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Volumn 14, Issue 12, 2015, Pages 1786-1798

Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors

Author keywords

Cytoskeleton; EMT; Invasion; Mitosis; Rho GTPases; Transcription

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1C; CYCLINE; PROTEIN P21; PROTEIN P27; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN E;

EID: 84943739158     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.1080/15384101.2014.998085     Document Type: Review
Times cited : (145)

References (141)
  • 1
    • 0035235736 scopus 로고    scopus 로고
    • Mitotic kinases as regulators of cell division and its checkpoints
    • PMID: 11413462
    • Nigg EA. Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol 2001; 2: 21-32; PMID: 11413462; http://dx. doi. org/10. 1038/35048096.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 21-32
    • Nigg, E.A.1
  • 2
    • 0033163714 scopus 로고    scopus 로고
    • Four-dimensional control of the cell cycle
    • PMID: 10559915
    • Pines J. Four-dimensional control of the cell cycle. Nat Cell Biol 1999; 1: E73-9; PMID: 10559915; http://dx. doi. org/10. 1038/11041.
    • (1999) Nat Cell Biol , vol.1 , pp. E73-E79
    • Pines, J.1
  • 4
    • 54549101258 scopus 로고    scopus 로고
    • Cyclin-dependent kinases and cell-cycle transitions: Does one fit all?
    • PMID: 18813291
    • Hochegger H, Takeda S, Hunt T. Cyclin-dependent kinases and cell-cycle transitions: does one fit all? Nat Rev Mol Cell Biol 2008; 9: 910-6; PMID: 18813291; http://dx. doi. org/10. 1038/nrm2510.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 910-916
    • Hochegger, H.1    Takeda, S.2    Hunt, T.3
  • 7
    • 0041828595 scopus 로고    scopus 로고
    • Cell proliferation without cyclin E-CDK2
    • PMID: 12941268
    • Mendez J. Cell proliferation without cyclin E-CDK2. Cell 2003; 114: 398-9; PMID: 12941268; http://dx. doi. org/10. 1016/S0092-8674(03)00649-4.
    • (2003) Cell , vol.114 , pp. 398-399
    • Mendez, J.1
  • 8
    • 0141737069 scopus 로고    scopus 로고
    • Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells
    • PMID: 12970191
    • Parisi T, Beck AR, Rougier N, McNeil T, Lucian L, Werb Z, Amati B. Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J 2003; 22: 4794-803; PMID: 12970191; http://dx. doi. org/10. 1093/emboj/cdg482.
    • (2003) EMBO J , vol.22 , pp. 4794-4803
    • Parisi, T.1    Beck, A.R.2    Rougier, N.3    McNeil, T.4    Lucian, L.5    Werb, Z.6    Amati, B.7
  • 11
    • 0028099631 scopus 로고
    • Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase
    • PMID: 7936635
    • Darbon JM, Devault A, Taviaux S, Fesquet D, Martinez AM, Galas S, Cavadore JC, Doree M, Blanchard JM. Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase. Oncogene 1994; 9: 3127-38; PMID: 7936635.
    • (1994) Oncogene , vol.9 , pp. 3127-3138
    • Darbon, J.M.1    Devault, A.2    Taviaux, S.3    Fesquet, D.4    Martinez, A.M.5    Galas, S.6    Cavadore, J.C.7    Doree, M.8    Blanchard, J.M.9
  • 12
    • 0027296041 scopus 로고
    • The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues
    • PMID: 8344251
    • Fesquet D, Labbe JC, Derancourt J, Capony JP, Galas S, Girard F, Lorca T, Shuttleworth J, Doree M, Cavadore JC. The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues. EMBO J 1993; 12: 3111-21; PMID: 8344251.
    • (1993) EMBO J , vol.12 , pp. 3111-3121
    • Fesquet, D.1    Labbe, J.C.2    Derancourt, J.3    Capony, J.P.4    Galas, S.5    Girard, F.6    Lorca, T.7    Shuttleworth, J.8    Doree, M.9    Cavadore, J.C.10
  • 13
    • 0027994603 scopus 로고
    • A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase
    • PMID: 8069918
    • Fisher RP, Morgan DO. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 1994; 78: 713-24; PMID: 8069918; http://dx. doi. org/10. 1016/0092-8674(94)90535-5.
    • (1994) Cell , vol.78 , pp. 713-724
    • Fisher, R.P.1    Morgan, D.O.2
  • 14
    • 0027251024 scopus 로고
    • The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2
    • PMID: 8393783
    • Poon RY, Yamashita K, Adamczewski JP, Hunt T, Shuttleworth J. The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2. EMBO J 1993; 12: 3123-32; PMID: 8393783.
    • (1993) EMBO J , vol.12 , pp. 3123-3132
    • Poon, R.Y.1    Yamashita, K.2    Adamczewski, J.P.3    Hunt, T.4    Shuttleworth, J.5
  • 15
    • 0027185999 scopus 로고
    • CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15
    • PMID: 8344252
    • Solomon MJ, Harper JW, Shuttleworth J. 1993. CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15. EMBO J. 12: 3133-42; PMID: 8344252.
    • (1993) EMBO J , vol.12 , pp. 3133-3142
    • Solomon, M.J.1    Harper, J.W.2    Shuttleworth, J.3
  • 16
    • 84861871242 scopus 로고    scopus 로고
    • Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion
    • PMID: 22505032
    • Ganuza M, Saiz-Ladera C, Canamero M, Gomez G, Schneider R, Blasco MA, Pisano D, Paramio JM, Santamaria D, Barbacid M. Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J 2012; 31: 2498-510; PMID: 22505032; http://dx. doi. org/10. 1038/emboj. 2012. 94.
    • (2012) EMBO J , vol.31 , pp. 2498-2510
    • Ganuza, M.1    Saiz-Ladera, C.2    Canamero, M.3    Gomez, G.4    Schneider, R.5    Blasco, M.A.6    Pisano, D.7    Paramio, J.M.8    Santamaria, D.9    Barbacid, M.10
  • 19
    • 79960377780 scopus 로고    scopus 로고
    • A history of TFIIH: Two decades of molecular biology on a pivotal transcription/repair factor
    • PMID: 21592869
    • Egly JM, Coin F. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. DNA Repair (Amst) 2011; 10: 714-21; PMID: 21592869.
    • (2011) DNA Repair (Amst) , vol.10 , pp. 714-721
    • Egly, J.M.1    Coin, F.2
  • 20
    • 25444444192 scopus 로고    scopus 로고
    • CAK-Cyclin-dependent Activating Kinase: A key kinase in cell cycle control and a target for drugs?
    • PMID: 15876871
    • Lolli G, Johnson LN. CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs? Cell Cycle 2005; 4: 572-7; PMID: 15876871; http://dx. doi. org/10. 4161/cc. 4. 4. 1607.
    • (2005) Cell Cycle , vol.4 , pp. 572-577
    • Lolli, G.1    Johnson, L.N.2
  • 21
    • 28044440089 scopus 로고    scopus 로고
    • Cyclin H binding to the RARalpha activation function (AF)-2 domain directs phosphorylation of the AF-1 domain by cyclin-dependent kinase 7
    • PMID: 16275922
    • Bour G, Gaillard E, Bruck N, Lalevee S, Plassat JL, Busso D, Samama JP, Rochette-Egly C. Cyclin H binding to the RARalpha activation function (AF)-2 domain directs phosphorylation of the AF-1 domain by cyclin-dependent kinase 7. Proc Natl Acad Sci U S A 2005; 102: 16608-13; PMID: 16275922; http://dx. doi. org/10. 1073/pnas. 0505556102.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 16608-16613
    • Bour, G.1    Gaillard, E.2    Bruck, N.3    Lalevee, S.4    Plassat, J.L.5    Busso, D.6    Samama, J.P.7    Rochette-Egly, C.8
  • 22
    • 0004080381 scopus 로고    scopus 로고
    • From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator
    • PMID: 10734072
    • Lee DK, Duan HO, Chang C. From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator. J Biol Chem 2000; 275: 9308-13; PMID: 10734072; http://dx. doi. org/10. 1074/jbc. 275. 13. 9308.
