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Volumn 8, Issue 21, 2009, Pages 3455-3461

p27 as Jekyll and Hyde: Regulation of cell cycle and cell motility

Author keywords

CDK inhibition; Cell cycle; Cell motility; Metastasis; mTOR; p27; Phosphorylation; PI3K; PKB; RhoA; RSK; SGK

Indexed keywords

ACTIN; CYCLIN DEPENDENT KINASE 2; CYCLIN E; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN P27; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; THREONINE;

EID: 70449710913     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.21.9789     Document Type: Review
Times cited : (110)

References (84)
  • 2
    • 0027318843 scopus 로고
    • Negative regulation of G1 in mammalian cells: Inhibition of cyclin E-dependent kinase by TGF-beta
    • Koff A, Ohtsuki M, Polyak K, Roberts JM, Massague J. Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta. Science 1993; 260:536-539 (Pubitemid 23161617)
    • (1993) Science , vol.260 , Issue.5107 , pp. 536-539
    • Koff, A.1    Ohtsuki, M.2    Polyak, K.3    Roberts, J.M.4    Massague, J.5
  • 3
    • 0028176483 scopus 로고
    • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • DOI 10.1016/0092-8674(94)90572-X
    • Polyak K, Lee MH, Erdjument-romage H, Koff A, Roberts J, Tempst P, et al. Cloning of p27KIP1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 1994; 78:59-66. (Pubitemid 2117026)
    • (1994) Cell , vol.78 , Issue.1 , pp. 59-66
    • Polyak, K.1    Lee Mong, H.2    Erdjument-Bromage, H.3    Koff, A.4    Roberts, J.M.5    Tempst, P.6    Massague, J.7
  • 5
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr CJ , Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999; 13:1501-1512
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 6
    • 34548268220 scopus 로고    scopus 로고
    • Regulation of p27Kip1 by miRNA 221/222 in Gliobastoma
    • Gillies JK , Lorimer IAJ. Regulation of p27Kip1 by miRNA 221/222 in Gliobastoma. Cell Cycle 2007; 6:2005-2009
    • (2007) Cell Cycle , vol.6 , pp. 2005-2009
    • Gillies, J.K.1    Lorimer, I.A.J.2
  • 7
    • 0041308069 scopus 로고    scopus 로고
    • Cell cycle-dependent translation of p27 involves a responsive element in its 5′-UTR that overlaps with a uORF
    • DOI 10.1093/hmg/ddg177
    • Gopfert U, Kullmann M, Hengst L. Cell cycle-dependent translation of p27 involves a responsive element in its 5′-UTR that overlaps with a uORF. Hum Mol Genet 2003; 12:1767-1779 (Pubitemid 36896668)
    • (2003) Human Molecular Genetics , vol.12 , Issue.14 , pp. 1767-1779
    • Gopfert, U.1    Kullmann, M.2    Hengst, L.3
  • 8
    • 0029670477 scopus 로고    scopus 로고
    • Translational control of p27Kip1 accumulation during the cell cycle
    • Hengst L , Reed SI. Translational control of p27Kip1 accumulation during the cell cycle. Science 1996; 271:1861-1864 (Pubitemid 3040861)
    • (1996) Science , vol.271 , Issue.5257 , pp. 1861-1864
    • Hengst, L.1    Reed, S.I.2
  • 9
    • 34547791273 scopus 로고    scopus 로고
    • Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation
    • le Sage C, Nagel R, Egan DA, Schrier M, Mesman E, Mangiola A, et al. Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J 2007; 26:3699-3708
    • (2007) EMBO J , vol.26 , pp. 3699-3708
    • Le Sage, C.1    Nagel, R.2    Egan, D.A.3    Schrier, M.4    Mesman, E.5    Mangiola, A.6
  • 10
    • 15144357686 scopus 로고    scopus 로고
    • Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest
    • DOI 10.1074/jbc.272.11.7093
    • Millard SS, Yan JS, Nguyen H, Pagano M, Kiyokawa H, Koff A. Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest. J Biol Chem 1997; 272:7093-7098 (Pubitemid 27166413)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.11 , pp. 7093-7098
    • Millard, S.S.1    Yan, J.S.2    Nguyen, H.3    Pagano, M.4    Kiyokawa, H.5    Koff, A.6
  • 11
    • 0029024015 scopus 로고
    • Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
    • Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, Chau V, et al. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 1995; 269:682-685
    • (1995) Science , vol.269 , pp. 682-685
    • Pagano, M.1    Tam, S.W.2    Theodoras, A.M.3    Beer-Romero, P.4    Del Sal, G.5    Chau, V.6
  • 12
    • 33646345376 scopus 로고    scopus 로고
    • Ubiquitin ligases: Cell-cycle control and cancer
    • Nakayama KI , Nakayama K. Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer 2006; 6:369-381
    • (2006) Nat Rev Cancer , vol.6 , pp. 369-381
    • Nakayama, K.I.1    Nakayama, K.2
  • 13
    • 41149150219 scopus 로고    scopus 로고
    • The Cdk inhibitor p27 in human cancer: Prognostic potential and relevance to anticancer therapy
    • Chu IM, Hengst L, Slingerland JM. The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat Rev Cancer 2008; 8:253-267
    • (2008) Nat Rev Cancer , vol.8 , pp. 253-267
    • Chu, I.M.1    Hengst, L.2    Slingerland, J.M.3
  • 14
    • 0033559264 scopus 로고    scopus 로고
    • The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
    • Cheng M, Olivier P, Diehl JA, Fero M, Roussel MF, Roberts JM, et al. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J 1999; 18:1571-1583
    • (1999) EMBO J , vol.18 , pp. 1571-1583
    • Cheng, M.1    Olivier, P.2    Diehl, J.A.3    Fero, M.4    Roussel, M.F.5    Roberts, J.M.6
  • 16
    • 0028169236 scopus 로고
    • P21-containing cyclin kinases exist in both active and inactive states
    • Zhang H, Hannon G, Beach D. p21-containing cyclin kinases exist in both active and inactive states. Genes Dev 1994; 8:1750-1758 (Pubitemid 2126572)
    • (1994) Genes and Development , vol.8 , Issue.15 , pp. 1750-1758
    • Zhang, H.1    Hannon, G.J.2    Beach, D.3
  • 17
    • 0028228907 scopus 로고
    • Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein
    • Bates S, Parry D, Bonetta L, Vousden K, Dickson C, Peters G. Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein. Oncogene 1994; 9:1633-1640 (Pubitemid 24163389)
    • (1994) Oncogene , vol.9 , Issue.6 , pp. 1633-1640
    • Bates, S.1    Parry, D.2    Bonetta, L.3    Vousden, K.4    Dickson, C.5    Peters, G.6
  • 18
    • 0028869884 scopus 로고
    • Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product
    • Parry D, Bates S, Mann DJ, Peters G. Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product. EMBO J 1995; 14:503-511
    • (1995) EMBO J , vol.14 , pp. 503-511
    • Parry, D.1    Bates, S.2    Mann, D.J.3    Peters, G.4
  • 19
    • 0036238894 scopus 로고    scopus 로고
    • Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest
    • Ciarallo S, Subramaniam V, Hung W, Lee JH, Kotchetkov R, Sandhu C, et al. Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest. Mol Cell Biol 2002; 22:2993-3002.
    • (2002) Mol Cell Biol , vol.22 , pp. 2993-3002
    • Ciarallo, S.1    Subramaniam, V.2    Hung, W.3    Lee, J.H.4    Kotchetkov, R.5    Sandhu, C.6
  • 20
    • 0141529760 scopus 로고    scopus 로고
    • p27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes
    • Bagui TK, Mohapatra S, Haura E, Pledger WJ. p27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes. Mol Cell Biol 2003; 23:7285-7290
    • (2003) Mol Cell Biol , vol.23 , pp. 7285-7290
    • Bagui, T.K.1    Mohapatra, S.2    Haura, E.3    Pledger, W.J.4
  • 21
    • 53549126089 scopus 로고    scopus 로고
    • Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4
    • Larrea MD, Liang J, Da ST, Hong F, Shao SH, Han K, et al. Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4. Mol Cell Biol 2008; 28:6462-6472
    • (2008) Mol Cell Biol , vol.28 , pp. 6462-6472
    • Larrea, M.D.1    Liang, J.2    Da, S.T.3    Hong, F.4    Shao, S.H.5    Han, K.6
  • 22
    • 37549061066 scopus 로고    scopus 로고
    • Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity
    • James M, Ray A, Leznova D, Blain SW. Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity. Mol Cell Biol 2007; 28:498-510.
