-
1
-
-
0028372227
-
Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite
-
Fujita T, Inoue K, Yamamoto S, et al. Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J Antibiot. 1994; 47: 208-15.
-
(1994)
J Antibiot
, vol.47
, pp. 208-215
-
-
Fujita, T.1
Inoue, K.2
Yamamoto, S.3
-
2
-
-
79955408396
-
Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite
-
Strader CR, Pearce CJ, Oberlies NH. Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite. J Nat Prod. 2011; 74: 900-7.
-
(2011)
J Nat Prod
, vol.74
, pp. 900-907
-
-
Strader, C.R.1
Pearce, C.J.2
Oberlies, N.H.3
-
3
-
-
77951073508
-
Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis
-
Chun J, Hartung HP. Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis. Clin Neuropharmacol. 2010; 33: 91-101.
-
(2010)
Clin Neuropharmacol
, vol.33
, pp. 91-101
-
-
Chun, J.1
Hartung, H.P.2
-
4
-
-
84889670659
-
Sphingosine-1-phosphate receptor 2
-
Adada M, Canals D, Hannun YA, et al. Sphingosine-1-phosphate receptor 2. FEBS J. 2013; 280: 6354-66.
-
(2013)
FEBS J
, vol.280
, pp. 6354-6366
-
-
Adada, M.1
Canals, D.2
Hannun, Y.A.3
-
5
-
-
78149426794
-
Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance
-
Ponnusamy S, Meyers-Needham M, Senkal CE, et al. Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncol. 2010; 6: 1603-24.
-
(2010)
Future Oncol
, vol.6
, pp. 1603-1624
-
-
Ponnusamy, S.1
Meyers-Needham, M.2
Senkal, C.E.3
-
6
-
-
84880537308
-
New perspectives on the role of sphingosine 1-phosphate in cancer
-
Pyne S, Pyne NJ. New perspectives on the role of sphingosine 1-phosphate in cancer. Handb Exp Pharmacol. 2013; 216. Doi: 10.1007/978-3-7091-1511-4_3:55-71.
-
(2013)
Handb Exp Pharmacol
, vol.216
-
-
Pyne, S.1
Pyne, N.J.2
-
8
-
-
0037077308
-
The immune modulator FTY720 targets sphingosine 1-phosphate receptors
-
Brinkmann V, Davis MD, Heise CE, et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem. 2002; 277: 21453-7.
-
(2002)
J Biol Chem
, vol.277
, pp. 21453-21457
-
-
Brinkmann, V.1
Davis, M.D.2
Heise, C.E.3
-
9
-
-
79952026310
-
Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis
-
Mehling M, Johnson TA, Antel J, et al. Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis. Neurology. 2011; 76: S20-7.
-
(2011)
Neurology
, vol.76
, pp. S20-S27
-
-
Mehling, M.1
Johnson, T.A.2
Antel, J.3
-
10
-
-
84872406787
-
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer
-
Liang J, Nagahashi M, Kim EY, et al. Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell. 2013; 23: 107-20.
-
(2013)
Cancer Cell
, vol.23
, pp. 107-120
-
-
Liang, J.1
Nagahashi, M.2
Kim, E.Y.3
-
11
-
-
33745124738
-
Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus
-
Chiba K, Matsuyuki H, Maeda Y, et al. Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus. Cell Mol Immunol. 2006; 3: 11-9.
-
(2006)
Cell Mol Immunol
, vol.3
, pp. 11-19
-
-
Chiba, K.1
Matsuyuki, H.2
Maeda, Y.3
-
12
-
-
78049480679
-
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
-
Brinkmann V, Billich A, Baumruker T, et al. Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat Rev Drug Discov. 2010; 9: 883-97.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 883-897
-
-
Brinkmann, V.1
Billich, A.2
Baumruker, T.3
-
13
-
-
84930416533
-
Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer
-
Lee JW, Ryu JY, Yoon G, et al. Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer. Int J Cancer. 2014; 137. Doi: 10.1002/ijc.29362.
-
(2014)
Int J Cancer
, vol.137
-
-
Lee, J.W.1
Ryu, J.Y.2
Yoon, G.3
-
14
-
-
84871982124
-
Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models
-
Rosa R, Marciano R, Malapelle U, et al. Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models. Clin Cancer Res. 2013; 19: 138-47.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 138-147
-
-
Rosa, R.1
Marciano, R.2
Malapelle, U.3
-
15
-
-
77954535502
-
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
-
Tonelli F, Lim KG, Loveridge C, et al. FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cell Signal. 2010; 22: 1536-42.
-
(2010)
Cell Signal
, vol.22
, pp. 1536-1542
-
-
Tonelli, F.1
Lim, K.G.2
Loveridge, C.3
-
16
-
-
84862766241
-
Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b
-
Lim KG, Tonelli F, Berdyshev E, et al. Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b. Int J Biochem Cell Biol. 2012; 44: 1457-64.