    • (2000) J Biol Chem , vol.275 , pp. 9308-9313
    • Lee, D.K.1    Duan, H.O.2    Chang, C.3
  • 23
    • 0031440878 scopus 로고    scopus 로고
    • Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7
    • PMID: 9230306
    • Rochette-Egly C, Adam S, Rossignol M, Egly JM, Chambon P. Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7. Cell 1997; 90: 97-107; PMID: 9230306; http://dx. doi. org/10. 1016/S0092-8674(00)80317-7.
    • (1997) Cell , vol.90 , pp. 97-107
    • Rochette-Egly, C.1    Adam, S.2    Rossignol, M.3    Egly, J.M.4    Chambon, P.5
  • 24
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • PMID: 10647931
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70; PMID: 10647931; http://dx. doi. org/10. 1016/S0092-8674(00)81683-9.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 25
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • PMID: 21376230
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-74; PMID: 21376230; http://dx. doi. org/10. 1016/j. cell. 2011. 02. 013.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 26
    • 0031028246 scopus 로고    scopus 로고
    • Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E
    • PMID: 8972226
    • Bortner DM, Rosenberg MP. Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E. Mol Cell Biol 1997; 17: 453-9; PMID: 8972226.
    • (1997) Mol Cell Biol , vol.17 , pp. 453-459
    • Bortner, D.M.1    Rosenberg, M.P.2
  • 27
    • 0033576570 scopus 로고    scopus 로고
    • Oncogenic potential of cyclin E in Tcell lymphomagenesis in transgenic mice: Evidence for cooperation between cyclin E and Ras but not Myc
    • PMID: 10618723
    • Karsunky H, Geisen C, Schmidt T, Haas K, Zevnik B, Gau E, Moroy T. Oncogenic potential of cyclin E in Tcell lymphomagenesis in transgenic mice: evidence for cooperation between cyclin E and Ras but not Myc. Oncogene 1999; 18: 7816-24; PMID: 10618723; http://dx. doi. org/10. 1038/sj. onc. 1203205.
    • (1999) Oncogene , vol.18 , pp. 7816-7824
    • Karsunky, H.1    Geisen, C.2    Schmidt, T.3    Haas, K.4    Zevnik, B.5    Gau, E.6    Moroy, T.7
  • 28
    • 0035963435 scopus 로고    scopus 로고
    • Specific protection against breast cancers by cyclin D1 ablation
    • PMID: 11429595
    • Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature 2001; 411: 1017-21; PMID: 11429595; http://dx. doi. org/10. 1038/35082500.
    • (2001) Nature , vol.411 , pp. 1017-1021
    • Yu, Q.1    Geng, Y.2    Sicinski, P.3
  • 29
    • 0027332123 scopus 로고
    • Altered regulation of G1 cyclins in senescent human diploid fibroblasts: Accumulation of inactive cyclin ECdk2 and cyclin D1-Cdk2 complexes
    • PMID: 8248208
    • Dulic V, Drullinger LF, Lees E, Reed SI, Stein GH. Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin ECdk2 and cyclin D1-Cdk2 complexes. Proc Natl Acad Sci U S A 1993; 90: 11034-8; PMID: 8248208; http://dx. doi. org/10. 1073/pnas. 90. 23. 11034.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 11034-11038
    • Dulic, V.1    Drullinger, L.F.2    Lees, E.3    Reed, S.I.4    Stein, G.H.5
  • 30
    • 0027269711 scopus 로고
    • Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts
    • PMID: 8360268
    • Lucibello FC, Sewing A, Brusselbach S, Burger C, Muller R. Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts. J Cell Sci 1993; 105 (Pt 1): 123-33; PMID: 8360268.
    • (1993) J Cell Sci , vol.105 , pp. 123-133
    • Lucibello, F.C.1    Sewing, A.2    Brusselbach, S.3    Burger, C.4    Muller, R.5
  • 31
    • 84884887531 scopus 로고    scopus 로고
    • CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: Duration of cell cycle arrest and MTOR activity determine geroconversion
    • PMID: 23974099
    • Leontieva OV, Blagosklonny MV. CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion. Cell Cycle 2013; 12: 3063-9; PMID: 23974099; http://dx. doi. org/10. 4161/cc. 26130.
    • (2013) Cell Cycle , vol.12 , pp. 3063-3069
    • Leontieva, O.V.1    Blagosklonny, M.V.2
  • 33
    • 0030696925 scopus 로고    scopus 로고
    • Malignant transformation by cyclin E and Ha-Ras correlates with lower sensitivity towards induction of cell death but requires functional Myc and CDK4
    • PMID: 9399649
    • Haas K, Johannes C, Geisen C, Schmidt T, Karsunky H, Blass-Kampmann S, Obe G, Moroy T. Malignant transformation by cyclin E and Ha-Ras correlates with lower sensitivity towards induction of cell death but requires functional Myc and CDK4. Oncogene 1997; 15: 2615-23; PMID: 9399649; http://dx. doi. org/10. 1038/sj. onc. 1201434.
    • (1997) Oncogene , vol.15 , pp. 2615-2623
    • Haas, K.1    Johannes, C.2    Geisen, C.3    Schmidt, T.4    Karsunky, H.5    Blass-Kampmann, S.6    Obe, G.7    Moroy, T.8
  • 34
    • 0037131309 scopus 로고    scopus 로고
    • The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein
    • PMID: 12149264
    • Geisen C, Moroy T. The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein. J Biol Chem 2002; 277: 39909-18; PMID: 12149264; http://dx. doi. org/10. 1074/jbc. M205919200.
    • (2002) J Biol Chem , vol.277 , pp. 39909-39918
    • Geisen, C.1    Moroy, T.2
  • 36
    • 84876314545 scopus 로고    scopus 로고
    • Differences in regulation and function of E-cyclins in human cancer cells
    • PMID: 23549169
    • Geng Y, Sicinski P. Differences in regulation and function of E-cyclins in human cancer cells. Cell Cycle 2013; 12: 1165; PMID: 23549169; http://dx. doi. org/10. 4161/cc. 24487.
    • (2013) Cell Cycle , vol.12 , pp. 1165
    • Geng, Y.1    Sicinski, P.2
  • 37
    • 0036305474 scopus 로고    scopus 로고
    • Distinct roles for cyclins E and A during DNA replication complex assembly and activation
    • PMID: 12080347
    • Coverley D, Laman H, Laskey RA. Distinct roles for cyclins E and A during DNA replication complex assembly and activation. Nat Cell Biol 2002; 4: 523-8; PMID: 12080347; http://dx. doi. org/10. 1038/ncb813.
    • (2002) Nat Cell Biol , vol.4 , pp. 523-528
    • Coverley, D.1    Laman, H.2    Laskey, R.A.3
  • 38
    • 77953127899 scopus 로고    scopus 로고
    • Centrosomal localization of cyclin E-Cdk2 is required for initiation of DNA synthesis
    • PMID: 20399658
    • Ferguson RL, Maller JL. Centrosomal localization of cyclin E-Cdk2 is required for initiation of DNA synthesis. Curr Biol 2010; 20: 856-60; PMID: 20399658; http://dx. doi. org/10. 1016/j. cub. 2010. 03. 028.
    • (2010) Curr Biol , vol.20 , pp. 856-860
    • Ferguson, R.L.1    Maller, J.L.2
  • 39
    • 77955995923 scopus 로고    scopus 로고
    • The cyclin A centrosomal localization sequence recruits MCM5 and Orc1 to regulate centrosome reduplication
    • PMID: 20663915
    • Ferguson RL, Pascreau G, Maller JL. The cyclin A centrosomal localization sequence recruits MCM5 and Orc1 to regulate centrosome reduplication. J Cell Sci 2010; 123: 2743-9; PMID: 20663915; http://dx. doi. org/10. 1242/jcs. 073098.
