Propofol protects cultured brain cells from iron ion-induced death: Comparison with trolox

European Journal of Pharmacology

Volumn 404, Issue 1-2, 2000, Pages 21-27

  Boland, André ^a   Delapierre, Danielle ^a   Mossay, Danielle ^a   Hans, Pol ^b   Dresse, Albert ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Antioxidant; Cortical culture; Free radical; Oxidative stress; Propofol; Vitamin E

Indexed keywords

FERROUS SULFATE; FLUORESCEIN DIACETATE; IRON; LACTATE DEHYDROGENASE; PEROXIDE; PROPOFOL; THIOBARBITURIC ACID; TROLOX C;

ARTICLE; BRAIN CELL; CELL DEATH; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; EMBRYO; FLUORESCENCE; LIPID PEROXIDATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; BRAIN; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CHROMANS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FERROUS COMPOUNDS; FREE RADICAL SCAVENGERS; IRON; LIPID PEROXIDATION; OXIDATIVE STRESS; PEROXIDES; PROPOFOL; PROTECTIVE AGENTS; RATS; RATS, WISTAR;

EID: 0034666647     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00496-9     Document Type: Article

References (23)

1. Aarts L., Van der Hee R., Dekker I., Jong J., Langemeijer H., Bast A. The widely used anesthetic agent propofol can replace alpha-tocopherol as an antioxidant. FEBS Lett. 357:1995;83-85.
2. q-11. J. Neurochem. 69:1997;570-580.
3. Blanc E.M., Toborek M., Mark R.J., Henning B., Mattson M.P. Amyloid β-peptide induces cell monolayer albumin permeability, impairs glucose transport, and induces apoptosis in vascular endothelial cells. J. Neurochem. 68:1997;1870-1881.
4. 2+ in hippocampal cell cultures. Pflügers Arch. - Eur. J. Physiol. 430:1995;R4. (Abstract).
5. Chow H.S., Lynch J.J., Rose K., Choi D.W. Trolox attenuates cortical neuronal injury induced by iron, ultraviolet light, glucose deprivation, or AMPA. Brain Res. 639:1994;102-108.
6. Eriksson O., Pollesello P., Saris N.-E.L. Inhibition of lipid peroxidation in isolated rat liver mitochondria by the general anesthetic propofol. Biochem. Pharmacol. 44(2):1992;391-393.
7. Furukawa K., Estus S., Fu W., Mark R.J., Mattson M.P. Neuroprotective action of cycloheximide involves induction of Bcl-2 and antioxidant pathways. J. Cell Biol. 136(5):1997;1137-1149.
8. Goodman Y., Mattson M.P. Ceramide protects hippocampal neurons against excitotoxic and oxidative insult, and amyloid β-peptide toxicity. J. Neurochem. 66:1996;869-872.
9. Green T.R., Bennett S.R., Nelson V.M. Specificity and properties of propofol as an antioxidant free radical scavenger. Pharmacology. 129(1):1994;163-169.
10. Halliwell B., Gutteridge J.M.C. Biologically relevant metal ion-dependent hydroxyl radical generation an update. FEBS Lett. 307(1):1992;108-112.
11. Hans P., Deby C., Deby-Dupont G., Vrijens B., Albert A., Lamy M. Effect of propofol on in vitro lipid peroxidation induced by different free radical generating systems: a comparison with vitamin E. J. Neurosurg. Anesth. 8(2):1996;154-158.
12. Kanto J., Gepts E. Pharmacokinetic implications for clinical use of propofol. Clin. Pharmacokinet. 17(5):1989;308-326.
13. Mattson M.P. Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity. Trends Neurosci. 21(2):1998;53-57.
14. Mattson M.P., Barger S.W., Begley J.G., Mark R.J. Calcium, free radicals and excitotoxic neuronal death in primary cell culture. Methods Cell. Biol. 46:1995;187-215.
15. Murphy P.G., Myers D.S., Daviest M.J., Webster N.R., Jones J.G. The antioxidant potential of propofol (2,6-di-isopropylphenol). Br. J. Anaesth. 68:1992;613-618.
16. Murphy P.G., Bennett J.R., Myers D.S., Daviest M.J., Jones J.G. The effect of propofol anaesthesia on free radical-induced lipid peroxidation in rat liver microsomes. Eur. J. Anaesthesiol. 10:1993;261-266.
17. Musacchio E., Rizzoli V., Bianchi M., Bindoli A., Galzigna I. Antioxidant action of propofol on liver microsomes, mitochondria and brain synaptosomes in the rat. Pharmacol. Toxicol. 69:1991;75-77.
18. Olanow C.W. A radical hypothesis for neurodegeneration. Trends Neurosci. 16(11):1993;439-444.
19. Richardson J.S. Free radicals in the genesis of Alzheimer's disease. Ann. N. Y. Acad. Sci. 695:1993;73-76.
20. Smith M.A., Sayre L.M., Monnier V.M., Perry G. Radical AGEing in Alzheimer's disease. Trends Neurosci. 18(4):1995;172-176.
21. Weir D.L., Goodchild C.S., Graham D.I. Propofol: effect on indices of cerebral ischemia. J. Neurosurg. Anesth. 1:1989;284-289.
22. Williams L.R. Oxidative stress, age-related neurodegeneration, and the potential for neurotrophic treatment. Cerebrovasc. Brain Metab. Rev. 7(1):1995;55-73.
23. Zhang Y., Tatsuno T., Carney J.M., Mattson M.P. Basic FGF, NGF, and IGFs protect hippocampal and cortical neurons against iron-induced degeneration. J. Cereb. Blood Flow Metab. 13:1993;378-388.