-
1
-
-
0001510491
-
The Rb and p53 pathways in cancer
-
Sherr, C. J. & McCormick, F. The Rb and p53 pathways in cancer. Cancer Cell 2, 103-112 (2002).
-
(2002)
Cancer Cell
, vol.2
, pp. 103-112
-
-
Sherr, C.J.1
McCormick, F.2
-
2
-
-
0344305784
-
Cell migration: Integrating signals from front to back
-
Ridley, A. J. et al. Cell migration: integrating signals from front to back. Science 302, 1704-1709 (2003).
-
(2003)
Science
, vol.302
, pp. 1704-1709
-
-
Ridley, A.J.1
-
3
-
-
0033564697
-
CDK inhibitors: Positive and negative regulators of G1-phase progression
-
Sherr, C. J. & Roberts, J. M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13, 1501-1512 (2001).
-
(2001)
Genes Dev.
, vol.13
, pp. 1501-1512
-
-
Sherr, C.J.1
Roberts, J.M.2
-
4
-
-
0028176483
-
Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
-
Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78, 59-66 (1994).
-
(1994)
Cell
, vol.78
, pp. 59-66
-
-
Polyak, K.1
-
6
-
-
15844384256
-
Kip1-deficient mice
-
Kip1-deficient mice. Cell 85, 733-744 (1996).
-
(1996)
Cell
, vol.85
, pp. 733-744
-
-
Fero, M.L.1
-
8
-
-
0037325853
-
Deregulated degradation of the CDK inhibitor p27 and malignant transformation
-
Bloom, J. & Pagano, M. Deregulated degradation of the CDK inhibitor p27 and malignant transformation. Semin. Cancer Biol. 13, 41-47 (2003).
-
(2003)
Semin. Cancer Biol.
, vol.13
, pp. 41-47
-
-
Bloom, J.1
Pagano, M.2
-
9
-
-
0034092911
-
Regulation of the CDK inhibitor p27 and its deregulation in cancer
-
Slingerland, J. & Pagano, M. Regulation of the CDK inhibitor p27 and its deregulation in cancer. J. Cell. Physiol. 183, 10-17 (2000).
-
(2000)
J. Cell. Physiol.
, vol.183
, pp. 10-17
-
-
Slingerland, J.1
Pagano, M.2
-
10
-
-
0035835828
-
Kip1: Regulation and function of a haploinsuffident tumor suppressor and its misregulation in cancer
-
Kip1: regulation and function of a haploinsuffident tumor suppressor and its misregulation in cancer. Exp. Cell Res. 264, 148-168 (2001).
-
(2001)
Exp. Cell Res.
, vol.264
, pp. 148-168
-
-
Philipp-Staheli, J.1
Payne, S.R.2
Kemp, C.J.3
-
11
-
-
0028986932
-
Kip1: Chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors
-
Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors. Cancer Res. 55, 1211-1214 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 1211-1214
-
-
Ponce-Castaneda, M.1
-
12
-
-
18644376449
-
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
-
Liang, J. et al. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nature Med. 8, 1153-1160 (2002).
-
(2002)
Nature Med.
, vol.8
, pp. 1153-1160
-
-
Liang, J.1
-
14
-
-
0032438868
-
Kip1, cyclin E and c-myc expression with progression and prognosis in HPV-positive cervical neoplasms
-
Kip1, cyclin E and c-myc expression with progression and prognosis in HPV-positive cervical neoplasms. Anticancer Res. 18, 3991-3998 (1998).
-
(1998)
Anticancer Res.
, vol.18
, pp. 3991-3998
-
-
Dellas, A.1
Schultheiss, E.2
Leivas, M.R.3
Moch, H.4
Torhorst, J.5
-
15
-
-
0031839322
-
Kip1 in chronic B-cell lymphocytic leukemia
-
Kip1 in chronic B-cell lymphocytic leukemia. Blood 91, 4694-4700 (1998).
-
(1998)
Blood
, vol.91
, pp. 4694-4700
-
-
Vrhovac, R.1
-
16
-
-
0032589191
-
Kip1 is abnormally expressed in diffuse large B-cell lymphomas and is associated with an adverse clinical outcome
-
Kip1 is abnormally expressed in diffuse large B-cell lymphomas and is associated with an adverse clinical outcome. Br. J. Cancer 80, 1427-1434 (1999).
