메뉴 건너뛰기




Volumn 10, Issue 3, 2015, Pages 222-241

The impact of docosahexaenoic acid on alzheimer’s disease: Is there a role of the blood-brain barrier?

Author keywords

Alzheimer s disease; Blood brain barrier; Docosahexaenoic acid; Fish oil; Omega 3 fatty acid; Polyunsaturated fatty acid

Indexed keywords

DOCOSAHEXAENOIC ACID; LIPID; OMEGA 3 FATTY ACID; FISH OIL;

EID: 84940905373     PISSN: 15748847     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488471003150820151532     Document Type: Article
Times cited : (39)

References (174)
  • 1
    • 31544438866 scopus 로고    scopus 로고
    • Pathophysiology of Alzheimer's disease. Neuroimaging
    • Imbimbo BP, Lombard J, Pomara N. Pathophysiology of Alzheimer's disease. Neuroimaging. Clin N Am. 2005; 15(4): 727-53.
    • (2005) Clin N Am , vol.15 , Issue.4 , pp. 727-753
    • Imbimbo, B.P.1    Lombard, J.2    Pomara, N.3
  • 2
    • 84875354777 scopus 로고    scopus 로고
    • Alzheimer's Association. 2013 Alzheimer's disease facts and figures
    • Thies W, Bleiler L, Alzheimer's Association. 2013 Alzheimer's disease facts and figures. Alzheimer's Dement 2013; 9(2): 208-45.
    • (2013) Alzheimer's Dement , vol.9 , Issue.2 , pp. 208-245
    • Thies, W.1    Bleiler, L.2
  • 3
    • 0034958224 scopus 로고    scopus 로고
    • Epidemiology and pathophysiology of Alzheimer's disease
    • DeKosky ST. Epidemiology and pathophysiology of Alzheimer's disease. Clin Cornerstone 2001; 3(4): 15-26.
    • (2001) Clin Cornerstone , vol.3 , Issue.4 , pp. 15-26
    • Dekosky, S.T.1
  • 6
    • 28944444905 scopus 로고    scopus 로고
    • Fish consumption and cognitive decline with age in a large community study
    • Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS. Fish consumption and cognitive decline with age in a large community study. Arch Neurol 2005; 62(12): 1849-53.
    • (2005) Arch Neurol , vol.62 , Issue.12 , pp. 1849-1853
    • Morris, M.C.1    Evans, D.A.2    Tangney, C.C.3    Bienias, J.L.4    Wilson, R.S.5
  • 7
    • 78650497794 scopus 로고    scopus 로고
    • Docosahexaenoic acid reduces amyloid-(1-42) secretion in human APP-transfected CHO-cells by mechanisms other than inflammation related to PGE2
    • de Wilde MC, van der Beek EM, Kiliaan AJ, et al. Docosahexaenoic acid reduces amyloid-(1-42) secretion in human APP-transfected CHO-cells by mechanisms other than inflammation related to PGE2. J Alzheimers Dis 2010; 21(4): 1271-81.
    • (2010) J Alzheimers Dis , vol.21 , Issue.4 , pp. 1271-1281
    • De Wilde, M.C.1    Van Der Beek, E.M.2    Kiliaan, A.J.3
  • 8
    • 16244416174 scopus 로고    scopus 로고
    • A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model
    • Lim GP, Calon F, Morihara T, et al. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci. 2005; 25(12): 3032-40.
    • (2005) J Neurosci , vol.25 , Issue.12 , pp. 3032-3040
    • Lim, G.P.1    Calon, F.2    Morihara, T.3
  • 9
    • 33747180133 scopus 로고    scopus 로고
    • Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta amyloid accumulation in APP/PS1 transgenic mice
    • Oksman M, Iivonen H, Hogyes E, et al. Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta amyloid accumulation in APP/PS1 transgenic mice. Neurobiol Dis 2006; 23(3): 563-72.
    • (2006) Neurobiol Dis , vol.23 , Issue.3 , pp. 563-572
    • Oksman, M.1    Iivonen, H.2    Hogyes, E.3
  • 10
    • 61549097218 scopus 로고    scopus 로고
    • DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice
    • Hooijmans CR, Van der Zee CEEM, Dederen PJ, et al. DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice. Neurobiol Dis 2009; 33(3): 482-98.
    • (2009) Neurobiol Dis , vol.33 , Issue.3 , pp. 482-498
    • Hooijmans, C.R.1    Van Der Zee, C.2    Dederen, P.J.3
  • 11
    • 34247380762 scopus 로고    scopus 로고
    • Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels
    • Green KN, Martinez-Coria H, Khashwji H, et al. Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J Neurosci 2007; 27(16): 4385-95.
    • (2007) J Neurosci , vol.27 , Issue.16 , pp. 4385-4395
    • Green, K.N.1    Martinez-Coria, H.2    Khashwji, H.3
  • 12
    • 79959973322 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acids in Alzheimer's disease: Key questions and partial answers
    • Calon F. Omega-3 polyunsaturated fatty acids in Alzheimer's disease: key questions and partial answers. Curr Alzheimer Res 2011; 8(5): 470-8.
    • (2011) Curr Alzheimer Res , vol.8 , Issue.5 , pp. 470-478
    • Calon, F.1
  • 13
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001; 81(2): 741-66.
    • (2001) Physiol Rev , vol.81 , Issue.2 , pp. 741-766
    • Selkoe, D.J.1
  • 14
    • 78650678688 scopus 로고    scopus 로고
    • Decreased clearance of CNS beta amyloid in Alzheimer's disease
    • Mawuenyega KG, Sigurdson W, Ovod V, et al. Decreased clearance of CNS beta amyloid in Alzheimer's disease. Science 2010; 330(6012): 1774.
    • (2010) Science , vol.330 , Issue.6012 , pp. 1774
    • Mawuenyega, K.G.1    Sigurdson, W.2    Ovod, V.3
  • 15
    • 84862953172 scopus 로고    scopus 로고
    • Amyloid precursor protein revisited: Neuron-specific expression and highly stable nature of soluble derivatives
    • Guo Q, Li H, Gaddam SSK, Justice NJ, Robertson CS, Zheng H. Amyloid precursor protein revisited: Neuron-specific expression and highly stable nature of soluble derivatives. J Biol Chem 2012; 287(4): 2437-45.