    • (2010) J Cell Sci , vol.123 , pp. 2743-2749
    • Ferguson, R.L.1    Pascreau, G.2    Maller, J.L.3
  • 40
    • 59849095061 scopus 로고    scopus 로고
    • Orc1 controls centriole and centrosome copy number in human cells
    • PMID: 19197067
    • Hemerly AS, Prasanth SG, Siddiqui K, Stillman B. Orc1 controls centriole and centrosome copy number in human cells. Science 2009; 323: 789-93; PMID: 19197067; http://dx. doi. org/10. 1126/science. 1166745.
    • (2009) Science , vol.323 , pp. 789-793
    • Hemerly, A.S.1    Prasanth, S.G.2    Siddiqui, K.3    Stillman, B.4
  • 41
    • 25444453781 scopus 로고    scopus 로고
    • Cyclin E acts under the control of Hox-genes as a cell fate determinant in the developing central nervous system
    • PMID: 15684605
    • Berger C, Pallavi SK, Prasad M, Shashidhara LS, Technau GM. Cyclin E acts under the control of Hox-genes as a cell fate determinant in the developing central nervous system. Cell Cycle 2005; 4: 422-5; PMID: 15684605; http://dx. doi. org/10. 4161/cc. 4. 3. 1524.
    • (2005) Cell Cycle , vol.4 , pp. 422-425
    • Berger, C.1    Pallavi, S.K.2    Prasad, M.3    Shashidhara, L.S.4    Technau, G.M.5
  • 42
    • 72649095555 scopus 로고    scopus 로고
    • Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function
    • PMID: 19914234
    • Berger C, Kannan R, Myneni S, Renner S, Shashidhara LS, Technau GM. Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function. Dev Biol 2010; 337: 415-24; PMID: 19914234; http://dx. doi. org/10. 1016/j. ydbio. 2009. 11. 012.
    • (2010) Dev Biol , vol.337 , pp. 415-424
    • Berger, C.1    Kannan, R.2    Myneni, S.3    Renner, S.4    Shashidhara, L.S.5    Technau, G.M.6
  • 44
    • 84859129533 scopus 로고    scopus 로고
    • Control of sleep by cyclin A and its regulator
    • Rogulja D, Young MW. Control of sleep by cyclin A and its regulator. Science 2012; 335: 1617-21.
    • (2012) Science , vol.335 , pp. 1617-1621
    • Rogulja, D.1    Young, M.W.2
  • 45
    • 0037121081 scopus 로고    scopus 로고
    • Linking cyclins to transcriptional control
    • PMID: 12459251
    • Coqueret O. Linking cyclins to transcriptional control. Gene 2002; 299: 35-55; PMID: 12459251; http://dx. doi. org/10. 1016/S0378-1119(02)01055-7.
    • (2002) Gene , vol.299 , pp. 35-55
    • Coqueret, O.1
  • 46
    • 9444236895 scopus 로고    scopus 로고
    • Minireview: Cyclin D1: Normal and abnormal functions
    • PMID: 15331580
    • Fu M, Wang C, Li Z, Sakamaki T, Pestell RG. Minireview: Cyclin D1: normal and abnormal functions. Endocrinology 2004; 145: 5439-47; PMID: 15331580; http://dx. doi. org/10. 1210/en. 2004-0959.
    • (2004) Endocrinology , vol.145 , pp. 5439-5447
    • Fu, M.1    Wang, C.2    Li, Z.3    Sakamaki, T.4    Pestell, R.G.5
  • 47
    • 0028889751 scopus 로고
    • Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
    • PMID: 7557388
    • Fantl V, Stamp G, Andrews A, Rosewell I, Dickson C. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev 1995; 9: 2364-72; PMID: 7557388; http://dx. doi. org/10. 1101/gad. 9. 19. 2364.
    • (1995) Genes Dev , vol.9 , pp. 2364-2372
    • Fantl, V.1    Stamp, G.2    Andrews, A.3    Rosewell, I.4    Dickson, C.5
  • 48
    • 0032937751 scopus 로고    scopus 로고
    • Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia
    • PMID: 10319860
    • Rane SG, Dubus P, Mettus RV, Galbreath EJ, Boden G, Reddy EP, Barbacid M. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet 1999; 22: 44-52; PMID: 10319860; http://dx. doi. org/10. 1038/8751.
    • (1999) Nat Genet , vol.22 , pp. 44-52
    • Rane, S.G.1    Dubus, P.2    Mettus, R.V.3    Galbreath, E.J.4    Boden, G.5    Reddy, E.P.6    Barbacid, M.7
  • 49
    • 33645118564 scopus 로고    scopus 로고
    • Cyclin D1: Polymorphism, aberrant splicing and cancer risk
    • PMID: 16550162
    • Knudsen KE, Diehl JA, Haiman CA, Knudsen ES. Cyclin D1: polymorphism, aberrant splicing and cancer risk. Oncogene 2006; 25: 1620-8; PMID: 16550162; http://dx. doi. org/10. 1038/sj. onc. 1209371.
    • (2006) Oncogene , vol.25 , pp. 1620-1628
    • Knudsen, K.E.1    Diehl, J.A.2    Haiman, C.A.3    Knudsen, E.S.4
  • 51
    • 33646893508 scopus 로고    scopus 로고
    • Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling
    • Li Z, Wang C, Jiao X, Lu Y, Fu M, Quong AA, Dye C, Yang J, Dai M, Ju X, et al. Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol 2006b; 26: 4240-56; http://dx. doi. org/10. 1128/MCB. 02124-05.
    • (2006) Mol Cell Biol , vol.26 , pp. 4240-4256
    • Li, Z.1    Wang, C.2    Jiao, X.3    Lu, Y.4    Fu, M.5    Quong, A.A.6    Dye, C.7    Yang, J.8    Dai, M.9    Ju, X.10
  • 52
    • 77950221878 scopus 로고    scopus 로고
    • Cyclin D1/cyclindependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells
    • PMID: 20179208
    • Zhong Z, Yeow WS, Zou C, Wassell R, Wang C, Pestell RG, Quong JN, Quong AA. Cyclin D1/cyclindependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells. Cancer Res 70: 2105-14; PMID: 20179208; http://dx. doi. org/10. 1158/0008-5472. CAN-08-1108.
    • Cancer Res , vol.70 , pp. 2105-2114
    • Zhong, Z.1    Yeow, W.S.2    Zou, C.3    Wassell, R.4    Wang, C.5    Pestell, R.G.6    Quong, J.N.7    Quong, A.A.8
  • 54
    • 33746814985 scopus 로고    scopus 로고
    • Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function
    • PMID: 16864783
    • Wang C, Li Z, Lu Y, Du R, Katiyar S, Yang J, Fu M, Leader JE, Quong A, Novikoff PM, Pestell RG. Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. Proc Natl Acad Sci U S A 2006; 103: 11567-72; PMID: 16864783; http://dx. doi. org/10. 1073/pnas. 0603363103.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 11567-11572
    • Wang, C.1    Li, Z.2    Lu, Y.3    Du, R.4    Katiyar, S.5    Yang, J.6    Fu, M.7    Leader, J.E.8    Quong, A.9    Novikoff, P.M.10    Pestell, R.G.11
  • 56
    • 0033545929 scopus 로고    scopus 로고
    • P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor
    • PMID: 10318892
    • McMahon C, Suthiphongchai T, DiRenzo J, Ewen ME. P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor. Proc Natl Acad Sci U S A 1999; 96: 5382-7; PMID: 10318892; http://dx. doi. org/10. 1073/pnas. 96. 10. 5382.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 5382-5387
    • McMahon, C.1    Suthiphongchai, T.2    DiRenzo, J.3    Ewen, M.E.4
  • 57
    • 0030968438 scopus 로고    scopus 로고
    • CDK-independent activation of estrogen receptor by cyclin D1
    • PMID: 9039267
    • Zwijsen RM, Wientjens E, Klompmaker R, van der Sman J, Bernards R, Michalides RJ. CDK-independent activation of estrogen receptor by cyclin D1. Cell 1997; 88: 405-15; PMID: 9039267; http://dx. doi. org/10. 1016/S0092-8674(00)81879-6.
