Propofol: An anesthetic possessing neuroprotective effects

European Review for Medical and Pharmacological Sciences

Volumn 19, Issue 8, 2015, Pages 1520-1529

  Fan, W ^a,b   Zhu, X ^c   Wu, L ^a   Wu, Z ^a   Li, D ^d   Huang, F ^a   He, H ^a  

^a Guangdong Provincial Key Laboratory of Stomatology   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c GUANGDONG MEDICAL UNIVERSITY   (China)

^d AUGUSTA UNIVERSITY   (United States)

Author keywords

Brain injury; Cerebral ischemia; Neuroprotection; Propofol

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; AQUAPORIN 4; EDETIC ACID; EXCITATORY AMINO ACID; EXCITATORY AMINO ACID TRANSPORTER; EXCITATORY AMINO ACID TRANSPORTER 3; HEME OXYGENASE 1; PROPOFOL; INTRAVENOUS ANESTHETIC AGENT; NEUROPROTECTIVE AGENT;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN CELL; CELL PROTECTION; DRUG EFFECT; DRUG MECHANISM; HUMAN; INFLAMMATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; ANIMAL; CHEMISTRY; DRUG EFFECTS; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ANESTHETICS, INTRAVENOUS; ANIMALS; APOPTOSIS; HUMANS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PROPOFOL; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84942236644     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (129)

1. HUTCHENS MP, MEMTSOUDIS S, SADOVNIKOFF N. Propofol for sedation in neuro-intensive care. Neurocrit Care 2006; 4: 54-62.
2. VASILEIOU I, XANTHOS T, KOUDOUNA E, PERREA D, KLONARIS C, KATSARGYRIS A, PAPADIMITRIOU L. Propofol: a review of its non-anaesthetic effects. Eur J Pharmacol 2009; 605: 1-8.
3. WANG P, CHEN J, MU LH, DU QH, NIU XH, ZHANG MY. Propofol inhibits invasion and enhances paclitaxel- induced apoptosis in ovarian cancer cells through the suppression of the transcription factor slug. Eur Rev Med Pharmacol Sci 2013; 17: 1722-1729.
4. KOTANI Y, SHIMAZAWA M, YOSHIMURA S, IWAMA T, HARA H. The experimental and clinical pharmacology of propofol, an anesthetic agent with neuroprotective properties. CNS Neurosci Ther 2008; 14: 95-106
5. HARMAN F, HASTURK AE, YAMAN M, ARCA T, KILINC K, SARGON MF, KAPTANOGLU E. Neuroprotective effects of propofol, thiopental, etomidate, and midazolam in fetal rat brain in ischemia-reperfusion model. Childs Nerv Syst 2012; 28: 1055-1062.
6. ERGUN R, AKDEMIR G, SEN S, TASCI A, ERGUNGOR F. Neuroprotective effects of propofol following global cerebral ischemia in rats. Neurosurg Rev 2002; 25: 95-98.
7. SOLAROGLU I, OKUTAN O, SOLAROGLU A, KAPTANOGLU E, BESKONAKLI E, KILINC K. Maternal treatment with propofol attenuates lipid peroxidation after transient intrauterine ischemia in the neonatal rat brain. Biol Neonate 2004; 85: 221-224.
8. LEE Y, CHUNG C, OH YS. Effectiveness of propofol pretreatment on the extent of deranged cerebral mitochondrial oxidative enzyme system after incomplete forebrain ischemia/reperfusion in rats. J Korean Med Sci 2000; 15: 627-630.
9. YAMAGUCHI S, MIDORIKAWA Y, OKUDA Y, KITAJIMA T. Propofol prevents delayed neuronal death following transient forebrain ischemia in gerbils. Can J Anaesth 1999; 46: 593-598.
10. ENGELHARD K, WERNER C, EBERSPACHER E, PAPE M, STEGEMANN U, KELLERMANN K, HOLLWECK R, HUTZLER P, KOCHS E. Influence of propofol on neuronal damage and apoptotic factors after incomplete cerebral ischemia and reperfusion in rats: a long-term observation. Anesthesiology 2004; 101: 912-917.
11. MA J, DONG Z, LI QG, WANG JR. Protective effect of propofol against intracerebral hemorrhage injury in rats.Yao Xue Xue Bao 2009; 44: 344-349.
