Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor

Journal of Cell Biology

Volumn 149, Issue 5, 2000, Pages 1073-1086

  Hirota, Toru ^a,b   Morisaki, Tetsuro ^a   Nishiyama, Yasuyuki ^a   Marumoto, Tomotoshi ^a   Tada, Kenji ^a   Hara, Toshihiro ^a   Masuko, Norio ^a   Inagaki, Masaki ^c   Hatakeyama, Katsuyoshi ^b   Saya, Hideyuki ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

Cdc2; Interaction; Mitotic spindle; Phosphorylation; Serine threonine kinase

Indexed keywords

ZYXIN;

ACTIN FILAMENT; ARTICLE; CELL DIVISION; CONTROLLED STUDY; GENE CONTROL; GENE FUNCTION; GENE LOCATION; GENE TARGETING; HUMAN; HUMAN CELL; MITOSIS; MITOSIS SPINDLE; PHOSPHORYLATION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ACTINS; AMINO ACID SEQUENCE; ANIMALS; ANTIBODY SPECIFICITY; CDC2 PROTEIN KINASE; COS CELLS; CYTOSKELETAL PROTEINS; DROSOPHILA PROTEINS; GENE EXPRESSION; GENES, TUMOR SUPPRESSOR; GLYCOPROTEINS; HELA CELLS; HUMANS; METALLOPROTEINS; MITOSIS; MITOTIC SPINDLE APPARATUS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PLASMIDS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; ZINC FINGERS;

EID: 18544412767     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.149.5.1073     Document Type: Article

References (46)

