Neuroprotective effects of pretreatment with propofol in LPSInduced BV-2 microglia cells: Role of TLR4 and GSK-3β

Inflammation

Volumn 35, Issue 5, 2012, Pages 1632-1640

  Gui, Bo ^a   Su, Mingyan ^a   Chen, Jie ^a   Jin, Lai ^a   Wan, Rong ^a   Qian, Yanning ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Glycogen synthase kinase 3 beta; Inflammation; Lipopolysaccharide; Propofol; Toll like receptor 4

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; INTERLEUKIN 10; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROPOFOL; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL STRAIN BV 2; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VITRO STUDY; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; UPREGULATION; WESTERN BLOTTING;

ANESTHETICS, INTRAVENOUS; ANIMALS; CELL LINE; CELL SURVIVAL; DOWN-REGULATION; GLYCOGEN SYNTHASE KINASE 3; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NEUROPROTECTIVE AGENTS; PROPOFOL; RNA, MESSENGER; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84866734236     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-012-9478-x     Document Type: Article

References (42)

1. Garcia-Bueno, B., J.R. Caso, and J.C. Leza. 2008. Stress as a neuroinflammatory condition in brain: Damaging and protective mechanisms. Neuroscience and Biobehavioral Reviews 32: 1136-1151.
2. Aloisi, F. 1999. The role of microglia and astrocytes in CNS immune surveillance and immunopathology. Advances in Experimental Medicine and Biology 468: 123-133.
3. Perry, V.H., and S. Gordon. 1988. Macrophages and microglia in the nervous system. Trends in Neurosciences 11: 273-277.
4. Qin, L., X. Wu, M.L. Block, Y. Liu, G.R. Breese, J.S. Hong, D.J. Knapp, and F.T. Crews. 2007. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 55: 453-462.
5. Wilms, H., J. Sievers, U. Rickert, M. Rostami-Yazdi, U. Mrowietz, and R. Lucius. 2010. Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation. Journal of Neuroinflammation 7: 30.
6. Choi, Y., M.K. Lee, S.Y. Lim, S.H. Sung, and Y.C. Kim. 2009. Inhibition of inducible NO synthase, cyclooxygenase-2 and interleukin-1beta by torilin is mediated by mitogen-activated protein kinases in microglial BV2 cells. British Journal of Phamrmaco1ogy 56: 933-940.
7. Blasi, E., R. Barluzzi, V. Bocchini, R. Mazzolla, and F. Bistoni. 1990. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. Journal of Neuroimmunology 27: 229-237.
8. Ooi, Y.Y., R. Ramasamy, Z. Rahmat, H. Subramaiam, S.W. Tan, M. Abdullah, D.A. Israf, and S. Vidyadaran. 2010. Bone marrowderived mesenchymal stem cells modulate BV2 microglia responses to lipopolysaccharide. International Immunopharmacology 10: 1532-1540.
9. Hsu, B.G., F.L. Yang, R.P. Lee, T.C. Peng, and H.I. Chen. 2005. Effects of post-treatment with low-dose propofol on inflammatory responses to lipopolysaccharide-induced shock in conscious rats. Clinical and Experimental Pharmacology and Physiology 32: 24-29.
10. Hsing, C.H., M.C. Lin, P.C. Choi, W.C. Huang, J.I. Kai, C.C. Tsai, Y.L. Cheng, C.Y. Hsieh, C.Y. Wang, Y.P. Chang, Y.H. Chen, C.L. Chen, and C.F. Lin. 2011. Anesthetic propofol reduces endotoxic inflammation by inhibiting reactive oxygen species-regulated Akt/ IKKβ/NF-κB signaling. PLoS One 6: E17598.
11. Ma, L., X. Wu, W. Chen, and Y. Fujino. 2010. Propofol has antiinflammatory effects on alveolar type II epithelial cells. Acta Anaesthesiologica Scandinavica 54: 362-369.
12. Wu, G.J., T.L. Chen, C.C. Chang, and R.M. Chen. 2009. Propofol suppresses tumor necrosis factor-alpha biosynthesis in lipopolysaccharide-stimulated macrophages possibly through downregulation of nuclear factor-kappa B-mediated toll-like receptor 4 gene expression. Chemico-Biological Interactions 180: 465-471.