    • (1997) Cell , vol.88 , pp. 405-415
    • Zwijsen, R.M.1    Wientjens, E.2    Klompmaker, R.3    van der Sman, J.4    Bernards, R.5    Michalides, R.J.6
  • 59
    • 0033563091 scopus 로고    scopus 로고
    • D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability
    • PMID: 10344732
    • Knudsen KE, Cavenee WK, Arden KC. D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability. Cancer Res 1999; 59: 2297-301; PMID: 10344732.
    • (1999) Cancer Res , vol.59 , pp. 2297-2301
    • Knudsen, K.E.1    Cavenee, W.K.2    Arden, K.C.3
  • 60
    • 0037088594 scopus 로고    scopus 로고
    • Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD
    • PMID: 11788592
    • Ratineau C, Petry MW, Mutoh H, Leiter AB. Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD. J Biol Chem 2002; 277: 8847-53; PMID: 11788592; http://dx. doi. org/10. 1074/jbc. M110747200.
    • (2002) J Biol Chem , vol.277 , pp. 8847-8853
    • Ratineau, C.1    Petry, M.W.2    Mutoh, H.3    Leiter, A.B.4
  • 61
    • 0035907245 scopus 로고    scopus 로고
    • Cyclin D1 represses STAT3 activation through a Cdk4-independent mechanism
    • PMID: 11279133
    • Bienvenu F, Gascan H, Coqueret O. Cyclin D1 represses STAT3 activation through a Cdk4-independent mechanism. J Biol Chem 2001; 276: 16840-7; PMID: 11279133; http://dx. doi. org/10. 1074/jbc. M100795200.
    • (2001) J Biol Chem , vol.276 , pp. 16840-16847
    • Bienvenu, F.1    Gascan, H.2    Coqueret, O.3
  • 62
    • 0042971664 scopus 로고    scopus 로고
    • Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation
    • PMID: 12917338
    • Wang C, Pattabiraman N, Zhou JN, Fu M, Sakamaki T, Albanese C, Li Z, Wu K, Hulit J, Neumeister P, et al. Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Mol Cell Biol 2003; 23: 6159-73; PMID: 12917338; http://dx. doi. org/10. 1128/MCB. 23. 17. 6159-6173. 2003.
    • (2003) Mol Cell Biol , vol.23 , pp. 6159-6173
    • Wang, C.1    Pattabiraman, N.2    Zhou, J.N.3    Fu, M.4    Sakamaki, T.5    Albanese, C.6    Li, Z.7    Wu, K.8    Hulit, J.9    Neumeister, P.10
  • 63
    • 84867254579 scopus 로고    scopus 로고
    • Cyclin D1 goes metabolic: Dual functions of cyclin D1 in regulating lipogenesis
    • PMID: 22951541
    • Knudsen KE. Cyclin D1 goes metabolic: dual functions of cyclin D1 in regulating lipogenesis. Cell Cycle 2012; 11: 3533-4; PMID: 22951541; http://dx. doi. org/10. 4161/cc. 22039.
    • (2012) Cell Cycle , vol.11 , pp. 3533-3534
    • Knudsen, K.E.1
  • 68
    • 0038100182 scopus 로고    scopus 로고
    • Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migration
    • PMID: 12771130
    • Manes T, Zheng DQ, Tognin S, Woodard AS, Marchisio PC, Languino LR. Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migration. J Cell Biol 2003; 161: 817-26; PMID: 12771130; http://dx. doi. org/10. 1083/jcb. 200212172.
    • (2003) J Cell Biol , vol.161 , pp. 817-826
    • Manes, T.1    Zheng, D.Q.2    Tognin, S.3    Woodard, A.S.4    Marchisio, P.C.5    Languino, L.R.6
  • 69
    • 40549092672 scopus 로고    scopus 로고
    • Overexpression of cyclin B1 in human esophageal squamous cell carcinoma cells induces tumor cell invasive growth and metastasis
    • PMID: 18048386
    • Song Y, Zhao C, Dong L, Fu M, Xue L, Huang Z, Tong T, Zhou Z, Chen A, Yang Z, Lu N, Zhan Q. Overexpression of cyclin B1 in human esophageal squamous cell carcinoma cells induces tumor cell invasive growth and metastasis. Carcinogenesis 2008; 29: 307-15; PMID: 18048386; http://dx. doi. org/10. 1093/carcin/bgm269.
    • (2008) Carcinogenesis , vol.29 , pp. 307-315
    • Song, Y.1    Zhao, C.2    Dong, L.3    Fu, M.4    Xue, L.5    Huang, Z.6    Tong, T.7    Zhou, Z.8    Chen, A.9    Yang, Z.10    Lu, N.11    Zhan, Q.12
  • 70
    • 40349092941 scopus 로고    scopus 로고
    • Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates
    • PMID: 18234856
    • Blethrow JD, Glavy JS, Morgan DO, Shokat KM. Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proc Natl Acad Sci U S A 2008; 105: 1442-7; PMID: 18234856; http://dx. doi. org/10. 1073/pnas. 0708966105.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 1442-1447
    • Blethrow, J.D.1    Glavy, J.S.2    Morgan, D.O.3    Shokat, K.M.4
  • 72
    • 18544412767 scopus 로고    scopus 로고
    • Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor
    • PMID: 10831611
    • Hirota T, Morisaki T, Nishiyama Y, Marumoto T, Tada K, Hara T, Masuko N, Inagaki M, Hatakeyama K, Saya H. Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. J Cell Biol 2000; 149: 1073-86; PMID: 10831611; http://dx. doi. org/10. 1083/jcb. 149. 5. 1073.
    • (2000) J Cell Biol , vol.149 , pp. 1073-1086
    • Hirota, T.1    Morisaki, T.2    Nishiyama, Y.3    Marumoto, T.4    Tada, K.5    Hara, T.6    Masuko, N.7    Inagaki, M.8    Hatakeyama, K.9    Saya, H.10
  • 73
    • 0842281652 scopus 로고    scopus 로고
    • Rho and Rac take center stage
    • PMID: 14744429
    • Burridge K, Wennerberg K. Rho and Rac take center stage. Cell 2004; 116: 167-79; PMID: 14744429; http://dx. doi. org/10. 1016/S0092-8674(04)00003-0.
    • (2004) Cell , vol.116 , pp. 167-179
    • Burridge, K.1    Wennerberg, K.2
  • 74
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: Biochemistry and biology
    • PMID: 16212495
    • Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005; 21: 247-69; PMID: 16212495; http://dx. doi. org/10. 1146/annurev. cellbio. 21. 020604. 150721.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 75
    • 27844604200 scopus 로고    scopus 로고
    • Rho GTPases and the control of cell behaviour
    • PMID: 16246005
    • Hall A. Rho GTPases and the control of cell behaviour. Biochem Soc Trans 2005; 33: 891-5; PMID: 16246005; http://dx. doi. org/10. 1042/BST20050891.
    • (2005) Biochem Soc Trans , vol.33 , pp. 891-895
    • Hall, A.1
  • 76
    • 50149083752 scopus 로고    scopus 로고
    • Mammalian Rho GTPases: New insights into their functions from in vivo studies
    • PMID: 18719708
    • Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 2008; 9: 690-701; PMID: 18719708; http://dx. doi. org/10. 1038/nrm2476.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 690-701
    • Heasman, S.J.1    Ridley, A.J.2
  • 78
    • 0345731237 scopus 로고    scopus 로고
    • Cell migration: Rho GTPases lead the way
    • PMID: 14697350
    • Raftopoulou M, Hall A. Cell migration: Rho GTPases lead the way. Dev Biol 2004; 265: 23-32; PMID: 14697350; http://dx. doi. org/10. 1016/j. ydbio. 2003. 06. 003.
