Markers of cellular senescence are elevated in murine blastocysts cultured in vitro: molecular consequences of culture in atmospheric oxygen

Journal of Assisted Reproduction and Genetics

Volumn 31, Issue 10, 2014, Pages 1259-1267

  Meuter, Alexandra ^a   Rogmann, Lisa Marlen ^a   Winterhoff, Boris J ^a   Tchkonia, Tamar ^a   Kirkland, James L ^a   Morbeck, Dean E ^a  

^a MAYO CLINIC   (United States)

Author keywords

Cellular senescence; Embryo culture; In vitro stress; Oxidative stress

Indexed keywords

BETA GALACTOSIDASE; HISTONE H2AX; INTERLEUKIN 6; MESSENGER RNA; OXYGEN; PROTEIN; PROTEIN P16; PROTEIN P21; ANTIOXIDANT; BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GAMMA-H2AX PROTEIN, MOUSE; HISTONE; P21 ACTIVATED KINASE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; BLASTOCYST; CELL AGING; DNA DAMAGE; EMBRYO; EMBRYO CULTURE; IMMUNOFLUORESCENCE; IN VITRO STUDY; MOUSE; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONCENTRATION; PHENOTYPE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SENESCENCE; ANIMAL; CELL CULTURE; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; PROCEDURES;

MURINAE;

ANIMALS; ANTIOXIDANTS; BETA-GALACTOSIDASE; BIOLOGICAL MARKERS; BLASTOCYST; CELL AGING; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA DAMAGE; HISTONES; IN VITRO TECHNIQUES; INTERLEUKIN-6; MICE; OXYGEN; P21-ACTIVATED KINASES; REACTIVE OXYGEN SPECIES; RNA, MESSENGER;

EID: 84918842703     PISSN: 10580468     EISSN: 15737330     Source Type: Journal    
DOI: 10.1007/s10815-014-0299-8     Document Type: Article

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