Effects of propofol on P2X7 receptors and the secretion of tumor necrosis factor-α in cultured astrocytes

Clinical and Experimental Medicine

Volumn 12, Issue 1, 2012, Pages 31-37

  Liu, Jia ^a   Gao, Xiao Fei ^b   Ni, Wen ^a   Li, Jin Bao ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Astrocytes; Propofol; Purinergic P2X7 receptor; Tumor necrosis factor

Indexed keywords

PROPOFOL; PURINERGIC P2X7 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL CULTURE; CYTOKINE RELEASE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; WHOLE CELL;

ADENOSINE TRIPHOSPHATE; ANIMALS; ASTROCYTES; CELLS, CULTURED; ELECTROPHYSIOLOGICAL PHENOMENA; ENZYME-LINKED IMMUNOSORBENT ASSAY; NEUROGLIA; NEUROPROTECTIVE AGENTS; PATCH-CLAMP TECHNIQUES; PROPOFOL; PURINERGIC P2X RECEPTOR AGONISTS; RATS; RECEPTORS, PURINERGIC P2X7; ROSANILINE DYES; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84858159768     PISSN: 15918890     EISSN: 15919528     Source Type: Journal    
DOI: 10.1007/s10238-011-0139-4     Document Type: Article

References (35)

1. Burnstock G (2008) Purinergic signalling and disorders of the central nervous system. Nat Rev Drug Discov 7:575-590
2. Wang X, Arcuino G, Takano T, Lin J, Peng WG, Wan P, Li P, Xu Q, Liu QS, Goldman SA, Nedergaard M (2004) P2X7 receptor inhibition improves recovery after spinal cord injury. Nat Med 10:821-827 (Pubitemid 39070855)
3. Phillis JW, O'Regan MH, Perkins LM (1993) Adenosine 50-triphosphate release from the normoxic and hypoxic in vivo rat cerebral cortex. Neurosci Lett 151:94-96 (Pubitemid 23144995)
4. Melani A, Turchi D, Vannucchi MG, Cipriani S, Gianfriddo M, Pedata F (2005) ATP extracellular concentrations are increased in the rat striatum during in vivo ischemia. Neurochem Int 47:442-448 (Pubitemid 41242625)
5. North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013-1067
6. Suzuki T, Hide I, Ido K, Kohsaka S, Inoue K, Nakata Y (2004) Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia. J Neurosci 24:1-7 (Pubitemid 38181664)
7. Ferrari D, Pizzirani C, Adinolfi E, Lemoli RM, Curti A, Idzko M, Panther E, Di Virgilio F (2006) The P2X7 receptor: a key player in IL-1 processing and release. J Immunol 176:3877-3883 (Pubitemid 44264361)
8. Kataoka A, Tozaki-Saitoh H, Koga Y, Tsuda M, Inoue K (2009) Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT. J Neurochem 108:115-125
9. Gendron FP, Chalimoniuk M, Strosznajder J, Shen S, González FA, Weisman GA, Sun GY (2003) P2X7 nucleotide receptor activation enhances IFN gamma-induced type II nitric oxide synthase activity in BV-2 microglial cells. J Neurochem 87:344-352 (Pubitemid 37255242)
10. Parvathenani LK, Tertyshnikova S, Greco CR, Roberts SB, Robertson B, Posmantur R (2003) P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease. J Biol Chem 278: 13309-13317 (Pubitemid 36800102)
11. Neary JT, Kang Y, Shi YF, Tran MD, Wanner IB (2006) P2 receptor signalling, proliferation of astrocytes, and expression of molecules involved in cell-cell interactions. Novartis Found Symp 276:131-143
12. Duan S, Anderson CM, Keung EC, Chen Y, Chen Y, Swanson RA (2003) P2X7 receptor-mediated release of excitatory amino acids from astrocytes. J Neurosci 23:1320-1328 (Pubitemid 36258910)
13. Kucher BM, Neary JT (2005) Bi-functional effects of ATP/P2 receptor activation on tumor necrosis factor-alpha release in lipopolysaccharide- stimulated astrocytes. J Neurochem 92:525-535 (Pubitemid 40189456)
14. Fulton B, Sorkin EM (1995) Propofol: an overview of its pharmacology and a review of its clinical efficacy in intensive care sedation. Drugs 50:636-657
15. Kochs E, Hoffman WE, Werner C, Thomas C, Albrecht RF, Schulte am Esch J (1992) The effects of propofol on brain electrical activity, neurologic outcome, and neuronal damage following incomplete ischemia in rats. Anesthesiology 76:245-252
