메뉴 건너뛰기




Volumn 76, Issue 8 SUPPL. 3, 2011, Pages

Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

FINGOLIMOD; INFLUENZA VACCINE; PLACEBO; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR;

EID: 79952026310     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e31820db341     Document Type: Article
Times cited : (115)

References (69)
  • 1
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • DOI 10.1146/annurev.immunol.23.021704.115707
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005;23:683-747. (Pubitemid 40563183)
    • (2005) Annual Review of Immunology , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 3
    • 39449110178 scopus 로고    scopus 로고
    • The immunology of multiple sclerosis
    • DOI 10.1055/s-2007-1019124
    • Bar-Or A. The immunology of multiple sclerosis. Semin Neurol 2008;28:29-45. (Pubitemid 351273082)
    • (2008) Seminars in Neurology , vol.28 , Issue.1 , pp. 29-45
    • Bar-Or, A.1
  • 4
    • 79952020828 scopus 로고    scopus 로고
    • Oral fingolimod (FTY720) treatment improves the performance of daily activities compared with intramuscular Interferon β-1a: Patient-reported indices for multiple sclerosis (PRIMUS)-activities results from a phase III study (TRANSFORMS)
    • Cohen J, Barkhof F, Comi G, et al. Oral fingolimod (FTY720) treatment improves the performance of daily activities compared with intramuscular Interferon β-1a: patient-reported indices for multiple sclerosis (PRIMUS)-activities results from a phase III study (TRANSFORMS). Neurology 2010;74(suppl 2):A543.
    • (2010) Neurology , vol.74 , Issue.SUPPL. 2
    • Cohen, J.1    Barkhof, F.2    Comi, G.3
  • 6
    • 76149093586 scopus 로고    scopus 로고
    • A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
    • Kappos L, Radue EW, O'Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 2010;362:387-401.
    • (2010) N Engl J Med , vol.362 , pp. 387-401
    • Kappos, L.1    Radue, E.W.2    O'Connor, P.3
  • 7
    • 40649122843 scopus 로고    scopus 로고
    • FTY720 story: Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacology
    • Adachi K, Chiba K. FTY720 story: its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacology. Perspect Medicin Chem 2007;1:11-12.
    • (2007) Perspect Medicin Chem , vol.1 , pp. 11-12
    • Adachi, K.1    Chiba, K.2
  • 8
    • 3242696730 scopus 로고    scopus 로고
    • Physiological and pathological actions of sphingosine 1-phosphate
    • DOI 10.1016/j.semcdb.2004.05.002, PII S1084952104000667
    • Hla T. Physiological and pathological actions of sphingosine 1-phosphate. Semin Cell Dev Biol 2004;15:513-520. (Pubitemid 38953947)
    • (2004) Seminars in Cell and Developmental Biology , vol.15 , Issue.5 , pp. 513-520
    • Hla, T.1
  • 9
    • 34548329395 scopus 로고    scopus 로고
    • The metabolism and function of sphingolipids and glycosphingolipids
    • DOI 10.1007/s00018-007-7076-0
    • Lahiri S, Futerman AH. The metabolism and function of sphingolipids and glycosphingolipids. Cell Mol Life Sci 2007;64:2270-2284. (Pubitemid 47347954)
    • (2007) Cellular and Molecular Life Sciences , vol.64 , Issue.17 , pp. 2270-2284
    • Lahiri, S.1    Futerman, A.H.2
  • 11
    • 0142215631 scopus 로고    scopus 로고
    • The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2
    • DOI 10.1016/S0014-5793(03)01168-2
    • Paugh SW, Payne SG, Barbour SE, Milstien S, Spiegel S. The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2. FEBS Lett 2003;554:189-193. (Pubitemid 37324838)
    • (2003) FEBS Letters , vol.554 , Issue.1-2 , pp. 189-193
    • Paugh, S.W.1    Payne, S.G.2    Barbour, S.E.3    Milstien, S.4    Spiegel, S.5
  • 14
    • 21844457949 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and its receptors: An autocrine and paracrine network
    • DOI 10.1038/nri1650
    • Rosen H, Goetzl EJ. Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat Rev Immunol 2005;5:560-570. (Pubitemid 40961333)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.7 , pp. 560-570
    • Rosen, H.1    Goetzl, E.J.2
  • 15
    • 23444434940 scopus 로고    scopus 로고
    • Autoreactive CD8+ T cells in multiple sclerosis: A new target for therapy?
    • Friese MA, Fugger L. Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy? Brain 2005;128:1747-1763.