-
(2012)
Int J Biochem Cell Biol
, vol.44
, pp. 1457-1464
-
-
Lim, K.G.1
Tonelli, F.2
Berdyshev, E.3
-
17
-
-
84880328774
-
FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway
-
Li MH, Hla T, Ferrer F. FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway. Pediatr Blood Cancer. 2013; 60: 1418-23.
-
(2013)
Pediatr Blood Cancer
, vol.60
, pp. 1418-1423
-
-
Li, M.H.1
Hla, T.2
Ferrer, F.3
-
18
-
-
84863809760
-
A fluorescent assay for ceramide synthase activity
-
Kim HJ, Qiao Q, Toop HD, et al. A fluorescent assay for ceramide synthase activity. J Lipid Res. 2012; 53: 1701-7.
-
(2012)
J Lipid Res
, vol.53
, pp. 1701-1707
-
-
Kim, H.J.1
Qiao, Q.2
Toop, H.D.3
-
19
-
-
67650264305
-
Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner
-
Lahiri S, Park H, Laviad EL, et al. Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner. J Biol Chem. 2009; 284: 16090-8.
-
(2009)
J Biol Chem
, vol.284
, pp. 16090-16098
-
-
Lahiri, S.1
Park, H.2
Laviad, E.L.3
-
20
-
-
26644434393
-
The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity
-
Bandhuvula P, Tam YY, Oskouian B, et al. The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. J Biol Chem. 2005; 280: 33697-700.
-
(2005)
J Biol Chem
, vol.280
, pp. 33697-33700
-
-
Bandhuvula, P.1
Tam, Y.Y.2
Oskouian, B.3
-
21
-
-
80052653011
-
Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia
-
Liao A, Broeg K, Fox T, et al. Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia. Blood. 2011; 118: 2793-800.
-
(2011)
Blood
, vol.118
, pp. 2793-2800
-
-
Liao, A.1
Broeg, K.2
Fox, T.3
-
22
-
-
78449267550
-
FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1
-
Pchejetski D, Bohler T, Brizuela L, et al. FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1. Cancer Res. 2010; 70: 8651-61.
-
(2010)
Cancer Res
, vol.70
, pp. 8651-8661
-
-
Pchejetski, D.1
Bohler, T.2
Brizuela, L.3
-
24
-
-
84857196624
-
Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways
-
Walter G, Ruediger R. Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways. Cell Cycle. 2012; 11: 451-9.
-
(2012)
Cell Cycle
, vol.11
, pp. 451-459
-
-
Walter, G.1
Ruediger, R.2
-
25
-
-
0029889342
-
The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A
-
Li M, Makkinje A, Damuni Z. The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. J Biol Chem. 1996; 271: 11059-62.
-
(1996)
J Biol Chem
, vol.271
, pp. 11059-11062
-
-
Li, M.1
Makkinje, A.2
Damuni, Z.3
-
26
-
-
84908300167
-
Effect of FTY720 on the SET-PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity
-
Pippa R, Dominguez A, Christensen DJ, et al. Effect of FTY720 on the SET-PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity. Leukemia. 2014; 28: 1915-8.
-
(2014)
Leukemia
, vol.28
, pp. 1915-1918
-
-
Pippa, R.1
Dominguez, A.2
Christensen, D.J.3
-
27
-
-
84863156383
-
Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation
-
Yang Y, Huang Q, Lu Y, et al. Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation. J Cell Biochem. 2012; 113: 1314-22.
-
(2012)
J Cell Biochem
, vol.113
, pp. 1314-1322
-
-
Yang, Y.1
Huang, Q.2
Lu, Y.3
-
28
-
-
84887391984
-
Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies
-
Oaks JJ, Santhanam R, Walker CJ, et al. Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies. Blood. 2013; 122: 1923-34.
-
(2013)
Blood
, vol.122
, pp. 1923-1934
-
-
Oaks, J.J.1
Santhanam, R.2
Walker, C.J.3
-
29
-
-
84871968824
-
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis
-
Saddoughi SA, Gencer S, Peterson YK, et al. Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. EMBO Mol Med. 2013; 5: 105-21.
-
(2013)
EMBO Mol Med
, vol.5
, pp. 105-121
-
-
Saddoughi, S.A.1
Gencer, S.2
Peterson, Y.K.3
-
30
-
-
67649814136
-
PI3K/PTEN signaling in angiogenesis and tumorigenesis
-
Jiang BH, Liu LZ. PI3K/PTEN signaling in angiogenesis and tumorigenesis. Adv Cancer Res. 2009; 102: 19-65.
-
(2009)
Adv Cancer Res
, vol.102
, pp. 19-65
-
-
Jiang, B.H.1
Liu, L.Z.2
-
31
-
-
84904003955
-
PP2A inhibition is a common event in colorectal cancer and its restoration using FTY720 shows promising therapeutic potential
-
Cristobal I, Manso R, Rincon R, et al. PP2A inhibition is a common event in colorectal cancer and its restoration using FTY720 shows promising therapeutic potential. Mol Cancer Ther. 2014; 13: 938-47.