12. PITTMAN JE, SHENG H, PEARLSTEIN R, BRINKHOUS A, DEXTER F, WARNER DS. Comparison of the effects of propofol and pentobarbital on neurologic outcome and cerebral infarct size after temporary focal is-chemia in the rat. Anesthesiology 1997; 87: 1139-1144.
13. GELB AW, BAYONA NA, WILSON JX, CECHETTO DF. Propofol anesthesia compared to awake reduces infarct size in rats. Anesthesiology 2002; 96: 1183-1190.
14. ADEMBRI C, VENTURI L, TANI A, CHIARUGI A, GRAMIGNI E, COZZI A, PANCANI T, DE GAUDIO RA, PELLEGRINI-GIAMPIETRO DE. Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanism. Anesthesiology 2006; 104: 80-89.
15. KOCHS E, HOFFMAN WE, WERNER C, THOMAS C, ALBRECHT RF, SCHULTE AM ESCH J. The effects of propofol on brain electrical activity, neurologic outcome, and neuronal damage following incomplete ischemia in rats. Anesthesiology 1992; 76: 245-252.
16. YAMASAKI T, NAKAKIMURA K, MATSUMOTO M, XIONG L, ISHIKAWA T, SAKABE T. Effects of graded suppression of the EEG with propofol on the neurological outcome following incomplete cerebral ischaemia in rats. Eur J Anaesthesiol 1999; 16: 320-329.
17. WANG HY, WANG GL, YU YH, WANG Y. The role of phosphoinositide-3-kinase/Akt pathway in propofol- induced postconditioning against focal cerebral ischemia-reperfusion injury in rats. Brain Res 2009; 1297: 177-184.
18. ISHII H, ARAI T, SEGAWA H, MORIKAWA S, INUBUSHI T, FUKUDA K. Effects of propofol on lactate accumulation and oedema formation in focal cerebral ischaemia in hyperglycaemic rats. Br J Anaesth 2002; 88: 412-417.
19. KUBO K, INADA T, SHINGU K. Possible role of propofol's cyclooxygenase-inhibiting property in alleviating dopaminergic neuronal loss in the substantia nigra in an MPTP-induced murine model of Parkinson's disease. Brain Res 2011; 1387: 125-133.
20. CHEN L, GONG Q, XIAO C. Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia- reperfusion in rats. Chin Med J (Engl) 2003; 116: 292-296.
21. WANG H, LUO M, LI C, WANG G. Propofol post-conditioning induced long-term neuroprotection and reduced internalization of AMPAR GluR2 subunit in a rat model of focal cerebral ischemia/reperfusion. J Neurochem 2011; 119: 210-219.
22. WANG J, YANG X, CAMPORESI CV, YANG Z, BOSCO G, CHEN C, CAMPORESI EM. Propofol reduces infarct size and striatal dopamine accumulation following transient middle cerebral artery occlusion: a microdialysis study. Eur J Pharmacol 2002; 452: 303-308.
23. KUMAGAI H, ISAKA M, SUGAWARA Y, OKADA K, IMAI K, ORIHASHI K, SUEDA T. Intra-aortic injection of propofol prevents spinal cord injury during aortic surgery. Eur J Cardiothorac Surg 2006; 29: 714-719.
24. JEVTOVIC-TODOROVIC V, KIRBY CO, OLNEY JW. Isoflurane and propofol block neurotoxicity caused by MK-801 in the rat posterior cingulate/retrosplenial cortex. J Cereb Blood Flow Metab 1997; 17: 168-174.
25. JEVTOVIC-TODOROVIC V, WOZNIAK DF, POWELL S, OLNEY JW. Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex. Brain Res 2001; 913: 185-189.
26. LEE SR, CHEUN JK. Propofol administration reduces hippocampal neuronal damage induced by kainic acid in rats. Neurol Res 1999; 21: 225-228.
27. ICHINOSE K, OKAMOTO T, TANIMOTO H, TAGUCHI H, TASHIRO M, SUGITA M, TAKEYA M, TERASAKI H. A moderate dose of propofol and rapidly induced mild hypothermia with extracorporeal lung and heart assist (ECLHA) improve the neurological outcome after prolonged cardiac arrest in dogs. Resuscitation 2006; 70: 275-284.