    • (2004) Dev Biol , vol.265 , pp. 23-32
    • Raftopoulou, M.1    Hall, A.2
  • 79
    • 0034886701 scopus 로고    scopus 로고
    • Integrin-specific activation of Rac controls progression through the G (1) phase of the cell cycle
    • PMID: 11511365
    • Mettouchi A, Klein S, Guo W, Lopez-Lago M, Lemichez E, Westwick JK, Giancotti FG. Integrin-specific activation of Rac controls progression through the G (1) phase of the cell cycle. Mol Cell 2001; 8: 115-27; PMID: 11511365; http://dx. doi. org/10. 1016/S1097-2765(01)00285-4.
    • (2001) Mol Cell , vol.8 , pp. 115-127
    • Mettouchi, A.1    Klein, S.2    Guo, W.3    Lopez-Lago, M.4    Lemichez, E.5    Westwick, J.K.6    Giancotti, F.G.7
  • 80
    • 0037641217 scopus 로고    scopus 로고
    • Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases
    • PMID: 12773570
    • Roovers K, Assoian RK. Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases. Mol Cell Biol 2003; 23: 4283-94; PMID: 12773570; http://dx. doi. org/10. 1128/MCB. 23. 12. 4283-4294. 2003.
    • (2003) Mol Cell Biol , vol.23 , pp. 4283-4294
    • Roovers, K.1    Assoian, R.K.2
  • 81
    • 0041440180 scopus 로고    scopus 로고
    • Nuclear translocation of LIM kinase mediates Rho-Rho kinase regulation of cyclin D1 expression
    • PMID: 12919678
    • Roovers K, Klein EA, Castagnino P, Assoian RK. Nuclear translocation of LIM kinase mediates Rho-Rho kinase regulation of cyclin D1 expression. Dev Cell 2003; 5: 273-84; PMID: 12919678; http://dx. doi. org/10. 1016/S1534-5807(03)00206-5.
    • (2003) Dev Cell , vol.5 , pp. 273-284
    • Roovers, K.1    Klein, E.A.2    Castagnino, P.3    Assoian, R.K.4
  • 82
    • 0035736485 scopus 로고    scopus 로고
    • Timing of cyclin D1 expression within G1 phase is controlled by Rho
    • PMID: 11715015
    • Welsh CF, Roovers K, Villanueva J, Liu Y, Schwartz MA, Assoian RK. Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol 2001; 3: 950-7; PMID: 11715015; http://dx. doi. org/10. 1038/ncb1101-950.
    • (2001) Nat Cell Biol , vol.3 , pp. 950-957
    • Welsh, C.F.1    Roovers, K.2    Villanueva, J.3    Liu, Y.4    Schwartz, M.A.5    Assoian, R.K.6
  • 83
    • 0034007088 scopus 로고    scopus 로고
    • Differential effect of Rac and Cdc42 on p38 kinase activity and cell cycle progression of nonadherent primary mouse fibroblasts
    • PMID: 10681583
    • Philips A, Roux P, Coulon V, Bellanger JM, Vie A, Vignais ML, Blanchard JM. Differential effect of Rac and Cdc42 on p38 kinase activity and cell cycle progression of nonadherent primary mouse fibroblasts. J Biol Chem 2000; 275: 5911-7; PMID: 10681583; http://dx. doi. org/10. 1074/jbc. 275. 8. 5911.
    • (2000) J Biol Chem , vol.275 , pp. 5911-5917
    • Philips, A.1    Roux, P.2    Coulon, V.3    Bellanger, J.M.4    Vie, A.5    Vignais, M.L.6    Blanchard, J.M.7
  • 84
    • 10344262906 scopus 로고    scopus 로고
    • Regulation of the cytoskeleton: An oncogenic function for CDK inhibitors?
    • Besson A, Assoian RK, Roberts JM. Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors? Nat Rev Cancer 2004a; 4: 948-55; http://dx. doi. org/10. 1038/nrc1501.
    • (2004) Nat Rev Cancer , vol.4 , pp. 948-955
    • Besson, A.1    Assoian, R.K.2    Roberts, J.M.3
  • 85
    • 0033788675 scopus 로고    scopus 로고
    • Nuclear sequestration of the exchange factor Cdc24 by Far1 regulates cell polarity during yeast mating
    • PMID: 10655592
    • Shimada Y, Gulli MP, Peter M. Nuclear sequestration of the exchange factor Cdc24 by Far1 regulates cell polarity during yeast mating. Nat Cell Biol 2000; 2: 117-24; PMID: 10655592; http://dx. doi. org/10. 1038/35000073.
    • (2000) Nat Cell Biol , vol.2 , pp. 117-124
    • Shimada, Y.1    Gulli, M.P.2    Peter, M.3
  • 86
    • 0346101745 scopus 로고    scopus 로고
    • p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus
    • PMID: 14530263
    • Yokoo T, Toyoshima H, Miura M, Wang Y, Iida KT, Suzuki H, Sone H, Shimano H, Gotoda T, Nishimori S, et al. p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus. J Biol Chem 2003; 278: 52919-23; PMID: 14530263; http://dx. doi. org/10. 1074/jbc. M309334200.
    • (2003) J Biol Chem , vol.278 , pp. 52919-52923
    • Yokoo, T.1    Toyoshima, H.2    Miura, M.3    Wang, Y.4    Iida, K.T.5    Suzuki, H.6    Sone, H.7    Shimano, H.8    Gotoda, T.9    Nishimori, S.10
  • 87
    • 1942466518 scopus 로고    scopus 로고
    • p27Kip1 modulates cell migration through the regulation of RhoA activation
    • Besson A, Gurian-West M, Schmidt A, Hall A, Roberts JM. p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 2004b; 18: 862-76; http://dx. doi. org/10. 1101/gad. 1185504.
    • (2004) Genes Dev , vol.18 , pp. 862-876
    • Besson, A.1    Gurian-West, M.2    Schmidt, A.3    Hall, A.4    Roberts, J.M.5
  • 88
    • 0347717882 scopus 로고    scopus 로고
    • Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway
    • PMID: 14559914
    • Lee S, Helfman DM. Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway. J Biol Chem 2004; 279: 1885-91; PMID: 14559914; http://dx. doi. org/10. 1074/jbc. M306968200.
    • (2004) J Biol Chem , vol.279 , pp. 1885-1891
    • Lee, S.1    Helfman, D.M.2
  • 89
    • 0037157872 scopus 로고    scopus 로고
    • Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity
    • PMID: 12119358
    • Tanaka H, Yamashita T, Asada M, Mizutani S, Yoshikawa H, Tohyama M. Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity. J Cell Biol 2002; 158: 321-9; PMID: 12119358; http://dx. doi. org/10. 1083/jcb. 200202071.
    • (2002) J Cell Biol , vol.158 , pp. 321-329
    • Tanaka, H.1    Yamashita, T.2    Asada, M.3    Mizutani, S.4    Yoshikawa, H.5    Tohyama, M.6
  • 90
    • 0034745353 scopus 로고    scopus 로고
    • Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
    • PMID: 11231573
    • Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 2001; 3: 245-52; PMID: 11231573; http://dx. doi. org/10. 1038/35060032.
    • (2001) Nat Cell Biol , vol.3 , pp. 245-252
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Spohn, B.4    Lee, M.H.5    Hung, M.C.6
  • 91
    • 3042552705 scopus 로고    scopus 로고
    • Cytoplasmic p21(Cip1/WAF1) enhances axonal regeneration and functional recovery after spinal cord injury in rats
    • PMID: 15219678
    • Tanaka H, Yamashita T, Yachi K, Fujiwara T, Yoshikawa H, Tohyama M. Cytoplasmic p21(Cip1/WAF1) enhances axonal regeneration and functional recovery after spinal cord injury in rats. Neuroscience 2004; 127: 155-64; PMID: 15219678; http://dx. doi. org/10. 1016/j. neuroscience. 2004. 05. 010.