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 938-947
-
-
Cristobal, I.1
Manso, R.2
Rincon, R.3
-
33
-
-
84886432489
-
FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors
-
Kiyota M, Kuroda J, Yamamoto-Sugitani M, et al. FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors. Apoptosis. 2013; 18: 1437-46.
-
(2013)
Apoptosis
, vol.18
, pp. 1437-1446
-
-
Kiyota, M.1
Kuroda, J.2
Yamamoto-Sugitani, M.3
-
34
-
-
39449103924
-
FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling
-
Hung JH, Lu YS, Wang YC, et al. FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling. Cancer Res. 2008; 68: 1204-12.
-
(2008)
Cancer Res
, vol.68
, pp. 1204-1212
-
-
Hung, J.H.1
Lu, Y.S.2
Wang, Y.C.3
-
35
-
-
10344231428
-
FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation
-
Lee TK, Man K, Ho JW, et al. FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation. Carcinogenesis. 2004; 25: 2397-405.
-
(2004)
Carcinogenesis
, vol.25
, pp. 2397-2405
-
-
Lee, T.K.1
Man, K.2
Ho, J.W.3
-
36
-
-
77956791246
-
PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice
-
Zheng T, Meng X, Wang J, et al. PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice. J Cell Biochem. 2010; 111: 218-28.
-
(2010)
J Cell Biochem
, vol.111
, pp. 218-228
-
-
Zheng, T.1
Meng, X.2
Wang, J.3
-
37
-
-
79954449794
-
PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect
-
Cristobal I, Garcia-Orti L, Cirauqui C, et al. PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect. Leukemia. 2011; 25: 606-14.
-
(2011)
Leukemia
, vol.25
, pp. 606-614
-
-
Cristobal, I.1
Garcia-Orti, L.2
Cirauqui, C.3
-
38
-
-
38049166147
-
FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma
-
Liu Q, Zhao X, Frissora F, et al. FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. Blood. 2008; 111: 275-84.
-
(2008)
Blood
, vol.111
, pp. 275-284
-
-
Liu, Q.1
Zhao, X.2
Frissora, F.3
-
39
-
-
34648832173
-
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia
-
Neviani P, Santhanam R, Oaks JJ, et al. FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. J Clin Invest. 2007; 117: 2408-21.
-
(2007)
J Clin Invest
, vol.117
, pp. 2408-2421
-
-
Neviani, P.1
Santhanam, R.2
Oaks, J.J.3
-
40
-
-
84907857808
-
14-3-3 proteins play a role in the cell cycle by shielding cdt2 from ubiquitin-mediated degradation
-
Dar A, Wu D, Lee N, et al. 14-3-3 proteins play a role in the cell cycle by shielding cdt2 from ubiquitin-mediated degradation. Mol Cell Biol. 2014; 34: 4049-61.
-
(2014)
Mol Cell Biol
, vol.34
, pp. 4049-4061
-
-
Dar, A.1
Wu, D.2
Lee, N.3
-
41
-
-
0035977072
-
14-3-3 proteins mediate an essential anti-apoptotic signal
-
Masters SC, Fu H. 14-3-3 proteins mediate an essential anti-apoptotic signal. J Biol Chem. 2001; 276: 45193-200.
-
(2001)
J Biol Chem
, vol.276
, pp. 45193-45200
-
-
Masters, S.C.1
Fu, H.2
-
42
-
-
77953694599
-
Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function
-
Woodcock JM, Ma Y, Coolen C, et al. Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function. Cell Signal. 2010; 22: 1291-9.
-
(2010)
Cell Signal
, vol.22
, pp. 1291-1299
-
-
Woodcock, J.M.1
Ma, Y.2
Coolen, C.3
-
43
-
-
84882973107
-
Molecular pathways: reactive oxygen species homeostasis in cancer cells and implications for cancer therapy
-
Nogueira V, Hay N. Molecular pathways: reactive oxygen species homeostasis in cancer cells and implications for cancer therapy. Clin Cancer Res. 2013; 19: 4309-14.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 4309-4314
-
-
Nogueira, V.1
Hay, N.2
-
44
-
-
84255176452
-
FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death
-
Alinari L, Mahoney E, Patton J, et al. FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death. Blood. 2011; 118: 6893-903.
-
(2011)
Blood
, vol.118
, pp. 6893-6903
-
-
Alinari, L.1
Mahoney, E.2
Patton, J.3
-
45
-
-
84881256674
-
FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune system
-
Pereira FV, Arruda DC, Figueiredo CR, et al. FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune system. Clinics. 2013; 68: 1018-27.
-
(2013)
Clinics
, vol.68
, pp. 1018-1027
-
-
Pereira, F.V.1
Arruda, D.C.2
Figueiredo, C.R.3
-
46
-
-
79959948518
-
FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells
-
Wallington-Beddoe CT, Hewson J, Bradstock KF, et al. FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells. Autophagy. 2011; 7: 707-15.