1. Adams, R.R., A.A. Tavares, A. Salzberg, H.J. Bellen, and D.M. Glover. 1998. pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis. Genes Dev. 12:1483-1494.
2. Bahler, J., A.B. Steever, S. Wheatley, Y. Wang, J.R. Pringle, K.L. Gould, and D. McCollum. 1998. Role of polo kinase and Mid1p in determining the site of cell division in fission yeast. J. Cell Biol. 143:1603-1616.
3. Bailly, E., M. Doree, P. Nurse, and M. Bornens. 1989. p34cdc2 is located in both nucleus and cytoplasm: part is centrosomally associated at G2/M and enters vesicles at anaphase. EMBO (Eur. Mol. Biol. Organ.) J. 8:3985-3995.
4. Balasubramanian, M.K., B.R. Hirani, J.D. Burke, and K.L. Gould. 1994. The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis. J. Cell Biol. 125:1289-1301.
5. Beekerle, M.C. 1997. Zyxin: zinc fingers at sites of cell adhesion. Bioessays. 19: 949-957.
6. Beckerle, M.C. 1998. Spatial control of actin filament assembly: lessons from Listeria. Cell. 95:741-748.
7. Bischoff, J.R., and G.D. Plowman. 1999. The Aurora/1p11p kinase family: regulators of chromosome segregation and cytokinesis. Trends Cell Biol. 9:454-459.
8. Craig, S.W., and R.P. Johnson. 1996. Assembly of focal adhesions: progress, paradigms, and portents. Curr. Opin. Cell Biol. 8:74-85.
9. Crawford, A.W., and M.C. Beckerle. 1991. Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions. J. Biol. Chem. 266: 5847-5853.
10. Crawford, A.W., J.W. Michelsen, and M.C. Beckerle. 1992. An interaction between zyxin and alpha-actinin. J. Cell Biol. 116:1381-1393.
11. Dawid, I.E., J.J. Breen, and R. Toyama. 1998. LIM domains: multiple roles as adapters and functional modifiers in protein interactions. Trends Genet. 14: 156-162.
12. Giansanti, M.G., S. Bonaccorsi, B. Williams, E.V. Williams, C. Santolamazza, M.L. Goldberg, and M. Gatti. 1998. Cooperative interactions between the central spindle and the contractile ring during Drosophila cytokinesis. Genes Dev. 12:396-410.
13. Glover, D.M., M.H. Leibowitz, D.A. McLean, and H. Parry. 1995. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell. 81:95-105.
14. Golsteyn, R.M., K.E. Mundt, A.M. Fry, and E.A. Nigg. 1995. Cell cycle regulation of the activity and suhcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function. J. Cell Biol. 129:1617-1628.
15. Hobert, O., J.W. Schilling, M.C. Beckerle, A. Ullrich, and B. Jallal. 1996. SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin. Oncogene. 12:1577-1581.
16. Izawa, I., N. Tainaki, and H. Saya. 1996. Phosphorylation of neurofibromatosis type 1 aene product (neurofibromin) by cAMP-dependent protein kinase. FEBS Lett. 382:53-59.
17. Jin, D.Y., F. Spencer, and K.T. Jeang. 1998. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell. 93:81-91.
18. Justice, R.W., O. Zilian, D.F. Woods, M. Noll, and P.J. Bryant. 1995. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev. 9:534-546.
19. Kimura, M., S. Kotani, T. Hattori, N. Sumi, T. Yoshioka, K. Todokoro, and Y. Okano. 1997. Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ip11. J. Biol. Chem. 272:13766-13771.
20. Kusubata, M., T. Tokui, Y. Matsuoka, E. Okumura, K. Tachibana, S. Hisanaga, T. Kishimoto, H. Yasuda, M. Kamijo, Y. Ohba, et al. 1992. p13suc1 suppresses the catalytic function of p34cdc2 kinase for intermediate filament proteins, in vitro. J. Biol. Chem. 267:20937-20942.
21. Macalma, T., J. Otte, M.E. Hensler, S.M. Bockholt, H.A. Louis, M. Kalff-Suske, K.H. Grzeschik, D. von der Ahe, and M.C. Beckerle. 1996. Molecular characterization of human zyxin. J. Biol. Chem. 271:31470-31478.
22. Madaule, P., M. Eda, N. Watanabe, K. Fujisawa, T. Matsuoka, H. Bito, T. Ishizaki, and S. Narumiya. 1998. Role of citron kinase as a target of the small GTPase Rho in cytokinesis. Nature. 394:491-494.
23. Masuko, N., K. Makino, H. Kuwahara, K. Fukunaga, T. Sudo, N. Araki, H. Yamamoto, Y. Yamada, E. Miyamoto, and H. Saya. 1999. Interaction of NE-dlg/SAP102. a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90. A possible regulatory role in molecular clustering at synaptic sites. J. Biol. Chem. 274:5782-5790.
24. Nigg, E.A. 1998. Polo-like kinases: positive regulators of cell division from start to finish. Curr. Opin. Cell Biol. 10:776-783.
25. Nigg, E.A., A. Blangy, and H.A. Lane. 1996. Dynamic changes in nuclear architecture during mitosis: on the role of protein phosphorylalion in spindle assembly and chromosome segregation. Exp. Cell Res. 229:174-180.
26. Nishiyama, Y., T. Hirota, T. Morisaki, T. Hara, T. Marumoto, S. Iida, K. Makino, H. Yamamoto, T. Hiraoka, N. Kitamura, and H. Saya. 1999. A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. FEBS Lett. 459:159-165.
27. Nix, D.A., and M.C. Beckerle. 1997. Nuclear-cytoplasmic shuttling of the local contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus. J. Cell Biol. 138:1139-1147.
28. Nurse, P. 2000. A long twentieth century of the cell cycle and beyond. Cell. 100: 71-78.
29. O'Connell, C.B., S.P. Wheatley, S. Ahmed, and Y.L. Wang. 1999. The small GTP-binding protein rho regulates cortical activities in cultured cells during division. J. Cell Biol. 144:305-313.
30. Prehoda, K.E., D.J. Lee, and W.A. Lim. 1999. Structure of the enabled/VASP homology I domain-peptide complex: a key component in the spatial control of actin assembly. Cell. 97:471-480.
31. Reinhard, M., K. Jouvenal, D. Tripier, and U. Walter. 1995. Identification, purification, and characterization of a zyxin-related protein that hinds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein). Proc. Natl. Acad. Sci. USA. 92:7956-7960.
32. Sadler, I., A.W. Crawford, J.W. Michelsen, and M.C. Beckerle. 1992. Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton. J. Cell Biol. 119:1573-1587.
33. Schmeichel, K.L., and M.C. Beckerle. 1994. The LIM domain is a modular protein-binding interface. Cell. 79:211-219.
34. Sparks, C.A., M. Morphew, and D. McCollum. 1999. Sid2p, a spindle pole body kinase that regulates the onset of cytokinesis. J. Cell Biol. 146:777-790.
35. St. John, M.A., W. Tao, X. Fei, R. Fukumoto, M.L. Carcangiu, D.G. Brownstein, A.F. Parlow, J. McGrath, and T. Xu. 1999. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat. Genet. 21:182-186.
36. Sunkel, C.E., and D.M. Glover. 1988. polo, a mitotic mutant of Drosophila displaying abnormal spindle poles. J. Cell Sci. 89:25-38.
37. Tao, W., S. Zhang, G.S. Turenchalk, R.A. Stewart, M.A. St. John, W. Chen, and T. Xu. 1999. Human homologue of the Drosophila melanagaster lats tumour suppressor modulates CDC2 activity. Nat. Genet. 21:177-181.
38. Terada, Y., M. Tatsuka, F. Suzuki, Y. Yasuda, S. Fujita, and M. Otsu. 1998. AIM-1: a mammalian midbody-associated protein required for cytokinesis. EMBO (Eur. Mol. Biol. Organ.) J. 17:667-676.
39. Toyn, J.H., and L.H. Johnston. 1994. The Dbf2 and Dbf20 protein kinases of budding yeast are activated after the metaphase to anaphase cell cycle transition. EMBO (Eur. Mol. Biol. Ortgan.) J. 13:1103-1113.
40. Verde, F., D.J. Wiley, and P. Nurse. 1998. Fission yeast orb6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle. Proc. Natl. Acad. Sci. USA. 95:7526-7531.
41. Vojtek, A.B., S.M. Hollenberg, and J.A. Cooper. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell. 74:205-214.
42. Williams, B.C., M.F. Riedy, E.V. Williams, M. Gatti, and M.L. Goldberg. 1995. The Drosophila kinesin-like protein KLP3A is a midbody component required for central spindle assembly and initiation of cytokinesis. J. Cell Biol. 129:709-723.
43. Xu, T., W. Wang, S. Zhang, R.A. Stewart, and W. Yu. 1995. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development. 121:1053-1063.
44. Yamaguchi, R., Y. Mazaki, K. Hirota, S. Hashimoto, and H. Sabe. 1997. Mitosis specific serine phosphorylation and down regulation of one of the focal adhesion protein, paxillin. Oncogene. 15:1753-1761.
45. Yamakita, Y., G. Totsukawa, S. Yamashiro, D. Fry, X. Zhang, S.K. Hanks, and F. Matsumura. 1999. Dissociation of FAK/p130(CAS)/c-Src complex during mitosis: role of mitosis-specific serine phosphorylation of FAK. J. Cell Biol. 144:315-324.
46. Yasui, Y., M. Amano, K. Nagata, N. Inagaki, H. Nakamura, H. Saya, K. Kaibuchi, and M. Inagaki. 1998. Roles of Rho-associated kinase in cytokinesis; mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments. J. Cell Biol. 143:1249-1258.