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Volumn 53, Issue 8, 2012, Pages 1701-1707

A fluorescent assay for ceramide synthase activity

Author keywords

Ceramides; Enzymology enzyme mechanisms; Fatty acid transferase; Mass spectrometry; Sphingolipids

Indexed keywords

2 AMINO 18 [(7 NITROBENZO[C][1,2,5]OXADIAZOL 4 YL)AMINO]OCTADECANE 1,3 DIOL; FINGOLIMOD; FLUORESCENT DYE; SPHINGANINE; SPHINGOSINE ACYLTRANSFERASE; UNCLASSIFIED DRUG;

EID: 84863809760     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.D025627     Document Type: Article
Times cited : (32)

References (23)
  • 1
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: Lessons from sphingolipids
    • DOI 10.1038/nrm2329, PII NRM2329
    • Hannun, Y. A., and L. M. Obeid. 2008. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat. Rev. Mol. Cell Biol. 9: 139-150. (Pubitemid 351158911)
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , Issue.2 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 2
    • 70349871692 scopus 로고    scopus 로고
    • Gangliosides in cell recognition and membrane protein regulation
    • Lopez, P. H., and R. L. Schnaar. 2009. Gangliosides in cell recognition and membrane protein regulation. Curr. Opin. Struct. Biol. 19: 549-557.
    • (2009) Curr. Opin. Struct. Biol. , vol.19 , pp. 549-557
    • Lopez, P.H.1    Schnaar, R.L.2
  • 3
    • 33750529276 scopus 로고    scopus 로고
    • Available from: Accessed February 15, 2012
    • Christie, W. W. The Lipid Library. Available from: http://www. lipidlibrary.aocs.org. Accessed February 15, 2012.
    • The Lipid Library
    • Christie, W.W.1
  • 4
    • 0037144554 scopus 로고    scopus 로고
    • Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells
    • Venkataraman, K., C. Riebeling, J. Bodennec, H. Riezman, J. C. Allegood, M. C. Sullards, A. H. Merrill, Jr., and A. H. Futerman. 2002. Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro) ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells. J. Biol. Chem. 277: 35642-35649.
    • (2002) J. Biol. Chem. , vol.277 , pp. 35642-35649
    • Venkataraman, K.1    Riebeling, C.2    Bodennec, J.3    Riezman, H.4    Allegood, J.C.5    Sullards, M.C.6    Merrill Jr., A.H.7    Futerman, A.H.8
  • 5
    • 41949140023 scopus 로고    scopus 로고
    • Characterization of ceramide synthase 2: Tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate
    • Laviad, E. L., L. Albee, I. Pankova-Kholmyansky, S. Epstein, H. Park, A. H. Merrill, Jr., and A. H. Futerman. 2008. Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. J. Biol. Chem. 283: 5677-5684.
    • (2008) J. Biol. Chem. , vol.283 , pp. 5677-5684
    • Laviad, E.L.1    Albee, L.2    Pankova-Kholmyansky, I.3    Epstein, S.4    Park, H.5    Merrill Jr., A.H.6    Futerman, A.H.7
  • 8
    • 75149176725 scopus 로고    scopus 로고
    • Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways
    • Senkal, C. E., S. Ponnusamy, J. Bielawski, Y. A. Hannun, and B. Ogretmen. 2010. Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J. 24: 296-308.
    • (2010) FASEB J. , vol.24 , pp. 296-308
    • Senkal, C.E.1    Ponnusamy, S.2    Bielawski, J.3    Hannun, Y.A.4    Ogretmen, B.5
  • 10
    • 35548948815 scopus 로고    scopus 로고
    • m values towards sphinganine
    • DOI 10.1016/j.febslet.2007.10.018, PII S0014579307010782
    • Lahiri, S., H. Lee, J. Mesicek, Z. Fuks, A. Haimovitz-Friedman, R. N. Kolesnick, and A. H. Futerman. 2007. Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett. 581: 5289-5294. (Pubitemid 350018756)
    • (2007) FEBS Letters , vol.581 , Issue.27 , pp. 5289-5294
    • Lahiri, S.1    Lee, H.2    Mesicek, J.3    Fuks, Z.4    Haimovitz-Friedman, A.5    Kolesnick, R.N.6    Futerman, A.H.7
  • 11
    • 23944483995 scopus 로고    scopus 로고
    • Mammalian Lass6 and its related family members regulate synthesis of specific ceramides
    • DOI 10.1042/BJ20050291
    • Mizutani, Y., A. Kihara, and Y. Igarashi. 2005. Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem. J. 390: 263-271. (Pubitemid 41192252)
    • (2005) Biochemical Journal , vol.390 , Issue.1 , pp. 263-271
    • Mizutani, Y.1    Kihara, A.2    Igarashi, Y.3
  • 12
    • 0033911710 scopus 로고    scopus 로고
    • Measurement of ceramide synthase activity