-
(2011)
Autophagy
, vol.7
, pp. 707-715
-
-
Wallington-Beddoe, C.T.1
Hewson, J.2
Bradstock, K.F.3
-
47
-
-
77953694847
-
FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma
-
Liu Q, Alinari L, Chen CS, et al. FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma. Clin Cancer Res. 2010; 16: 3182-92.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3182-3192
-
-
Liu, Q.1
Alinari, L.2
Chen, C.S.3
-
48
-
-
78649305851
-
FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy
-
Zhang N, Qi Y, Wadham C, et al. FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy. Autophagy. 2010; 6: 1157-67.
-
(2010)
Autophagy
, vol.6
, pp. 1157-1167
-
-
Zhang, N.1
Qi, Y.2
Wadham, C.3
-
49
-
-
84898926856
-
FTY720 enhances chemosensitivity of colon cancer cells to doxorubicin and etoposide via the modulation of P-glycoprotein and multidrug resistance protein 1
-
Xing Y, Wang ZH, Ma DH, et al. FTY720 enhances chemosensitivity of colon cancer cells to doxorubicin and etoposide via the modulation of P-glycoprotein and multidrug resistance protein 1. J Dig Dis. 2014; 15: 246-59.
-
(2014)
J Dig Dis
, vol.15
, pp. 246-259
-
-
Xing, Y.1
Wang, Z.H.2
Ma, D.H.3
-
50
-
-
45749139274
-
Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells
-
Nagaoka Y, Otsuki K, Fujita T, et al. Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells. Biol Pharm Bull. 2008; 31: 1177-81.
-
(2008)
Biol Pharm Bull
, vol.31
, pp. 1177-1181
-
-
Nagaoka, Y.1
Otsuki, K.2
Fujita, T.3
-
51
-
-
0042029408
-
Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity
-
Azuma H, Horie S, Muto S, et al. Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity. Anticancer Res. 2003; 23: 3183-93.
-
(2003)
Anticancer Res
, vol.23
, pp. 3183-3193
-
-
Azuma, H.1
Horie, S.2
Muto, S.3
-
52
-
-
0036494268
-
Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models
-
Azuma H, Takahara S, Ichimaru N, et al. Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models. Cancer Res. 2002; 62: 1410-9.
-
(2002)
Cancer Res
, vol.62
, pp. 1410-1419
-
-
Azuma, H.1
Takahara, S.2
Ichimaru, N.3
-
53
-
-
32244448999
-
FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase
-
Zhou C, Ling MT, Kin-Wah Lee T, et al. FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase. Cancer Lett. 2006; 233: 36-47.
-
(2006)
Cancer Lett
, vol.233
, pp. 36-47
-
-
Zhou, C.1
Ling, M.T.2
Kin-Wah Lee, T.3
-
54
-
-
84865159639
-
S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma
-
Liu Y, Deng J, Wang L, et al. S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma. Blood. 2012; 120: 1458-65.
-
(2012)
Blood
, vol.120
, pp. 1458-1465
-
-
Liu, Y.1
Deng, J.2
Wang, L.3
-
55
-
-
23844515685
-
FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance
-
Yasui H, Hideshima T, Raje N, et al. FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. Cancer Res. 2005; 65: 7478-84.
-
(2005)
Cancer Res
, vol.65
, pp. 7478-7484
-
-
Yasui, H.1
Hideshima, T.2
Raje, N.3
-
56
-
-
50949132631
-
Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes
-
Shah MV, Zhang R, Irby R, et al. Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes. Blood. 2008; 112: 770-81.
-
(2008)
Blood
, vol.112
, pp. 770-781
-
-
Shah, M.V.1
Zhang, R.2
Irby, R.3
-
57
-
-
84892428560
-
FTY720 for cancer therapy
-
Zhang L, Wang HD, Ji XJ, et al. FTY720 for cancer therapy. Oncol Rep. 2013; 30: 2571-8.
-
(2013)
Oncol Rep
, vol.30
, pp. 2571-2578
-
-
Zhang, L.1
Wang, H.D.2
Ji, X.J.3
-
58
-
-
84885085996
-
PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells
-
Neviani P, Harb JG, Oaks JJ, et al. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. J Clin Invest. 2013; 123: 4144-57.
-
(2013)
J Clin Invest
, vol.123
, pp. 4144-4157
-
-
Neviani, P.1
Harb, J.G.2
Oaks, J.J.3
-
59
-
-
80053259864
-
Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins
-
Romero Rosales K, Singh G, Wu K, et al. Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins. Biochem J. 2011; 439: 299-311.
-
(2011)
Biochem J
, vol.439
, pp. 299-311
-
-
Romero Rosales, K.1
Singh, G.2
Wu, K.3
-
60
-
-
33847644587
-
FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft
-
Ubai T, Azuma H, Kotake Y, et al. FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft. Anticancer Res. 2007; 27: 75-88.
