General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of γ-aminobutyric acid (GABA) current at the GABAa receptor but not with lipid solubility

Journal of Pharmacology and Experimental Therapeutics

Volumn 297, Issue 1, 2001, Pages 338-351

  Krasowski, M D ^a   Jenkins, A ^a   Flood, P ^a   Kung, A Y ^a   Hopfinger, A J ^a   Harrison, N L ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYCLOPENTYLPHENOL; 2 HYDROXY 3 ISOPROPYLBENZOIC ACID; 2 ISOPROPYLPHENOL; 2 ISOPROPYLTHIOPHENOL; 2 TERT BUTYL 6 METHYLPHENOL; 2,4 DI SEC BUTYLPHENOL; 2,4 DI(TERT BUTYL)PHENOL; 2,6 DI SEC BUTYLPHENOL; 2,6 DI TERT BUTYLPHENOL; 2,6 DIBROMOPHENOL; 2,6 DICYCLOHEXYLPHENOL; 2,6 DICYCLOPENTYLPHENOL; 2,6 DIETHYLPHENOL; 2,6 DIETHYLPHENYLBROMIDE; 2,6 DIETHYLPHENYLISOCYANATE; 2,6 DIISOPROPYLPHENYLISOCYANATE; 2,6 DIISOPROPYLPHENYLISOTHIOCYANATE; 2,6 DIMETHYLTHIOPHENOL; 2,6 XYLENOL; 3,5 DI TERT BUTYLPHENOL; 3,5 DIISOPROPYLCATECHOL; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 IODO 2,6 DIISOPROPYLPHENOL; PHENOL DERIVATIVE; PROPOFOL; RECOMBINANT RECEPTOR; SYRINGOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CORRELATION FUNCTION; DRUG ACTIVITY; DRUG POTENCY; DRUG SOLUBILITY; GENERAL ANESTHESIA; NONHUMAN; PRIORITY JOURNAL; RIGHTING REFLEX; TADPOLE; XENOPUS LAEVIS;

ALLOSTERIC REGULATION; ANESTHETICS, INTRAVENOUS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; PROPOFOL; RECEPTORS, GABA-A; REFLEX; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 0035079043     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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