16. Ito H, Watanabe Y, Isshiki A, Uchino H (1999) Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. Acta Anaesthesiol Scand 43:153-162 (Pubitemid 29059308)
17. Buggy DJ, Nicol B, Rowbotham DJ, Lambert DG (2000) Effects of intravenous anesthetic agents on glutamate release: a role for GABAA receptor-mediated inhibition. Anesthesiology 92:1067-1073 (Pubitemid 30180984)
18. Yamakura T, Sakimura K, Shimoji K, Mishina M (1995) Effects of propofol on various AMPA-, kainate- and NMDA-selective glutamate receptor channels expressed in Xenopus oocytes. Neurosci Lett 188:187-190
19. Orser BA, Bertlik M, Wang LY, MacDonald JF (1995) Inhibition by propofol (2, 6 di-isopropylphenol) of the N-methyl-D-aspartate subtype of glutamate receptor in cultured hippocampal neurones. Br J Pharmacol 116:1761-1768
20. Lingamaneni R, Birch ML, Hemmings HC Jr (2001) Widespread inhibition of sodium channel-dependent glutamate release from isolated nerve terminals by isoflurane and propofol. Anesthesiology 95:1460-1466 (Pubitemid 33126759)
21. Sitar SM, Hanifi-Moghaddam P, Gelb A, Cechetto DF, Siushansian R, Wilson JX (1999) Propofol prevents peroxideinduced inhibition of glutamate transport in cultured astrocytes. Anesthesiology 90:1446-1453 (Pubitemid 29205650)
22. Murphy PG, Myers DS, Davies MJ, Webster NR, Jones JG (1992) The antioxidant potential of propofol (2, 6-diisopropylphenol). Br J Anaesth 68:613-618
23. Tsuchiya M, Asada A, Maeda K, Ueda Y, Sato EF, Shindo M, Inoue M (2001) Propofol versus midazolam regarding their antioxidant activities. Am J Respir Crit Care Med 163:26-31 (Pubitemid 32095248)
24. Adembri C, Venturi L, Tani A, Chiarugi A, Gramigni E, Cozzi A, Pancani T, De Gaudio RA, Pellegrini-Giampietro DE (2006) Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanism. Anesthesiology 104:80-89
25. McNaught KS, Jenner P (2000) Extracellular accumulation of nitric oxide, hydrogen peroxide, and glutamate in astrocytic cultures following glutathione depletion, complex I inhibition, and/or lipopolysaccharide-induced activation. Biochem Pharmacol 60:979-988
26. McCarthy KD, de Vellis J (1980) Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 85:890-902 (Pubitemid 10007455)
27. Becker D, Woltersdorf R, Boldt W, Schmitz S, Braam U, Schmalzing G, Markwardt F (2008) The P2X7 carboxyl tail is a regulatory module of P2X7 receptor channel activity. J Biol Chem 283:25725-25734
28. Miller RD (2005) Miller's Anesthesia: Churchill Livingstone
29. Nakanishi M, Mori T, Nishikawa K, Sawada M, Kuno M, Asada A (2007) The effects of general anesthetics on P2X7 and P2Y receptors in a rat microglial cell line. Anes Anal 104:1136-1144 (Pubitemid 46649934)
30. Zhu SM, Xiong XX, Zheng YY, Pan CF (2009) Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation. Anesth Analg 109:1493-1499
31. Hung AC, Chu YJ, Lin YH, Weng JY, Chen HB, Au YC, Sun SH (2005) Roles of protein kinase C in regulation of P2X7 receptor-mediated calcium signalling of cultured type-2 astrocyte cell line, RBA-2. Cell Signal 17:1384-1396 (Pubitemid 41206648)
32. Lorz C, Mehmet H (2009) The role of death receptors in neural injury. Front Biosci 14:583-595
33. Shibakawa YS, Sasaki Y, Goshima Y, Echigo N, Kamiya Y, Kurahashi K, Yamada Y, Andoh T (2005) Effects of ketamine and propofol on inflammatory responses of primary glial cell cultures stimulated with lipopolysaccharide. Br J Anaesth 95:803-810 (Pubitemid 41762381)
34. Mingam R, De Smedt V, Amédée T, Bluthé RM, Kelley KW, Dantzer R, Layé S (2008) In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain. Brain Behav Immun 22:234-244
35. Wu GJ, Chen TL, Chang CC, Chen RM (2009) Propofol suppresses tumor necrosis factor-alpha biosynthesis in lipopolysaccharide- stimulated macrophages possibly through downregulation of nuclear factor-kappa B-mediated toll-like receptor 4 gene expression. Chem Biol Interact 180:465-471