    • (2005) Brain , vol.128 , pp. 1747-1763
    • Friese, M.A.1    Fugger, L.2
  • 16
    • 67349216357 scopus 로고    scopus 로고
    • Autoimmune T cell responses in the central nervous system
    • Goverman J. Autoimmune T cell responses in the central nervous system. Nat Rev Immunol 2009;9:393-407.
    • (2009) Nat Rev Immunol , vol.9 , pp. 393-407
    • Goverman, J.1
  • 17
    • 0034609968 scopus 로고    scopus 로고
    • T-cell function and migration: Two sides of the same coin
    • von Andrian UH, Mackay CR. T-cell function and migration: two sides of the same coin. N Engl J Med 2000;343:1020-1034.
    • (2000) N Engl J Med , vol.343 , pp. 1020-1034
    • Von Andrian, U.H.1    Mackay, C.R.2
  • 19
    • 2442679391 scopus 로고    scopus 로고
    • The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors
    • Graler MH, Goetzl EJ. The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. FASEB J 2004;18:551-553.
    • (2004) FASEB J , vol.18 , pp. 551-553
    • Graler, M.H.1    Goetzl, E.J.2
  • 20
    • 0032525049 scopus 로고    scopus 로고
    • FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing
    • Chiba K, Yanagawa Y, Masubuchi Y, et al. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J Immunol 1998;160:5037-5044.
    • (1998) J Immunol , vol.160 , pp. 5037-5044
    • Chiba, K.1    Yanagawa, Y.2    Masubuchi, Y.3
  • 21
    • 54449099880 scopus 로고    scopus 로고
    • FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis
    • Mehling M, Brinkmann V, Antel J, et al. FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis. Neurology 2008;71:1261-1267.
    • (2008) Neurology , vol.71 , pp. 1261-1267
    • Mehling, M.1    Brinkmann, V.2    Antel, J.3
  • 22
    • 1942508223 scopus 로고    scopus 로고
    • Multiple-Dose FTY720: Tolerability, Pharmacokinetics, and Lymphocyte Responses in Healthy Subjects
    • DOI 10.1177/0091270004264165
    • Kovarik JM, Schmouder R, Barilla D, Riviere GJ, Wang Y, Hunt T. Multiple-dose FTY720: tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects. J Clin Pharmacol 2004;44:532-537. (Pubitemid 38509722)
    • (2004) Journal of Clinical Pharmacology , vol.44 , Issue.5 , pp. 532-537
    • Kovarik, J.M.1    Schmouder, R.2    Barilla, D.3    Riviere, G.-J.4    Wang, Y.5    Hunt, T.6
  • 23
    • 79952015080 scopus 로고    scopus 로고
    • Lymphocytes and fingolimod - Temporal pattern and relationship with infections
    • Francis GS, Kappos L, O'Connor P, et al. Lymphocytes and fingolimod - temporal pattern and relationship with infections. Mult Scler 2010;16:S146.
    • (2010) Mult Scler , vol.16
    • Francis, G.S.1    Kappos, L.2    O'Connor, P.3
  • 24
    • 77956610988 scopus 로고    scopus 로고
    • Reconstitution of circulating lymphocyte counts in FTY720-treated MS patients
    • Johnson TA, Shames I, Keezer M, et al. Reconstitution of circulating lymphocyte counts in FTY720-treated MS patients. Clin Immunol 2010;137:15-20.
    • (2010) Clin Immunol , vol.137 , pp. 15-20
    • Johnson, T.A.1    Shames, I.2    Keezer, M.3
  • 25
    • 0033554726 scopus 로고    scopus 로고
    • Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    • Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999;401:708-712.
    • (1999) Nature , vol.401 , pp. 708-712
    • Sallusto, F.1    Lenig, D.2    Forster, R.3    Lipp, M.4    Lanzavecchia, A.5
  • 26
    • 78650144281 scopus 로고    scopus 로고
    • Distinct properties of circulating CD8+ T cells in FTY720 treated multiple sclerosis patients
    • Johnson TA, Lapierre Y, Bar-Or A, Antel J. Distinct properties of circulating CD8+ T cells in FTY720 treated multiple sclerosis patients. Arch Neurol 2010;67:1449-1455.
    • (2010) Arch Neurol , vol.67 , pp. 1449-1455
    • Johnson, T.A.1    Lapierre, Y.2    Bar-Or, A.3    Antel, J.4
  • 28
    • 65249175159 scopus 로고    scopus 로고
    • C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
    • Reboldi A, Coisne C, Baumjohann D, et al. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol 2009;10:514-523.