28. YOUNG Y, MENON DK, TISAVIPAT N, MATTA BF, JONES JG. Propofol neuroprotection in a rat model of ischaemia reperfusion injury. Eur J Anaesthesiol 1997; 14: 320-326.
29. HE J, HUANG C, JIANG J, LV L. Propofol exerts hippocampal neuron protective effects via up-regulation of metallothionein-3. Neurol Sci 2013; 34: 165-171.
30. WU GJ, CHEN WF, HUNG HC, JEAN YH, SUNG CS, CHAKRABORTY C, LEE HP, CHEN NF, WEN ZH. Effects of propofol on proliferation and anti-apoptosis of neuroblastoma SH-SY5Y cell line: new insights into neuroprotection. Brain Res 2011; 1384: 42-50.
31. VELLY LJ, GUILLET BA, MASMEJEAN FM, NIEOULLON AL, BRUDER NJ, GOUIN FM, PISANO PM. Neuroprotective effects of propofol in a model of ischemic cortical cell cultures: role of glutamate and its transporters. Anesthesiology 2003; 99: 368-375.
32. ROSSAINT J, ROSSAINT R, WEIS J, FRIES M, REX S, COBURN M. Propofol: neuroprotection in an in vitro model of traumatic brain injury. Crit Care 2009; 13: R61.
33. FEINER JR, BICKLER PE, ESTRADA S, DONOHOE PH, FAHLMAN CS, SCHUYLER JA. Mild hypothermia, but not propofol, is neuroprotective in organotypic hippocampal cultures. Anesth Analg 2005; 100: 215-225.
34. IIJIMA T, MISHIMA T, AKAGAWA K, IWAO Y. Neuroprotective effect of propofol on necrosis and apoptosis following oxygen-glucose deprivation-relationship between mitochondrial membrane potential and mode of death. Brain Res 2006; 1099: 25-32.
35. MA G, CHEN J, MENG X, DENG L, GAO Y, MENG J. High-dose propofol reduces S-100beta protein and neuron-specific enolase levels in patients undergoing cardiac surgery. J Cardiothorac Vasc Anesth 2013; 27: 510-515.
36. ADEMBRI C, VENTURI L, PELLEGRINI-GIAMPIETRO DE. Neuroprotective effects of propofol in acute cerebral injury. CNS Drug Rev 2007; 13: 333-351.
37. BOWERY NG, SMART TG. GABA and glycine as neurotransmitters: a brief history. Br J Pharmacol 2006; 147(Suppl 1): S109-119.
38. TRAPANI G, ALTOMARE C, LISO G, SANNA E, BIGGIO G. Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. Curr Med Chem 2000; 7: 249-271.
39. KRASOWSKI MD, JENKINS A, FLOOD P, KUNG AY, HOPFINGER AJ, HARRISON NL. General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility. J Pharmacol Exp Ther 2001; 297: 338-351.
40. HAESELER G, KARST M, FOADI N, GUDEHUS S, ROEDER A, HECKER H, DENGLER R, LEUWER M. High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues. Br J Pharmacol 2008; 155: 265-275.
41. ITO H, WATANABE Y, ISSHIKI A, UCHINO H. Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. Acta Anaesthesiol Scand 1999; 43: 153-162.
42. HOLLRIGEL GS, TOTH K, SOLTESZ I. Neuroprotection by propofol in acute mechanical injury: role of GABAergic inhibition. J Neurophysiol 1996; 76: 2412-2422.
43. BERNS M, SEEBERG L, SCHMIDT M, KERNER T. Highdose propofol triggers short-term neuroprotection and long-term neurodegeneration in primary neuronal cultures from rat embryos. J Int Med Res 2009; 37: 680-688.
44. COYLE JT, PUTTFARCKEN P. Oxidative stress, glutamate, and neurodegenerative disorders. Science 1993; 262: 689-695.
45. AARTS L, VAN DER HEE R, DEKKER I, DE JONG J, LANGEMEIJER H, BAST A. The widely used anesthetic agent propofol can replace alpha-tocopherol as an antioxidant. FEBS Lett 1995; 357: 83-85.