-
(2007)
Anticancer Res
, vol.27
, pp. 75-88
-
-
Ubai, T.1
Azuma, H.2
Kotake, Y.3
-
61
-
-
33644697587
-
Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma
-
Ho JW, Man K, Sun CK, et al. Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma. Mol Cancer Ther. 2005; 4: 1430-8.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 1430-1438
-
-
Ho, J.W.1
Man, K.2
Sun, C.K.3
-
62
-
-
84923058186
-
Involvement of vacuolar H -ATPase in killing of human melanoma cells by the sphingosine kinase analogue FTY720
-
Tay KH, Liu X, Chi M, et al. Involvement of vacuolar H -ATPase in killing of human melanoma cells by the sphingosine kinase analogue FTY720. Pigment Cell Melanoma Res. 2014; 28. Doi: 10.1111/pcmr.12326.
-
(2014)
Pigment Cell Melanoma Res
, vol.28
-
-
Tay, K.H.1
Liu, X.2
Chi, M.3
-
63
-
-
28044460091
-
FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer
-
Chua CW, Lee DT, Ling MT, et al. FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer. Int J Cancer. 2005; 117: 1039-48.
-
(2005)
Int J Cancer
, vol.117
, pp. 1039-1048
-
-
Chua, C.W.1
Lee, D.T.2
Ling, M.T.3
-
64
-
-
0038286415
-
Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment
-
Azuma H, Takahara S, Horie S, et al. Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment. J Urol. 2003; 169: 2372-7.
-
(2003)
J Urol
, vol.169
, pp. 2372-2377
-
-
Azuma, H.1
Takahara, S.2
Horie, S.3
-
65
-
-
84929940184
-
FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling
-
Lu Z, Wang J, Zheng T, et al. FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling. BMC Cancer. 2014; 14: 783.
-
(2014)
BMC Cancer
, vol.14
, pp. 783
-
-
Lu, Z.1
Wang, J.2
Zheng, T.3
-
66
-
-
0041922480
-
Elimination of cell-cycle regulators during caspase-3-dependent apoptosis caused by an immunosuppressant, FTY720
-
Lee YS, Nakajima H, Tsuruga M, et al. Elimination of cell-cycle regulators during caspase-3-dependent apoptosis caused by an immunosuppressant, FTY720. Biosci Biotechnol Biochem. 2003; 67: 467-74.
-
(2003)
Biosci Biotechnol Biochem
, vol.67
, pp. 467-474
-
-
Lee, Y.S.1
Nakajima, H.2
Tsuruga, M.3
-
67
-
-
0037051102
-
Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis
-
Permpongkosol S, Wang JD, Takahara S, et al. Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis. Int J Cancer. 2002; 98: 167-72.
-
(2002)
Int J Cancer
, vol.98
, pp. 167-172
-
-
Permpongkosol, S.1
Wang, J.D.2
Takahara, S.3
-
68
-
-
84862829250
-
Autophagy induced by FTY720 promotes apoptosis in U266 cells
-
Liao A, Hu R, Zhao Q, et al. Autophagy induced by FTY720 promotes apoptosis in U266 cells. Eur J Pharm Sci. 2012; 45: 600-5.
-
(2012)
Eur J Pharm Sci
, vol.45
, pp. 600-605
-
-
Liao, A.1
Hu, R.2
Zhao, Q.3
-
69
-
-
84859519656
-
Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma
-
Estrada-Bernal A, Palanichamy K, Ray Chaudhury A, et al. Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma. Neuro Oncol. 2012; 14: 405-15.
-
(2012)
Neuro Oncol
, vol.14
, pp. 405-415
-
-
Estrada-Bernal, A.1
Palanichamy, K.2
Ray Chaudhury, A.3
-
71
-
-
84901717453
-
Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro
-
Marvaso G, Barone A, Amodio N, et al. Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro. Cancer Biol Ther. 2014; 15: 797-805.
-
(2014)
Cancer Biol Ther
, vol.15
, pp. 797-805
-
-
Marvaso, G.1
Barone, A.2
Amodio, N.3
-
72
-
-
84890285272
-
miRNA-95 mediates radioresistance in tumors by targeting the sphingolipid phosphatase SGPP1
-
Huang X, Taeb S, Jahangiri S, et al. miRNA-95 mediates radioresistance in tumors by targeting the sphingolipid phosphatase SGPP1. Cancer Res. 2013; 73: 6972-86.
-
(2013)
Cancer Res
, vol.73
, pp. 6972-6986
-
-
Huang, X.1
Taeb, S.2
Jahangiri, S.3
-
73
-
-
0034929391
-
Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720
-
Nagahara Y, Matsuoka Y, Saito K, et al. Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720. Jpn J Cancer Res. 2001; 92: 680-7.
-
(2001)
Jpn J Cancer Res
, vol.92
, pp. 680-687
-
-
Nagahara, Y.1
Matsuoka, Y.2
Saito, K.3
-
74
-
-
84918827750
-
Cellular and metabolic functions for autophagy in cancer cells
-
Kenific CM, Debnath J. Cellular and metabolic functions for autophagy in cancer cells. Trends Cell Biol. 2015; 25: 37-45.