13. Li, X., S. Jiang, and R.I. Tapping. 2010. Toll-like receptor signaling in cell proliferation and survival. Cytokine 49: 1-9.
14. Björkqvist, M., E.J. Wild, J. Thiele, A. Silvestroni, R. Andre, N. Lahiri, E. Raibon, R.V. Lee, C.L. Benn, D. Soulet, A. Magnusson, B. Woodman, C. Landles, M.A. Pouladi, M.R. Hayden, A. Khalili-Shirazi, M.W. Lowdell, P. Brundin, G.P. Bates, B.R. Leavitt, T. Möller, and S.J. Tabrizi. 2008. A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease. The Journal of Experimental Medicine 205: 1869-1877.
15. Martin, M., K. Rehani, R.S. Jope, and S.M. Michalek. 2005. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nature Immunology 6: 777-784.
16. Hu, X., P.K. Paik, J. Chen, A. Yarilina, L. Kockeritz, T.T. Lu, J.R. Woodgett, and L.B. Ivashkiv. 2006. IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. Immunity 24: 563-574.
17. Rehani, K., H. Wang, C.A. Garcia, D.F. Kinane, and M. Martin. 2009. Toll-like receptor-mediated production of IL-1Ra is negatively regulated by GSK3 via the MAPK ERK1/2. Journal of Immunology 182: 547-553.
18. Zhao, L., F. Wang, B. Gui, F. Hua, and Y. Qian. 2011. Prophylactic lithium alleviates postoperative cognition impairment by phosphorylating hippocampal glycogen synthase kinase-3β (Ser9) in aged rats. Experimental Gerontology 46: 1031-1036.
19. Chen, R.M., C.H. Wu, H.C. Chang, G.J. Wu, Y.L. Lin, J.R. Sheu, and T.L. Chen. 2003. Propofol suppresses macrophage functions through modulating mitochondrial membrane potential and cellular adenosine triphosphate levels. Anesthesiology 98: 1178-1185.
20. Xi, H.J., T.H. Zhang, T. Tao, C.Y. Song, S.J. Lu, X.G. Cui, and Z.Y. Yue. 2011. Propofol improved neurobehavioral outcome of cerebral ischemia-reperfusion rats by regulating Bcl-2 and Bax expression. Brain Research 1410: 24-32.
21. Tan, S.W., R. Ramasamy, M. Abdullah, and S. Vidyadaran. 2011. Inhibitory effects of palm α-, γ-and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Cellular Immunology 271: 205-209.
22. Labuzek, K., S. Liber, B. Gabryel, and B. Okopień. 2010. AICAR (5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside) increases the production of toxic molecules and affects the profile of cytokines release in LPS-stimulated rat primary microglial cultures. Neurotoxicology 31: 134-146.
23. Smith, C., A.I. McEwan, R. Jhaveri, M. Wilkinson, D. Goodman, L.R. Smith, A.T. Canada, and P.S. Glass. 1994. The interaction of fentanyl on the Cp50 of propofol for loss of consciousness and skin incision. Anesthesiology 81: 820-828.
24. Krogh-Madsen, R., P. Plomgaard, T. Akerstrom, K. Møller, O. Schmitz, and B.K. Pedersen. 2008. Effect of short-term intralipid infusion on the immune response during low-dose endotoxemia in humans. American Journal of Physiology, Endocrinology and Metabolism 294: E371-E379.
25. Crozier, T.A., J.E. Müller, D. Quittkatt, W. Weyland, M. Sydow, W. Wuttke, and D. Kettler. 1993. Interleukin-1 beta and interleukin-6-plasma concentrations in laparotomies. Interaction with neuroendocrine secretion and postoperative temperature regulation? Anaesthetist 42: 343-349.
26. Grivennikov, S.I., A.V. Tumanov, D.J. Liepinsh, A.A. Kruglov, B.I. Marakusha, A.N. Shakhov, T. Murakami, L.N. Drutskaya, I. Förster, B.E. Clausen, L. Tessarollo, B. Ryffel, D.V. Kuprash, and S.A. Nedospasov. 2005. Distinct and nonredundant in vivo functions of TNF produced by T cells and macrophages/neutrophils: Protective and deleterious effects. Immunity 22: 93-104.
