-
1
-
-
33947694370
-
TLR signaling
-
DOI 10.1016/j.smim.2006.12.004, PII S1044532306001242, TLR-Mediated Innate Immune Recognition
-
Kawai T, Akira S (2007) TLR signaling. Semin Immunol 19(1):24-32. (Pubitemid 46498752)
-
(2007)
Seminars in Immunology
, vol.19
, Issue.1
, pp. 24-32
-
-
Kawai, T.1
Akira, S.2
-
2
-
-
34548656855
-
Signaling pathways downstream of pattern-recognition receptors and their cross talk
-
Lee MS, Kim YJ (2007) Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem 76:447-480.
-
(2007)
Annu Rev Biochem
, vol.76
, pp. 447-480
-
-
Lee, M.S.1
Kim, Y.J.2
-
3
-
-
34547154349
-
p38 MAP-Kinases pathway regulation, function and role in human diseases
-
DOI 10.1016/j.bbamcr.2007.03.010, PII S0167488907000705
-
Cuenda A, Rousseau S (2007) p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta 1773:1358-1375. (Pubitemid 47125981)
-
(2007)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.1773
, Issue.8
, pp. 1358-1375
-
-
Cuenda, A.1
Rousseau, S.2
-
4
-
-
66749134594
-
Targeting innate immunity protein kinase signalling in inflammation
-
Gaestel M, Kotlyarov A, Kracht M (2009) Targeting innate immunity protein kinase signalling in inflammation. Nat Rev Drug Discov 8:480-499.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 480-499
-
-
Gaestel, M.1
Kotlyarov, A.2
Kracht, M.3
-
5
-
-
0033622470
-
Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development
-
Adams RH, et al. (2000) Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell 6(1):109-116.
-
(2000)
Mol Cell
, vol.6
, Issue.1
, pp. 109-116
-
-
Adams, R.H.1
-
6
-
-
0034641614
-
Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis
-
Mudgett JS, et al. (2000) Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci USA 97:10454-10459.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10454-10459
-
-
Mudgett, J.S.1
-
7
-
-
0034697904
-
Requirement for p38alpha in erythropoietin expression: A role for stress kinases in erythropoiesis
-
Tamura K, et al. (2000) Requirement for p38alpha in erythropoietin expression: A role for stress kinases in erythropoiesis. Cell 102:221-231.
-
(2000)
Cell
, vol.102
, pp. 221-231
-
-
Tamura, K.1
-
8
-
-
44449100233
-
Macrophage deletion of p38alpha partially impairs lipopolysaccharide- induced cellular activation
-
Kang YJ, et al. (2008) Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation. J Immunol 180:5075-5082.
-
(2008)
J Immunol
, vol.180
, pp. 5075-5082
-
-
Kang, Y.J.1
-
9
-
-
50049122380
-
The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- And anti-inflammatory gene expression
-
Kim C, et al. (2008) The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression. Nat Immunol 9:1019-1027.
-
(2008)
Nat Immunol
, vol.9
, pp. 1019-1027
-
-
Kim, C.1
-
10
-
-
77949841924
-
Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease
-
Otsuka M, et al. (2010) Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease. Gastroenterology 138(4):1255-1265, 1265.e1-9.
-
(2010)
Gastroenterology
, vol.138
, Issue.4
-
-
Otsuka, M.1
-
11
-
-
27944461325
-
Generation and characterization of p38beta (MAPK11) gene-targeted mice
-
DOI 10.1128/MCB.25.23.10454-10464.2005
-
Beardmore VA, et al. (2005) Generation and characterization of p38beta (MAPK11) gene-targeted mice. Mol Cell Biol 25:10454-10464. (Pubitemid 41681967)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.23
, pp. 10454-10464
-
-
Beardmore, V.A.1
Hinton, H.J.2
Eftychi, C.3
Apostolaki, M.4
Armaka, M.5
Darragh, J.6
McIlrath, J.7
Carr, J.M.8
Armit, L.J.9
Clacher, C.10
Malone, L.11
Kollias, G.12
Arthur, J.S.C.13
-
12
-
-
58249087541
-
Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis
-
Sumara G, et al. (2009) Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. Cell 136:235-248.
-
(2009)
Cell
, vol.136
, pp. 235-248
-
-
Sumara, G.1
-
13
-
-
76149089145
-
P38-gamma-dependent gene silencing restricts entry into the myogenic differentiation program
-
Gillespie MA, et al. (2009) p38-gamma-dependent gene silencing restricts entry into the myogenic differentiation program. J Cell Biol 187:991-1005.
-
(2009)
J Cell Biol
, vol.187
, pp. 991-1005
-
-
Gillespie, M.A.1
-
14
-
-
66349138173
-
P38delta mitogen-activated protein kinase is essential for skin tumor development in mice
-
Schindler EM, et al. (2009) p38delta mitogen-activated protein kinase is essential for skin tumor development in mice. Cancer Res 69:4648-4655.