-
(2015)
Trends Cell Biol
, vol.25
, pp. 37-45
-
-
Kenific, C.M.1
Debnath, J.2
-
75
-
-
84928589926
-
FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K/AKT/mTOR/p70S6K signaling pathway
-
Zhang L, Wang H, Zhu J, et al. FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K/AKT/mTOR/p70S6K signaling pathway. Tumour Biol. 2014; 35: 10707-14.
-
(2014)
Tumour Biol
, vol.35
, pp. 10707-10714
-
-
Zhang, L.1
Wang, H.2
Zhu, J.3
-
76
-
-
67650369580
-
Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform
-
Chua CW, Chiu YT, Yuen HF, et al. Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform. Clin Cancer Res. 2009; 15: 4322-35.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4322-4335
-
-
Chua, C.W.1
Chiu, Y.T.2
Yuen, H.F.3
-
77
-
-
70350444557
-
Suppression of hepatocellular carcinoma recurrence after rat liver transplantation by FTY720, a sphingosine-1-phosphate analog
-
Ushitora Y, Tashiro H, Ogawa T, et al. Suppression of hepatocellular carcinoma recurrence after rat liver transplantation by FTY720, a sphingosine-1-phosphate analog. Transplantation. 2009; 88: 980-6.
-
(2009)
Transplantation
, vol.88
, pp. 980-986
-
-
Ushitora, Y.1
Tashiro, H.2
Ogawa, T.3
-
78
-
-
16244415893
-
Significance of the Rac signaling pathway in HCC cell motility: implications for a new therapeutic target
-
Lee TK, Man K, Ho JW, et al. Significance of the Rac signaling pathway in HCC cell motility: implications for a new therapeutic target. Carcinogenesis. 2005; 26: 681-7.
-
(2005)
Carcinogenesis
, vol.26
, pp. 681-687
-
-
Lee, T.K.1
Man, K.2
Ho, J.W.3
-
79
-
-
28544451354
-
FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma
-
Lee TK, Man K, Ho JW, et al. FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma. Clin Cancer Res. 2005; 11: 8458-66.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 8458-8466
-
-
Lee, T.K.1
Man, K.2
Ho, J.W.3
-
80
-
-
34547408777
-
FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells
-
Shen Y, Cai M, Xia W, et al. FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells. Cancer Lett. 2007; 254: 288-97.
-
(2007)
Cancer Lett
, vol.254
, pp. 288-297
-
-
Shen, Y.1
Cai, M.2
Xia, W.3
-
81
-
-
31544447428
-
Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization
-
LaMontagne K, Littlewood-Evans A, Schnell C, et al. Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer Res. 2006; 66: 221-31.
-
(2006)
Cancer Res
, vol.66
, pp. 221-231
-
-
LaMontagne, K.1
Littlewood-Evans, A.2
Schnell, C.3
-
82
-
-
84875723927
-
Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration
-
Kluk MJ, Ryan KP, Wang B, et al. Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration. Lab Invest. 2013; 93: 462-71.
-
(2013)
Lab Invest
, vol.93
, pp. 462-471
-
-
Kluk, M.J.1
Ryan, K.P.2
Wang, B.3
-
83
-
-
84899442348
-
Small Rho GTPases in the control of cell shape and mobility
-
Murali A, Rajalingam K. Small Rho GTPases in the control of cell shape and mobility. Cell Mol Life Sci. 2014; 71: 1703-21.
-
(2014)
Cell Mol Life Sci
, vol.71
, pp. 1703-1721
-
-
Murali, A.1
Rajalingam, K.2
-
84
-
-
84920120629
-
Clinical significance of epithelial-mesenchymal transition
-
Steinestel K, Eder S, Schrader AJ, et al. Clinical significance of epithelial-mesenchymal transition. Clin Transl Med. 2014; 3: 17.
-
(2014)
Clin Transl Med
, vol.3
, pp. 17
-
-
Steinestel, K.1
Eder, S.2
Schrader, A.J.3
-
85
-
-
84907609978
-
SET-mediated NDRG1 inhibition is involved in acquisition of epithelial-to-mesenchymal transition phenotype and cisplatin resistance in human lung cancer cell
-
Liu H, Gu Y, Yin J, et al. SET-mediated NDRG1 inhibition is involved in acquisition of epithelial-to-mesenchymal transition phenotype and cisplatin resistance in human lung cancer cell. Cell Signal. 2014; 26: 2710-20.
-
(2014)
Cell Signal
, vol.26
, pp. 2710-2720
-
-
Liu, H.1
Gu, Y.2
Yin, J.3
-
86
-
-
0037967272
-
Tumorigenesis and the angiogenic switch
-
Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 2003; 3: 401-10.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 401-410
-
-
Bergers, G.1
Benjamin, L.E.2
-
87
-
-
34147095398
-
The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1
-
Schmid G, Guba M, Ischenko I, et al. The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1. J Cell Biochem. 2007; 101: 259-70.
-
(2007)
J Cell Biochem
, vol.101
, pp. 259-270
-
-
Schmid, G.1
Guba, M.2
Ischenko, I.3
-
88
-
-
84863981803
-
Fingolimod potentiates the effects of sunitinib malate in a rat breast cancer model
-
Mousseau Y, Mollard S, Faucher-Durand K, et al. Fingolimod potentiates the effects of sunitinib malate in a rat breast cancer model. Breast Cancer Res Treat. 2012; 134: 31-40.
