General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo

Neuropharmacology

Volumn 53, Issue 5, 2007, Pages 619-630

  Snyder, Gretchen L ^a   Galdi, Stacey ^a   Hendrick, Joseph P ^a   Hemmings Jr , Hugh C ^b  

^a Intra Cellular Therapies Inc   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

AMPA glutamate receptor GluR1; DARPP 32; Dopamine; ERK1 2; Glutamate; Isoflurane; Ketamine; NMDA receptor NR1; Phospho specific antibody; Propofol; Tyrosine hydroxylase

Indexed keywords

AMPA RECEPTOR; ANESTHETIC AGENT; ANTIBODY; CELL PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DOPAMINE; GLUTAMATE RECEPTOR 1; GLUTAMIC ACID; IONOTROPIC RECEPTOR; ISOFLURANE; KETAMINE; MITOGEN ACTIVATED PROTEIN KINASE 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; PHOSPHOPROTEIN DARPP 32; PROPOFOL; RECEPTOR SUBUNIT; SPINOPHILIN; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DAMAGE; BRAIN ISCHEMIA; CENTRAL NERVOUS SYSTEM DEPRESSION; CORPUS STRIATUM; DOPAMINERGIC SYSTEM; DOPAMINERGIC TRANSMISSION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FRONTAL CORTEX; IMMUNOBLOTTING; IN VIVO STUDY; MALE; MICROWAVE IRRADIATION; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; POSTSYNAPTIC MEMBRANE; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RIGHTING REFLEX; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ANESTHETICS, DISSOCIATIVE; ANESTHETICS, GENERAL; ANESTHETICS, INHALATION; ANESTHETICS, INTRAVENOUS; ANIMALS; BLOTTING, WESTERN; CEREBRAL CORTEX; DOPAMINE; DOPAMINE AND CAMP-REGULATED PHOSPHOPROTEIN 32; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUTAMIC ACID; ISOFLURANE; KETAMINE; MALE; MICE; MICE, INBRED C57BL; MICROFILAMENT PROTEINS; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PROPOFOL; RECEPTORS, GLUTAMATE; SIGNAL TRANSDUCTION; TYROSINE 3-MONOOXYGENASE;

EID: 34848889357     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2007.07.008     Document Type: Article

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