P. Pradere, G.Y. Gwak Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition Gastroenterology 138 2010 347 359
45. M.E. Cleasby, N. Dzamko, B.D. Hegarty Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms Diabetes 53 2004 3258 3266
46. J. Hirosumi, G. Tuncman, L. Chang A central role for JNK in obesity and insulin resistance Nature 420 2002 333 336
47. R. Nogueiras, P. Wiedmer, D. Perez-Tilve The central melanocortin system directly controls peripheral lipid metabolism J Clin Invest 117 2007 3475 3488
48. C. Theander-Carrillo, P. Wiedmer, P. Cettour-Rose Ghrelin action in the brain controls adipocyte metabolism J Clin Invest 116 2006 1983 1993
49. O. Della-Zuana, F. Presse, C. Ortola Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats Int J Obes Relat Metab Disord 26 2002 1289 1295
50. R. Nogueiras, D. Perez-Tilve, C. Veyrat-Durebex Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity J Neurosci 29 2009 5916 5925
51. L.M. Seoane, O. Al-Massadi, J.E. Caminos Sensory stimuli directly acting at the central nervous system regulate gastric ghrelin secretion. An ex vivo organ culture study Endocrinology 148 2007 3998 4006
52. F. Mallo, J.A. Lamas, F.F. Casanueva Effect of retinoic acid deficiency on in vivo and in vitro GH responses to GHRH in male rats Neuroendocrinology 55 1992 642 647
53. M. Lopez, R. Lage, A.K. Saha Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin Cell Metab 7 2008 389 399
54. C.R. Gonzalez, J.E. Caminos, M.J. Vazquez Regulation of visceral adipose tissue-derived serine protease inhibitor by nutritional status, metformin, gender and pituitary factors in rat white adipose tissue J Physiol 587 2008 3741 3750
55. M. Lopez, L. Varela, M.J. Vazquez Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance Nat Med 16 2010 1001 1008
56. Z. Trost, J. Marc, M. Sok Increased apolipoprotein E gene expression and protein concentration in lung cancer tissue do not contribute to the clinical assessment of non-small cell lung cancer patients Arch Med Res 39 2008 663 667