-
(2012)
Breast Cancer Res Treat
, vol.134
, pp. 31-40
-
-
Mousseau, Y.1
Mollard, S.2
Faucher-Durand, K.3
-
89
-
-
77949553030
-
Improved intratumoral oxygenation through vascular normalization increases glioma sensitivity to ionizing radiation
-
McGee MC, Hamner JB, Williams RF, et al. Improved intratumoral oxygenation through vascular normalization increases glioma sensitivity to ionizing radiation. Int J Radiat Oncol Biol Phys. 2010; 76: 1537-45.
-
(2010)
Int J Radiat Oncol Biol Phys
, vol.76
, pp. 1537-1545
-
-
McGee, M.C.1
Hamner, J.B.2
Williams, R.F.3
-
90
-
-
77954579874
-
Recombinant human endostatin improves anti-tumor efficacy of paclitaxel by normalizing tumor vasculature in Lewis lung carcinoma
-
Huang G, Chen L. Recombinant human endostatin improves anti-tumor efficacy of paclitaxel by normalizing tumor vasculature in Lewis lung carcinoma. J Cancer Res Clin Oncol. 2010; 136: 1201-11.
-
(2010)
J Cancer Res Clin Oncol
, vol.136
, pp. 1201-1211
-
-
Huang, G.1
Chen, L.2
-
91
-
-
79955750260
-
Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants
-
Soleimani R, Heytens E, Oktay K. Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants. PLoS ONE. 2011; 6: e19475.
-
(2011)
PLoS ONE
, vol.6
, pp. e19475
-
-
Soleimani, R.1
Heytens, E.2
Oktay, K.3
-
92
-
-
84863291987
-
FTY720 suppresses liver tumor metastasis by reducing the population of circulating endothelial progenitor cells
-
Li CX, Shao Y, Ng KT, et al. FTY720 suppresses liver tumor metastasis by reducing the population of circulating endothelial progenitor cells. PLoS ONE. 2012; 7: e32380.
-
(2012)
PLoS ONE
, vol.7
, pp. e32380
-
-
Li, C.X.1
Shao, Y.2
Ng, K.T.3
-
93
-
-
84908149118
-
Cancer-related inflammation and treatment effectiveness
-
Diakos CI, Charles KA, McMillan DC, et al. Cancer-related inflammation and treatment effectiveness. Lancet Oncol. 2014; 15: e493-503.
-
(2014)
Lancet Oncol
, vol.15
, pp. e493-e503
-
-
Diakos, C.I.1
Charles, K.A.2
McMillan, D.C.3
-
94
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011; 144: 646-74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
95
-
-
80051688285
-
Melanoma occurring during treatment with fingolimod for multiple sclerosis: a case report
-
Conzett KB, Kolm I, Jelcic I, et al. Melanoma occurring during treatment with fingolimod for multiple sclerosis: a case report. Arch Dermatol. 2011; 147: 991-2.
-
(2011)
Arch Dermatol
, vol.147
, pp. 991-992
-
-
Conzett, K.B.1
Kolm, I.2
Jelcic, I.3
-
96
-
-
84856209651
-
Fingolimod in multiple sclerosis: mechanisms of action and clinical efficacy
-
Ingwersen J, Aktas O, Kuery P, et al. Fingolimod in multiple sclerosis: mechanisms of action and clinical efficacy. Clin Immunol. 2012; 142: 15-24.
-
(2012)
Clin Immunol
, vol.142
, pp. 15-24
-
-
Ingwersen, J.1
Aktas, O.2
Kuery, P.3
-
97
-
-
84857739670
-
Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice
-
Lorvik KB, Bogen B, Corthay A. Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice. Blood. 2012; 119: 2176-7.
-
(2012)
Blood
, vol.119
, pp. 2176-2177
-
-
Lorvik, K.B.1
Bogen, B.2
Corthay, A.3
-
98
-
-
79957525337
-
Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma
-
Omar HA, Chou CC, Berman-Booty LD, et al. Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma. Hepatology. 2011; 53: 1943-58.
-
(2011)
Hepatology
, vol.53
, pp. 1943-1958
-
-
Omar, H.A.1
Chou, C.C.2
Berman-Booty, L.D.3
-
99
-
-
84922460048
-
Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia
-
Mani R, Mao Y, Frissora FW, et al. Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia. Leukemia. 2015; 29: 346-55.
-
(2015)
Leukemia
, vol.29
, pp. 346-355
-
-
Mani, R.1
Mao, Y.2
Frissora, F.W.3
-
100
-
-
84885461398
-
Design, synthesis, and anti-leukemic activity of stereochemically defined constrained analogs of FTY720 (Gilenya)
-
Fransson R, McCracken AN, Chen B, et al. Design, synthesis, and anti-leukemic activity of stereochemically defined constrained analogs of FTY720 (Gilenya). ACS Med Chem Lett. 2013; 4: 969-73.