    • (2012) J Biol Chem , vol.287 , Issue.4 , pp. 2437-2445
    • Guo, Q.1    Li, H.2    Gaddam, S.3    Justice, N.J.4    Robertson, C.S.5    Zheng, H.6
  • 16
    • 0141867783 scopus 로고    scopus 로고
    • Efflux of human and mouse amyloid β proteins 1–40 and 1–42 from brain: Impairmentin a mouse model of Alzheimer's disease
    • Banks WA, Robinson SM, Verma S, Morley JE. Efflux of human and mouse amyloid β proteins 1–40 and 1–42 from brain: impairmentin a mouse model of Alzheimer's disease. Neuroscience 2003; 121(2): 487-92.
    • (2003) Neuroscience , vol.121 , Issue.2 , pp. 487-492
    • Banks, W.A.1    Robinson, S.M.2    Verma, S.3    Morley, J.E.4
  • 17
    • 84885018413 scopus 로고    scopus 로고
    • Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease
    • Erickson MA, Banks WA. Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease. J Cereb Blood Flow Metab 2013; 33(10): 1500-13.
    • (2013) J Cereb Blood Flow Metab , vol.33 , Issue.10 , pp. 1500-1513
    • Erickson, M.A.1    Banks, W.A.2
  • 19
    • 0027318860 scopus 로고
    • Molecular pathology of Alzheimer neurofibrillary degeneration
    • Iqbal K, Alonso A, Gong C, et al. Molecular pathology of Alzheimer neurofibrillary degeneration. Acta Neurobiol Exp 1993; 53(1): 325-35.
    • (1993) Acta Neurobiol Exp , vol.53 , Issue.1 , pp. 325-335
    • Iqbal, K.1    Alonso, A.2    Gong, C.3
  • 20
    • 0036931159 scopus 로고    scopus 로고
    • Tau neurofibrillary pathology and microtubule stability
    • Michaelis ML, Dobrowsky RT, Li G. Tau neurofibrillary pathology and microtubule stability. J Mol Neurosci 2002; 19(3): 289-93.
    • (2002) J Mol Neurosci , vol.19 , Issue.3 , pp. 289-293
    • Michaelis, M.L.1    Dobrowsky, R.T.2    Li, G.3
  • 21
    • 0036047004 scopus 로고    scopus 로고
    • Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease
    • Terwel D, Dewachter I, Van Leuven F. Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease. Neuromolecular Med 2002; 2(2): 151-65.
    • (2002) Neuromolecular Med , vol.2 , Issue.2 , pp. 151-165
    • Terwel, D.1    Dewachter, I.2    Van Leuven, F.3
  • 22
    • 33644851265 scopus 로고    scopus 로고
    • Inducible expression of Tau repeat domain in cell models of tauopathy: Aggregation is toxic to cells but can be reversed by inhibitor drugs
    • Khlistunova I, Biernat J, Wang Y, et al. Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs. J Biol Chem 2006; 281(2): 1205-14.
    • (2006) J Biol Chem , vol.281 , Issue.2 , pp. 1205-1214
    • Khlistunova, I.1    Biernat, J.2    Wang, Y.3
  • 23
    • 33846015514 scopus 로고    scopus 로고
    • Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
    • Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs DH, LaFerla FM. Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem 2006; 281(51): 39413-23.
    • (2006) J Biol Chem , vol.281 , Issue.51 , pp. 39413-39423
    • Oddo, S.1    Vasilevko, V.2    Caccamo, A.3    Kitazawa, M.4    Cribbs, D.H.5    Laferla, F.M.6
  • 24
    • 22344438508 scopus 로고    scopus 로고
    • Tau suppression in a neurodegenerative mouse model improves memory function
    • Santacruz K, Lewis J, Spires T, et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science 2005; 309(5733): 476-81.
    • (2005) Science , vol.309 , Issue.5733 , pp. 476-481
    • Santacruz, K.1    Lewis, J.2    Spires, T.3
  • 25
    • 0035943436 scopus 로고    scopus 로고
    • Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
    • Gotz J, Chen F, van Dorpe J, Nitsch RM. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science 2001; 293(5534): 1491-5.
    • (2001) Science , vol.293 , Issue.5534 , pp. 1491-1495
    • Gotz, J.1    Chen, F.2    Van Dorpe, J.3    Nitsch, R.M.4
  • 26
    • 17944382037 scopus 로고    scopus 로고
    • Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
    • Lewis J, Dickson DW, Lin WL, et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 2001; 293(5534): 1487-91.
    • (2001) Science , vol.293 , Issue.5534 , pp. 1487-1491
    • Lewis, J.1    Dickson, D.W.2    Lin, W.L.3
  • 27
    • 0042697305 scopus 로고    scopus 로고
    • Triple transgenic model of Alzheimer's disease with plaques and tangles intracellular Abeta and synaptic dysfunction
    • Oddo S, Caccamo A, Shepherd JD, et al. Triple transgenic model of Alzheimer's disease with plaques and tangles intracellular Abeta and synaptic dysfunction. Neuron 2003; 39(3): 409-21.
    • (2003) Neuron , vol.39 , Issue.3 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3
  • 29
    • 0037333633 scopus 로고    scopus 로고
    • Immune reactive cells in senile plaques and cognitive decline in Alzheimer's disease
    • Vehmas AK, Kawas CH, Stewart WF, Troncoso JC. Immune reactive cells in senile plaques and cognitive decline in Alzheimer's disease. Neurobiol Aging 2003; 24(2): 321-31.
    • (2003) Neurobiol Aging , vol.24 , Issue.2 , pp. 321-331
    • Vehmas, A.K.1    Kawas, C.H.2    Stewart, W.F.3    Troncoso, J.C.4
  • 30
    • 44149083565 scopus 로고    scopus 로고
    • Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease
    • Farfara D, Lifshitz V, Frenkel D. Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease. J Cell Mol Med 2008; 12(3): 762-80.
    • (2008) J Cell Mol Med , vol.12 , Issue.3 , pp. 762-780
    • Farfara, D.1    Lifshitz, V.2    Frenkel, D.3
  • 32
    • 0037168780 scopus 로고    scopus 로고
    • Diet and risk of dementia Does fat matter? The Rotterdam Study
    • Engelhart MJ, Geerlings MI, Ruitenberg A, et al. Diet and risk of dementia Does fat matter? The Rotterdam Study. Neurology 2002; 59(12): 1915-21.