46. TRABER MG, ATKINSON J. VITAMIN E, antioxidant and nothing more. Free Radic Biol Med 2007; 43: 4-15.
47. HANS P, DEBY-DUPONT G, DEBY C, PIERON F, VERBESSELT R, FRANSSEN C, LAMY M. Increase in antioxidant capacity of plasma during propofol anesthesia. J Neurosurg Anesthesiol 1997; 9: 234-236.
48. MANATAKI AD, TSELEPIS AD, GLANTZOUNIS GK, ARNAOUTOGLOU HM, TSIMOYIANNIS EC, STAVROPOULOS NE. Lipid peroxidation and the use of emulsified propofol in laparoscopic surgery. Surg Endosc 2001; 15: 950-953.
49. STRATFORD N, MURPHY P. Antioxidant activity of propofol in blood from anaesthetized patients. Eur J Anaesthesiol 1998; 15: 158-160.
50. BOLAND A, DELAPIERRE D, MOSSAY D, HANS P, DRESSE A. Propofol protects cultured brain cells from iron ion-induced death: comparison with trolox. Eur J Pharmacol 2000; 404: 21-27.
51. LEE H, JANG YH, LEE SR. Protective effect of propofol against kainic acid-induced lipid peroxidation in mouse brain homogenates: comparison with trolox and melatonin. J Neurosurg Anesthesiol 2005; 17: 144-148.
52. GRASSHOFF C, GILLESSEN T. The effect of propofol on increased superoxide concentration in cultured rat cerebrocortical neurons after stimulation of Nmethyl- d-aspartate receptors. Anesth Analg 2002; 95: 920-922.
53. ACQUAVIVA R, CAMPISI A, MURABITO P, RACITI G, AVOLA R, MANGIAMELI S, MUSUMECI I, BARCELLONA ML, VANELLA A, LI VOLTI G. Propofol attenuates peroxynitritemediated DNA damage and apoptosis in cultured astrocytes: an alternative protective mechanism. Anesthesiology 2004; 101: 1363-1371.
54. SAGARA Y, HENDLER S, KHOH-REITER S, GILLENWATER G, CARLO D, SCHUBERT D, CHANG J. Propofol hemisuccinate protects neuronal cells from oxidative injury. J Neurochem 1999; 73: 2524-2530.
55. KOBAYASHI K, YOSHINO F, TAKAHASHI SS, TODOKI K, MAEHATA Y, KOMATSU T, YOSHIDA K, LEE MC. Direct assessments of the antioxidant effects of propofol medium chain triglyceride/long chain triglyceride on the brain of stroke-prone spontaneously hypertensive rats using electron spin resonance spectroscopy. Anesthesiology 2008; 109: 426-435.
56. KAPTANOGLU E, SEN S, BESKONAKLI E, SURUCU HS, TUNCEL M, KILINC K, TASKIN Y. Antioxidant actions and early ultrastructural findings of thiopental and propofol in experimental spinal cord injury. J Neurosurg Anesthesiol 2002; 14: 114-122.
57. MENKU A, OGDEN M, SARAYMEN R. The protective effects of propofol and citicoline combination in experimental head injury in rats. Turk Neurosurg 2010; 20: 57-62.
58. LARSSON M, BROMAN J. Synaptic plasticity and pain: role of ionotropic glutamate receptors. Neuroscientist 2011; 17: 256-273.
59. SINGH S, KUSHWAH AS, SINGH R, FARSWAN M, KAUR R. Current therapeutic strategy in Alzheimer's disease. Eur Rev Med Pharmacol Sci 2012; 16: 1651-1664.
60. KOBAYASHI M, TAKEDA Y, TANINISHI H, TAKATA K, AOE H, MORITA K. Quantitative evaluation of the neuroprotective effects of thiopental sodium, propofol, and halothane on brain ischemia in the gerbil: effects of the anesthetics on ischemic depolarization and extracellular glutamate concentration. J Neurosurg Anesthesiol 2007; 19: 171-178.
61. ENGELHARD K, WERNER C, HOFFMAN WE, MATTHES B, BLOBNER M, KOCHS E. The effect of sevoflurane and propofol on cerebral neurotransmitter concentrations during cerebral ischemia in rats. Anesth Analg 2003; 97: 1155-1161.