    • (2004) Neuroscience , vol.127 , pp. 155-164
    • Tanaka, H.1    Yamashita, T.2    Yachi, K.3    Fujiwara, T.4    Yoshikawa, H.5    Tohyama, M.6
  • 92
    • 38849187293 scopus 로고    scopus 로고
    • CDK inhibitors: Cell cycle regulators and beyond
    • PMID: 18267085
    • Besson A, Dowdy SF, Roberts JM. CDK inhibitors: cell cycle regulators and beyond. Dev Cell 2008; 14: 159-69; PMID: 18267085; http://dx. doi. org/10. 1016/j. devcel. 2008. 01. 013.
    • (2008) Dev Cell , vol.14 , pp. 159-169
    • Besson, A.1    Dowdy, S.F.2    Roberts, J.M.3
  • 93
    • 77951553359 scopus 로고    scopus 로고
    • p57: A multifunctional protein in cancer (Review)
    • PMID: 20428755
    • Guo H, Tian T, Nan K, Wang W. p57: A multifunctional protein in cancer (Review). Int J Oncol 2010; 36: 1321-9; PMID: 20428755; http://dx. doi. org/10. 3892/ijo_00000536.
    • (2010) Int J Oncol , vol.36 , pp. 1321-1329
    • Guo, H.1    Tian, T.2    Nan, K.3    Wang, W.4
  • 94
    • 70949083516 scopus 로고    scopus 로고
    • The Cdk inhibitor p57(Kip2) controls LIM-kinase 1 activity and regulates actin cytoskeleton dynamics
    • PMID: 19734939
    • Vlachos P, Joseph B. The Cdk inhibitor p57(Kip2) controls LIM-kinase 1 activity and regulates actin cytoskeleton dynamics. Oncogene 2009; 28: 4175-88; PMID: 19734939; http://dx. doi. org/10. 1038/onc. 2009. 269.
    • (2009) Oncogene , vol.28 , pp. 4175-4188
    • Vlachos, P.1    Joseph, B.2
  • 95
    • 81855183840 scopus 로고    scopus 로고
    • Downregulation of p57 accelerates the growth and invasion of hepatocellular carcinoma
    • PMID: 22002319
    • Guo H, Lv Y, Tian T, Hu TH, Wang WJ, Sui X, Jiang L, Ruan ZP, Nan KJ. Downregulation of p57 accelerates the growth and invasion of hepatocellular carcinoma. Carcinogenesis 2011; 32: 1897-904; PMID: 22002319; http://dx. doi. org/10. 1093/carcin/bgr220.
    • (2011) Carcinogenesis , vol.32 , pp. 1897-1904
    • Guo, H.1    Lv, Y.2    Tian, T.3    Hu, T.H.4    Wang, W.J.5    Sui, X.6    Jiang, L.7    Ruan, Z.P.8    Nan, K.J.9
  • 96
    • 3042814308 scopus 로고    scopus 로고
    • Inducible expression of p57KIP2 inhibits glioma cell motility and invasion
    • PMID: 15332324
    • Sakai K, Peraud A, Mainprize T, Nakayama J, Tsugu A, Hongo K, Kobayashi S, Rutka JT. Inducible expression of p57KIP2 inhibits glioma cell motility and invasion. J Neurooncol 2004; 68: 217-23; PMID: 15332324; http://dx. doi. org/10. 1023/B: NEON. 0000033380. 08940. c8.
    • (2004) J Neurooncol , vol.68 , pp. 217-223
    • Sakai, K.1    Peraud, A.2    Mainprize, T.3    Nakayama, J.4    Tsugu, A.5    Hongo, K.6    Kobayashi, S.7    Rutka, J.T.8
  • 97
    • 33846997178 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex
    • PMID: 17092932
    • Itoh Y, Masuyama N, Nakayama K, Nakayama KI, Gotoh Y. The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex. J Biol Chem 2007; 282: 390-6; PMID: 17092932; http://dx. doi. org/10. 1074/jbc. M609944200.
    • (2007) J Biol Chem , vol.282 , pp. 390-396
    • Itoh, Y.1    Masuyama, N.2    Nakayama, K.3    Nakayama, K.I.4    Gotoh, Y.5
  • 98
    • 1842479209 scopus 로고    scopus 로고
    • Stopping and going with p27kip1
    • PMID: 15068785
    • Assoian RK. Stopping and going with p27kip1. Dev Cell 2004; 6: 458-9; PMID: 15068785; http://dx. doi. org/10. 1016/S1534-5807(04)00103-0.
    • (2004) Dev Cell , vol.6 , pp. 458-459
    • Assoian, R.K.1
  • 99
    • 70449710913 scopus 로고    scopus 로고
    • p27 as Jekyll and Hyde: Regulation of cell cycle and cell motility
    • Larrea MD, Wander SA, Slingerland JM. p27 as Jekyll and Hyde: regulation of cell cycle and cell motility. Cell Cycle 2009b; 8: 3455-61; http://dx. doi. org/10. 4161/cc. 8. 21. 9789.
    • (2009) Cell Cycle , vol.8 , pp. 3455-3461
    • Larrea, M.D.1    Wander, S.A.2    Slingerland, J.M.3
  • 100
    • 30344457896 scopus 로고    scopus 로고
    • Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration
    • PMID: 16341208
    • Kawauchi T, Chihama K, Nabeshima Y, Hoshino M. Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration. Nat Cell Biol 2006; 8: 17-26; PMID: 16341208; http://dx. doi. org/10. 1038/ncb1338.
    • (2006) Nat Cell Biol , vol.8 , pp. 17-26
    • Kawauchi, T.1    Chihama, K.2    Nabeshima, Y.3    Hoshino, M.4
  • 102
    • 35148901042 scopus 로고    scopus 로고
    • Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma
    • PMID: 17909030
    • Denicourt C, Saenz CC, Datnow B, Cui XS, Dowdy SF. Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma. Cancer Res 2007; 67: 9238-43; PMID: 17909030; http://dx. doi. org/10. 1158/0008-5472. CAN-07-1375.
    • (2007) Cancer Res , vol.67 , pp. 9238-9243
    • Denicourt, C.1    Saenz, C.C.2    Datnow, B.3    Cui, X.S.4    Dowdy, S.F.5
  • 103
    • 0037216528 scopus 로고    scopus 로고
    • Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions
    • PMID: 12482975
    • McAllister SS, Becker-Hapak M, Pintucci G, Pagano M, Dowdy SF. Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions. Mol Cell Biol 2003; 23: 216-28; PMID: 12482975; http://dx. doi. org/10. 1128/MCB. 23. 1. 216-228. 2003.
    • (2003) Mol Cell Biol , vol.23 , pp. 216-228
    • McAllister, S.S.1    Becker-Hapak, M.2    Pintucci, G.3    Pagano, M.4    Dowdy, S.F.5
  • 105
    • 33644509197 scopus 로고    scopus 로고
    • Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, tumorigenicity
    • PMID: 16489017
    • Wu FY, Wang SE, Sanders ME, Shin I, Rojo F, Baselga J, Arteaga CL. Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, tumorigenicity. Cancer Res 2006; 66: 2162-72; PMID: 16489017; http://dx. doi. org/10. 1158/0008-5472. CAN-05-3304.
    • (2006) Cancer Res , vol.66 , pp. 2162-2172
    • Wu, F.Y.1    Wang, S.E.2    Sanders, M.E.3    Shin, I.4    Rojo, F.5    Baselga, J.6    Arteaga, C.L.7
  • 107
    • 0037423864 scopus 로고    scopus 로고
    • Coordinate control of proliferation and migration by the p27Kip1/cyclin-dependent kinase/retinoblastoma pathway in vascular smooth muscle cells and fibroblasts
    • PMID: 12600894
    • Diez-Juan A, Andres V. Coordinate control of proliferation and migration by the p27Kip1/cyclin-dependent kinase/retinoblastoma pathway in vascular smooth muscle cells and fibroblasts. Circ Res 2003; 92: 402-10; PMID: 12600894; http://dx. doi. org/10. 1161/01. RES. 0000059306. 71961. ED.
