Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy

Journal of Diabetes and its Complications

Volumn 28, Issue 5, 2014, Pages 604-611

  Kitada, Kento ^a   Nakano, Daisuke ^a   Ohsaki, Hiroyuki ^b   Hitomi, Hirofumi ^a   Minamino, Tohru ^c   Yatabe, Junichi ^d   Felder, Robin A ^e   Mori, Hirohito ^a   Masaki, Tsutomu ^a   Kobori, Hiroyuki ^a   Nishiyama, Akira ^a  

^a KAGAWA UNIVERSITY   (Japan)

^b EHIME PREFECTURAL UNIVERSITY OF HEALTH SCIENCES   (Japan)

^c NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^d FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^e UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Cellular senescence; Diabetic nephropathy; Insulin; p21; Proximal tubular cells; Sodium glucose cotransporter 2

Indexed keywords

ALBUMIN; BETA GALACTOSIDASE; GLUCOSE; INSULIN; PROTEIN P16; PROTEIN P21; PROTEIN P27; SODIUM GLUCOSE COTRANSPORTER 2; STREPTOZOCIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; SLC5A2 PROTEIN, MOUSE;

ALBUMIN BLOOD LEVEL; ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE EPITHELIUM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; SIGNAL TRANSDUCTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; C57BL MOUSE; CELL AGING; CELL CULTURE; COMPLICATION; DISEASE COURSE; EXPERIMENTAL DIABETES MELLITUS; GENETICS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; CELL AGING; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; DISEASE PROGRESSION; HYPERGLYCEMIA; KIDNEY TUBULES, PROXIMAL; MALE; MICE; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; SODIUM-GLUCOSE TRANSPORTER 2; STREPTOZOCIN;

EID: 84906795005     PISSN: 10568727     EISSN: 1873460X     Source Type: Journal    
DOI: 10.1016/j.jdiacomp.2014.05.010     Document Type: Article

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