62. YANO T, NAKAYAMA R, USHIJIMA K. Intracerebroventricular propofol is neuroprotective against transient global ischemia in rats: extracellular glutamate level is not a major determinant. Brain Res 2000; 883: 69-76.
63. RATNAKUMARI L, HEMMINGS HC, JR. Effects of propofol on sodium channel-dependent sodium influx and glutamate release in rat cerebrocortical synaptosomes. Anesthesiology 1997; 86: 428-439.
64. LINGAMANENI R, BIRCH ML, HEMMINGS HC, JR. Widespread inhibition of sodium channel-dependent glutamate release from isolated nerve terminals by isoflurane and propofol. Anesthesiology 2001; 95: 1460-1466.
65. RATNAKUMARI L, HEMMINGS HC, JR. Inhibition by propofol of [3H]-batrachotoxinin-A 20-alphabenzoate binding to voltage-dependent sodium channels in rat cortical synaptosomes. Br J Pharmacol 1996; 119: 1498-1504.
66. SITAR SM, HANIFI-MOGHADDAM P, GELB A, CECHETTO DF, SIUSHANSIAN R, WILSON JX. Propofol prevents peroxide-induced inhibition of glutamate transport in cultured astrocytes. Anesthesiology 1999; 90: 1446-1453.
67. YUN JY, PARK KS, KIM JH, DO SH, ZUO Z. Propofol reverses oxidative stress-attenuated glutamate transporter EAAT3 activity: evidence of protein kinase C involvement. Eur J Pharmacol 2007; 565: 83-88.
68. CAI J, HU Y, LI W, LI L, LI S, ZHANG M, LI Q. The neuroprotective effect of propofol against brain ischemia mediated by the glutamatergic signaling pathway in rats. Neurochem Res 2011; 36: 1724-1731
69. DO SH, HAM BM, ZUO Z. Effects of propofol on the activity of rat glutamate transporter type 3 expressed in Xenopus oocytes: the role of protein kinase C. Neurosci Lett 2003;343:113-116.
70. GRASSHOFF C, GILLESSEN T. Effects of propofol on Nmethyl- D-aspartate receptor-mediated calcium increase in cultured rat cerebrocortical neurons. Eur J Anaesthesiol 2005; 22: 467-470.
71. HANS P, BONHOMME V, COLLETTE J, ALBERT A, MOONEN G. Propofol protects cultured rat hippocampal neurons against N-methyl-D-aspartate receptormediated glutamate toxicity. J Neurosurg Anesthesiol 1994; 6: 249-253.
72. SNYDER GL, GALDI S, HENDRICK JP, HEMMINGS HC, JR. General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo. Neuropharmacology 2007; 53: 619-630.
73. WANG H, WANG G, WANG C, WEI Y, WEN Z, ZHU A. The early stage formation of PI3K-AMPAR GluR2 subunit complex facilitates the long term neuroprotection induced by propofol post-conditioning in rats. PLoS One 2013; 8: e65187.
74. KAWAGUCHI M, FURUYA H, PATEL PM. Neuroprotective effects of anesthetic agents. J Anesth 2005; 19: 150-156.
75. CHEN L, XUE Z, JIANG H. Effect of propofol on pathologic time-course and apoptosis after cerebral ischemia-reperfusion injury. Acta Anaesthesiol Scand 2008; 52: 413-419.
76. XI HJ, ZHANG TH, TAO T, SONG CY, LU SJ, CUI XG, YUE ZY. Propofol improved neurobehavioral outcome of cerebral ischemia-reperfusion rats by regulating Bcl-2 and Bax expression. Brain Res 2011; 1410: 24-32.
77. ENGELHARD K, WERNER C, EBERSPACHER E, PAPE M, BLOBNER M, HUTZLER P, KOCHS E. Sevoflurane and propofol influence the expression of apoptosisregulating proteins after cerebral ischaemia and reperfusion in rats. Eur J Anaesthesiol 2004; 21: 530-537.
78. WU XJ, ZHENG YJ, CUI YY, ZHU L, LU Y, CHEN HZ. Propofol attenuates oxidative stress-induced PC12 cell injury via p38 MAP kinase dependent pathway. Acta Pharmacol Sin 2007; 28: 1123-1128.