    • (2002) Neurology , vol.59 , Issue.12 , pp. 1915-1921
    • Engelhart, M.J.1    Geerlings, M.I.2    Ruitenberg, A.3
  • 33
    • 18144410635 scopus 로고    scopus 로고
    • Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease
    • Patel NS, Paris D, Mathura V, Quadros AN, Crawford FC, Mullan MJ. Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease. J Neuroinflammation 2005; 2: 1-10.
    • (2005) J Neuroinflammation , vol.2 , pp. 1-10
    • Patel, N.S.1    Paris, D.2    Mathura, V.3    Quadros, A.N.4    Crawford, F.C.5    Mullan, M.J.6
  • 34
    • 83755183781 scopus 로고    scopus 로고
    • Blocking IL-1 signaling rescues cognition, attenuates tau pathology and restores neuronal beta-catenin pathway function in an Alzheimer's disease model
    • Kitazawa M, Cheng D, Tsukamoto MR, et al. Blocking IL-1 signaling rescues cognition, attenuates tau pathology and restores neuronal beta-catenin pathway function in an Alzheimer's disease model. J Immunol 2011; 187(12): 6539-49.
    • (2011) J Immunol , vol.187 , Issue.12 , pp. 6539-6549
    • Kitazawa, M.1    Cheng, D.2    Tsukamoto, M.R.3
  • 35
    • 62249200515 scopus 로고    scopus 로고
    • Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway
    • Vukic V, Callaghan D, Walker D, et al. Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway. Neurobiol Dis 2009; 34(1): 95-106.
    • (2009) Neurobiol Dis , vol.34 , Issue.1 , pp. 95-106
    • Vukic, V.1    Callaghan, D.2    Walker, D.3
  • 36
    • 0035831189 scopus 로고    scopus 로고
    • Beta amyloid induced glial expression of both pro and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology
    • Apelt J, Schliebs R. Beta amyloid induced glial expression of both pro and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology. Brain Res 2001; 894(1): 21-30.
    • (2001) Brain Res , vol.894 , Issue.1 , pp. 21-30
    • Apelt, J.1    Schliebs, R.2
  • 37
    • 0026470167 scopus 로고
    • MHC class IIpositive microglia in human brain association with Alzheimer lesions
    • Perlmutter LS, Scott SA, Barron E, Chui HC. MHC class IIpositive microglia in human brain association with Alzheimer lesions. J Neurosci Res 1992; 33(4): 549-58.
    • (1992) J Neurosci Res , vol.33 , Issue.4 , pp. 549-558
    • Perlmutter, L.S.1    Scott, S.A.2    Barron, E.3    Chui, H.C.4
  • 38
    • 0025335717 scopus 로고
    • Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease
    • Tooyama I, Kimura H, Akiyama H, McGeer PL. Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease. Brain Res 1990; 523(2): 273-80.
    • (1990) Brain Res , vol.523 , Issue.2 , pp. 273-280
    • Tooyama, I.1    Kimura, H.2    Akiyama, H.3    McGeer, P.L.4
  • 39
    • 0030691019 scopus 로고    scopus 로고
    • Activated microglial cells are colocalized with perivascular deposits of amyloid-beta protein in Alzheimer's disease brain
    • Uchihara T, Akiyama H, Kondo H, Ikeda K. Activated microglial cells are colocalized with perivascular deposits of amyloid-beta protein in Alzheimer's disease brain. Stroke 1997; 28(10): 1948-50.
    • (1997) Stroke , vol.28 , Issue.10 , pp. 1948-1950
    • Uchihara, T.1    Akiyama, H.2    Kondo, H.3    Ikeda, K.4
  • 40
    • 2542424033 scopus 로고    scopus 로고
    • Roles of unsaturated fatty acids (Especially omega-3 fatty acids) in the brain at various ages and during ageing
    • Bourre JM. Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing. J Nutr Health Aging 2004; 8(3): 163-74.
    • (2004) J Nutr Health Aging , vol.8 , Issue.3 , pp. 163-174
    • Bourre, J.M.1
  • 41
    • 0345401494 scopus 로고
    • Stability of the myelin membrane
    • O'Brien JS. Stability of the myelin membrane. Science 1965; 147(3662): 1099-107.
    • (1965) Science , vol.147 , Issue.3662 , pp. 1099-1107
    • O'brien, J.S.1
  • 42
    • 84940937852 scopus 로고    scopus 로고
    • Nutritional Influences in the Evolution of Mammalian Brain. Ciba Foundation Symposium 3-Lipids, Malnutrition & the Developing Brain
    • Crawford MA, Sinclair AJ. Nutritional Influences in the Evolution of Mammalian Brain. Ciba Foundation Symposium 3-Lipids, Malnutrition & the Developing Brain, John Wiley and Sons Ltd 2008: 267-92.
    • (2008) John Wiley and Sons Ltd , pp. 267-292
    • Crawford, M.A.1    Sinclair, A.J.2
  • 43
    • 0025913434 scopus 로고
    • Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease
    • Soderberg M, Edlund C, Kristensson K, Dallner G. Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease. Lipids 1991; 26(6): 421-5.
    • (1991) Lipids , vol.26 , Issue.6 , pp. 421-425
    • Soderberg, M.1    Edlund, C.2    Kristensson, K.3    Dallner, G.4
  • 44
    • 0032571154 scopus 로고    scopus 로고
    • Abnormal content of n-6 and n-3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content
    • Corrigan FM, Horrobin DF, Skinner ER, Besson JA, Cooper MB. Abnormal content of n-6 and n-3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content. Int J Biochem Cell Biol 1998; 30(2): 197-207.
    • (1998) Int J Biochem Cell Biol , vol.30 , Issue.2 , pp. 197-207
    • Corrigan, F.M.1    Horrobin, D.F.2    Skinner, E.R.3    Besson, J.A.4    Cooper, M.B.5
  • 45
    • 0030474703 scopus 로고    scopus 로고
    • The fatty acid composition of human gliomas differs from that found in nonmalignant brain tissue
    • Martin DD, Robbins ME, Spector AA, Wen BC, Hussey DH. The fatty acid composition of human gliomas differs from that found in nonmalignant brain tissue. Lipids 1996; 31(12): 1283-8.
    • (1996) Lipids , vol.31 , Issue.12 , pp. 1283-1288
    • Martin, D.D.1    Robbins, M.E.2    Spector, A.A.3    Wen, B.C.4    Hussey, D.H.5
  • 46
    • 0028068555 scopus 로고
    • Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males
    • Emken EA, Adlof RO, Gulley RM. Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. Biochem Biophys Acta 1994; 1213(3): 277-88.