    • (2007) Mol Cell Biol , vol.28 , pp. 498-510
    • James, M.1    Ray, A.2    Leznova, D.3    Blain, S.W.4
  • 24
    • 0035798683 scopus 로고    scopus 로고
    • Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells
    • Donovan JC, Milic A, Slingerland JM. Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells. J Biol Chem 2001; 276:40888-40895
    • (2001) J Biol Chem , vol.276 , pp. 40888-40895
    • Donovan, J.C.1    Milic, A.2    Slingerland, J.M.3
  • 25
    • 0030863161 scopus 로고    scopus 로고
    • Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway
    • Kawada M, Yamagoe S, Murakami Y, Suzuki K, Mizuno S, Uehara Y. Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway. Oncogene 1997; 15:629-637 (Pubitemid 27389926)
    • (1997) Oncogene , vol.15 , Issue.6 , pp. 629-637
    • Kawada, M.1    Yamagoe, S.2    Murakami, Y.3    Suzuki, K.4    Mizuno, S.5    Uehara, Y.6
  • 26
    • 0034637527 scopus 로고    scopus 로고
    • Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27
    • Yang HY, Zhou BP, Hung MC, Lee MH. Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27. J Biol Chem 2000; 275:24735-24739
    • (2000) J Biol Chem , vol.275 , pp. 24735-24739
    • Yang, H.Y.1    Zhou, B.P.2    Hung, M.C.3    Lee, M.H.4
  • 27
    • 0033996361 scopus 로고    scopus 로고
    • ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: Receptor overexpression does not determine growth dependency
    • Lane HA, Beuvink I, Motoyama AB, Daly JM, Neve RM, Hynes NE. ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency. Mol Cell Biol 2000; 20:3210-3223
    • (2000) Mol Cell Biol , vol.20 , pp. 3210-3223
    • Lane, H.A.1    Beuvink, I.2    Motoyama, A.B.3    Daly, J.M.4    Neve, R.M.5    Hynes, N.E.6
  • 28
    • 0032477854 scopus 로고    scopus 로고
    • Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
    • Cheng M, Sexl V, Sherr CJ, Roussel MF. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1). Proc Natl Acad Sci USA 1998; 95:1091-1096
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 1091-1096
    • Cheng, M.1    Sexl, V.2    Sherr, C.J.3    Roussel, M.F.4
  • 29
    • 0034653608 scopus 로고    scopus 로고
    • The PI3K-PDK1 connection: More than just a road to PKB
    • Vanhaesebroeck B , Alessi DR. The PI3K-PDK1 connection: more than just a road to PKB. Biochem J 2000; 346:561-576
    • (2000) Biochem J , vol.346 , pp. 561-576
    • Vanhaesebroeck, B.1    Alessi, D.R.2
  • 31
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco I , Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2:489-501. (Pubitemid 37328931)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 33
    • 0036799377 scopus 로고    scopus 로고
    • Kip1 at threonine 157 and modulation of its cellular localization
    • DOI 10.1038/nm759
    • Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, et al. PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med 2002; 8:1145-1152 (Pubitemid 35175970)
    • (2002) Nature Medicine , vol.8 , Issue.10 , pp. 1145-1152
    • Shin, I.1    Yakes, F.M.2    Rojo, F.3    Shin, N.-Y.4    Bakin, A.V.5    Baselga, J.6    Arteaga, C.L.7
  • 35
    • 3142512358 scopus 로고    scopus 로고
    • 14-3-3 Suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)
    • Sekimoto T, Fukumoto M, Yoneda Y. 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J 2004; 23:1934-1942.
    • (2004) EMBO J , vol.23 , pp. 1934-1942
    • Sekimoto, T.1    Fukumoto, M.2    Yoneda, Y.3
  • 36
    • 44949201143 scopus 로고    scopus 로고
    • MTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation
    • DOI 10.1016/j.molcel.2008.04.027, PII S1097276508003377
    • Hong F, Larrea MD, Doughty C, Kwiatkowski DJ, Squillace R, Slingerland JM. mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol Cell 2008; 30:701-711 (Pubitemid 351815130)
    • (2008) Molecular Cell , vol.30 , Issue.6 , pp. 701-711
    • Hong, F.1    Larrea, M.D.2    Doughty, C.3    Kwiatkowski, D.J.4    Squillace, R.5    Slingerland, J.M.6
  • 37
  • 38
    • 1542677089 scopus 로고    scopus 로고
    • Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization
    • Fujita N, Sato S, Tsuruo T. Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization. J Biol Chem 2003; 278:49254-49260
    • (2003) J Biol Chem , vol.278 , pp. 49254-49260
    • Fujita, N.1    Sato, S.2    Tsuruo, T.3
  • 39
    • 0036712741 scopus 로고    scopus 로고
    • TSC1-TSC2: A complex tale of PKB-mediated S6K regulation
    • McManus EJ , Alessi DR. TSC1-TSC2: a complex tale of PKB-mediated S6K regulation. Nat Cell Biol 2002; 4:E214-E216.
