Propofol: Neuroprotection in an in vitro model of traumatic brain injury

Critical Care

Volumn 13, Issue 2, 2009, Pages

  Rossaint, Jan ^a   Rossaint, Rolf ^a   Weis, Joachim ^a   Fries, Michael ^a   Rex, Steffen ^a   Coburn, Mark ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROPOFOL; HYPNOTIC SEDATIVE AGENT; NEUROPROTECTIVE AGENT;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; EXPERIMENTAL ANIMAL; HIPPOCAMPUS; HISTOCHEMISTRY; HYPOTHERMIA; IN VITRO STUDY; INJURY SEVERITY; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TISSUE INJURY; TISSUE SLICE; TRAUMATIC BRAIN INJURY; ANIMAL; BRAIN INJURY; DISEASE MODEL; DOSE RESPONSE;

ANIMALS; BRAIN INJURIES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPNOTICS AND SEDATIVES; MICE; NEUROPROTECTIVE AGENTS; PROPOFOL;

EID: 65649150380     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc7795     Document Type: Article

References (56)

1. Moppett IK Traumatic brain injury: Assessment, resuscitation and early management Br J Anaesth 2007, 99:18-31. 10.1093/bja/aem128 17545555
2. Stoppini L Buchs PA Muller D A simple method for organotypic cultures of nervous tissue J Neurosci Methods 1991, 37:173-182. 10.1016/ 0165-0270(91)90128-M 1715499
3. Coburn M Maze M Franks NP The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury Crit Care Med 2008, 36:588-595. 10.1097/01.CCM.0B013E3181611F8A6 18216607
4. Adamchik Y Frantseva MV Weisspapir M Carlen PL Perez Velazquez JL Methods to induce primary and secondary traumatic damage in organotypic hippocampal slice cultures Brain Res Brain Res Protoc 2000, 5:153-158. 10.1016/S1385-299X(00)00007-6 10775835
5. Adembri C Bechi A Meli E Gramigni E Venturi L Moroni F De Gaudio AR Pellegrini-Giampietro DE Erythropoietin attenuates post-traumatic injury in organotypic hippocampal slices J Neurotrauma 2004, 21:1103-1112. 10.1089/0897715041651079 15319009
6. Adembri C Massagrande A Tani A Miranda M Margheri M De Gaudio R Pellegrini-Giampietro DE Carbamylated erythropoietin derivative is neuroprotective in an experimental model of traumatic brain injury Crit Care Med 2008, 36:975-978. 10.1097/CCM.0B013E3181644343 18176311
7. Macklis JD Madison RD Progressive incorporation of propidium iodide in cultured mouse neurons correlates with declining electrophysiological status: A fluorescence scale of membrane integrity J Neurosci Methods 1990, 31:43-46. 10.1016/0165-0270(90)90007-3 2308380
8. Abdel-Hamid KM Tymianski M Mechanisms and effects of intracellular calcium buffering on neuronal survival in organotypic hippocampal cultures exposed to anoxia/aglycemia or to excitotoxins J Neurosci 1997, 17:3538-3553. 9133378
9. Adembri C Venturi L Tani A Chiarugi A Gramigni E Cozzi A Pancani T De Gaudio RA Pellegrini-Giampietro DE Neuroprotective effects of propofol in models of cerebral ischemia: Inhibition of mitochondrial swelling as a possible mechanism Anesthesiology 2006, 104:80-89. 10.1097/ 00000542-200601000-00014 16394694
10. Feiner JR Bickler PE Estrada S Donohoe PH Fahlman CS Schuyler JA Mild hypothermia, but not propofol, is neuroprotective in organotypic hippocampal cultures Anesth Analg 2005, 100:215-225. 10.1213/ 01.ANE.0000142129.17005.73 15616081
11. Finley M Fairman D Liu D Li P Wood A Cho S Functional validation of adult hippocampal organotypic cultures as an in vitro model of brain injury Brain Res 2004, 1001:125-132. 10.1016/j.brainres.2003.12.009 14972661