79. PORTER AG, JANICKE RU. Emerging roles of caspase- 3 in apoptosis. Cell Death Differ 1999; 6: 99-104.
80. ZHANG Y, DONG Y, XU Z, XIE Z. Propofol and magnesium attenuate isoflurane-induced caspase-3 activation via inhibiting mitochondrial permeability transition pore. Med Gas Res 2012; 2: 20.
81. ACQUAVIVA R, CAMPISI A, RACITI G, AVOLA R, BARCELLONA ML, VANELLA L, LI VOLTI G. Propofol inhibits caspase-3 in astroglial cells: role of heme oxygenase- 1. Curr Neurovasc Res 2005; 2: 141-148.
82. QIN X, SUN ZQ, ZHANG XW, DAI XJ, MAO SS, ZHANG YM. TLR4 signaling is involved in the protective effect of propofol in BV2 microglia against OGD/reoxygenation. J Physiol Biochem 2013; 69: 707-718.
83. CUI D, WANG L, QI A, ZHOU Q, ZHANG X, JIANG W. Propofol prevents autophagic cell death following oxygen and glucose deprivation in PC12 cells and cerebral ischemia-reperfusion injury in rats. PLoS One 2012; 7: e35324.
84. CUI DR, WANG L, JIANG W, QI AH, ZHOU QH, ZHANG XL. Propofol prevents cerebral ischemia-triggered autophagy activation and cell death in the rat hippocampus through the NF-kappaB/p53 signaling pathway. Neuroscience 2013; 246: 117-132.
85. GUI B, SU M, CHEN J, JIN L, WAN R, QIAN Y. Neuroprotective effects of pretreatment with propofol in LPS-induced BV-2 microglia cells: role of TLR4 and GSK-3beta: role of TLR4 and GSK-3beta. Inflammation 2012; 35: 1632-1640.
86. GILL R, TSUNG A, BILLIAR T. Linking oxidative stress to inflammation: Toll-like receptors. Free Radic Biol Med 2010; 48: 1121-1132.
87. HUANG WC, LIN YS, WANG CY, TSAI CC, TSENG HC, CHEN CL, LU PJ, CHEN PS, QIAN L, HONG JS, LIN CF. Glycogen synthase kinase-3 negatively regulates anti-inflammatory interleukin-10 for lipopolysaccharide- induced iNOS/NO biosynthesis and RANTES production in microglial cells. Immunology 2009; 128: e275-286.
88. WANG MJ, HUANG HY, CHEN WF, CHANG HF, KUO JS. Glycogen synthase kinase-3βinactivation inhibits tumor necrosis factor-α production in microglia by modulating nuclear factor κB and MLK3/JNK signaling cascades. J Neuroinflammation 2010; 7: 99.
89. NAKANISHI M, MORI T, NISHIKAWA K, SAWADA M, KUNO M, ASADA A. The effects of general anesthetics on P2X7 and P2Y receptors in a rat microglial cell line. Anesth Analg 2007; 104: 1136-1144.
90. LIU J, GAO XF, NI W, LI JB. Effects of propofol on P2X7 receptors and the secretion of tumor necrosis factor-alpha in cultured astrocytes. Clin Exp Med 2012; 12: 31-37.
91. FENG CS, MA HC, YUE Y, ZHANG YQ, QU XD. Effect of propofol on the activation of nuclear factorkappa B and expression of inflammatory cytokines in cerebral cortex during transient focal cerebral ischemia-reperfusion: experiment with rats. Zhonghua Yi Xue Za Zhi 2004; 84: 2110-2114.
92. MAINES MD. The heme oxygenase system: past, present, and future. Antioxid Redox Signal 2004; 6: 797-801.
93. KITAMURA Y, ISHIDA Y, TAKATA K, MIZUTANI H, KAKIMURA J, INDEN M, NAKATA J, TANIGUCHI T, TSUKAHARA T, AKAIKE A, SHIMOHAMA S. Hyperbilirubinemia protects against focal ischemia in rats. J Neurosci Res 2003; 71: 544-550
94. LIANG C, CANG J, WANG H, XUE Z. Propofol attenuates cerebral ischemia/reperfusion injury partially using heme oxygenase-1. J Neurosurg Anesthesiol 2013; 25: 311-316.