27. Takaono, M., T. Yogosawa, M. Okawa-Takatsuji, and S. Aotsuka. 2002. Effects of intravenous anesthetics on interleukin (IL)-6 and IL-10 production by lipopolysaccharide-stimulated mononuclear cells from healthy volunteers. Acta Anaesthesiologica Scandinavica 46: 176-179.
28. Gao, J., B.X. Zeng, L.J. Zhou, and S.Y. Yuan. 2004. Protective effects of early treatment with propofol on endotoxin-induced acute lung injury in rats. British Journal of Anaesthesia 92: 277-279.
29. Taniguchi, T., K. Yamamoto, N. Ohmoto, K. Ohta, and T. Kobayashi. 2000. Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats. Critical Care Medicine 28: 1101-1106.
30. Shibakawa, Y.S., Y. Sasaki, Y. Goshima, N. Echigo, Y. Kamiya, K. Kurahashi, Y. Yamada, and T. Andoh. 2005. Effects of ketamine and propofol on inflammatory responses of primary glial cell cultures stimulated with lipopolysaccharide. British Journal of Anaesthesia 95: 803-810.
31. Nakanishi, M., T. Mori, K. Nishikawa, M. Sawada, M. Kuno, and A. Asada. 2007. The effects of general anesthetics on P2X7 andP2Y receptors in a rat microglial cell line. Anesthesia and Analgesia 104: 1136-1144.
32. Larsen, B., G. Hoff, W. Wilhelm, H. Buchinger, G.A. Wanner, and M. Bauer. 1998. Effect of intravenous anesthetics on spontaneous and endotoxin-stimulated cytokine response in cultured human whole blood. Anesthesiology 89: 1218-1227.
33. Fredriksson, A., E. Pontén, T. Gordh, and P. Eriksson. 2007. Neonatal exposure to a combination of N-methyl-D-aspartate and gamma-aminobutyric acid type A receptor anesthetic agents potentiates apoptotic neurodegeneration and persistent behavioral deficits. Anesthesiology 107: 427-436.
34. Cattano, D., C. Young, M.M. Straiko, and J.W. Olney. 2008. Subanesthetic doses of propofol induce neuroapoptosis in the infant mouse brain. Anesthesia and Analgesia 106: 1712-1714.
35. El-Beheiry, H., and B. Kavanagh. 2006. Is propofol neurotoxic to the developing brain? Canadian Journal of Anaesthesia 53: 1069-1073.
36. Pontén, E., A. Fredriksson, T. Gordh, P. Eriksson, and H. Viberg. 2011. Neonatal exposure to propofol affects BDNF but not CaMKII, GAP-43, synaptophysin and tau in the neonatal brain and causes an altered behavioural response to diazepam in the adult mouse brain. Behavioural Brain Research 223: 75-80.
37. Willis, L.M., D.F. Bielinski, D.R. Fisher, N.R. Matthan, and J.A. Joseph. 2010. Walnut extract inhibits LPS-induced activation of BV-2 microglia via internalization of TLR4: Possible involvement of phospholipase D2. Inflammation 33: 325-333.
38. Barsness, K.A., J. Arcaroli, A.H. Harken, E. Abraham, A. Banerjee, L. Reznikov, and R.C. McIntyre. 2004. Hemorrhageinduced acute lung injury is TLR-4 dependent. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 287: R592-R599.
39. Kamada, N., N. Kanaya, N. Hirata, S. Kimura, and A. Namiki. 2008. Cardioprotective effects of propofol in isolated ischemiareperfused guinea pig hearts: Role of KATP channels and GSK-3beta. Canadian Journal of Anaesthesia 55: 595-605.
40. Wang, M.J., H.Y. Huang, W.F. Chen, H.F. Chang, and J.S. Kuo. 2010. Glycogen synthase kinase-3β inactivation inhibits tumor necrosis factor-α production in microglia by modulating nuclear factor κB and MLK3/JNK signaling cascades. Journal of Neuroinflammation 7: 99.
41. Li, H., X. Sun, G. LeSage, Y. Zhang, Z. Liang, J. Chen, G. Hanley, L. He, S. Sun, and D. Yin. 2010. β-Arrestin 2 regulates Toll-like receptor 4-mediated apoptotic signalling through glycogen synthase kinase-3β. Immunology 130: 556-563.
42. Rodionova, E., M. Conzelmann, E. Maraskovsky, M. Hess, M. Kirsch, T. Giese, A.D. Ho, M. Zöller, P. Dreger, and T. Luft. 2007. GSK-3 mediates differentiation and activation of proinflammatory dendritic cells. Blood 109: 1584-1592.