    • Bose, R., and R. Kolesnick. 2000. Measurement of ceramide synthase activity. Methods Enzymol. 322: 378-382. (Pubitemid 30482071)
    • (2000) Methods in Enzymology , vol.322 , pp. 378-382
    • Bose, R.1    Kolesnick, R.2
  • 14
    • 0037020584 scopus 로고    scopus 로고
    • First asymmetric synthesis of chiral analogues of the novel immunosuppressant FTY720
    • DOI 10.1016/S0040-4039(02)01925-1, PII S0040403902019251
    • Hinterding, K., R. Albert, and S. Cottens. 2002. First asymmetric synthesis of chiral analogues of the novel immunosuppressant FTY720. Tetrahedron Lett. 43: 8095-8097. (Pubitemid 35232421)
    • (2002) Tetrahedron Letters , vol.43 , Issue.45 , pp. 8095-8097
    • Hinterding, K.1    Albert, R.2    Cottens, S.3
  • 15
    • 33745912405 scopus 로고    scopus 로고
    • A time- and cost-efficient system for high-level protein production in mammalian cells
    • DOI 10.1107/S0907444906029799
    • Aricescu, A. R., W. Lu, and E. Y. Jones. 2006. A time- and cost-efficient system for high-level protein production in mammalian cells. Acta Crystallogr. D Biol. Crystallogr. 62: 1243-1250. (Pubitemid 44526216)
    • (2006) Acta Crystallographica Section D: Biological Crystallography , vol.62 , Issue.10 , pp. 1243-1250
    • Aricescu, A.R.1    Lu, W.2    Jones, E.Y.3
  • 16
    • 0033794113 scopus 로고    scopus 로고
    • Sphingolipid extraction and analysis by thin-layer chromatography
    • van Echten-Deckert, G. 2000. Sphingolipid extraction and analysis by thin-layer chromatography. Methods Enzymol. 312: 64-79.
    • (2000) Methods Enzymol. , vol.312 , pp. 64-79
    • Van Echten-Deckert, G.1
  • 17
    • 67650264305 scopus 로고    scopus 로고
    • Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner
    • Lahiri, S., H. Park, E. L. Laviad, X. Lu, R. Bittman, and A. H. Futerman. 2009. Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner. J. Biol. Chem. 284: 16090-16098.
    • (2009) J. Biol. Chem. , vol.284 , pp. 16090-16098
    • Lahiri, S.1    Park, H.2    Laviad, E.L.3    Lu, X.4    Bittman, R.5    Futerman, A.H.6
  • 18
    • 34447530934 scopus 로고    scopus 로고
    • Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues
    • DOI 10.1074/jbc.M609124200
    • Don, A. S., C. Martinez-Lamenca, W. R. Webb, R. L. Proia, E. Roberts, and H. Rosen. 2007. Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues. J. Biol. Chem. 282: 15833-15842. (Pubitemid 47093290)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.21 , pp. 15833-15842
    • Don, A.S.1    Martinez-Lamenca, C.2    Webb, W.R.3    Proia, R.L.4    Roberts, E.5    Rosen, H.6
  • 20
    • 0027787984 scopus 로고
    • Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ
    • Merrill, A. H., Jr., G. van Echten, E. Wang, and K. Sandhoff. 1993. Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J. Biol. Chem. 268: 27299-27306.
    • (1993) J. Biol. Chem. , vol.268 , pp. 27299-27306
    • Merrill Jr., A.H.1    Van Echten, G.2    Wang, E.3    Sandhoff, K.4
  • 21
    • 77951761289 scopus 로고    scopus 로고
    • The biological significance of substrate inhibition: A mechanism with diverse functions
    • Reed, M. C., A. Lieb, and H. F. Nijhout. 2010. The biological significance of substrate inhibition: a mechanism with diverse functions. Bioessays. 32: 422-429.
    • (2010) Bioessays , vol.32 , pp. 422-429
    • Reed, M.C.1    Lieb, A.2    Nijhout, H.F.3
  • 22
    • 0027413499 scopus 로고
    • The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver
    • Hirschberg, K., J. Rodger, and A. H. Futerman. 1993. The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver. Biochem. J. 290: 751-757. (Pubitemid 23100434)
    • (1993) Biochemical Journal , vol.290 , Issue.3 , pp. 751-757
    • Hirschberg, K.1    Rodger, J.2    Futerman, A.H.3
  • 23
    • 77956928859 scopus 로고    scopus 로고
    • Gender-dependent accumulation of ceramides in the cerebral cortex of the APP(SL)/PS1Ki mouse model of Alzheimer's disease
    • Barrier, L., S. Ingrand, B. Fauconneau, and G. Page. 2010. Gender-dependent accumulation of ceramides in the cerebral cortex of the APP(SL)/PS1Ki mouse model of Alzheimer's disease. Neurobiol. Aging. 31: 1843-1853.
    • (2010) Neurobiol. Aging , vol.31 , pp. 1843-1853
    • Barrier, L.1    Ingrand, S.2    Fauconneau, B.3    Page, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.