    • (1994) Biochem Biophys Acta , vol.1213 , Issue.3 , pp. 277-288
    • Emken, E.A.1    Adlof, R.O.2    Gulley, R.M.3
  • 47
    • 84855973361 scopus 로고    scopus 로고
    • Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease
    • Fabelo N, Martin V, Santpere G, et al. Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. Mol Med 2011; 17(9-10): 1107-18.
    • (2011) Mol Med , vol.17 , Issue.9-10 , pp. 1107-1118
    • Fabelo, N.1    Martin, V.2    Santpere, G.3
  • 48
    • 0026732790 scopus 로고
    • Lipid composition in different regions of the brain in Alzheimer's disease senile dementia of Alzheimer's type
    • Soderberg M, Edlund C, Alafuzoff I, Kristensson K, Dallner G. Lipid composition in different regions of the brain in Alzheimer's disease senile dementia of Alzheimer's type. J Neurochem 1992; 59(5): 1646-53.
    • (1992) J Neurochem , vol.59 , Issue.5 , pp. 1646-1653
    • Soderberg, M.1    Edlund, C.2    Alafuzoff, I.3    Kristensson, K.4    Dallner, G.5
  • 49
    • 0025651620 scopus 로고
    • Membrane fatty acid composition shows delta-6-desaturase abnormalities in Alzheimer's disease
    • Nakada T, Kwee IL, Ellis WG. Membrane fatty acid composition shows delta-6-desaturase abnormalities in Alzheimer's disease. Neuroreport 1990; 1(2): 153-5.
    • (1990) Neuroreport , vol.1 , Issue.2 , pp. 153-155
    • Nakada, T.1    Kwee, I.L.2    Ellis, W.G.3
  • 51
    • 0027163166 scopus 로고
    • Differences in the fatty acid composition of the grey and white matter of different regions of the brains of patients with Alzheimer's disease and control subjects
    • Skinner ER, Watt C, Besson JA, Best PV. Differences in the fatty acid composition of the grey and white matter of different regions of the brains of patients with Alzheimer's disease and control subjects. Brain 1993; 116(3): 717-25.
    • (1993) Brain , vol.116 , Issue.3 , pp. 717-725
    • Skinner, E.R.1    Watt, C.2    Besson, J.A.3    Best, P.V.4
  • 52
    • 26444598506 scopus 로고    scopus 로고
    • A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease
    • Lukiw WJ, Cui JG, Marcheselli VL, et al. A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J Clin Invest 2005; 115(10): 2774-83.
    • (2005) J Clin Invest , vol.115 , Issue.10 , pp. 2774-2783
    • Lukiw, W.J.1    Cui, J.G.2    Marcheselli, V.L.3
  • 53
    • 80054704470 scopus 로고    scopus 로고
    • Peroxisomal alterations in Alzheimer's disease
    • Kou J, Kovacs GG, Hoftberger R, et al. Peroxisomal alterations in Alzheimer's disease. Acta Neuropathol 2011; 122(3): 271-83.
    • (2011) Acta Neuropathol , vol.122 , Issue.3 , pp. 271-283
    • Kou, J.1    Kovacs, G.G.2    Hoftberger, R.3
  • 54
    • 77952103357 scopus 로고    scopus 로고
    • Phosphatidyl serine-dependent neuroprotective signaling promoted by docosahexaenoic acid
    • Kim HY, Akbar M, Kim YS. Phosphatidyl serine-dependent neuroprotective signaling promoted by docosahexaenoic acid. Prostag Leukotr Ess 2010; 82(4-6): 165-72.
    • (2010) Prostag Leukotr Ess , vol.82 , Issue.4-6 , pp. 165-172
    • Kim, H.Y.1    Akbar, M.2    Kim, Y.S.3
  • 55
    • 0032770167 scopus 로고    scopus 로고
    • Decrease and structural modifications of phosphatidyl ethanolamine plasmalogen in the brain with Alzheimer disease
    • Guan Z, Wang Y, Cairns NJ, Lantos PL, Dallner G, Sindelar PJ. Decrease and structural modifications of phosphatidyl ethanolamine plasmalogen in the brain with Alzheimer disease. J Neuropathol Exp Neurol 1999; 58(7): 740-7.
    • (1999) J Neuropathol Exp Neurol , vol.58 , Issue.7 , pp. 740-747
    • Guan, Z.1    Wang, Y.2    Cairns, N.J.3    Lantos, P.L.4    Dallner, G.5    Sindelar, P.J.6
  • 56
    • 77958518079 scopus 로고    scopus 로고
    • Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease
    • Astarita G, Jung KM, Berchtold NC, et al. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. PLoS One 2010;5(9):e12538.
    • (2010) Plos One , vol.5 , Issue.9
    • Astarita, G.1    Jung, K.M.2    Berchtold, N.C.3
  • 57
    • 0039369595 scopus 로고
    • Membrane docosahexaenoate is supplied to the developing brain and retina by the liver
    • Scott BL, Bazan NG. Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. Proc Natl Acad Sci USA 1989; 86(8): 2903-7.
    • (1989) Proc Natl Acad Sci USA , vol.86 , Issue.8 , pp. 2903-2907
    • Scott, B.L.1    Bazan, N.G.2
  • 58
    • 76849108962 scopus 로고    scopus 로고
    • Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer's disease
    • Fraser T, Tayler H, Love S. Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer's disease. Neurochem Res 2010; 35(3): 503-13.
    • (2010) Neurochem Res , vol.35 , Issue.3 , pp. 503-513
    • Fraser, T.1    Tayler, H.2    Love, S.3
  • 59
    • 84859374049 scopus 로고    scopus 로고
    • Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease
    • Cunnane SC, Schneider JA, Tangney C, et al. Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis 2012; 29(3): 691-7.
    • (2012) J Alzheimers Dis , vol.29 , Issue.3 , pp. 691-697
    • Cunnane, S.C.1    Schneider, J.A.2    Tangney, C.3
  • 60
    • 77950150108 scopus 로고    scopus 로고
    • DHA diet reduces AD pathology in young APPswe/PS1 Delta E9 transgenic mice possible gender effects
    • Perez SE, Berg BM, Moore KA, et al. DHA diet reduces AD pathology in young APPswe/PS1 Delta E9 transgenic mice possible gender effects. J Neurosci Res 2010; 88(5): 1026-40.