    • (2002) Nat Cell Biol , vol.4
    • McManus, E.J.1    Alessi, D.R.2
  • 40
    • 0037137380 scopus 로고    scopus 로고
    • Growth Signaling: TSC Takes Its Place
    • Marygold SJ , Leevers SJ. Growth Signaling: TSC Takes Its Place. Curr Biol 2002; 12:R785-R787.
    • (2002) Curr Biol , vol.12
    • Marygold, S.J.1    Leevers, S.J.2
  • 41
    • 0032560521 scopus 로고    scopus 로고
    • Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
    • Scott PH, Brunn GJ, Kohn AD, Roth RA, Lawrence JC, Jr. Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc Natl Acad Sci USA 1998; 95:7772-7777
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7772-7777
    • Scott, P.H.1    Brunn, G.J.2    Kohn, A.D.3    Roth, R.A.4    Lawrence Jr., J.C.5
  • 42
    • 0033429554 scopus 로고    scopus 로고
    • Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
    • Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR. Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J 1999; 344:427-431
    • (1999) Biochem J , vol.344 , pp. 427-431
    • Nave, B.T.1    Ouwens, M.2    Withers, D.J.3    Alessi, D.R.4    Shepherd, P.R.5
  • 43
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T , Hall MN. TOR, a central controller of cell growth. Cell 2000; 103:253-262
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 44
    • 0035803593 scopus 로고    scopus 로고
    • P27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis
    • DOI 10.1093/emboj/20.23.6672
    • Rodier G, Montagnoli A, Di Marcotullio L, Coulombe P, Draetta GF, Pagano M, et al. p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J 2001; 20:6672-6682 (Pubitemid 33134197)
    • (2001) EMBO Journal , vol.20 , Issue.23 , pp. 6672-6682
    • Rodier, G.1    Montagnoli, A.2    Di Marcotullio, L.3    Coulombe, P.4    Draetta, G.F.5    Pagano, M.6    Meloche, S.7
  • 47
    • 33846268807 scopus 로고    scopus 로고
    • p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2
    • Chu I, Sun J, Arnaout A, Kahn H, Hanna W, Narod S, et al. p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell 2007; 128:281-294
    • (2007) Cell , vol.128 , pp. 281-294
    • Chu, I.1    Sun, J.2    Arnaout, A.3    Kahn, H.4    Hanna, W.5    Narod, S.6
  • 48
    • 0030847760 scopus 로고    scopus 로고
    • Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
    • Vlach J, Hennecke S, Amati B. Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J 1997; 16:5334-5344
    • (1997) EMBO J , vol.16 , pp. 5334-5344
    • Vlach, J.1    Hennecke, S.2    Amati, B.3
  • 51
    • 33947250696 scopus 로고    scopus 로고
    • The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
    • Liang J, Shao SH, Xu Z, Hennessy B, Ding Z, Larrea M, et al. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 2007; 9:218-224
    • (2007) Nat Cell Biol , vol.9 , pp. 218-224
    • Liang, J.1    Shao, S.H.2    Xu, Z.3    Hennessy, B.4    Ding, Z.5    Larrea, M.6
  • 54
    • 0032980308 scopus 로고    scopus 로고
    • The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer
    • DOI 10.1146/annurev.med.50.1.401
    • Tsihlias J, Kapusta L, Slingerland J. The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. Annu Rev Med 1999; 50:401-423 (Pubitemid 29117075)
    • (1999) Annual Review of Medicine , vol.50 , pp. 401-423
