Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABA(A) receptors

Acta Anaesthesiologica Scandinavica

Volumn 43, Issue 2, 1999, Pages 153-162

  Ito, Hiroyuki ^a   Watanabe, Y ^a   Isshiki, A ^a   Uchino, H ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Forebrain ischemia; GABA receptor subtypes; Midazolam; Neuronal death; Neuroprotection; Pentobarbital; Propofol

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BACLOFEN; BICUCULLINE; MIDAZOLAM; MIDAZOLAM MALEATE; MUSCIMOL; PENTOBARBITAL; PHACLOFEN; PROPOFOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CAUDATE NUCLEUS; CONTROLLED STUDY; GERBIL; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PARIETAL LOBE; PRIORITY JOURNAL; THALAMUS;

EID: 0032913843     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-6576.1999.430206.x     Document Type: Article

References (33)

1. 1. Arcadi F, Rapisarda A, De Luca R, Trimarchi G, Costa G. Effect of 2,6-diisopropylphenol on the delayed hippocampal cell loss following transient forebrain ischemia in the gerbil. Life Sci 1996: 12: 961-970.
2. 2. Cervantes M, Ruelas R, Chavez-Carrillo I, Contreras-Gomez A, Antonio-Ocampo A. Effects of propofol on alterations of multineuronal activity of limbic and mesencephalic structures and neurological deficit eliminated by acute global cerebral ischemia. Arch Med Res 1995: 4: 385-395.
3. 3. Henrik H, Anders L, Mats S, Britta N, Ingemar J, Anders H. Ischemia-induced shift of inhibitory and excitatory amino acids from intra-to extracellular compartment. J Cereb Blood Flow Metab 1985: 5: 413-419.
4. 4. Nakashima K, Todd M. Effects of hypothermia, pentobarbital, and isoflurane on postdepolarization amino acid release during complete global cerebral ischemia. Anesthesiology 1996: 85: 161-168.
5. 5. Young Y, Menon D, Matta B, Jones J. Propofol neuroprotection in a rat model of ischemia reperfusion injury. Eur J Anaesthesiol 1997: 3: 320-326.
6. 2O. Anesthesiology 1988: 69: 192-198.
7. 7. Jensen U, Becker H. Preservation of cerebral ischemia under general anesthesia. Eur J Vasc Endovasc Surg 1993: 7 (Suppl A): 8-12.
8. 8. Globus M-T, Busto R, Dietrich WD, Martinez E, Valdes I, Ginsberg MD. Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and γ-amino-butyric acid studied by intracerebral microdialysis. J Neurochem 1988: 51: 1455-1464.
9. 9. Ohnishi M, Watanabe Y, Shibuya T. Potentiation of excitotoxicity by glutamate up-take rather than glutamine synthetase inhibitor. Jpn J Pharmacol 1995: 68: 315-321.
10. 10. O'Regan M, Smith-Barbour M, Perkins L, Phillis J. A possible role for phospholipases in the release of neurotransmitter amino acids from ischemic rat cerebral cortex. Neurosci Let 1995: 3: 191-194.
11. 11. Yamada K, Goto S, Yoshikawa M, Ushio Y. Gabaergic transmission and tyrosine hydroxylase expression in the nigral dopaminergic neurons: an in vivo study using a reversible ischemia model of rats. Neuroscience 1996: 3: 783-789.
12. 12. Hillered L, Hallstrom A, Segersvard S, Persson L, Ungerstedt U. Dynamics of extracellular metabolism in the striatum after middle cerebral artery occlusion in the rat monitored by intracerebral microdialysis. J Cereb Blood Flow Metab 1989: 9: 607-616.
13. 13. Kahn R, Panah M, Weinberger J. Modulation of ischemic excitatory neurotransmitter and γ-aminobutyric acid release during global temporary cerebral ischemia by selective neuronal nitric oxide synthase inhibition. Anesth Analg 1997: 84: 997-1003.