    • (2010) J Neurosci Res , vol.88 , Issue.5 , pp. 1026-1040
    • Perez, S.E.1    Berg, B.M.2    Moore, K.A.3
  • 61
    • 32544435097 scopus 로고    scopus 로고
    • The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments
    • Offe K, Dodson SE, Shoemaker JT, et al. The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments. J Neurosci 2006; 26(5): 1596-603.
    • (2006) J Neurosci , vol.26 , Issue.5 , pp. 1596-1603
    • Offe, K.1    Dodson, S.E.2    Shoemaker, J.T.3
  • 62
    • 33644516276 scopus 로고    scopus 로고
    • Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11
    • Andersen OM, Schmidt V, Spoelgen R, et al. Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry 2006; 45(8): 2618-28.
    • (2006) Biochemistry , vol.45 , Issue.8 , pp. 2618-2628
    • Andersen, O.M.1    Schmidt, V.2    Spoelgen, R.3
  • 63
    • 32544432195 scopus 로고    scopus 로고
    • Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme
    • Spoelgen R, von Arnim CAF, Thomas AV, et al. Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. J Neurosci 2006; 26(2): 418-28.
    • (2006) J Neurosci , vol.26 , Issue.2 , pp. 418-428
    • Spoelgen, R.1    Von Arnim, C.2    Thomas, A.V.3
  • 64
    • 37549040611 scopus 로고    scopus 로고
    • Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): Relevance to AD prevention
    • Ma QL, Teter B, Ubeda OJ, et al. Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention. J Neurosci 2007; 27(52): 14299-307.
    • (2007) J Neurosci , vol.27 , Issue.52 , pp. 14299-14307
    • Ma, Q.L.1    Teter, B.2    Ubeda, O.J.3
  • 65
    • 79251559674 scopus 로고    scopus 로고
    • Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase-and PPAR-mediated mechanisms in Alzheimer's disease models
    • Zhao Y, Calon F, Julien C, et al. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase-and PPAR-mediated mechanisms in Alzheimer's disease models. PLoS One 2011; 6(1): e15816.
    • (2011) Plos One , vol.6 , Issue.1
    • Zhao, Y.1    Calon, F.2    Julien, C.3
  • 66
    • 70349256214 scopus 로고    scopus 로고
    • Robust docosahexaenoic acid-mediated neuroprotection in a rat model of transient, focal cerebral ischemia
    • Belayev L, Khoutorova L, Atkins KD, Bazan NG. Robust docosahexaenoic acid-mediated neuroprotection in a rat model of transient, focal cerebral ischemia. Stroke 2009; 40(9): 3121-6.
    • (2009) Stroke , vol.40 , Issue.9 , pp. 3121-3126
    • Belayev, L.1    Khoutorova, L.2    Atkins, K.D.3    Bazan, N.G.4
  • 67
    • 11144224909 scopus 로고    scopus 로고
    • Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection
    • Belayev L, Marcheselli VL, Khoutorova L, et al. Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection. Stroke 2005; 36(1): 118-23.
    • (2005) Stroke , vol.36 , Issue.1 , pp. 118-123
    • Belayev, L.1    Marcheselli, V.L.2    Khoutorova, L.3
  • 68
    • 0037017399 scopus 로고    scopus 로고
    • Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons
    • Zhang Y, McLaughlin R, Goodyer C, LeBlanc A. Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons. J Cell Biol. 2002; 156(3): 519-29.
    • (2002) J Cell Biol , vol.156 , Issue.3 , pp. 519-529
    • Zhang, Y.1    McLaughlin, R.2    Goodyer, C.3    Leblanc, A.4
  • 69
    • 0345307739 scopus 로고    scopus 로고
    • Genetic programming by the proteolytic fragments of the amyloid precursor protein somewhere between confusion and clarity
    • Stein TD, Johnson JA. Genetic programming by the proteolytic fragments of the amyloid precursor protein somewhere between confusion and clarity. Rev Neurosci 2003; 14(4): 317-41.
    • (2003) Rev Neurosci , vol.14 , Issue.4 , pp. 317-341
    • Stein, T.D.1    Johnson, J.A.2
  • 70
    • 84863230047 scopus 로고    scopus 로고
    • . (n-3) fatty acids and cardiovascular health: Are effects of EPA and DHA shared or complementary?
    • Mozaffarian D, Wu JHY. (n-3) fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary? J Nutr 2012; 142(3): 614S-25S.
    • (2012) J Nutr , vol.142 , Issue.3
    • Mozaffarian, D.1    Wu, J.2
  • 71
    • 84858991184 scopus 로고    scopus 로고
    • Omega-3 fatty acids EPA and DHA: Health benefits throughout life
    • Swanson D, Block R, Mousa SA. Omega-3 fatty acids EPA and DHA: health benefits throughout life. Adv Nutr 2012; 3(1): 1-7.
    • (2012) Adv Nutr , vol.3 , Issue.1 , pp. 1-7
    • Swanson, D.1    Block, R.2    Mousa, S.A.3
  • 72
    • 36649010031 scopus 로고    scopus 로고
    • Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: Evidence from animal studies
    • Calon F, Cole G. Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. Prostag Leukotr Ess 2007; 77(5-6): 287-93.
    • (2007) Prostag Leukotr Ess , vol.77 , Issue.5-6 , pp. 287-293
    • Calon, F.1    Cole, G.2
  • 73
    • 33747893267 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids and inflammation
    • Calder PC. Polyunsaturated fatty acids and inflammation. Prostag Leukotr Ess 2006; 75(3): 197-202.
    • (2006) Prostag Leukotr Ess , vol.75 , Issue.3 , pp. 197-202
    • Calder, P.C.1
  • 75
    • 34548656056 scopus 로고    scopus 로고
    • Dietary patterns and risk of dementia the Three-City cohort study
    • Barberger Gateau P, Raffaitin C, Letenneur L, et al. Dietary patterns and risk of dementia the Three-City cohort study. Neurology 2007; 69(20): 1921-30.
    • (2007) Neurology , vol.69 , Issue.20 , pp. 1921-1930
    • Barberger Gateau, P.1    Raffaitin, C.2    Letenneur, L.3
  • 76
    • 33745191471 scopus 로고    scopus 로고
    • Fat intake at midlife and risk of dementia and Alzheimer's disease a population based study
    • Laitinen MH, Ngandu T, Rovio S, et al. Fat intake at midlife and risk of dementia and Alzheimer's disease a population based study. Dement Geriatr Cogn Disord 2006; 22(1): 99-107.
