Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27(Kip1) induces cell migration

Nature Medicine

Volumn 4, Issue 12, 1998, Pages 1449-1452

  Nagahara, Hikaru ^a   Vocero Akbani, Adamina M ^a   Snyder, Eric L ^a   Ho, Alan ^a   Latham, Dawn G ^a   Lissy, Natalie A ^a   Becker Hapak, Michelle ^a   Ezhevsky, Sergei A ^a   Dowdy, Steven F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; PROTEIN P27; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; CELL CYCLE; CELL MIGRATION; CELL SPREADING; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PSEUDOPODIUM; REVIEW;

CELL CYCLE PROTEINS; CELL MOVEMENT; CELL SEPARATION; CROSSES, GENETIC; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FLOW CYTOMETRY; GENE PRODUCTS, TAT; HUMANS; JURKAT CELLS; MICROTUBULE-ASSOCIATED PROTEINS; PROTEIN DENATURATION; RECOMBINANT FUSION PROTEINS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; MAMMALIA;

EID: 0031759170     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/4042     Document Type: Review

References (19)

1. Anderson, W.F. Human gene therapy. Nature 392, 25-30 (1998).
2. Bar-Sagi, D. Mammalian cell microinjection assay. Meth. Enzymol. 255, 436-442 (1995).
3. Green, M. & Loewenstein, P.M. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein. Cell 55, 1179-1188 (1988).
4. Frankel, A.D. & Pabo, C.O. Cellular uptake of the tat protein from human immunodeficiency virus. Cell 55, 1189-1193 (1988).
5. Fawell, S. et al. Tat-mediated delivery of heterologous proteins into cells. Proc. Natl. Acad. Sci USA 91, 664-668 (1994).
6. Vives, E., Brodin, P. & Leblus, B. A truncated Tat basic domain rapidly translocates through the plasma membrane and accumulates in the nucleus. J. Biol. Chem. 272, 16010-16017 (1997).
7. Elliott, G. & O'Hare, P. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 88, 223-233 (1997).
8. Derossi, D., Joliot, A.H., Chassaings, G. & Prochiantz, A. The third helix of the antennapedia homodomain translocates through biological membranes. J. Biol. Chem. 269, 10444-10450 (1994).
9. cip1. Nature 375, 159-161 (1995).
10. Van den Heuvel, S. & Harlow, E. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262, 2050-2054 (1993).
11. Gottesman, S., Wickmer, S. & Maurizi, M.R. Protein quality control: Triage by chaperones and proteases. Genes Dev. 11, 815-823 (1997).
12. Schneider, C. et al. Pharmacologic shifting of a balance between protein refolding and degradation mediated by HSP90. Proc. Natl. Acad. Sci. USA 93, 14536-14541 (1996).
13. Jeffers, M., Rong, S. & Vande Woude, G.F. Hepatocyte growth factor/scatter factor -Met signaling in tumorigenicity and invasion/metastasis. J. Mol. Med. 74, 505-513 (1996).
14. Matsumoto, K. & Nakamura, T. Hepatocyte growth factor: Molecular structure, roles in liver regeneration, and other biological functions. Crit. Rev. Oncol. 3, 27-54 (1992).
15. 1 phase cell-cycle check point. Immunity 8, 57-65 (1998).
16. Ezhevsky, S.A. et al. Hypo-phosphorylation of the retinoblastoma protein by cyclin D:Cdk4/6 complexes results in active pRb. Proc. Natl. Acad. Sci. USA 94, 10699-10704 (1997).
17. Van Aelst, L. & D'Souza-Schorey, C. Rho GTPases and signaling networks. Genes Dev. 11, 2295-2322 (1997).
18. cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control. Science 280, 1069-1072 (1998).
19. Fahraeus, R., Paramio, J.M., Ball, K.L., Lain, S. & Lane, D.P. Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16. Curr. Biol. 6, 84-91 (1996).