-
(1999)
Br. J. Cancer
, vol.80
, pp. 1427-1434
-
-
Saez, A.1
-
17
-
-
0344731443
-
Kip1-cyclin D3 colocalization in tumor cells
-
Kip1-cyclin D3 colocalization in tumor cells. Blood 94, 765-772 (1999).
-
(1999)
Blood
, vol.94
, pp. 765-772
-
-
Sanchez-Beato, M.1
-
18
-
-
0035892762
-
Kip1 in normal squamous epithelium, cervical intraepithelial neoplasia, and invasive squamous cell carcinoma of the uterine cervix
-
Kip1 in normal squamous epithelium, cervical intraepithelial neoplasia, and invasive squamous cell carcinoma of the uterine cervix. Cancer 92, 3005-3011 (2001).
-
(2001)
Cancer
, vol.92
, pp. 3005-3011
-
-
Shiozawa, T.1
-
19
-
-
0036569518
-
High expression levels of p27 correlate with lymph node status in a subset of advanced invasive breast carcinomas
-
Kouvaraki, M. et al. High expression levels of p27 correlate with lymph node status in a subset of advanced invasive breast carcinomas. Cancer 94, 2454-2465 (2002).
-
(2002)
Cancer
, vol.94
, pp. 2454-2465
-
-
Kouvaraki, M.1
-
20
-
-
18544367664
-
Paradoxical expression of cell cycle inhibitor p27 in endometrioid adenocarcinomas of the uterine corpus with proliferation and clinicopathological parameters
-
Watanabe, J. et al. Paradoxical expression of cell cycle inhibitor p27 in endometrioid adenocarcinomas of the uterine corpus with proliferation and clinicopathological parameters. Br. J. Cancer 87, 81-85 (2002).
-
(2002)
Br. J. Cancer
, vol.87
, pp. 81-85
-
-
Watanabe, J.1
-
21
-
-
0037216528
-
kip1 C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions
-
kip1 C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions. Mol. Cell. Biol. 23, 216-228 (2003). Overexpression of p27 induces cell scattering, independently of its ability to bind the cyclin-CDK complex. Hepatocyte growth factor (HGF) stimulation induced p27 phosphorylation on Ser10 and its cytoplasmic translocation, which was required for cell scattering.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 216-228
-
-
McAllister, S.S.1
Becker-Hapak, M.2
Pintucci, G.3
Pagano, M.4
Dowdy, S.5
-
22
-
-
0029417238
-
Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo
-
Blangy, A. et al. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell 83, 1159-1169 (1995).
-
(1995)
Cell
, vol.83
, pp. 1159-1169
-
-
Blangy, A.1
-
23
-
-
0242300176
-
Targets of the cyclin-dependent kinase Cdk1
-
Ubersax, J. et al. Targets of the cyclin-dependent kinase Cdk1. Nature 425, 859-864 (2003).
-
(2003)
Nature
, vol.425
, pp. 859-864
-
-
Ubersax, J.1
-
24
-
-
0026078926
-
Phosphorylation of non-muscle caldesmon by p34cdc2 kinase during mitosis
-
Yamashiro, S., Yamakita, Y., Hosoya, H. & Matsumura, F. Phosphorylation of non-muscle caldesmon by p34cdc2 kinase during mitosis. Nature 349, 169-172 (1991).
-
(1991)
Nature
, vol.349
, pp. 169-172
-
-
Yamashiro, S.1
Yamakita, Y.2
Hosoya, H.3
Matsumura, F.4
-
25
-
-
0347917093
-
Cell-cycle targeted therapies
-
Swanton, C. Cell-cycle targeted therapies. Lancet Oncol 5, 27-36 (2004).
-
(2004)
Lancet Oncol
, vol.5
, pp. 27-36
-
-
Swanton, C.1
-
26
-
-
0037042177
-
Waf1/Cip1/Sdi1: Association with cell senescence and tumour promoting activities of stromal fibroblasts
-
Waf1/Cip1/Sdi1: association with cell senescence and tumour promoting activities of stromal fibroblasts. Cancer Left. 179, 1-14 (2002).
-
(2002)
Cancer Left.