    • (2006) Dement Geriatr Cogn Disord , vol.22 , Issue.1 , pp. 99-107
    • Laitinen, M.H.1    Ngandu, T.2    Rovio, S.3
  • 78
    • 0038115068 scopus 로고    scopus 로고
    • Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease
    • Morris MC, Evans DA, Bienias JL, et al. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol 2003; 60(7): 940-6.
    • (2003) Arch Neurol , vol.60 , Issue.7 , pp. 940-946
    • Morris, M.C.1    Evans, D.A.2    Bienias, J.L.3
  • 79
    • 27644537715 scopus 로고    scopus 로고
    • Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4
    • Huang TL, Zandi PP, Tucker KL, et al. Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4. Neurology 2005; 65(9): 1409-14.
    • (2005) Neurology , vol.65 , Issue.9 , pp. 1409-1414
    • Huang, T.L.1    Zandi, P.P.2    Tucker, K.L.3
  • 81
    • 66349085616 scopus 로고    scopus 로고
    • Apolipoprotein E: Structure determines function from atherosclerosis to Alzheimer's disease to AIDS
    • Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E: structure determines function from atherosclerosis to Alzheimer's disease to AIDS. J Lipid Res 2009; 50: S183-8.
    • (2009) J Lipid Res , vol.50
    • Mahley, R.W.1    Weisgraber, K.H.2    Huang, Y.3
  • 82
    • 0024299370 scopus 로고
    • Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
    • Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 1988; 240(4852): 622-30.
    • (1988) Science , vol.240 , Issue.4852 , pp. 622-630
    • Mahley, R.W.1
  • 84
    • 67649853276 scopus 로고    scopus 로고
    • Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk
    • Devore EE, Grodstein F, van Rooij FJA, et al. Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. Am J Clin Nutr 2009; 90(1): 170-6.
    • (2009) Am J Clin Nutr , vol.90 , Issue.1 , pp. 170-176
    • Devore, E.E.1    Grodstein, F.2    Van Rooij, F.3
  • 85
    • 80054717387 scopus 로고    scopus 로고
    • The Rotterdam Study 2012 objectives and design update
    • Hofman A, van Duijn CM, Franco OH, et al. The Rotterdam Study 2012 objectives and design update. Eur J Epidemiol 2011; 26(8): 657-86.
    • (2011) Eur J Epidemiol , vol.26 , Issue.8 , pp. 657-686
    • Hofman, A.1    Van Duijn, C.M.2    Franco, O.H.3
  • 86
    • 35348953761 scopus 로고    scopus 로고
    • Low plasma N-3 fatty acids and dementia in older persons: The InCHIANTI study
    • Cherubini A, Andres-Lacueva C, Martin A, et al. Low plasma N-3 fatty acids and dementia in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 2007; 62(10): 1120-6.
    • (2007) J Gerontol a Biol Sci Med Sci , vol.62 , Issue.10 , pp. 1120-1126
    • Cherubini, A.1    Res-Lacueva, C.2    Martin, A.3
  • 88
    • 0034500422 scopus 로고    scopus 로고
    • Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment
    • Conquer JA, Tierney MC, Zecevic J, Bettger WJ, Fisher RH. Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment.Lipids. 2000; 35(12): 1305-12.
    • (2000) Lipids , vol.35 , Issue.12 , pp. 1305-1312
    • Conquer, J.A.1    Tierney, M.C.2    Zecevic, J.3    Bettger, W.J.4    Fisher, R.H.5
  • 89
    • 40549113353 scopus 로고    scopus 로고
    • Nutritional biomarkers in Alzheimer's disease: The association between carotenoids, n-3 fatty acids, and dementia severity
    • Wang W, Shinto L, Connor WE, Quinn JF. Nutritional biomarkers in Alzheimer's disease: the association between carotenoids, n-3 fatty acids, and dementia severity. J Alzheimers Dis 2008; 13(1): 31-8.
    • (2008) J Alzheimers Dis , vol.13 , Issue.1 , pp. 31-38
    • Wang, W.1    Shinto, L.2    Connor, W.E.3    Quinn, J.F.4
  • 90
    • 0037650162 scopus 로고    scopus 로고
    • Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: A casecontrol study
    • Tully AM, Roche HM, Doyle R, et al. Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a casecontrol study. Br J Nut 2003; 89(4): 483-9.
    • (2003) Br J Nut , vol.89 , Issue.4 , pp. 483-489
    • Tully, A.M.1    Roche, H.M.2    Doyle, R.3
  • 91
    • 33750982113 scopus 로고    scopus 로고
    • Plasma phosphatidyl choline docosahexaenoic acid content and risk of dementia and Alzheimer disease: The Framingham Heart Study
    • Schaefer EJ, Bongard V, Beiser AS, et al. Plasma phosphatidyl choline docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Arch Neurol 2006; 63(11): 1545-50.
    • (2006) Arch Neurol , vol.63 , Issue.11 , pp. 1545-1550
    • Schaefer, E.J.1    Bongard, V.2    Beiser, A.S.3
  • 92
    • 38949110024 scopus 로고    scopus 로고
    • Starr JM, et al. N-3 Fatty acid erythrocyte membrane content, APOE varepsilon4, and cognitive variation: An observational follow-up study in late adulthood
    • Whalley LJ, Deary IJ, Starr JM, et al. n-3 Fatty acid erythrocyte membrane content, APOE varepsilon4, and cognitive variation: an observational follow-up study in late adulthood. Am J Clin Nutr 2008; 87(2): 449-54.
    • (2008) Am J Clin Nutr , vol.87 , Issue.2 , pp. 449-454
    • Whalley, L.J.1    Deary, I.J.2
  • 93
    • 67649884689 scopus 로고    scopus 로고
    • Omega-3 fatty acids and risk of dementia the Canadian Study of Health and Aging
    • Kroger E, Verreault R, Carmichael PH, et al. Omega-3 fatty acids and risk of dementia the Canadian Study of Health and Aging. Am J Clin Nutr 2009; 90(1): 184-92.
    • (2009) Am J Clin Nutr , vol.90 , Issue.1 , pp. 184-192
    • Kroger, E.1    Verreault, R.2    Carmichael, P.H.3
  • 94
    • 51749102898 scopus 로고    scopus 로고
    • Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk
    • Samieri C, Feart C, Letenneur L, et al. Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk. Am J Clin Nutr 2008; 88(3): 714-21.