12. Morrison B 3rd Eberwine JH Meaney DF McIntosh TK Traumatic injury induces differential expression of cell death genes in organotypic brain slice cultures determined by complementary DNA array hybridization Neuroscience 2000, 96:131-139. 10.1016/S0306-4522(99)00537-0 10683418
13. Noraberg J Poulsen FR Blaabjerg M Kristensen BW Bonde C Montero M Meyer M Gramsbergen JB Zimmer J Organotypic hippocampal slice cultures for studies of brain damage, neuroprotection and neurorepair Curr Drug Targets CNS Neurol Disord 2005, 4:435-452. 10.2174/1568007054546108 16101559
14. Pellegrini-Giampietro DE Cozzi A Peruginelli F Leonardi P Meli E Pellicciari R Moroni F 1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3′-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia Eur J Neurosci 1999, 11:3637-3647. 10.1046/j.1460-9568.1999.00786.x 10564371
15. Qi S Zhan RZ Wu C Fujihara H Taga K Shimoji K The effects of thiopental and propofol on cell swelling induced by oxygen/glucose deprivation in the CA1 pyramidal cell layer of rat hippocampal slices Anesth Analg 2002, 94:655-660. table of contents. 10.1097/00000539-200203000-00032 11867392
16. Sundstrom L Morrison B 3rd Bradley M Pringle A Organotypic cultures as tools for functional screening in the CNS Drug Discov Today 2005, 10:993-1000. 10.1016/S1359-6446(05)03502-6 16023058
17. Tasker RC Coyle JT Vornov JJ The regional vulnerability to hypoglycemia-induced neurotoxicity in organotypic hippocampal culture: protection by early tetrodotoxin or delayed MK-801 J Neurosci 1992, 12:4298-4308. 1359034
18. Muller D Buchs PA Stoppini L Time course of synaptic development in hippocampal organotypic cultures Brain Res Dev Brain Res 1993, 71:93-100. 10.1016/0165-3806(93)90109-N 8432004
19. Bahr BA Long-term hippocampal slices: A model system for investigating synaptic mechanisms and pathologic processes J Neurosci Res 1995, 42:294-305. 10.1002/jnr.490420303 8583497
20. Crain SM Development of specific synaptic network functions in organotypic central nervous system (CNS) cultures: Implications for transplantation of CNS neural cells in vivo Methods 1998, 16:228-238. 10.1006/meth.1998.0681 100710630
21. Frantseva MV Kokarovtseva L Perez Velazquez JL Ischemia-induced brain damage depends on specific gap-junctional coupling J Cereb Blood Flow Metab 2002, 22:453-462.10.1097/00004647-200204000-00009 11919516
22. Morrison B 3rd Saatman KE Meaney DF McIntosh TK In vitro central nervous system models of mechanically induced trauma: A review J Neurotrauma 1998, 15:911-928. 10.1089/neu.1998.15.911 9840765
23. Lahtinen H Autere AM Paalasmaa P Lauri SE Kaila K Post-insult activity is a major cause of delayed neuronal death in organotypic hippocampal slices exposed to glutamate Neuroscience 2001, 105:131-137. 10.1016/ S0306-4522(01)00168-3 11483307
24. Allen JW Knoblach SM Faden AI Combined mechanical trauma and metabolic impairment in vitro induces NMDA receptor-dependent neuronal cell death and caspase-3-dependent apoptosis FASEB J 1999, 13:1875-1882. 10506592
25. Kochanek PM Clark RS Ruppel RA Adelson PD Bell MJ Whalen MJ Robertson CL Satchell MA Seidberg NA Marion DW Jenkins LW Biochemical, cellular, and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: Lessons learned from the bedside Pediatr Crit Care Med 2000, 1:4-19. 10.1097/ 00130478-200007000-00003 12813280