    • (2009) Nat Immunol , vol.10 , pp. 514-523
    • Reboldi, A.1    Coisne, C.2    Baumjohann, D.3
  • 29
    • 72649089874 scopus 로고    scopus 로고
    • Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis
    • Brucklacher-Waldert V, Stuerner K, Kolster M, Wolthausen J, Tolosa E. Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis. Brain 2009;132:3329-3341.
    • (2009) Brain , vol.132 , pp. 3329-3341
    • Brucklacher-Waldert, V.1    Stuerner, K.2    Kolster, M.3    Wolthausen, J.4    Tolosa, E.5
  • 31
    • 38749143286 scopus 로고    scopus 로고
    • Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis
    • DOI 10.2353/ajpath.2008.070690
    • Tzartos JS, Friese MA, Craner MJ, et al. Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am J Pathol 2008;172:146-155. (Pubitemid 351186376)
    • (2008) American Journal of Pathology , vol.172 , Issue.1 , pp. 146-155
    • Tzartos, J.S.1    Friese, M.A.2    Craner, M.J.3    Palace, J.4    Newcombe, J.5    Esiri, M.M.6    Fugger, L.7
  • 33
    • 77955358808 scopus 로고    scopus 로고
    • Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis
    • Mehling M, Lindberg R, Raulf F, et al. Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis. Neurology 2010;75:403-410.
    • (2010) Neurology , vol.75 , pp. 403-410
    • Mehling, M.1    Lindberg, R.2    Raulf, F.3
  • 34
    • 33845215896 scopus 로고    scopus 로고
    • Differential effects of single dose FTY720 on CD62L+ B-cells in stable renal allograft recipients
    • DOI 10.1016/j.intimp.2006.08.018, PII S156757690600275X
    • Bohler T, Schutz M, Budde K, Neumayer HH, Waiser J. Differential effects of single dose FTY720 on CD62L+ B-cells in stable renal allograft recipients. Int Immunopharmacol 2007;7:88-95. (Pubitemid 44856391)
    • (2007) International Immunopharmacology , vol.7 , Issue.1 , pp. 88-95
    • Bohler, T.1    Schutz, M.2    Budde, K.3    Neumayer, H.-H.4    Waiser, J.5
  • 36
    • 10244246559 scopus 로고    scopus 로고
    • FTY720 suppresses humoral immunity by inhibiting germinal center reaction
    • DOI 10.1182/blood-2004-06-2075
    • Han S, Zhang X, Wang G, et al. FTY720 suppresses humoral immunity by inhibiting germinal center reaction. Blood 2004;104:4129-4133. (Pubitemid 39620165)
    • (2004) Blood , vol.104 , Issue.13 , pp. 4129-4133
    • Han, S.1    Zhang, X.2    Wang, G.3    Guan, H.4    Garcia, G.5    Li, P.6    Feng, L.7    Zheng, B.8
  • 37
    • 0033969247 scopus 로고    scopus 로고
    • T-cell immunodeficiency following cytotoxic antineoplastic therapy: A review
    • Mackall CL. T-cell immunodeficiency following cytotoxic antineoplastic therapy: a review. Stem Cells 2000;18:10-18. (Pubitemid 30064888)
    • (2000) Stem Cells , vol.18 , Issue.1 , pp. 10-18
    • Mackall, C.L.1
  • 39
    • 79952034469 scopus 로고    scopus 로고
    • Long-term safety of oral (FTY720) in relapsing multiple sclerosis: Integrated analyses of phase 2 and 3 studies
    • Collins W, Cohens JA, O'Connor PW, et al. Long-term safety of oral (FTY720) in relapsing multiple sclerosis: integrated analyses of phase 2 and 3 studies. Mult Scler 2010;16:S295.
    • (2010) Mult Scler , vol.16
    • Collins, W.1    Cohens, J.A.2    O'Connor, P.W.3
  • 40
    • 49449116795 scopus 로고    scopus 로고
    • Infections cast cloud over Novartis' MS therapy
    • Garber K. Infections cast cloud over Novartis' MS therapy. Nat Biotechnol 2008;26:844-845.
    • (2008) Nat Biotechnol , vol.26 , pp. 844-845
    • Garber, K.1
  • 41
    • 63849147004 scopus 로고    scopus 로고
    • Oral fingolimod (FTY720) in multiple sclerosis: Two-year results of a phase II extension study
    • O'Connor P, Comi G, Montalban X, et al. Oral fingolimod (FTY720) in multiple sclerosis: two-year results of a phase II extension study. Neurology 2009;72:73-79.
