Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion

EMBO Journal

Volumn 31, Issue 11, 2012, Pages 2498-2510

  Ganuza, Miguel ^a   Sáiz Ladera, Cristina ^b   Cañamero, Marta ^a   Gómez, Gonzalo ^a   Schneider, Ralph ^a   Blasco, María A ^a   Pisano, David ^a   Paramio, Jesús M ^b   Santamaría, David ^a   Barbacid, Mariano ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b CIEMAT   (Spain)

Author keywords

CAK; Cdk7; in vivo elimination; mouse model; stem cell exhaustion

Indexed keywords

CYCLIN DEPENDENT KINASE 7; CYCLIN DEPENDENT KINASE ACTIVATING KINASE; RNA POLYMERASE II;

ADULT STEM CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRESS; CONTROLLED STUDY; EMBRYO DEVELOPMENT; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; FEMALE; GENE EXPRESSION; GENE INACTIVATION; GENE LOCUS; HOMEOSTASIS; MOUSE; NONHUMAN; PHENOTYPE; PREMATURE AGING; PRIORITY JOURNAL; TELOMERE SHORTENING;

ADULT STEM CELLS; AGING, PREMATURE; ANIMALS; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASES; EMBRYONIC DEVELOPMENT; FEMALE; HOMEOSTASIS; MICE; TELOMERE SHORTENING;

EID: 84861871242     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.94     Document Type: Article

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