-
(2009)
Cancer Res
, vol.69
, pp. 4648-4655
-
-
Schindler, E.M.1
-
15
-
-
79960051270
-
Evidence of p38γ and p38δ involvement in cell transformation processes
-
Cerezo-Guisado MI, et al. (2011) Evidence of p38γ and p38δ involvement in cell transformation processes. Carcinogenesis 32:1093-1099.
-
(2011)
Carcinogenesis
, vol.32
, pp. 1093-1099
-
-
Cerezo-Guisado, M.I.1
-
16
-
-
0033840329
-
Coordinate activation of endogenous p38alpha, beta, gamma, and delta by inflammatory stimuli
-
Fearns C, et al. (2000) Coordinate activation of endogenous p38alpha, beta, gamma, and delta by inflammatory stimuli. J Leukoc Biol 67:705-711.
-
(2000)
J Leukoc Biol
, vol.67
, pp. 705-711
-
-
Fearns, C.1
-
17
-
-
0033120590
-
Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages
-
Hale KK, Trollinger D, Rihanek M, Manthey CL (1999) Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages. J Immunol 162:4246-4252. (Pubitemid 29314814)
-
(1999)
Journal of Immunology
, vol.162
, Issue.7
, pp. 4246-4252
-
-
Hale, K.K.1
Trollinger, D.2
Rihanek, M.3
Manthey, C.L.4
-
19
-
-
3142724031
-
Toll-like receptor signalling
-
Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4:499-511. (Pubitemid 38931765)
-
(2004)
Nature Reviews Immunology
, vol.4
, Issue.7
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
20
-
-
78650887845
-
Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase
-
Gantke T, Sriskantharajah S, Ley SC (2011) Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase. Cell Res 21(1):131-145.
-
(2011)
Cell Res
, vol.21
, Issue.1
, pp. 131-145
-
-
Gantke, T.1
Sriskantharajah, S.2
Ley, S.C.3
-
21
-
-
17744371331
-
TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway
-
DOI 10.1016/S0092-8674(00)00210-5
-
Dumitru CD, et al. (2000) TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 103:1071-1083. (Pubitemid 32040907)
-
(2000)
Cell
, vol.103
, Issue.7
, pp. 1071-1083
-
-
Dumitru, C.D.1
Ceci, J.D.2
Tsatsanis, C.3
Kontoyiannis, D.4
Stamatakis, K.5
Lin, J.-H.6
Patriotis, C.7
Jenkins, N.A.8
Copeland, N.G.9
Kollias, G.10
Tsichlis, P.N.11
-
22
-
-
0042525945
-
Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40
-
DOI 10.1093/emboj/cdg386
-
Eliopoulos AG, Wang CC, Dumitru CD, Tsichlis PN (2003) Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40. EMBO J 22:3855-3864. (Pubitemid 36975712)
-
(2003)
EMBO Journal
, vol.22
, Issue.15
, pp. 3855-3864
-
-
Eliopoulos, A.G.1
Wang, C.-C.2
Dumitru, C.D.3
Tsichlis, P.N.4
-
23
-
-
0038112098
-
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
-
DOI 10.1128/MCB.23.14.4739-4752.2003
-
Beinke S, et al. (2003) NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity. Mol Cell Biol 23:4739-4752. (Pubitemid 36793322)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.14
, pp. 4739-4752
-
-
Beinke, S.1
Deka, J.2
Lang, V.3
Belich, M.P.4
Walker, P.A.5
Howell, S.6
Smerdon, S.J.7
Gamblin, S.J.8
Ley, S.C.9
-
24
-
-
33744455163
-
ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses
-
DOI 10.1038/ni1334, PII N1334
-
Papoutsopoulou S, et al. (2006) ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses. Nat Immunol 7:606-615. (Pubitemid 43797342)
-
(2006)
Nature Immunology
, vol.7
, Issue.6
, pp. 606-615
-
-
Papoutsopoulou, S.1
Symons, A.2
Tharmalingham, T.3
Belich, M.P.4
Kaiser, F.5
Kioussis, D.6
O'Garra, A.7
Tybulewicz, V.8
Ley, S.C.9
-
25
-
-
0037349601
-
NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase
-
DOI 10.1016/S1097-2765(03)00070-4
-
Waterfield MR, Zhang M, Norman LP, Sun SC (2003) NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase. Mol Cell 11:685-694. (Pubitemid 36385122)
-
(2003)
Molecular Cell
, vol.11
, Issue.3
, pp. 685-694
-
-
Waterfield, M.R.1
Zhang, M.2
Norman, L.P.3
Sun, S.-C.4
-
26
-
-
6344264987
-
Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105
-
DOI 10.1128/MCB.24.21.9658-9667.2004
-
Beinke S, Robinson MJ, Hugunin M, Ley SC (2004) Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105. Mol Cell Biol 24:9658-9667. (Pubitemid 39391700)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.21