95. RIBEIRO MDE C, HIRT L, BOGOUSSLAVSKY J, REGLI L, BADAUT J. Time course of aquaporin expression after transient focal cerebral ischemia in mice. J Neurosci Res 2006; 83: 1231-1240.
96. ZHENG YY, LAN YP, TANG HF, ZHU SM. Propofol pretreatment attenuates aquaporin-4 over-expression and alleviates cerebral edema after transient focal brain ischemia reperfusion in rats. Anesth Analg 2008; 107: 2009-2016.
97. DING Z, ZHANG J, XU J, SHENG G, HUANG G. Propofol Administration Modulates AQP-4 Expression and Brain Edema After Traumatic Brain Injury. Cell Biochem Biophys 2013; 67: 615-622.
98. ZHU SM, XIONG XX, ZHENG YY, PAN CF. Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation. Anesth Analg 2009; 109: 1493-1499.
99. MORRIS DR, LEVENSON CW. Zinc in traumatic brain injury: from neuroprotection to neurotoxicity. Curr Opin Clin Nutr Metab Care 2013; 16: 708-711.
100. SUH SW, CHEN JW, MOTAMEDI M, BELL B, LISTIAK K, PONS NF, DANSCHER G, FREDERICKSON CJ. Evidence that synaptically-released zinc contributes to neuronal injury after traumatic brain injury. Brain Res 2000; 852: 268-273.
101. SZEWCZYK B. Zinc homeostasis and neurodegenerative disorders. Front Aging Neurosci 2013; 5: 33.
102. KOTANI Y, NAKAJIMA Y, HASEGAWA T, SATOH M, NAGASE H, SHIMAZAWA M, YOSHIMURA S, IWAMA T, HARA H. Propofol exerts greater neuroprotection with disodium edetate than without it. J Cereb Blood Flow Metab 2008; 28: 354-366.
103. ISHII H, BERTRAND N, STANIMIROVIC D, STRASSER A, MRSULJA BB, SPATZ M. The relationship between cerebral ischemic edema and monoamines: revisited. Acta Neurochir Suppl (Wien) 1994; 60: 238-241.
104. OUYANG W, WANG G, HEMMINGS HC, JR. Isoflurane and propofol inhibit voltage-gated sodium channels in isolated rat neurohypophysial nerve terminals. Mol Pharmacol 2003;64:373-381.
105. MINAMI K, YANAGIHARA N, SEGAWA K, TSUTSUI M, SHIGEMATSU A, IZUMI F. Inhibitory effects of propofol on catecholamine secretion and uptake in cultured bovine adrenal medullary cells. Naunyn Schmiedebergs Arch Pharmacol 1996; 353: 572-578.
106. ANDREWS DT, ROYSE C, ROYSE AG. The mitochondrial permeability transition pore and its role in anaesthesia-triggered cellular protection during ischaemia-reperfusion injury. Anaesth Intensive Care 2012; 40: 46-70.
107. JIAO S, LIU Z, REN WH, DING Y, ZHANG YQ, ZHANG ZH, MEI YA. cAMP/protein kinase A signalling pathway protects against neuronal apoptosis and is associated with modulation of Kv2.1 in cerebellar granule cells. J Neurochem 2007; 100: 979-991.
108. SONG CY, XI HJ, YANG L, QU LH, YUE ZY, ZHOU J, CUI XG, GAO W, WANG N, PAN ZW, LI WZ. Propofol inhibited the delayed rectifier potassium current (I(k)) via activation of protein kinase C epsilon in rat parietal cortical neurons. Eur J Pharmacol 2011; 653: 16-20.
109. RAIVICH G. c-Jun expression, activation and function in neural cell death, inflammation and repair. J Neurochem 2008; 107: 898-906.
110. WANG L, JING W, HANG YN. Glutamate-induced c- Jun expression in neuronal PC12 cells: the effects of ketamine and propofol. J Neurosurg Anesthesiol 2008; 20: 124-130.
111. LEE B, BUTCHER GQ, HOYT KR, IMPEY S, OBRIETAN K. Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133. J Neurosci 2005; 25: 1137-1148.
112. SHU L, LI T, HAN S, JI F, PAN C, ZHANG B, LI J. Inhibition of neuron-specific CREB dephosphorylation is involved in propofol and ketamine-induced neuroprotection against cerebral ischemic injuries of mice. Neurochem Res 2012; 37: 49-58.