26. Raghupathi R Graham DI McIntosh TK Apoptosis after traumatic brain injury J Neurotrauma 2000, 17:927-938. 10.1089/neu.2000.17.927 11063058
27. Leker RR Shohami E Cerebral ischemia and trauma-different etiologies yet similar mechanisms: Neuroprotective opportunities Brain Res Brain Res Rev 2002, 39:55-73. 10.1016/S0165-0173(02)00157-1 12086708
28. Vornov JJ Tasker RC Coyle JT Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures Exp Neurol 1991, 114:11-22. 10.1016/ 0014-4886(91)90079-R 1717307
29. Adembri C Venturi L Pellegrini-Giampietro DE Neuroprotective effects of propofol in acute cerebral injury CNS Drug Rev 2007, 13:333-351. 10.1111/ j.1527-3458.2007.00015.x 17894649
30. Alkire MT Haier RJ Correlating in vivo anaesthetic effects with ex vivo receptor density data supports a GABAergic mechanism of action for propofol, but not for isoflurane Br J Anaesth 2001, 86:618-626. 10.1093/ bja/86.5.618 11575335
31. Trapani G Altomare C Liso G Sanna E Biggio G Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery Curr Med Chem 2000, 7:249-271. 10637364
32. Franks NP Molecular targets underlying general anaesthesia Br J Pharmacol 2006, 147(Suppl 1):S72-81. 1760740 16402123 10.1038/ sj.bjp.0706441
33. Fowler CJ Possible involvement of the endocannabinoid system in the actions of three clinically used drugs Trends Pharmacol Sci 2004, 25:59-61. 10.1016/j.tips.2003.12.001 15106622
34. Patel S Wohlfeil ER Rademacher DJ Carrier EJ Perry LJ Kundu A Falck JR Nithipatikom K Campbell WB Hillard CJ The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase Br J Pharmacol 2003, 139:1005-1013. 1573928 12839875 10.1038/sj.bjp.0705334
35. Daskalopoulos R Korcok J Farhangkhgoee P Karmazyn M Gelb AW Wilson JX Propofol protection of sodium-hydrogen exchange activity sustains glutamate uptake during oxidative stress Anesth Analg 2001, 93:1199-1204. 10.1097/00000539-200111000-00030 11682397
36. Peters CE Korcok J Gelb AW Wilson JX Anesthetic concentrations of propofol protect against oxidative stress in primary astrocyte cultures: comparison with hypothermia Anesthesiology 2001, 94:313-321. 10.1097/ 00000542-200102000-00022 11176097
37. Sitar SM Hanifi-Moghaddam P Gelb A Cechetto DF Siushansian R Wilson JX Propofol prevents peroxide-induced inhibition of glutamate transport in cultured astrocytes Anesthesiology 1999, 90:1446-1453. 10.1097/ 00000542-199905000-00030 10319794
38. Velly LJ Guillet BA Masmejean FM Nieoullon AL Bruder NJ Gouin FM Pisano PM Neuroprotective effects of propofol in a model of ischemic cortical cell cultures: Role of glutamate and its transporters Anesthesiology 2003, 99:368-375. 10.1097/00000542-200308000-00018 12883409
39. Zhu H Cottrell JE Kass IS The effect of thiopental and propofol on NMDA- and AMPA-mediated glutamate excitotoxicity Anesthesiology 1997, 87:944-951. 10.1097/00000542-199710000-00030 9357898
40. Bayona NA Gelb AW Jiang Z Wilson JX Urquhart BL Cechetto DF Propofol neuroprotection in cerebral ischemia and its effects on low-molecular-weight antioxidants and skilled motor tasks Anesthesiology 2004, 100:1151-1159. 10.1097/00000542-200405000-00017 15114212
41. Gelb AW Bayona NA Wilson JX Cechetto DF Propofol anesthesia compared to awake reduces infarct size in rats Anesthesiology 2002, 96:1183-1190. 10.1097/00000542-200205000-00023 11981160