, vol.179
, pp. 1-14
-
-
Roninson, I.1
-
27
-
-
0842281652
-
Rho and Rac take the center stage
-
Burridge, K. & Wennerberg, K. Rho and Rac take the center stage. Cell 116, 167-179 (2004).
-
(2004)
Cell
, vol.116
, pp. 167-179
-
-
Burridge, K.1
Wennerberg, K.2
-
28
-
-
0037069690
-
Rho GTPases in cell biology
-
Etienne-Manneville, S. & Hall, A. Rho GTPases in cell biology. Nature 420, 629-635 (2002).
-
(2002)
Nature
, vol.420
, pp. 629-635
-
-
Etienne-Manneville, S.1
Hall, A.2
-
29
-
-
0032541613
-
Rho family proteins and Ras transformation: The RHOad less traveled gets congested
-
Zohn, I. M., Campbell, S. L., Khosravi-Far, R., Rossman, K. L. & Der, C. J. Rho family proteins and Ras transformation: the RHOad less traveled gets congested. Oncogene 17, 1415-1438 (1998).
-
(1998)
Oncogene
, vol.17
, pp. 1415-1438
-
-
Zohn, I.M.1
Campbell, S.L.2
Khosravi-Far, R.3
Rossman, K.L.4
Der, C.J.5
-
32
-
-
0034738482
-
A growing role for Rho family GTPases as intermediaries in growth factor- and adhesion-dependent cell cycle progression
-
Welsh, C. F. & Assoian, R. K. A growing role for Rho family GTPases as intermediaries in growth factor- and adhesion-dependent cell cycle progression. Biochim. Biophys. Acta 1471, M21-29 (2000).
-
(2000)
Biochim. Biophys. Acta
, vol.1471
-
-
Welsh, C.F.1
Assoian, R.K.2
-
33
-
-
0033848878
-
Integrating the MAP kinase signal into the G1 phase cell cycle machinery
-
Roovers, K. & Assoian, R. K. Integrating the MAP kinase signal into the G1 phase cell cycle machinery. Bioessays 22, 818-826 (2000).
-
(2000)
Bioessays
, vol.22
, pp. 818-826
-
-
Roovers, K.1
Assoian, R.K.2
-
34
-
-
0034886701
-
1 phase of the cell cycle
-
1 phase of the cell cycle. Mol. Cell 8, 115-127 (2001).
-
(2001)
Mol. Cell
, vol.8
, pp. 115-127
-
-
Mettouchi, A.1
-
35
-
-
0041440180
-
Nuclear translocation of LIM kinase mediates Rho-Rho kinase regulation of cyclin D1 expression
-
Roovers, K., Klein, E. A., Castagnino, P. & Assoian, R. K. Nuclear translocation of LIM kinase mediates Rho-Rho kinase regulation of cyclin D1 expression. Dev. Cell 5, 273-64 (2003). The expression of cyclin D1 during the G1 phase of the cell cycle is promoted by Rac and antagonized by Rho-ROCK-LIMK signalling, thereby controlling the duration of the G1 phase. The inhibition of cyclin D1 expression requires the nuclear translocation of LIMK.
-
(2003)
Dev. Cell
, vol.5
, pp. 273-64
-
-
Roovers, K.1
Klein, E.A.2
Castagnino, P.3
Assoian, R.K.4
-
36
-
-
0035865137
-
Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility
-
Sahai, E., Olson, M. F. & Marshall, C. J. Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO J. 20, 755-766 (2001). Ras-transformed cells have elevated RhoA activity, which inhibits p21 expression. Ras-induced ERK activation downregulates Rho kinases, thereby uncoupling Rho signalling from stress-fibre formation, which results in increased Ras-transformed cell motility.
-
(2001)
EMBO J.
, vol.20
, pp. 755-766
-
-
Sahai, E.1
Olson, M.F.2
Marshall, C.J.3
-
38
-
-
0038219632
-
Waf1/Cip1 protein stability via a cyclin D1-imposed block in proteasome-mediated degradation
-
Waf1/Cip1 protein stability via a cyclin D1-imposed block in proteasome-mediated degradation. EMBO J. 22, 2036-2046 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 2036-2046
-
-
Coleman, M.L.1
Marshall, C.J.2
Olson, M.F.3
-
39
-
-
0037053407
-
Rho activity can alter the translation of p27 mRNA and is important for RasV12-induced transformation in a manner dependent on p27 status
-
Vidal, A., Millard, S. S., Miller, J. P. & Koff, A. Rho activity can alter the translation of p27 mRNA and is important for RasV12-induced transformation in a manner dependent on p27 status. J. Biol. Chem. 277, 16433-16440 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 16433-16440
-
-
Vidal, A.1
Millard, S.S.2
Miller, J.P.3
Koff, A.4
-
41
-
-
0035921821
-
Kip1 in G1 and S phase
-
Kip1 in G1 and S phase. Nature 413, 323-327 (2001).
