RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 23, 2009, Pages 9268-9273

  Larrea, Michelle D ^a   Hong, Feng ^a   Wander, Seth A ^a,b   Da Silva, Thiago G ^a   Helfman, David ^a,b   Lannigan, Deborah ^c   Smith, Jeffrey A ^c   Slingerland, Joyce M ^a  

^a UNIVERSITY OF MIAMI   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Actin cytoskeleton; p27 phosphorylation; PI3K

Indexed keywords

ACTIN; COFILIN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MYOSIN ADENOSINE TRIPHOSPHATASE; P90 RIBOSOMAL S6 KINASE 1; PHOSPHOCOFILIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; S6 KINASE; TYROSINE; UNCLASSIFIED DRUG; CDKN1B PROTEIN, HUMAN; RHOA PROTEIN, HUMAN; RPS6KA1 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ARTICLE; CELL CYCLE G1 PHASE; CELL MOTILITY; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRECIPITATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; STRESS FIBER; CELL MOTION; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ACTINS; CELL LINE, TUMOR; CELL MOVEMENT; CYTOPLASM; G1 PHASE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; RHOA GTP-BINDING PROTEIN; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SIGNAL TRANSDUCTION;

EID: 67249107699     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0805057106     Document Type: Article

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