Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells

Bone

Volumn 45, Issue 4, 2009, Pages 726-735

  Bajada, Stefan ^a   Marshall, Michael J ^b   Wright, Karina T ^a   Richardson, James B ^a   Johnson, William E B ^a  

^a KEELE UNIVERSITY   (United Kingdom)

^b ROBERT JONES AND AGNES HUNT ORTHOPAEDIC HOSPITAL   (United Kingdom)

Author keywords

Cell senescence; Differentiation; Dkk 1; Fracture non union; Non union stromal cells

Indexed keywords

BETA GALACTOSIDASE; CD34 ANTIGEN; CD45 ANTIGEN; DICKKOPF 1 PROTEIN; ENDOGLIN; WNT PROTEIN;

ADIPOCYTE; ADIPOGENESIS; ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; CARTILAGE CELL; CELL AGING; CELL DIFFERENTIATION; CELL EXPANSION; CELL GROWTH; CELL LINEAGE; CHONDROGENESIS; CLINICAL ARTICLE; ENZYME ACTIVITY; FEMALE; FRACTURE NONUNION; GROWTH INHIBITION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IN VITRO STUDY; MALE; MESENCHYMAL STEM CELL; OSTEOBLAST; PROTEIN SECRETION; SENESCENCE; SIGNAL TRANSDUCTION; STROMA CELL;

ADULT; AGED; ANTIGENS, CD; ATROPHY; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SEPARATION; CELLS, CULTURED; FEMALE; FRACTURES, UNUNITED; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MESENCHYMAL STEM CELLS; MIDDLE AGED; OSTEOBLASTS; OSTEOGENESIS; STROMAL CELLS;

EID: 68949099454     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.06.015     Document Type: Article

References (60)