    • (2003) Circ Res , vol.92 , pp. 402-410
    • Diez-Juan, A.1    Andres, V.2
  • 108
    • 0034842489 scopus 로고    scopus 로고
    • Overexpression of p27(Kip1) by doxycycline-regulated adenoviral vectors inhibits endothelial cell proliferation and migration and impairs angiogenesis
    • PMID: 11532967
    • Goukassian D, Diez-Juan A, Asahara T, Schratzberger P, Silver M, Murayama T, Isner JM, Andres V. Overexpression of p27(Kip1) by doxycycline-regulated adenoviral vectors inhibits endothelial cell proliferation and migration and impairs angiogenesis. FASEB J 2001; 15: 1877-85; PMID: 11532967; http://dx. doi. org/10. 1096/fj. 01-0065com.
    • (2001) FASEB J , vol.15 , pp. 1877-1885
    • Goukassian, D.1    Diez-Juan, A.2    Asahara, T.3    Schratzberger, P.4    Silver, M.5    Murayama, T.6    Isner, J.M.7    Andres, V.8
  • 109
    • 0035912863 scopus 로고    scopus 로고
    • Role for p27(Kip1) in Vascular Smooth Muscle Cell Migration
    • PMID: 11413088
    • Sun J, Marx SO, Chen HJ, Poon M, Marks AR, Rabbani LE. Role for p27(Kip1) in Vascular Smooth Muscle Cell Migration. Circulation 2001; 103: 2967-72; PMID: 11413088; http://dx. doi. org/10. 1161/01. CIR. 103. 24. 2967.
    • (2001) Circulation , vol.103 , pp. 2967-2972
    • Sun, J.1    Marx, S.O.2    Chen, H.J.3    Poon, M.4    Marks, A.R.5    Rabbani, L.E.6
  • 111
    • 0029302825 scopus 로고
    • Macrophage cell cycle control by MCSF/CSF-1
    • PMID: 7783343
    • Matsushime H. Macrophage cell cycle control by MCSF/CSF-1. Rinsho Ketsueki 1995; 36: 406-9; PMID: 7783343.
    • (1995) Rinsho Ketsueki , vol.36 , pp. 406-409
    • Matsushime, H.1
  • 112
    • 0034084926 scopus 로고    scopus 로고
    • Overexpression of cyclin D1 is associated with metastatic prostate cancer to bone
    • PMID: 10815912
    • Drobnjak M, Osman I, Scher HI, Fazzari M, Cordon-Cardo C. Overexpression of cyclin D1 is associated with metastatic prostate cancer to bone. Clin Cancer Res 2000; 6: 1891-5; PMID: 10815912.
    • (2000) Clin Cancer Res , vol.6 , pp. 1891-1895
    • Drobnjak, M.1    Osman, I.2    Scher, H.I.3    Fazzari, M.4    Cordon-Cardo, C.5
  • 113
    • 0027229136 scopus 로고
    • Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
    • PMID: 8343202
    • Ewen ME, Sluss HK, Sherr CJ, Matsushime H, Kato J, Livingston DM. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 1993; 73: 487-97; PMID: 8343202; http://dx. doi. org/10. 1016/0092-8674(93)90136-E.
    • (1993) Cell , vol.73 , pp. 487-497
    • Ewen, M.E.1    Sluss, H.K.2    Sherr, C.J.3    Matsushime, H.4    Kato, J.5    Livingston, D.M.6
  • 114
    • 43749108882 scopus 로고    scopus 로고
    • Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration
    • PMID: 18180298
    • Li Z, Wang C, Jiao X, Katiyar S, Casimiro MC, Prendergast GC, Powell MJ, Pestell RG. Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration. J Biol Chem 2008; 283: 7007-15; PMID: 18180298; http://dx. doi. org/10. 1074/jbc. M706992200.
    • (2008) J Biol Chem , vol.283 , pp. 7007-7015
    • Li, Z.1    Wang, C.2    Jiao, X.3    Katiyar, S.4    Casimiro, M.C.5    Prendergast, G.C.6    Powell, M.J.7    Pestell, R.G.8
  • 115
    • 33751250793 scopus 로고    scopus 로고
    • Cyclin D1 functions in cell migration
    • Li Z, Wang C, Prendergast GC, Pestell RG. Cyclin D1 functions in cell migration. Cell Cycle 2006c; 5: 2440-2; http://dx. doi. org/10. 4161/cc. 5. 21. 3428.
    • (2006) Cell Cycle , vol.5 , pp. 2440-2442
    • Li, Z.1    Wang, C.2    Prendergast, G.C.3    Pestell, R.G.4
  • 116
    • 84879377397 scopus 로고    scopus 로고
    • New roles of cyclin D1
    • PMID: 23790801
    • Pestell RG. New roles of cyclin D1. Am J Pathol 2013; 183: 3-9; PMID: 23790801; http://dx. doi. org/10. 1016/j. ajpath. 2013. 03. 001.
    • (2013) Am J Pathol , vol.183 , pp. 3-9
    • Pestell, R.G.1
  • 119
    • 84870178710 scopus 로고    scopus 로고
    • Cyclin A2, Rho GTPases and EMT
    • PMID: 22735340
    • Bendris N, Arsic N, Lemmers B, Blanchard JM. Cyclin A2, Rho GTPases and EMT. Small GTPases 2012; 3: 225-8; PMID: 22735340; http://dx. doi. org/10. 4161/sgtp. 20791.
    • (2012) Small GTPases , vol.3 , pp. 225-228
    • Bendris, N.1    Arsic, N.2    Lemmers, B.3    Blanchard, J.M.4
  • 120
    • 0036201059 scopus 로고    scopus 로고
    • Cyclin A-and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm
    • PMID: 11907280
    • Jackman M, Kubota Y, den Elzen N, Hagting A, Pines J. Cyclin A-and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm. Mol Biol Cell 2002; 13: 1030-45; PMID: 11907280; http://dx. doi. org/10. 1091/mbc. 01-07-0361.
    • (2002) Mol Biol Cell , vol.13 , pp. 1030-1045
    • Jackman, M.1    Kubota, Y.2    den Elzen, N.3    Hagting, A.4    Pines, J.5
  • 121
    • 79960855404 scopus 로고    scopus 로고
    • Cyclin A2 mutagenesis analysis: A new insight into CDK activation and cellular localization requirements
    • Bendris N, Lemmers B, Blanchard JM, Arsic N. Cyclin A2 mutagenesis analysis: a new insight into CDK activation and cellular localization requirements. PLoS One 2011; 6: e22879.
    • (2011) PLoS One , vol.6
    • Bendris, N.1    Lemmers, B.2    Blanchard, J.M.3    Arsic, N.4
  • 122
    • 0344731443 scopus 로고    scopus 로고
    • Anomalous high p27/KIP1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression. p27/KIP1-cyclin D3 colocalization in tumor cells
    • PMID: 10397744
    • Sanchez-Beato M, Camacho FI, Martinez-Montero JC, Saez AI, Villuendas R, Sanchez-Verde L, Garcia JF, Piris MA. Anomalous high p27/KIP1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression. p27/KIP1-cyclin D3 colocalization in tumor cells. Blood 1999; 94: 765-72; PMID: 10397744.
    • (1999) Blood , vol.94 , pp. 765-772
    • Sanchez-Beato, M.1    Camacho, F.I.2    Martinez-Montero, J.C.3    Saez, A.I.4    Villuendas, R.5    Sanchez-Verde, L.6    Garcia, J.F.7    Piris, M.A.8
  • 123
    • 0033214080 scopus 로고    scopus 로고
    • Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27
    • PMID: 10508165
    • Bouchard C, Thieke K, Maier A, Saffrich R, Hanley-Hyde J, Ansorge W, Reed S, Sicinski P, Bartek J, Eilers M. Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27. EMBO J 1999; 18: 5321-33; PMID: 10508165; http://dx. doi. org/10. 1093/emboj/18. 19. 5321.
