Inhibition of RhoA by p120 catenin

Nature Cell Biology

Volumn 2, Issue 9, 2000, Pages 637-644

  Anastasiadis, Panos Z ^a   Moon, Sun Y ^b   Thoreson, Molly A ^a   Mariner, Debbie J ^a   Crawford, Howard C ^a   Zheng, Yi ^b   Reynolds, Albert B ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATENIN; GUANOSINE TRIPHOSPHATASE; PROTEIN P120; RHO FACTOR;

ANIMAL CELL; ARTICLE; CYTOSKELETON; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

3T3 CELLS; ANIMAL; CADHERINS; CDC42 GTP-BINDING PROTEIN; CELL ADHESION MOLECULES; GUANOSINE DIPHOSPHATE; HUMAN; LYSOPHOSPHOLIPIDS; MICE; PHENOTYPE; PHOSPHOPROTEINS; RAC1 GTP-BINDING PROTEIN; RHOA GTP-BINDING PROTEIN; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0001468710     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35023588     Document Type: Article

References (39)

1. Takeichi, M. Morphogenetic roles of classic cadherins. Curr. Opin. Cell Biol. 7, 619-627 (1995).
2. Yap, A. S. The morphogenetic role of cadherin cell adhesion molecules in human cancer: a thematic review. Cancer Invest. 16, 252-261 (1998).
3. Frixen, U. H. et al. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J. Cell Biol. 113, 173-185 (1991).
4. Perl, A. K., Wilgenbus, P., Dahl, U., Semb, H. & Christofori, G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392, 190-193 (1998).
5. Vleminckx, K., Vakaet, L., Jr., Mareel, M., Fiers, W. & van Roy, F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 66, 107-119 (1991).
6. Anastasiadis, P. Z. & Reynolds, A. B. The p120 catenin family: complex roles in adhesion, signalling and cancer. J. Cell Sci. 113, 1319-1334 (2000).
7. Nobes, C. C. & Hall, A. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibres, lamellipodia, and filopodia. Cell 81, 53-62 (1995).
8. Braga, V. M., Machesky, L. M., Hall, A. & Hotchin, N. A. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol. 137, 1421-1431 (1997).
9. Takaishi, K., Sasaki, T., Kotani, H., Nishioka, H. & Takai, Y. Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J. Cell Biol. 139, 1047-1059 (1997).
10. Jou, T.S. & Nelson, W.J. Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity. J. Cell Biol. 142, 85-100 (1998).
11. Kaibuchi, K., Kuroda, S., Fukata, M. & Nakagawa, M. Regulation of cadherin-mediated cell-cell adhesion by the Rho family GTPases. Curr. Opin. Cell Biol. 11, 591-596 (1999).
12. cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts. Exp. Cell Res. 225, 328-337 (1996).
13. Sekimata, M., Kabuyama, Y., Emori, Y. & Homma, Y. Morphological changes and detachment of adherent cells induced by p122, a GTPase-activating protein for Rho. J. Biol. Chem. 274, 17757-17762 (1999).
14. Kranenburg, O. et al. Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction. Mol. Biol. Cell 10, 1851-1857 (1999).
15. Chrzanowska-Wodnicka, M. & Burridge, K. Rho-stimulated contractility drives the formation of stress fibres and focal adhesions. J. Cell Biol. 133, 1403-1415 (1996).
16. An, S., Goetzl, E. J. & Lee, H. Signalling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. J. Cell Biochem. Suppl. 31, 147-157 (1998).
17. Dong, J. M., Leung, T., Manser, E. & Lim, L. cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalpha. J. Biol. Chem. 273, 22554-22562 (1998).
18. Ramakers, G. J. A. & Moolenaar, W. H. Regulation of astrocyte morphology by RhoA and lysophosphatidic acid. Exp. Cell Res. 245, 252-262 (1998).
19. Debant, A. et al. The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc. Natl Acad. Sci. USA 93, 5466-5471 (1996).
20. Sasaki, T. & Takai, Y. The Rho small G protein family-Rho GDI system as a temporal and spatial determinant for cytoskeletal control. Biochem. Biophys. Res. Commun. 245, 641-645 (1998).
21. Olofsson, B. Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling. Cell Signal. 11, 545-554 (1999).
22. ctn in E-cadherin complexes. J. Cell Sci. 113, 1481-1490 (2000).
23. Ren, X. D., Kiosses, W. B. & Schwartz, M. A. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J. 18, 578-585 (1999).
24. Thoreson, M. A. et al. Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion. J. Cell Biol. 148, 189-202 (2000).
25. Hirao, M. et al. Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signalling pathway. J. Cell Biol. 135, 37-51 (1996).
26. Kotani, H., Takaishi, K., Sasaki, T. & Takai, Y. Rho regulates association of both the ERM family and vinculin with the plasma membrane in MDCK cells. Oncogene 14, 1705-1713 (1997).
27. Keirsebilck, A. et al. Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. Genomics 50, 129-146 (1998).
28. Kinch, M. S., Clark, G. J., Der, C. J. & Burridge, K. Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. J. Cell Biol. 130, 461-471 (1995).
29. Calautti, E. et al. Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion. J. Cell Biol. 141, 1449-1465 (1998).
30. Ozawa, M. & Kemler, R. The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity. J. Cell Biol. 142, 1605-1613 (1998).
31. Aono, S., Nakagawa, S., Reynolds, A. B. & Takeichi, M. p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells. J. Cell Biol. 145, 551-562 (1999).
32. Takeuchi, K. et al. Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. J. Cell Biol. 125, 1371-1384 (1994).
33. Mackay, D. J., Esch, F., Furthmayr, H. & Hall, A. Rho- and rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: an essential role for ezrin/radixin/moesin proteins. J. Cell Biol. 138, 927-938 (1997).
34. Lampugnani, M. G. et al. Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells. J. Cell Sci. 110, 2065-2077 (1997).
35. Reynolds, A. B. et al. Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes. Mol. Cell. Biol. 14, 8333-8342 (1994).
36. Wu, J., Mariner, D. J., Thoreson, M. A. & Reynolds, A. B. Production and characterization of monoclonal antibodies to the catenin p120ctn. Hybridoma 17, 175-183 (1998).
37. Zhang, B., Zhang, Y., Collins, C.C., Johnson, D. I. & Zheng, Y. A built-in arginine finger triggers the self-stimulatory GTPase-activating activity of rho family GTPases. J. Biol. Chem. 274, 2609-2612 (1999).
38. Li, R., Zhang, B. & Zheng, Y. Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190. J. Biol Chem. 272, 32830-32835 (1997).
39. Li, R. & Zheng, Y. Residues of the Rho family GTPases Rho and Cdc42 that specify sensitivity to Dbl-like guanine nucleotide exchange factors. J. Biol. Chem. 272, 4671-4679 (1997).