    • (2009) Neurology , vol.72 , pp. 73-79
    • O'Connor, P.1    Comi, G.2    Montalban, X.3
  • 42
    • 76449120437 scopus 로고    scopus 로고
    • Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results
    • Comi G, O'Connor P, Montalban X, et al. Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results. Mult Scler 2010;16:197-207.
    • (2010) Mult Scler , vol.16 , pp. 197-207
    • Comi, G.1    O'Connor, P.2    Montalban, X.3
  • 43
    • 75949104159 scopus 로고    scopus 로고
    • Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection
    • Walsh KB, Marsolais D, Welch MJ, Rosen H, Oldstone MB. Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection. Virology 2010;397:260-269.
    • (2010) Virology , vol.397 , pp. 260-269
    • Walsh, K.B.1    Marsolais, D.2    Welch, M.J.3    Rosen, H.4    Oldstone, M.B.5
  • 44
    • 62549151797 scopus 로고    scopus 로고
    • Evaluation of the lymphocyte trafficking drug FTY720 in SHIVSF162P3-infected rhesus macaques
    • Kersh EN, Luo W, Adams DR, et al. Evaluation of the lymphocyte trafficking drug FTY720 in SHIVSF162P3-infected rhesus macaques. J Antimicrob Chemother 2009;63:758-762.
    • (2009) J Antimicrob Chemother , vol.63 , pp. 758-762
    • Kersh, E.N.1    Luo, W.2    Adams, D.R.3
  • 45
    • 79952033925 scopus 로고    scopus 로고
    • Effects of fingolimod on antibody response following steady state dosing in healthy volunteers: A 4-week, randomized, placebo-controlled study
    • Schmouder R, Boulton C, Wang N, David O. Effects of fingolimod on antibody response following steady state dosing in healthy volunteers: a 4-week, randomized, placebo-controlled study. Mult Scler 2010;16:S135.
    • (2010) Mult Scler , vol.16
    • Schmouder, R.1    Boulton, C.2    Wang, N.3    David, O.4
  • 46
    • 79952017059 scopus 로고    scopus 로고
    • Antigen-specific adaptive immune responses in fingolimod-treated patients
    • Dec 13 [Epub ahead of print]
    • Mehling M, Hilbert P, Fritz S, et al. Antigen-specific adaptive immune responses in fingolimod-treated patients. Ann Neurol 2010 Dec 13 [Epub ahead of print].
    • (2010) Ann Neurol
    • Mehling, M.1    Hilbert, P.2    Fritz, S.3
  • 47
    • 37849033437 scopus 로고    scopus 로고
    • S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress
    • Pham TH, Okada T, Matloubian M, Lo CG, Cyster JG. S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Immunity 2008;28:122-133.
    • (2008) Immunity , vol.28 , pp. 122-133
    • Pham, T.H.1    Okada, T.2    Matloubian, M.3    Lo, C.G.4    Cyster, J.G.5
  • 48
    • 2442561611 scopus 로고    scopus 로고
    • Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration
    • Allende ML, Dreier JL, Mandala S, Proia RL. Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration J Biol Chem 2004;279:15396-15401.
    • (2004) J Biol Chem , vol.279 , pp. 15396-15401
    • Allende, M.L.1    Dreier, J.L.2    Mandala, S.3    Proia, R.L.4
  • 51
    • 77952309720 scopus 로고    scopus 로고
    • S1P1 receptor directs the release of immature B cells from bone marrow into blood
    • Allende ML, Tuymetova G, Lee BG, Bonifacino E, Wu YP, Proia RL. S1P1 receptor directs the release of immature B cells from bone marrow into blood. J Exp Med 2010;207:1113-1124.
    • (2010) J Exp Med , vol.207 , pp. 1113-1124
    • Allende, M.L.1    Tuymetova, G.2    Lee, B.G.3    Bonifacino, E.4    Wu, Y.P.5    Proia, R.L.6
  • 52
    • 74049160871 scopus 로고    scopus 로고
    • FTY720 ameliorates MOG-induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses
    • Papadopoulos D, Rundle J, Patel R, et al. FTY720 ameliorates MOG-induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses. J Neurosci Res 2010;88:346-359.
    • (2010) J Neurosci Res , vol.88 , pp. 346-359
    • Papadopoulos, D.1    Rundle, J.2    Patel, R.3
  • 54
    • 77949332336 scopus 로고    scopus 로고
    • Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation
    • Michaud J, Im DS, Hla T. Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation. J Immunol 2010;184:1475-1483.