    • (1999) EMBO J , vol.18 , pp. 5321-5333
    • Bouchard, C.1    Thieke, K.2    Maier, A.3    Saffrich, R.4    Hanley-Hyde, J.5    Ansorge, W.6    Reed, S.7    Sicinski, P.8    Bartek, J.9    Eilers, M.10
  • 124
    • 0033214995 scopus 로고    scopus 로고
    • Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1)
    • PMID: 10508164
    • Perez-Roger I, Kim SH, Griffiths B, Sewing A, Land H. Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1). EMBO J 1999; 18: 5310-20; PMID: 10508164; http://dx. doi. org/10. 1093/emboj/18. 19. 5310.
    • (1999) EMBO J , vol.18 , pp. 5310-5320
    • Perez-Roger, I.1    Kim, S.H.2    Griffiths, B.3    Sewing, A.4    Land, H.5
  • 125
    • 36849077813 scopus 로고    scopus 로고
    • Nm23-H1 expression of metastatic tumors in the lymph nodes is a prognostic indicator of oral squamous cell carcinoma
    • PMID: 17918157
    • Wang YF, Chen JY, Chang SY, Chiu JH, Li WY, Chu PY, Tai SK, Wang LS. Nm23-H1 expression of metastatic tumors in the lymph nodes is a prognostic indicator of oral squamous cell carcinoma. Int J Cancer 2008; 122: 377-86; PMID: 17918157.
    • (2008) Int J Cancer , vol.122 , pp. 377-386
    • Wang, Y.F.1    Chen, J.Y.2    Chang, S.Y.3    Chiu, J.H.4    Li, W.Y.5    Chu, P.Y.6    Tai, S.K.7    Wang, L.S.8
  • 126
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • PMID: 12189386
    • Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2: 442-54; PMID: 12189386; http://dx. doi. org/10. 1038/nrc822.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 127
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumormetastasis
    • PMID: 18539112
    • Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumormetastasis. Dev Cell 2008; 14: 818-29; PMID: 18539112; http://dx. doi. org/10. 1016/j. devcel. 2008. 05. 009.
    • (2008) Dev Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 128
    • 84876451247 scopus 로고    scopus 로고
    • Tumor dissemination: An EMT affair
    • PMID: 23518345
    • Thiery JP, Lim CT. Tumor dissemination: an EMT affair. Cancer Cell 2013; 23: 272-3; PMID: 23518345; http://dx. doi. org/10. 1016/j. ccr. 2013. 03. 004.
    • (2013) Cancer Cell , vol.23 , pp. 272-273
    • Thiery, J.P.1    Lim, C.T.2
  • 130
    • 33750594388 scopus 로고    scopus 로고
    • Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma
    • PMID: 16715134
    • Bellovin DI, Simpson KJ, Danilov T, Maynard E, RimmDL, Oettgen P, MercurioAM. Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma. Oncogene 2006; 25: 6959-67; PMID: 16715134; http://dx. doi. org/10. 1038/sj. onc. 1209682.
    • (2006) Oncogene , vol.25 , pp. 6959-6967
    • Bellovin, D.I.1    Simpson, K.J.2    Danilov, T.3    Maynard, E.4    Rimm, D.L.5    Oettgen, P.6    Mercurio, A.M.7
  • 131
    • 0036488510 scopus 로고    scopus 로고
    • RHO-GTPases and cancer
    • PMID: 12635176
    • Sahai E, Marshall CJ. RHO-GTPases and cancer. Nat Rev Cancer 2002; 2: 133-42; PMID: 12635176; http://dx. doi. org/10. 1038/nrc725.
    • (2002) Nat Rev Cancer , vol.2 , pp. 133-142
    • Sahai, E.1    Marshall, C.J.2
  • 132
    • 24344486013 scopus 로고    scopus 로고
    • RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis
    • PMID: 16107613
    • Hakem A, Sanchez-Sweatman O, You-Ten A, Duncan G, Wakeham A, Khokha R, Mak TW. RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev 2005; 19: 1974-9; PMID: 16107613; http://dx. doi. org/10. 1101/gad. 1310805.
    • (2005) Genes Dev , vol.19 , pp. 1974-1979
    • Hakem, A.1    Sanchez-Sweatman, O.2    You-Ten, A.3    Duncan, G.4    Wakeham, A.5    Khokha, R.6    Mak, T.W.7
  • 134
    • 0035084335 scopus 로고    scopus 로고
    • p120 catenin affects cell motility via modulation of activity of Rho-family GTPases: A link between cell-cell contact formation and regulation of cell locomotion
    • PMID: 11171375
    • Grosheva I, Shtutman M, Elbaum M, Bershadsky AD. p120 catenin affects cell motility via modulation of activity of Rho-family GTPases: a link between cell-cell contact formation and regulation of cell locomotion. J Cell Sci 2001; 114: 695-707; PMID: 11171375.
    • (2001) J Cell Sci , vol.114 , pp. 695-707
    • Grosheva, I.1    Shtutman, M.2    Elbaum, M.3    Bershadsky, A.D.4
  • 135
    • 84900805843 scopus 로고    scopus 로고
    • High-resolution live-cell imaging reveals novel cyclin A2 degradation foci involving autophagy
    • PMID: 24634511
    • Loukil A, Zonca M, Rebouissou C, Baldin V, Coux O, Biard-Piechaczyk M, Blanchard JM, Peter M. High-resolution live-cell imaging reveals novel cyclin A2 degradation foci involving autophagy. J Cell Sci 2014; 127: 2145-50; PMID: 24634511; http://dx. doi. org/10. 1242/jcs. 139188.
    • (2014) J Cell Sci , vol.127 , pp. 2145-2150
    • Loukil, A.1    Zonca, M.2    Rebouissou, C.3    Baldin, V.4    Coux, O.5    Biard-Piechaczyk, M.6    Blanchard, J.M.7    Peter, M.8
  • 136
    • 78649891511 scopus 로고    scopus 로고
    • Balancing biosynthesis and bioenergetics: Metabolic programs in oncogenesis
    • PMID: 20699334
    • Barger JF, Plas DR. Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis. Endocr Relat Cancer 2010; 17: R287-304; PMID: 20699334; http://dx. doi. org/10. 1677/ERC-10-0106.
    • (2010) Endocr Relat Cancer , vol.17 , pp. R287-R304
    • Barger, J.F.1    Plas, D.R.2
  • 137
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • PMID: 22549953
    • Dang CV. Links between metabolism and cancer. Genes Dev 2012; 26: 877-90; PMID: 22549953; http://dx. doi. org/10. 1101/gad. 189365. 112.
    • (2012) Genes Dev , vol.26 , pp. 877-890
    • Dang, C.V.1
  • 138
    • 84858414020 scopus 로고    scopus 로고
    • Cellular metabolism and disease: What do metabolic outliers teach us?
    • PMID: 22424225
    • DeBerardinis RJ, Thompson CB. Cellular metabolism and disease: what do metabolic outliers teach us? Cell 2012; 148: 1132-44; PMID: 22424225; http://dx. doi. org/10. 1016/j. cell. 2012. 02. 032.
    • (2012) Cell , vol.148 , pp. 1132-1144
    • DeBerardinis, R.J.1    Thompson, C.B.2
  • 139
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
    • PMID: 22439925
    • Ward PS, Thompson CB. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012; 21: 297-308; PMID: 22439925; http://dx. doi. org/10. 1016/j. ccr. 2012. 02. 014.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 140
    • 33745684527 scopus 로고    scopus 로고
    • Metastasis: A question of life or death
    • PMID: 16723991
    • Mehlen P, Puisieux A. Metastasis: a question of life or death. Nat Rev Cancer 2006; 6: 449-58; PMID: 16723991; http://dx. doi. org/10. 1038/nrc1886.
    • (2006) Nat Rev Cancer , vol.6 , pp. 449-458
    • Mehlen, P.1    Puisieux, A.2
  • 141
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • PMID: 16493418
    • Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 2006; 7: 131-42; PMID: 16493418; http://dx. doi. org/10. 1038/nrm1835.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2


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