-
(2013)
ACS Med Chem Lett
, vol.4
, pp. 969-973
-
-
Fransson, R.1
McCracken, A.N.2
Chen, B.3
-
101
-
-
84927161862
-
The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells
-
Tonelli F, Alossaimi M, Natarajan V, et al. The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells. Biomolecules. 2013; 3: 316-33.
-
(2013)
Biomolecules
, vol.3
, pp. 316-333
-
-
Tonelli, F.1
Alossaimi, M.2
Natarajan, V.3
-
102
-
-
84874425286
-
The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism
-
Tonelli F, Alossaimi M, Williamson L, et al. The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism. Br J Pharmacol. 2013; 168: 1497-505.
-
(2013)
Br J Pharmacol
, vol.168
, pp. 1497-1505
-
-
Tonelli, F.1
Alossaimi, M.2
Williamson, L.3
-
103
-
-
79956301884
-
FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells
-
Lim KG, Tonelli F, Li Z, et al. FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells. J Biol Chem. 2011; 286: 18633-40.
-
(2011)
J Biol Chem
, vol.286
, pp. 18633-18640
-
-
Lim, K.G.1
Tonelli, F.2
Li, Z.3
-
104
-
-
84867850672
-
Effect of alkyl chain length on sphingosine kinase 2 selectivity
-
Knott K, Kharel Y, Raje MR, et al. Effect of alkyl chain length on sphingosine kinase 2 selectivity. Bioorg Med Chem Lett. 2012; 22: 6817-20.
-
(2012)
Bioorg Med Chem Lett
, vol.22
, pp. 6817-6820
-
-
Knott, K.1
Kharel, Y.2
Raje, M.R.3
-
105
-
-
79960730615
-
(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells
-
Lim KG, Sun C, Bittman R, et al. (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. Cell Signal. 2011; 23: 1590-5.
-
(2011)
Cell Signal
, vol.23
, pp. 1590-1595
-
-
Lim, K.G.1
Sun, C.2
Bittman, R.3
-
106
-
-
84873673109
-
The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells
-
Watson DG, Tonelli F, Alossaimi M, et al. The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. Cell Signal. 2013; 25: 1011-7.
-
(2013)
Cell Signal
, vol.25
, pp. 1011-1017
-
-
Watson, D.G.1
Tonelli, F.2
Alossaimi, M.3
-
107
-
-
84895071225
-
A novel liposomal formulation of FTY720 (fingolimod) for promising enhanced targeted delivery
-
Mao Y, Wang J, Zhao Y, et al. A novel liposomal formulation of FTY720 (fingolimod) for promising enhanced targeted delivery. Nanomedicine. 2014; 10: 393-400.
-
(2014)
Nanomedicine
, vol.10
, pp. 393-400
-
-
Mao, Y.1
Wang, J.2
Zhao, Y.3
-
108
-
-
84878654009
-
Targeted drug delivery and cross-linking induced apoptosis with anti-CD37 based dual-ligand immunoliposomes in B chronic lymphocytic leukemia cells
-
Yu B, Mao Y, Yuan Y, et al. Targeted drug delivery and cross-linking induced apoptosis with anti-CD37 based dual-ligand immunoliposomes in B chronic lymphocytic leukemia cells. Biomaterials. 2013; 34: 6185-93.
-
(2013)
Biomaterials
, vol.34
, pp. 6185-6193
-
-
Yu, B.1
Mao, Y.2
Yuan, Y.3
-
109
-
-
84921362531
-
Repurposing drugs in your medicine cabinet: untapped opportunities for cancer therapy?
-
Pantziarka P, Bouche G, Meheus L, et al. Repurposing drugs in your medicine cabinet: untapped opportunities for cancer therapy? Future Oncol. 2015; 11: 181-4.
-
(2015)
Future Oncol
, vol.11
, pp. 181-184
-
-
Pantziarka, P.1
Bouche, G.2
Meheus, L.3
-
110
-
-
84885357375
-
PKR negatively regulates leukemia progression in association with PP2A activation, Bcl-2 inhibition and increased apoptosis
-
Cheng X, Bennett RL, Liu X, et al. PKR negatively regulates leukemia progression in association with PP2A activation, Bcl-2 inhibition and increased apoptosis. Blood Cancer J. 2013; 3: e144.
-
(2013)
Blood Cancer J
, vol.3
, pp. e144
-
-
Cheng, X.1
Bennett, R.L.2
Liu, X.3
-
111
-
-
45749146180
-
Antiproliferative and overadditive effects of rapamycin and FTY720 in pancreatic cancer cells in vitro
-
Shen Y, Wang X, Xia W, et al. Antiproliferative and overadditive effects of rapamycin and FTY720 in pancreatic cancer cells in vitro. Transplant Proc. 2008; 40: 1727-33.
-
(2008)
Transplant Proc
, vol.40
, pp. 1727-1733
-
-
Shen, Y.1
Wang, X.2
Xia, W.3
|