1. Bruder S.P., Fink D.J., and Caplan A.I. Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J. Cell Biochem. 56 3 (1994) 283-294
2. Yoo J.U., and Johnstone B. The role of osteochondral progenitor cells in fracture repair. Clin. Orthop. Relat. Res. 355 Suppl. (1998) S73-S81
3. Street J., Winter D., Wang J.H., Wakai A., McGuinness A., and Redmond H.P. Is human fracture hematoma inherently angiogenic?. Clin. Orthop. Relat. Res. 378 (2000) 224-237
4. Einhorn T.A., and Lee C.A. Bone regeneration: new findings and potential clinical applications. J. Am. Acad. Orthop. Surg. 9 3 (2001) 157-165
5. Einhorn T.A. Enhancement of fracture-healing. J. Bone Joint Surg. Am. 77 6 (1995) 940-956
6. Marsh D. Concepts of fracture union, delayed union, and nonunion. Clin Orthop Relat Res. 355 Suppl (1998) S22-S30
7. Tzioupis C., and Giannoudis P.V. Prevalence of long-bone non unions. Injury 38 Suppl. 2 (2007) S3-S9
8. Megas P. Classification of non union. Injury 36 Suppl. 4 (2005) S30-S37
9. Calori G.M., Albisetti W., Agus A., Iori S., and Tagliabue L. Risk factors contributing to fracture non unions. Injury 38 Suppl. 2 (2007) S11-S18
10. Hietaniemi K., Lehto M.U., and Paavolainen P. Major fibrillar collagens and fibronectin in an experimental nonunion: an immunohistochemical study. Acta Orthop. Scand. 69 5 (1998) 545-549
11. Kloen P., Doty S.B., Gordon E., Rubel I.F., Goumans M.J., and Helfet D.L. Expression and activation of the BMP-signaling components in human fracture nonunions. J. Bone Joint Surg. Am. 84-A 11 (2002) 1909-1918
12. Reed A.A., Joyner C.J., Brownlow H.C., and Simpson A.H. Human atrophic fracture non unions are not avascular. J. Orthop. Res. 20 3 (2002) 593-599
13. Dahabreh Z., Dimitriou R., and Giannoudis P.V. Health economics: a cost analysis of treatment of persistent fracture non unions using bone morphogenetic protein-7. Injury. 38 3 (2007) 371-377
14. Geesink R.G., Hoefnagels N.H., and Bulstra S.K. Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect. J. Bone Joint Surg. Br. 81 4 (1999) 710-718
15. Friedlaender G.E., Perry C.R., Cole J.D., Cook S.D., Cierny G., Muschler G.F., et al. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J. Bone Joint Surg. Am 83-A Suppl 1 Pt 2 (2001) S151-S158
16. Schmidmaier G., Schwabe P., Wildemann B., and Haas N.P. Use of bone morphogenetic proteins for treatment of non unions and future perspectives. Injury 38 Suppl. 4 (2007) S35-S41
17. Chiang C.C., Su C.Y., Huang C.K., Chen W.M., Chen T.H., and Tzeng Y.H. Early experience and results of bone graft enriched with autologous platelet gel for recalcitrant nonunions of lower extremity. J. Trauma. 63 3 (2007) 655-661
18. Khan Y., and Laurencin C.T. Fracture repair with ultrasound: clinical and cell-based evaluation. J. Bone Joint Surg. Am. 90 Suppl. 1 (2008) 138-144
19. Termaat M.F., Den Boer F.C., Bakker F.C., Patka P., and Haarman H.J. Bone morphogenetic proteins. Development and clinical efficacy in the treatment of fractures and bone defects. J. Bone Joint Surg. Am. 87 6 (2005) 1367-1378
20. Oe K., Miwa M., Sakai Y., Lee S.Y., Kuroda R., and Kurosaka M. An in vitro study demonstrating that haematomas found at the site of human fractures contain progenitor cells with multilineage capacity. J. Bone Joint Surg. Br. 89 1 (2007) 133-138
21. Hernigou P., and Beaujean F. Bone marrow in patients with pseudarthrosis. A study of progenitor cells by in vitro cloning. Rev. Chir. Orthop. Reparatrice Appar. Mot. 83 1 (1997) 33-40
22. Seebach C., Henrich D., Tewksbury R., Wilhelm K., and Marzi I. Number and proliferative capacity of human mesenchymal stem cells are modulated positively in multiple trauma patients and negatively in atrophic nonunions. Calcif. Tissue Int. 80 4 (2007) 294-300
23. Wan C., He Q., McCaigue M.D., Marsh D., and Li G. Circulating mesenchymal stem cells in the fracture non-union patients. J. Bone Joint Surg. SUPP_III 88B (2005) 403-404
24. Hofmann A., Ritz U., Hessmann M.H., Schmid C., Tresch A., Rompe J.D., et al. Cell viability, osteoblast differentiation, and gene expression are altered in human osteoblasts from hypertrophic fracture non unions. Bone. 42 5 (2008) 894-906
25. Chen Y., Whetstone H.C., Lin A.C., Nadesan P., Wei Q., Poon R., et al. Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. PLoS Med. 4 7 (2007) e249
26. Santavirta S., Konttinen Y.T., Nordström D., Mäkelä A., Sorsa T., Hukkanen M., et al. Immunologic studies of nonunited fractures. Acta Orthop. Scand. 63 6 (1992) 579-586
27. Harrison P.E., Ashton I.K., Johnson W.E., Turner S.L., Richardson J.B., and Ashton B.A. The in vitro growth of human chondrocytes. Cell Tissue Bank 1 4 (2000) 255-260
28. Wright K.T., El Masri W., Osman A., Roberts S., Trivedi J., Ashton B.A., et al. The cell culture expansion of bone marrow stromal cells from humans with spinal cord injury: implications for future cell transplantation therapy. Spinal Cord 46 12 (2008) 811-817
29. Stenderup K., Justesen J., Clausen C., and Kassem M. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone. 33 6 (2003) 919-926
30. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U. S. A. 92 20 (1995) 9363-9367
31. Jaiswal N., Haynesworth S.E., Caplan A.I., and Bruder S.P. Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J. Cell Biochem. 64 2 (1997) 295-312
32. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., et al. Multilineage potential of adult human mesenchymal stem cells. Science 284 5411 (1999) 143-147
33. Johnstone B., Hering T.M., Caplan A.I., Goldberg V.M., and Yoo J.U. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp. Cell Res. 238 1 (1998) 265-272
34. Roberts S., McCall I.W., Darby A.J., Menage J., Evans H., Harrison P.E., et al. Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology. Arthritis Res. Ther. 5 1 (2003) R60-R73
35. Bajada S., Harrison P.E., Ashton B.A., Cassar-Pullicino V.N., Ashammakhi N., and Richardson J.B. Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation. J. Bone Joint Surg. Br. 89 10 (2007) 1382-1386
36. Hayflick L., and Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25 (1961) 585-621
37. Carter D.R., Beaupré G.S., Giori N.J., and Helms J.A. Mechanobiology of skeletal regeneration. Clin. Orthop. Relat. Res. 355 Suppl. (1998) S41-S55
38. Martin J.A., and Buckwalter J.A. The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair. J. Bone Joint Surg. Am. 85-A Suppl. 2 (2003) 106-110
39. Martin J.A., Brown T.D., Heiner A.D., and Buckwalter J.A. Chondrocyte senescence, joint loading and osteoarthritis. Clin. Orthop. Relat. Res. 427 Suppl. (2004) S96-103
40. Stanley A.C., Fernandez N.N., Lounsbury K.M., Corrow K., Osler T., Healey C., et al. Pressure-induced cellular senescence: a mechanism linking venous hypertension to venous ulcers. J. Surg. Res. 124 1 (2005) 112-117
41. Jackson J.G., and Pereira-Smith O.M. p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts. Cancer Res. 66 17 (2006) 8356-8360
42. West M.D., Pereira-Smith O.M., and Smith J.R. Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity. Exp. Cell Res. 184 1 (1989) 138-147
43. Shelton D.N., Chang E., Whittier P.S., Choi D., and Funk W.D. Microarray analysis of replicative senescence. Curr. Biol. 9 17 (1999) 939-945
44. Gorgoulis V.G., Pratsinis H., Zacharatos P., Demoliou C., Sigala F., Asimacopoulos P.J., et al. p53-dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions. Lab. Invest. 85 4 (2005) 502-511
45. Behonick D.J., Xing Z., Lieu S., Buckley J.M., Lotz J.C., Marcucio R.S., et al. Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. PLoS ONE 2 11 (2007) e1150
46. Kosaki N., Takaishi H., Kamekura S., Kimura T., Okada Y., Minqi L., et al. Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice. Biochem. Biophys. Res. Commun. 354 4 (2007) 846-851
47. Henle P., Zimmermann G., and Weiss S. Matrix metalloproteinases and failed fracture healing. Bone 37 6 (2005) 791-798
48. Kretlow J.D., Jin Y.Q., Liu W., Zhang W.J., Hong T.H., Zhou G., et al. Donor age and cell passage affects differentiation potential of murine bone marrow-derived stem cells. BMC Cell Biol. 9 (2008) 60
49. Holmen S.L., Giambernardi T.A., Zylstra C.R., Buckner-Berghuis B.D., Resau J.H., Hess J.F., et al. Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J. Bone Miner. Res. 19 12 (2004) 2033-2040
50. Kim J.B., Leucht P., Lam K., Luppen C., Ten Berge D., Nusse R., et al. Bone regeneration is regulated by wnt signaling. J. Bone Miner. Res. 22 12 (2007) 1913-1923
51. Leucht P., Kim J.B., and Helms J.A. Beta-catenin-dependent Wnt signaling in mandibular bone regeneration. J. Bone Joint Surg. Am. 90 Suppl. 1 (2008) 3-8
52. Moon R.T., Bowerman B., Boutros M., and Perrimon N. The promise and perils of Wnt signaling through beta-catenin. Science. 296 5573 (2002) 1644-1646
53. Bafico A., Liu G., Yaniv A., Gazit A., and Aaronson S.A. Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat. Cell Biol. 3 7 (2001) 683-686
54. Mao B., Wu W., Davidson G., Marhold J., Li M., Mechler B.M., et al. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 417 6889 (2002) 664-667
55. Hadjiargyrou M., Lombardo F., Zhao S., Ahrens W., Joo J., Ahn H., et al. Transcriptional profiling of bone regeneration. Insight into the molecular complexity of wound repair. J. Biol. Chem. 277 33 (2002) 30177-30182
56. Tian E., Zhan F., Walker R., Rasmussen E., Ma Y., Barlogie B., et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N. Engl. J. Med. 349 26 (2003) 2483-2494
57. Kaiser M., Mieth M., Liebisch P., Oberländer R., Rademacher J., Jakob C., et al. Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma. Eur. J. Haematol. 80 6 (2008) 490-494
58. Diarra D., Stolina M., Polzer K., Zwerina J., Ominsky M.S., Dwyer D., et al. Dickkopf-1 is a master regulator of joint remodeling. Nat. Med. 13 2 (2007) 156-163
59. Morvan F., Boulukos K., Clément-Lacroix P., Roman Roman S., Suc-Royer I., Vayssière B., et al. Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J. Bone Miner. Res. 21 6 (2006) 934-945
60. Politou M.C., Heath D.J., Rahemtulla A., Szydlo R., Anagnostopoulos A., Dimopoulos M.A., et al. Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation. Int. J. Cancer. 119 7 (2006) 1728-1731