-
(2001)
Nature
, vol.413
, pp. 323-327
-
-
Malek, N.P.1
-
43
-
-
0033545354
-
Transformation mediated by RhoA requires activity of ROCK kinases
-
Sahai, E., Ishizaki, T., Narumiya, S. & Treisman, R. Transformation mediated by RhoA requires activity of ROCK kinases. Curr. Biol. 9, 136-145 (1999).
-
(1999)
Curr. Biol.
, vol.9
, pp. 136-145
-
-
Sahai, E.1
Ishizaki, T.2
Narumiya, S.3
Treisman, R.4
-
44
-
-
0033788675
-
Nuclear sequestration of the exchange factor Cdc24 by Far1 regulates cell polarity during yeast mating
-
Shimada, Y., Gulli, M. & Peter, M. Nuclear sequestration of the exchange factor Cdc24 by Far1 regulates cell polarity during yeast mating. Nature Cell Biol. 2, 117-124 (2000).
-
(2000)
Nature Cell Biol.
, vol.2
, pp. 117-124
-
-
Shimada, Y.1
Gulli, M.2
Peter, M.3
-
45
-
-
0346101745
-
Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus
-
Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus. J. Biol. Chem. 278, 52919-52923 (2003). p57 interacts with LIMK1 independently of its ability to bind the cyclin-CDK complex. Overexpression of p57 results in the nuclear localization of LIMK1 and loss of actin stress fibres.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 52919-52923
-
-
Yokoo, T.1
-
46
-
-
0037157872
-
Cip1/Waf1 regulates neurite remodeling by inhibiting Rho-kinase activity
-
Cip1/Waf1 regulates neurite remodeling by inhibiting Rho-kinase activity. J. Cell Biol. 158, 321-329 (2002). Ectopic expression of p21 in the cytoplasm promotes neurite outgrowth and branching of hippocampal neurons and neuroblastoma cells. p21 directly binds to and inhibits Rho kinase, thereby preventing Rho-ROCK signalling induced growth cone collapse.
-
(2002)
J. Cell Biol.
, vol.158
, pp. 321-329
-
-
Tanaka, H.1
-
47
-
-
0347717882
-
Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/Cofilin pathway
-
Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/Cofilin pathway. J. Biol. Chem. 279, 1885-1891 (2003). Activated Ras-induced loss of actin stress fibres requires p21. p21 inhibits Rho kinase, thereby uncoupling Rho signalling from stress-fibre formation.
-
(2003)
J. Biol. Chem.
, vol.279
, pp. 1885-1891
-
-
Lee, S.1
Helfman, D.M.2
-
48
-
-
0034745353
-
Cip1/Waf1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
-
Cip1/Waf1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Mature Cell Biol. 3, 245-252 (2001).
-
(2001)
Mature Cell Biol.
, vol.3
, pp. 245-252
-
-
Zhou, B.1
-
49
-
-
1942466518
-
p27Kip1 modulates cell migration through the regulation of RhoA activation
-
Besson, A., Gurian-West, M., Schmidt, A., Hall, A & Roberts, J. p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev. 18, 862-876 (2004). Loss of p27 results in decreased migratory ability, owing to elevated Rho-ROCK signalling. p27 binds to RhoA to prevent the interaction of RhoA with GTP exchange factors and thereby RhoA activation
-
(2004)
Genes Dev.
, vol.18
, pp. 862-876
-
-
Besson, A.1
Gurian-West, M.2
Schmidt, A.3
Hall, A.4
Roberts, J.5
-
50
-
-
0037423864
-
Kip1/cyclin-dependent kinase/Retinoblastoma pathway in vascular smooth muscle cells and fibroblasts
-
Kip1/cyclin-dependent kinase/Retinoblastoma pathway in vascular smooth muscle cells and fibroblasts. Circ. Res. 92, 402-410 (2003).