113. SIESJO BK. Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology. J Neurosurg 1992; 77: 169-184.
114. LI Q, STEPHENSON D. Postischemic administration of basic fibroblast growth factor improves sensorimotor function and reduces infarct size following permanent focal cerebral ischemia in the rat. Exp Neurol 2002; 177: 531-537.
115. DIETRICH WD, ALONSO O, BUSTO R, FINKLESTEIN SP. Posttreatment with intravenous basic fibroblast growth factor reduces histopathological damage following fluid-percussion brain injury in rats. J Neurotrauma 1996; 13: 309-316.
116. ZHAO XC, ZHANG LM, TONG DY, AN P, JIANG C, ZHAO P, CHEN WM, WANG J. Propofol increases expression of basic fibroblast growth factor after transient cerebral ischemia in rats. Neurochem Res 2013; 38: 530-537.
117. TAWFEEQ NA, HALAWANI MM, AL-FARIDI K, AAL-SHAYA WA, TAHA WS. Traumatic brain injury: neuropro-tective anaesthetic techniques, an update. Injury 2009; 40(Suppl 4): S75-81.
118. HANS P, BONHOMME V. Why we still use intravenous drugs as the basic regimen for neurosurgical anaesthesia. Curr Opin Anaesthesiol 2006; 19: 498-503.
119. KOERNER IP, BRAMBRINK AM. Brain protection by anesthetic agents. Curr Opin Anaesthesiol 2006; 19: 481-486.
120. KANBAK M, SARICAOGLU F, AVCI A, OCAL T, KORAY Z, AYPAR U. Propofol offers no advantage over isoflurane anesthesia for cerebral protection during cardiopulmonary bypass: a preliminary study of S-100beta protein levels. Can J Anaesth 2004; 51: 712-717.
121. SCHOEN J, HUSEMANN L, TIEMEYER C, LUELOH A, SEDEMUND- ADIB B, BERGER KU, HUEPPE M, HERINGLAKE M. Cognitive function after sevoflurane- vs propofolbased anaesthesia for on-pump cardiac surgery: a randomized controlled trial. Br J Anaesth 2011; 106: 840-850.
122. WERNER C, HOFFMAN WE, KOCHS E, ALBRECHT RF, AM ESCH JS. The effects of propofol on cerebral blood flow in correlation to cerebral blood flow velocity in dogs. J Neurosurg Anesthesiol 1992; 4: 41-46.
123. SCHLUNZEN L, JUUL N, HANSEN KV, COLD GE. Regional cerebral blood flow and glucose metabolism during propofol anaesthesia in healthy subjects studied with positron emission tomography. Acta Anaesthesiol Scand 2012; 56: 248-255.
124. ENGELHARD K, WERNER C. Inhalational or intravenous anesthetics for craniotomies? Pro inhalational. Curr Opin Anaesthesiol 2006;19: 504-508.
125. TANAKA T, KAI S, KOYAMA T, DAIJO H, ADACHI T, FUKUDA K, HIROTA K. General anesthetics inhibit erythropoietin induction under hypoxic conditions in the mouse brain. PLoS One 2011; 6: e29378.
126. XUE QS, YU BW, WANG ZJ, CHEN HZ. Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices. Acta Pharmacol Sin 2004; 25: 115-120.
127. ZHAN RZ, QI S, WU C, FUJIHARA H, TAGA K, SHIMOJI K. Intravenous anesthetics differentially reduce neurotransmission damage caused by oxygen-glucose deprivation in rat hippocampal slices in correlation with N-methyl-D-aspartate receptor inhibition. Crit Care Med 2001; 29: 808-813.
128. KAREN T, SCHLAGER GW, BENDIX I, SIFRINGER M, HERRMANN R, PANTAZIS C, ENOT D, KELLER M, KERNER T, FELDERHOFF-MUESER U. Effect of propofol in the immature rat brain on short- and long-term neurodevelopmental outcome. PLoS One 2013; 8: e64480.
129. BAYONA NA, GELB AW, JIANG Z, WILSON JX, URQUHART BL, CECHETTO DF. Propofol neuroprotection in cerebral ischemia and its effects on lowmolecular- weight antioxidants and skilled motor tasks. Anesthesiology 2004; 100: 1151-1159.