    • (2010) J Immunol , vol.184 , pp. 1475-1483
    • Michaud, J.1    Im, D.S.2    Hla, T.3
  • 55
  • 56
    • 33748178875 scopus 로고    scopus 로고
    • Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate
    • DOI 10.1182/blood-2006-04-014852
    • Weigert A, Johann AM, von Knethen A, Schmidt H, Geisslinger G, Brune B. Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. Blood 2006;108:1635-1642. (Pubitemid 44316132)
    • (2006) Blood , vol.108 , Issue.5 , pp. 1635-1642
    • Weigert, A.1    Johann, A.M.2    Von, K.A.3    Schmidt, H.4    Geisslinger, G.5    Brune, B.6
  • 57
    • 38049160707 scopus 로고    scopus 로고
    • S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues
    • Allende ML, Zhou D, Kalkofen DN, et al. S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues. Faseb J 2008;22:307-315.
    • (2008) Faseb J , vol.22 , pp. 307-315
    • Allende, M.L.1    Zhou, D.2    Kalkofen, D.N.3
  • 58
    • 70449732610 scopus 로고    scopus 로고
    • T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow
    • Jenne CN, Enders A, Rivera R, et al. T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med 2009;206:2469-2481.
    • (2009) J Exp Med , vol.206 , pp. 2469-2481
    • Jenne, C.N.1    Enders, A.2    Rivera, R.3
  • 59
    • 73349109123 scopus 로고    scopus 로고
    • FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration
    • Hwang SJ, Kim JH, Kim HY, Kim S, Chung DH. FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration. Lab Invest 2010;90:9-19.
    • (2010) Lab Invest , vol.90 , pp. 9-19
    • Hwang, S.J.1    Kim, J.H.2    Kim, H.Y.3    Kim, S.4    Chung, D.H.5
  • 60
  • 62
    • 53149089045 scopus 로고    scopus 로고
    • Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod
    • Miron VE, Hall JA, Kennedy TE, Soliven B, Antel JP. Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod. Am J Pathol 2008;173:1143-1152.
    • (2008) Am J Pathol , vol.173 , pp. 1143-1152
    • Miron, V.E.1    Hall, J.A.2    Kennedy, T.E.3    Soliven, B.4    Antel, J.P.5
  • 63
    • 77953225859 scopus 로고    scopus 로고
    • Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices
    • Miron VE, Ludwin SK, Darlington PJ, et al. Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices. Am J Pathol 2010;176:2682-2694.
    • (2010) Am J Pathol , vol.176 , pp. 2682-2694
    • Miron, V.E.1    Ludwin, S.K.2    Darlington, P.J.3
  • 65
    • 39049125218 scopus 로고    scopus 로고
    • FTY720 modulates human oligodendrocyte progenitor process extension and survival
    • DOI 10.1002/ana.21227
    • Miron VE, Jung CG, Kim HJ, Kennedy TE, Soliven B, Antel JP. FTY720 modulates human oligodendrocyte progenitor process extension and survival. Ann Neurol 2008;63:61-71. (Pubitemid 351240552)
    • (2008) Annals of Neurology , vol.63 , Issue.1 , pp. 61-71
    • Miron, V.E.1    Jung, C.G.2    Kim, H.J.3    Kennedy, T.E.4    Soliven, B.5    Antel, J.P.6
  • 67
    • 34047253376 scopus 로고    scopus 로고
    • Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors
    • DOI 10.1016/j.neuropharm.2006.11.010, PII S0028390806003972
    • Osinde M, Mullershausen F, Dev KK. Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors. Neuropharmacology 2007;52:1210-1218. (Pubitemid 46546406)
    • (2007) Neuropharmacology , vol.52 , Issue.5 , pp. 1210-1218
    • Osinde, M.1    Mullershausen, F.2    Dev, K.K.3
  • 68
    • 77956568581 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions
    • Van Doorn R, Van Horssen J, Verzijl D, et al. Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions. Glia 2010;58:1465-1476.
    • (2010) Glia , vol.58 , pp. 1465-1476
    • Van Doorn, R.1    Van Horssen, J.2    Verzijl, D.3
  • 69
    • 77449106966 scopus 로고    scopus 로고
    • Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats
    • Hasegawa Y, Suzuki H, Sozen T, Rolland W, Zhang JH. Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats. Stroke 2010;41:368-374.
    • (2010) Stroke , vol.41 , pp. 368-374
    • Hasegawa, Y.1    Suzuki, H.2    Sozen, T.3    Rolland, W.4    Zhang, J.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.