-
(2003)
Circ. Res.
, vol.92
, pp. 402-410
-
-
Diez-Juan, A.1
Andres, V.2
-
51
-
-
0042354574
-
Differing modes of tumor cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
-
Sahai, E. & Marshall, C. J. Differing modes of tumor cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nature Cell Biol. 5, 711-719 (2003). Two modes of tumour cell invasion are identified: a rounded cell migration requires Rho-ROCK signalling and is independent of pericellular proteolysis. By contrast, an elongated mode of migration is dependent on Rac activity, is antagonized by Rho-ROCK signalling and requires pericellular proteolytic activity.
-
(2003)
Nature Cell Biol.
, vol.5
, pp. 711-719
-
-
Sahai, E.1
Marshall, C.J.2
-
52
-
-
18444414614
-
ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts
-
Tsuji, T. et al. ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts. J. Cell Biol. 157, 819-830 (2002).
-
(2002)
J. Cell Biol.
, vol.157
, pp. 819-830
-
-
Tsuji, T.1
-
53
-
-
0036645678
-
Kip1 and regulates cell cycle progression
-
Kip1 and regulates cell cycle progression. EMBO J. 21, 3390-3401 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 3390-3401
-
-
Boehm, M.1
-
55
-
-
0033561310
-
3 to focal contacts
-
3 to focal contacts. EMBO J. 18, 2106-2118 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 2106-2118
-
-
Fahraeus, R.1
Lane, D.2
-
56
-
-
0038100182
-
3 integrin expression up-regulates cdc2, which modulates cell migration
-
3 integrin expression up-regulates cdc2, which modulates cell migration. J. Cell Biol. 161, 817-826 (2003).
-
(2003)
J. Cell Biol.
, vol.161
, pp. 817-826
-
-
Manes, T.1
-
57
-
-
12444334543
-
Cyclin D1 governs adhesion and motility of macrophages
-
Neumeister, P. et al. Cyclin D1 governs adhesion and motility of macrophages. Mol. Biol. Cell 14, 2005-2015 (2003).
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 2005-2015
-
-
Neumeister, P.1
-
58
-
-
0030728496
-
Cyclin and cyclin-dependent kinase expression in human astrocytoma cell lines
-
Dirks, P., Hubbard, S., Murakami, M. & Rutka, J. Cyclin and cyclin-dependent kinase expression in human astrocytoma cell lines. J. Neuropathol. Exp. Neurol. 56, 291-300 (1997).
-
(1997)
J. Neuropathol. Exp. Neurol.
, vol.56
, pp. 291-300
-
-
Dirks, P.1
Hubbard, S.2
Murakami, M.3
Rutka, J.4
-
59
-
-
0033916771
-
Expression and prognostic role of cyclin-dependent kinase 1 (cdc2) in hepatocellular carcinoma
-
Ito, Y. et al. Expression and prognostic role of cyclin-dependent kinase 1 (cdc2) in hepatocellular carcinoma. Oncology 59, 68-74 (2000).
-
(2000)
Oncology
, vol.59
, pp. 68-74
-
-
Ito, Y.1
-
60
-
-
0030611850
-
cdc2 and cyclin D1 protein expression in prostate adenocarcinoma
-
cdc2 and cyclin D1 protein expression in prostate adenocarcinoma. Cancer 80, 753-763 (1997).
-
(1997)
Cancer
, vol.80
, pp. 753-763
-
-
Kallakury, B.1
-
61
-
-
0034907213
-
mDia mediates Rho-regulated formation and orientation of stable microtubules
-
Palazzo, A., Cook, T., Alberts, A. & Gundersen, G. mDia mediates Rho-regulated formation and orientation of stable microtubules. Nature Cell Biol. 3, 723-729 (2001).
-
(2001)
Nature Cell Biol.
, vol.3
, pp. 723-729
-
-
Palazzo, A.1
Cook, T.2
Alberts, A.3
Gundersen, G.4
-
62
-
-
0035141074
-
Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1
-
Ishizaki, T. et al. Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1. Nature Cell Biol. 3, 8-14 (2001).
-
(2001)
Nature Cell Biol.
, vol.3
, pp. 8-14
-
-
Ishizaki, T.1
|