    • Tsihlias, J.1    Kapusta, L.2    Slingerland, J.3
  • 56
    • 0031048236 scopus 로고    scopus 로고
    • Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
    • DOI 10.1038/nm0297-231
    • Loda M, Cukor B, Tam SW, Lavin P, Fiorentino M, Draetta GF, et al. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med 1997; 3:231-234 (Pubitemid 27064711)
    • (1997) Nature Medicine , vol.3 , Issue.2 , pp. 231-234
    • Loda, M.1    Cukor, B.2    Tam, S.W.3    Lavin, P.4    Fiorentino, M.5    Draetta, G.F.6    Milburn Jessup, J.7    Pagano, M.8
  • 58
    • 0034092911 scopus 로고    scopus 로고
    • Regulation of the Cdk inhibitor p27 and its deregulation in cancer
    • DOI 10.1002/(SICI)1097-4652(200004)183:1<10::AID-JCP2>3.0.CO;2-I
    • Slingerland J , Pagano M. Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol 2000; 183:10-17 (Pubitemid 30130220)
    • (2000) Journal of Cellular Physiology , vol.183 , Issue.1 , pp. 10-17
    • Slingerland, J.1    Pagano, M.2
  • 59
    • 37249079598 scopus 로고    scopus 로고
    • Kip1 function: MiRNAs come into play
    • le Sage C, Nagel R, Agami R. Diverse ways to control p27(Kip1) function: miRNAs come into play. Cell Cycle 2007; 6:2742-2749 (Pubitemid 350277164)
    • (2007) Cell Cycle , vol.6 , Issue.22 , pp. 2742-2749
    • Le Sage, C.1    Nagel, R.2    Agami, R.3
  • 66
    • 0344731443 scopus 로고    scopus 로고
    • Anomalous high p27/KIP1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression. p27/KIP1 - Cyclin D3 colocalization in tumor cells
    • Sanchez-Beato M, Camacho FI, Martinez-Montero JC, Saez AI, Villuendas R, Sanchez-Verde L, et al. Anomalous high p27/KIP1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression. p27/KIP1-cyclin D3 colocalization in tumor cells. Blood 1999; 94:765-772 (Pubitemid 29323891)
    • (1999) Blood , vol.94 , Issue.2 , pp. 765-772
    • Sanchez-Beato, M.1    Camacho, F.I.2    Martinez-Montero, J.C.3    Saez, A.I.4    Villuendas, R.5    Sanchez-Verde, L.6    Garcia, J.F.7    Piris, M.A.8
  • 68
    • 0033214995 scopus 로고    scopus 로고
    • Cyclins D1 and D2 mediate Myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1)
    • DOI 10.1093/emboj/18.19.5310
    • Perez-Roger I, Kim SH, Griffiths B, Sweing A, Land H. Cyclins D1 and D2 mediate Myc-induced proliferation via sequestration of p27Kip1 and p21 Cip1. EMBO J 1999; 18:5310-5320 (Pubitemid 29465581)
    • (1999) EMBO Journal , vol.18 , Issue.19 , pp. 5310-5320
    • Perez-Roger, I.1    Kim, S.-H.2    Griffiths, B.3    Sewing, A.4    Land, H.5
  • 71
    • 35148901042 scopus 로고    scopus 로고
    • Relocalized p27(KiP1) tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma
    • Denicourt C, Saenz CC, Datnow B, Cui XS, Dowdy SF. Relocalized p27(KiP1) tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma. Cancer Res 2007; 67:9238-9243
    • (2007) Cancer Res , vol.67 , pp. 9238-9243
    • Denicourt, C.1    Saenz, C.C.2    Datnow, B.3    Cui, X.S.4    Dowdy, S.F.5
  • 72
    • 10044244277 scopus 로고    scopus 로고
    • Akt-Dependent T198 Phosphorylation of Cyclin-Dependent Kinase Inhibitor p27(kip1) in Breast Cancer
    • Motti ML, De Marco C, Califano D, Fusco A, Viglietto G. Akt-Dependent T198 Phosphorylation of Cyclin-Dependent Kinase Inhibitor p27(kip1) in Breast Cancer. Cell Cycle 2004; 3:e89-e95.