14. 14. Nishimoto F, Watanabe Y. Hara I, Issiki A. Neuronal regulation modulated by intracellular Ca levels and pH gradients in cultured cerebellar granule cells under extracelular acidosis. Comm Appl Cell Biol 1997: 14: 17-28.
15. 15. Ooboshi H, Sasashima S, Yao H, Nakahara T, Uchimura H, Fujishima M. Inhibition of ischemia-induced dopamine release by ω-conotoxin, a calcium channel blocker, in the striatum of spontaneously hypertensive rats: an in vivo brain dialysis study. J Neurochem 1992: 58: 298-303.
16. 16. Shuaib A, Mazagri R, Ijaz S. GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbils. Exp Neurol 1993: 123: 284-288.
17. 17. Kahn R, Panah M, Kiffel S, Weinberger J. Modulation of ischemic excitatory neurotransmitter and γ-aminobutyric acid release during global temporary cerebral ischemia by local nitric oxide synthase inhibition. Anesth Analg 1997: 84: 1004-1010.
18. 18. Romijn HJ, Jansen AW, Van den Bogert C. Permanent increase of immmunocytochemical reactivity for gamma-aminobutyric acid (GABA), glutamate acid decarboxylase, mitochondrial enzymes, and glial fibrillary acidic protein in rat cerebral cortex damaged by early postnatal hypoxia-ischemia. Acta Neuropathol (Berl) 1994: 6: 612-627.
19. B receptor subtypes. Trends Neurosci 1988: 11: 112-116.
20. 20. Abel SA, McCandless DW. Elevated γ-aminobutyric acid levels attenuate the metabolic response to bilateral ischemia. J Neurochem 1992: 58: 740-744.
21. 21. Cataltape O, Towfighi J, Vannucci R. Cerebrospinal fluid concentrations of glutamate and GABA during perinatal cerebral hypoxia-ischemia and seizures. Brain Res 1995: 2: 326-330.
22. 22. Smith M-L, Auer RN, Siesjo BK. The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain ischemia. Acta Neuropathol (Berl) 1984: 64: 319-332.
23. 23. Uchino H, Elmer E, Uchino K, Lindvall O, Siesjo BK. Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischemia in the rat. Acta Physiol Scand 1995: 155: 469-471.
24. 24. Sivan SP, Ho IK. GABA in morphine analgesia and tolerance. Life Sci 1985: 37: 199-208.
25. 25. Phillis J. Indomethacin modulates ischemia-evoked release of glutamate and adenosine from the rat cerebral cortex. Brain Res 1994: 652: 353-356.
26. 26. Schwartz RD, Yu X, Wanger J, Ehrmann M, Mileson BE. Cellular regulation of the benzodiazepine/GABA receptor; arachidonic acid, calcium, and cerebral ischemia. Neuropsychophamacology 1992: 6: 119-125.
27. A receptor subunit. Nature 1997: 385: 820-823.
28. B receptor pharmacology. Annu Rev Pharmacol Toxicol 1993: 33: 109-117.
29. 29. Hans P, Bonhomme V, Collette J, Albert A, Moonen G. Propofol protects cultured rat hippocampal neurons against N-methyl-D-aspartate receptor-mediated glutamate toxicity. J Neurosurg Anesthesiol 1994: 4: 249-253.
30. 30. Saransaari P, Oja S. Enhanced GABA release in cell-damaging conditions in the adult and developing mouse hipppo-campus. Int J Dev Neurosci 1997: 2: 163-174.
31. 31. John BC, William JN. The metabolism of rat brain mitochondria. J Biol Chem 1970: 245: 4724-4731.
32. 32. Kiso K, Watanabe Y, Shibuya T. Central mechanism of a novel neurotoxin, paraquat, and its relationship to increased amounts of excitatory amino acids. Neuroscience 1994: 20: 169-179.
33. 33. Watanabe Y, Miura I, Ohgami Y, Fujiwara M. Extracellular expression of IL-8 in the astrocyte-rich cultured cerebellar granule cells under acidosis. Life Sci 1998: 63: 1037-1046.