42. Kochs E Hoffman WE Werner C Thomas C Albrecht RF Schulte am Esch J The effects of propofol on brain electrical activity, neurologic outcome, and neuronal damage following incomplete ischemia in rats Anesthesiology 1992, 76:245-252. 10.1097/00000542-199202000-00014 1736701
43. Pittman JE Sheng H Pearlstein R Brinkhous A Dexter F Warner DS Comparison of the effects of propofol and pentobarbital on neurologic outcome and cerebral infarct size after temporary focal ischemia in the rat Anesthesiology 1997, 87:1139-1144. 10.1097/00000542-199711000-00018 9366466
44. Ridenour TR Warner DS Todd MM Gionet TX Comparative effects of propofol and halothane on outcome from temporary middle cerebral artery occlusion in the rat Anesthesiology 1992, 76:807-812. 10.1097/ 00000542-199205000-00020 1575350
45. Tsai YC Huang SJ Lai YY Chang CL Cheng JT Propofol does not reduce infarct volume in rats undergoing permanent middle cerebral artery occlusion Acta Anaesthesiol Sin 1994, 32:99-104. 8038982
46. Hollrigel GS Toth K Soltesz I Neuroprotection by propofol in acute mechanical injury: Role of GABAergic inhibition J Neurophysiol 1996, 76:2412-2422. 8899614
47. Eberspacher E Heimann K Hollweck R Werner C Schneider G Engelhard K The effect of electroencephalogram-targeted high- and low-dose propofol infusion on histopathological damage after traumatic brain injury in the rat Anesth Analg 2006, 103:1527-1533. 10.1213/01.ane.0000247803.30582.2d 17122234
48. Statler KD Alexander H Vagni V Dixon CE Clark RS Jenkins L Kochanek PM Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats J Neurotrauma 2006, 23:97-108. 10.1089/neu.2006.23.97 16430376
49. Gredell JA Turnquist PA Maciver MB Pearce RA Determination of diffusion and partition coefficients of propofol in rat brain tissue: Implications for studies of drug action in vitro Br J Anaesth 2004, 93:810-817. 10.1093/bja/aeh272 15377586
50. Tisherman SA Hypothermia and injury Curr Opin Crit Care 2004, 10:512-519. 10.1097/01.ccx.0000145096.28446.f7 15616395
51. Wilson JX Gelb AW Free radicals, antioxidants, and neurologic injury: possible relationship to cerebral protection by anesthetics J Neurosurg Anesthesiol 2002, 14:66-79. 10.1097/00008506-200201000-00014 11773828
52. Riu PL Riu G Testa C Mulas M Caria MA Mameli S Mameli O Disposition of propofol between red blood cells, plasma, brain and cerebrospinal fluid in rabbits Eur J Anaesthesiol 2000, 17:18-22. 10.1046/ j.1365-2346.2000.00573.x 10758439
53. Shyr MH Tsai TH Tan PP Chen CF Chan SH Concentration and regional distribution of propofol in brain and spinal cord during propofol anesthesia in the rat Neurosci Lett 1995, 184:212-215. 10.1016/ 0304-3940(94)11209-2 7715849
54. Tsuchiya M Asada A Arita K Utsumi T Yoshida T Sato EF Utsumi K Inoue M Induction and mechanism of apoptotic cell death by propofol in HL-60 cells Acta Anaesthesiol Scand 2002, 46:1068-1074. 10.1034/ j.1399-6576.2002.460903.x 12366500
55. Ludbrook GL Visco E Lam AM Propofol: Relation between brain concentrations, electroencephalogram, middle cerebral artery blood flow velocity, and cerebral oxygen extraction during induction of anesthesia Anesthesiology 2002, 97:1363-1370. 10.1097/00000542-200212000-00006 12459660
56. Engdahl O Abrahams M Bjornsson A Vegfors M Norlander B Ahlner J Eintrei C Cerebrospinal fluid concentrations of propofol during anaesthesia in humans Br J Anaesth 1998, 81:957-959. 10211025