Nuclear sequestration of the exchange factor Cdc24 by Far1 regulates cell polarity during yeast mating

Nature Cell Biology

Volumn 2, Issue 2, 2000, Pages 117-124

  Shimada, Y ^a   Gulli, M P ^a   Peter, M ^a  

^a SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; PHEROMONE; PROTEIN CDC24; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL GROWTH; CELL MEMBRANE; CELL NUCLEUS; CELL POLARITY; CELL VIABILITY; CONTROLLED STUDY; CYTOSKELETON; MATING; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE;

BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CDC28 PROTEIN KINASE; CELL COMPARTMENTATION; CELL CYCLE PROTEINS; CELL NUCLEUS; CELL POLARITY; FUNGAL PROTEINS; MODELS, BIOLOGICAL; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; REPRODUCTION; SACCHAROMYCES CEREVISIAE; SUPPORT, NON-U.S. GOV'T;

EID: 0033788675     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35000073     Document Type: Article

References (50)

1. Rho GTPases and the actin cytoskeleton
2. CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae
3. Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity
4. A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains
5. Interactions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeast
6. Pheromone response in yeast: Association of Bem1p with proteins of the MAP kinase cascade and actin
7. A Cdc24-Far1-G beta gamma protein complex required for yeast orientation during mating
8. The guanine-nucleotide-exchange factor Cdc24 is targeted to the nucleus and polarized growth sites
9. GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more
10. Polarization of yeast cells in spatial gradients of alpha mating factor
11. MAP kinase pathways in yeast: For mating and more
12. FAR1 is required for oriented polarization of yeast cells in response to mating pheromones
13. A GTP-exchange factor required for cell orientation
14. The role of Far1 in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating
15. Cell cycle control of morphogenesis in budding yeast
16. FAR1 and the G1 phase specificity of cell cycle arrest by mating factor in Saccharomyces cerevisiae
17. Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1 in budding yeast
18. Negative regulation of FAR1 at the Start of the yeast cell cycle
19. Identification of a gent necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2
20. Nuclear export of Far1 in response to pheromones requires the export receptor Msn5/Ste 21p
21. Morphogenesis in the yeast cell cycle: Regulation by Cdc28 and cyclins
22. Direct inhibition of the yeast cyclin-dependent kinase Cdc28-Cln by Far1
23. Generation of cell polarity in yeast
24. Cell polarization directed by extracellular cues in yeast
25. Responding to attraction: Chemotaxis and chemotropism in Dictyostelium and yeast
26. Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1
27. Two active states of the Ras-ralated Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity
28. Nuclear shuttling of yeast scaffold Ste5 is required for its recruitment to the plasma membrane and activation of the mating MAPK cascade
29. The Saccharomyces cerevisiae RanGTP binding protein Msn5 is involved in different signal transduction pathways
30. Saccharomyces cerevisiae cells execute a default pathway to select a mate in the absence of pheromone gradients
31. Regulation of nuclear localization: A key to a door
32. In or out? Regulating nuclear transport
33. I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: A mechanism for cytoplasmic retention
34. Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit
35. Nuclear localization of I kappa B alpha promotes active transport of NF-kappa B from the nucleus to the cytoplasm
36. Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast
37. Moe1, a conserved protein in Schizosaccharomyces pombe, interacts with a Ras effector, Scd1, to affect proper spindle formation
38. Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-gamma1 and phosphoinositide 3-kinase during granulocytic differentiation of HL-60 cells
39. Functional analysis of FAR1 in yeast
40. Requirement of STE50 for osmostress-induced activation of the STE11 mitogen-activated protein kinase kinase kinase in the high-osmolarity glycerol response pathway
41. Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds
42. Novel Cdc42-binding proteins Gic 1 and Gic2 control cell polarity in yeast
43. Use of conditional promoters for expression of heterologous proteins in Saccharomyces cerevisiae
44. Elutriation of budding yeast
45. CLB5: A novel B cyclin from budding yeast with a role in S phase