, pp. 9658-9667
-
-
Beinke, S.1
Robinson, M.J.2
Hugunin, M.3
Ley, S.C.4
-
27
-
-
2942707765
-
IkappaB kinase is an essential component of the Tpl2 signaling pathway
-
DOI 10.1128/MCB.24.13.6040-6048.2004
-
Waterfield M, Jin W, Reiley W, Zhang M, Sun SC (2004) IkappaB kinase is an essential component of the Tpl2 signaling pathway. Mol Cell Biol 24:6040-6048. (Pubitemid 38787986)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.13
, pp. 6040-6048
-
-
Waterfield, M.1
Jin, W.2
Reiley, W.3
Zhang, M.4
Sun, S.-C.5
-
28
-
-
2942594766
-
ABIN-2 forms a ternary complex with TPL-2 and NF-kappaB1 p105 and is essential for TPL-2 protein stability
-
DOI 10.1128/MCB.24.12.5235-5248.2004
-
Lang V, et al. (2004) ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. Mol Cell Biol 24:5235-5248. (Pubitemid 38738159)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.12
, pp. 5235-5248
-
-
Lang, V.1
Symons, A.2
Watton, S.J.3
Janzen, J.4
Soneji, Y.5
Beinke, S.6
Howell, S.7
Ley, S.C.8
-
29
-
-
21244463215
-
Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner
-
Das S, et al. (2005) Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner. J Biol Chem 280:23748-23757.
-
(2005)
J Biol Chem
, vol.280
, pp. 23748-23757
-
-
Das, S.1
-
31
-
-
76249111625
-
Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production
-
Mielke LA, et al. (2009) Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production. J Immunol 183:7984-7993.
-
(2009)
J Immunol
, vol.183
, pp. 7984-7993
-
-
Mielke, L.A.1
-
32
-
-
38949132532
-
TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNFalpha in LPS-stimulated macrophages
-
DOI 10.1242/jcs.018671
-
Rousseau S, et al. (2008) TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages. J Cell Sci 121(2):149-154. (Pubitemid 351228446)
-
(2008)
Journal of Cell Science
, vol.121
, Issue.2
, pp. 149-154
-
-
Rousseau, S.1
Papoutsopoulou, M.2
Symons, A.3
Cook, D.4
Lucocq, J.M.5
Prescott, A.R.6
O'Garra, A.7
Ley, S.C.8
Cohen, P.9
-
33
-
-
21044444181
-
ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking
-
DOI 10.1242/jcs.02357
-
Soond SM, Everson B, Riches DW, Murphy G (2005) ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking. J Cell Sci 118:2371-2380. (Pubitemid 40873077)
-
(2005)
Journal of Cell Science
, vol.118
, Issue.11
, pp. 2371-2380
-
-
Soond, S.M.1
Everson, B.2
Riches, D.W.H.3
Murphy, G.4
-
34
-
-
69549129472
-
TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells
-
Kaiser F, et al. (2009) TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells. J Exp Med 206:1863-1871.
-
(2009)
J Exp Med
, vol.206
, pp. 1863-1871
-
-
Kaiser, F.1
-
35
-
-
47949129523
-
Dynamic protein associations define two phases of IL-1beta transcriptional activation
-
Zhang Y, Saccani S, Shin H, Nikolajczyk BS (2008) Dynamic protein associations define two phases of IL-1beta transcriptional activation. J Immunol 181:503-512.
-
(2008)
J Immunol
, vol.181
, pp. 503-512
-
-
Zhang, Y.1
Saccani, S.2
Shin, H.3
Nikolajczyk, B.S.4
-
36
-
-
63749083925
-
Targeting protein kinases for the development of anti-inflammatory drugs
-
Cohen P (2009) Targeting protein kinases for the development of anti-inflammatory drugs. Curr Opin Cell Biol 21:317-324.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 317-324
-
-
Cohen, P.1
-
37
-
-
59649127763
-
Inhibition of p38: Has the fat lady sung?
-
Genovese MC (2009) Inhibition of p38: Has the fat lady sung? Arthritis Rheum 60: 317-320.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 317-320
-
-
Genovese, M.C.1
-
38
-
-
0022185367
-
Preparation and characterization of human bone marrow-derived macrophages
-
Hume DA, et al. (1985) Preparation and characterization of human bone marrow-derived macrophages. J Leukoc Biol 38:541-552. (Pubitemid 16256751)
-
(1985)
Journal of Leukocyte Biology
, vol.38
, Issue.4
, pp. 541-552
-
-
Hume, D.A.1
Allan, W.2
Golder, J.3
|