    • (2004) Cell Cycle , vol.3
    • Motti, M.L.1    De Marco, C.2    Califano, D.3    Fusco, A.4    Viglietto, G.5
  • 73
    • 3442890875 scopus 로고    scopus 로고
    • Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia
    • Min YH, Cheong JW, Kim JY, Eom JI, Lee ST, Hahn JS, et al. Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia. Cancer Res 2004; 64:5225-5231
    • (2004) Cancer Res , vol.64 , pp. 5225-5231
    • Min, Y.H.1    Cheong, J.W.2    Kim, J.Y.3    Eom, J.I.4    Lee, S.T.5    Hahn, J.S.6
  • 74
    • 3242806804 scopus 로고    scopus 로고
    • Prognostic significance of localized p27Kip1 and potential role of Jab1/CSN5 in pancreatic cancer
    • Fukumoto A, Ikeda N, Sho M, Tomoda K, Kanehiro H, Hisanaga M, et al. Prognostic significance of localized p27Kip1 and potential role of Jab1/CSN5 in pancreatic cancer. Oncol Rep 2004; 11:277-284
    • (2004) Oncol Rep , vol.11 , pp. 277-284
    • Fukumoto, A.1    Ikeda, N.2    Sho, M.3    Tomoda, K.4    Kanehiro, H.5    Hisanaga, M.6
  • 76
    • 0034644537 scopus 로고    scopus 로고
    • Ras and Rho GTPases: A family reunion
    • Bar-Sagi D , Hall A. Ras and Rho GTPases: A family reunion. Cell 2000; 103:227-238
    • (2000) Cell , vol.103 , pp. 227-238
    • Bar-Sagi, D.1    Hall, A.2
  • 77
    • 10344262906 scopus 로고    scopus 로고
    • Regulation of the cytoskeleton: An oncogenic function for CDK inhibitors?
    • Besson A, Assoian RK, Roberts JM. Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors? Nat Rev Cancer 2004; 4:948-955
    • (2004) Nat Rev Cancer , vol.4 , pp. 948-955
    • Besson, A.1    Assoian, R.K.2    Roberts, J.M.3
  • 78
    • 0347717882 scopus 로고    scopus 로고
    • Cip1 Is Involved in Ras-induced Inhibition of the ROCK/LIMK/Cofilin Pathway
    • DOI 10.1074/jbc.M306968200
    • Lee S, Helfman DM. Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway. J Biol Chem 2004; 279:1885-1891 (Pubitemid 38084458)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.3 , pp. 1885-1891
    • Lee, S.1    Helfman, D.M.2
  • 80
    • 0031759170 scopus 로고    scopus 로고
    • Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration
    • Nagahara H, Vocero-Akbani AM, Synder EL, Ho A, Latham DG, Lissy NA, et al. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat Med 1998; 4:1449-1452
    • (1998) Nat Med , vol.4 , pp. 1449-1452
    • Nagahara, H.1    Vocero-Akbani, A.M.2    Synder, E.L.3    Ho, A.4    Latham, D.G.5    Lissy, N.A.6
  • 81
    • 0037216528 scopus 로고    scopus 로고
    • kip1 C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions
    • DOI 10.1128/MCB.23.1.216-228.2003
    • McAllister SS, Becker-Hapak M, Pintucci G, Pagano M, Dowdy SF. Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions. Mol Cell Biol 2003; 23:216-228 (Pubitemid 36008515)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.1 , pp. 216-228
    • McAllister, S.S.1    Becker-Hapak, M.2    Pintucci, G.3    Pagano, M.4    Dowdy, S.F.5
  • 82
    • 1942466518 scopus 로고    scopus 로고
    • p27Kip1 modulates cell migration through the regulation of RhoA activation
    • Besson A, Gurian-West M, Schmidt A, Hall A, Roberts JM. p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 2004; 18:862-876
    • (2004) Genes Dev , vol.18 , pp. 862-876
    • Besson, A.1    Gurian-West, M.2    Schmidt, A.3    Hall, A.4    Roberts, J.M.5
  • 83
    • 33644509197 scopus 로고    scopus 로고
    • Kip1 inhibits cancer cell motility, survival, and tumorigenicity
    • DOI 10.1158/0008-5472.CAN-05-3304
    • Wu FY, Wang SE, Sanders ME, Shin I, Rojo F, Baselga J, et al. Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity. Cancer Res 2006; 66:2162-2172 (Pubitemid 43294926)
    • (2006) Cancer Research , vol.66 , Issue.4 , pp. 2162-2172
    • Wu, F.Y.1    Wang, S.E.2    Sanders, M.E.3    Shin, I.4    Rojo, F.5    Baselga, J.6    Arteaga, C.L.7


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