    • (2008) Am J Clin Nutr , vol.88 , Issue.3 , pp. 714-721
    • Samieri, C.1    Feart, C.2    Letenneur, L.3
  • 95
    • 84864842688 scopus 로고    scopus 로고
    • Serum fatty acid composition and the risk of Alzheimer's disease: A longitudinal population based study
    • Ronnemaa E, Zethelius B, Vessby B, Lannfelt L, Byberg L, Kilander L. Serum fatty acid composition and the risk of Alzheimer's disease: a longitudinal population based study. Eur J Clin Nutr 2012; 66(8): 885-90.
    • (2012) Eur J Clin Nutr , vol.66 , Issue.8 , pp. 885-890
    • Ronnemaa, E.1    Zethelius, B.2    Vessby, B.3    Lannfelt, L.4    Byberg, L.5    Kilander, L.6
  • 96
    • 0033067503 scopus 로고    scopus 로고
    • Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia
    • Kyle DJ, Schaefer E, Patton G, Beiser A. Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia. Lipids 1999; 34: S245.
    • (1999) Lipids , vol.34
    • Kyle, D.J.1    Schaefer, E.2    Patton, G.3    Beiser, A.4
  • 97
    • 77953066352 scopus 로고    scopus 로고
    • Effect of 2-y n-3 longchain polyunsaturated fatty acid supplementation on cognitive function in older people: A randomized, double-blind, controlled trial
    • Dangour AD, Allen E, Elbourne D, et al. Effect of 2-y n-3 longchain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial. Am J Clin Nutr 2010;91(6):1725-32.
    • (2010) Am J Clin Nutr , vol.91 , Issue.6 , pp. 1725-1732
    • Dangour, A.D.1    Allen, E.2    Elbourne, D.3
  • 98
    • 84897024194 scopus 로고    scopus 로고
    • Transfer of omega-3 fatty acids across the blood–brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer's disease: The OmegAD study
    • Freund Levi Y, Vedin I, Cederholm T, et al. Transfer of omega-3 fatty acids across the blood–brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer's disease: the OmegAD study. J Int Med 2014; 275(4): 428-36.
    • (2014) J Int Med , vol.275 , Issue.4 , pp. 428-436
    • Freund Levi, Y.1    Vedin, I.2    Cederholm, T.3
  • 99
    • 50449090701 scopus 로고    scopus 로고
    • Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women
    • Johnson EJ, McDonald K, Caldarella SM, Chung HY, Troen AM, Snodderly DM. Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women. Nutr Neurosci 2008; 11(2): 75-83.
    • (2008) Nutr Neurosci , vol.11 , Issue.2 , pp. 75-83
    • Johnson, E.J.1    McDonald, K.2    Caldarella, S.M.3    Chung, H.Y.4    Troen, A.M.5    Snodderly, D.M.6
  • 100
    • 49049099040 scopus 로고    scopus 로고
    • Effect of fish oil on cognitive performance in older subjects: A randomized, controlled trial
    • van de Rest O, Geleijnse JM, Kok FJ, et al. Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial. Neurology 2008; 71(6): 430-8.
    • (2008) Neurology , vol.71 , Issue.6 , pp. 430-438
    • Van De Rest, O.1    Geleijnse, J.M.2    Kok, F.J.3
  • 101
    • 78049528932 scopus 로고    scopus 로고
    • Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline
    • Yurko Mauro K, McCarthy D, Rom D, et al. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimer's Dement 2010; 6(6): 456-64.
    • (2010) Alzheimer's Dement , vol.6 , Issue.6 , pp. 456-464
    • Yurko Mauro, K.1    McCarthy, D.2    Rom, D.3
  • 102
    • 79959449537 scopus 로고    scopus 로고
    • Cognitive function after supplementation with B vitamins and long-chain omega-3 fatty acids ancillary findings from the SU.FOL.OM3 randomized trial
    • Andreeva VA, Kesse-Guyot E, Barberger-Gateau P, Fezeu L, Hercberg S, Galan P. Cognitive function after supplementation with B vitamins and long-chain omega-3 fatty acids ancillary findings from the SU.FOL.OM3 randomized trial. Am J Clin Nutr 2011; 94(1): 278-86.
    • (2011) Am J Clin Nutr , vol.94 , Issue.1 , pp. 278-286
    • Andreeva, V.A.1    Kesse-Guyot, E.2    Barberger-Gateau, P.3    Fezeu, L.4    Hercberg, S.5    Galan, P.6
  • 103
    • 84863222938 scopus 로고    scopus 로고
    • Effects of n-3 fatty acids on cognitive decline: A randomized, double-blind, placebo-controlled trial in stable myocardial infarction patients
    • Geleijnse JM, Giltay EJ, Kromhout D. Effects of n-3 fatty acids on cognitive decline: a randomized, double-blind, placebo-controlled trial in stable myocardial infarction patients. Alzheimer's Dement 2012; 8(4): 278-87.
    • (2012) Alzheimer's Dement , vol.8 , Issue.4 , pp. 278-287
    • Geleijnse, J.M.1    Giltay, E.J.2    Kromhout, D.3
  • 104
    • 65549164405 scopus 로고    scopus 로고
    • Effects of omega-3 fatty Acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer’s disease the OmegADstudy
    • Freund Levi Y, Hjorth E, Lindberg C, et al. Effects of omega-3 fatty Acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer’s disease the OmegADstudy. Dement Geriatr CognDisord 2009; 27(5): 481-90.
    • (2009) Dement Geriatr Cogndisord , vol.27 , Issue.5 , pp. 481-490
    • Freund Levi, Y.1    Hjorth, E.2    Lindberg, C.3
  • 105
    • 33749633921 scopus 로고    scopus 로고
    • Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: A randomized double-blind trial
    • Freund Levi Y, Eriksdotter Jonhagen M, Cederholm T, et al. Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. Arch Neurol 2006; 63(10): 1402-8.
    • (2006) Arch Neurol , vol.63 , Issue.10 , pp. 1402-1408
    • Freund Levi, Y.1    Eriksdotter Jonhagen, M.2    Cederholm, T.3
  • 106
    • 78049407029 scopus 로고    scopus 로고
    • Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease a randomized trial
    • Quinn JF, Raman R, Thomas RG, et al. Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease a randomized trial. JAMA 2010; 304(17): 1903-11.
    • (2010) JAMA , vol.304 , Issue.17 , pp. 1903-1911
    • Quinn, J.F.1    Raman, R.2    Thomas, R.G.3
  • 108
    • 0034063784 scopus 로고    scopus 로고
    • High dietary 18:3n-3 increases the 18:3n-3 but not the 22:6n-3 content in the whole body, brain, skin, epididymal fat pads, and muscles of suckling rat pups
    • Bowen RA, Clandinin MT. High dietary 18:3n-3 increases the 18:3n-3 but not the 22:6n-3 content in the whole body, brain, skin, epididymal fat pads, and muscles of suckling rat pups. Lipids 2000; 35(4): 389-94.
    • (2000) Lipids , vol.35 , Issue.4 , pp. 389-394
    • Bowen, R.A.1    Clandinin, M.T.2
  • 109
    • 0027143636 scopus 로고
    • Elongation, desaturation, and esterification of essential fatty acids by fetal rat brain in vivo
    • Green P, Yavin E. Elongation, desaturation, and esterification of essential fatty acids by fetal rat brain in vivo. J Lipid Res 1993; 34(12): 2099-107.
    • (1993) J Lipid Res , vol.34 , Issue.12 , pp. 2099-2107
    • Green, P.1    Yavin, E.2
  • 110
    • 0035063527 scopus 로고    scopus 로고
    • Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study
    • Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. J Lipid Res 2001; 42(4): 581-6.
    • (2001) J Lipid Res , vol.42 , Issue.4 , pp. 581-586
    • Su, H.M.1    Huang, M.C.2    Saad, N.M.3    Nathanielsz, P.W.4    Brenna, J.T.5
  • 111
    • 0028232052 scopus 로고
    • Complete discrimination of docosahexaenoate from arachidonate by 85 kDa cytosolic phospholipase A2 during the hydrolysis of diacyl-and alkenyl acylglycerophosphoethanolamine
    • Shikano M, Masuzawa Y, Yazawa K, Takayama K, Kudo I, Inoue K. Complete discrimination of docosahexaenoate from arachidonate by 85 kDa cytosolic phospholipase A2 during the hydrolysis of diacyl-and alkenyl acylglycerophosphoethanolamine. Biochem Biophys Acta 1994; 1212(2): 211-6.
    • (1994) Biochem Biophys Acta , vol.1212 , Issue.2 , pp. 211-216
    • Shikano, M.1    Masuzawa, Y.2    Yazawa, K.3    Takayama, K.4    Kudo, I.5    Inoue, K.6
  • 112
    • 84899462816 scopus 로고    scopus 로고
    • Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2
    • Vandal M, Alata W, Tremblay C, et al. Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2. J Neurochem 2014; 129(3): 516-26.
    • (2014) J Neurochem , vol.129 , Issue.3 , pp. 516-526
    • Vandal, M.1    Alata, W.2    Tremblay, C.3
  • 113
    • 33749157416 scopus 로고    scopus 로고
    • RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease
    • Donahue JE, Flaherty SL, Johanson CE, et al. RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease. ActaNeuropathol 2006; 112(4): 405-15.
    • (2006) Actaneuropathol , vol.112 , Issue.4 , pp. 405-415
    • Donahue, J.E.1    Flaherty, S.L.2    Johanson, C.E.3
  • 114
    • 0036797713 scopus 로고    scopus 로고
    • Deposition of Alzheimer's beta-amyloid is inversely correlated with Pglycoprotein expression in the brains of elderly non-demented humans
    • Vogelgesang S, Cascorbi I, Schroeder E, et al. Deposition of Alzheimer's beta-amyloid is inversely correlated with Pglycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics 2002; 12(7): 535-41.
    • (2002) Pharmacogenetics , vol.12 , Issue.7 , pp. 535-541
    • Vogelgesang, S.1    Cascorbi, I.2    Schroeder, E.3
  • 115
    • 0027073117 scopus 로고
    • Changes in the glucose transporter of brain capillaries
    • Harik SI. Changes in the glucose transporter of brain capillaries. Can J Physiol Pharmacol 1992; 70: S113-7.
    • (1992) Can J Physiol Pharmacol , vol.70
    • Harik, S.I.1
  • 116
    • 0024780235 scopus 로고
    • Abnormalities of the glucose transporter at the blood-brain barrier and in brain in Alzheimer's disease
    • Kalaria RN, Harik SI. Abnormalities of the glucose transporter at the blood-brain barrier and in brain in Alzheimer's disease. Prog Clin Biol Res 1989; 317: 415-21.
    • (1989) Prog Clin Biol Res , vol.317 , pp. 415-421
    • Kalaria, R.N.1    Harik, S.I.2
  • 117
    • 0032850581 scopus 로고    scopus 로고
    • Clinical and pathological evidence for a frontal variant of Alzheimer disease
    • Johnson JK, Head E, Kim R, Starr A, Cotman CW. Clinical and pathological evidence for a frontal variant of Alzheimer disease. Arch Neurol 1999; 56(10): 1233-9.
    • (1999) Arch Neurol , vol.56 , Issue.10 , pp. 1233-1239
    • Johnson, J.K.1    Head, E.2    Kim, R.3    Starr, A.4    Cotman, C.W.5
  • 118
    • 0031937355 scopus 로고    scopus 로고
    • Phospholipid metabolizing enzymes in Alzheimer's disease increased lysophospholipidacyl transferase activity and decreased phospholipase A2 activity
    • Ross BM, Moszczynska A, Erlich J, Kish SJ. Phospholipid metabolizing enzymes in Alzheimer's disease increased lysophospholipidacyl transferase activity and decreased phospholipase A2 activity. J Neurochem 1998; 70(2): 786-93.
    • (1998) J Neurochem , vol.70 , Issue.2 , pp. 786-793
    • Ross, B.M.1    Moszczynska, A.2    Erlich, J.3    Kish, S.J.4
  • 119
    • 0032588611 scopus 로고    scopus 로고
    • Increased CSF F2-isoprostane concentration in probable AD
    • Montine TJ, Beal MF, Cudkowicz ME, et al. Increased CSF F2-isoprostane concentration in probable AD. Neurology 1999; 52(3): 562-5.
    • (1999) Neurology , vol.52 , Issue.3 , pp. 562-565
    • Montine, T.J.1    Beal, M.F.2    Cudkowicz, M.E.3
  • 120
    • 0032586942 scopus 로고    scopus 로고
    • F4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease
    • Nourooz Zadeh J, Liu EH, Yhlen B, Anggard EE, Halliwell B. F4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease. J Neurochem 1999; 72(2): 734-40.
    • (1999) J Neurochem , vol.72 , Issue.2 , pp. 734-740
    • Nourooz Zadeh, J.1    Liu, E.H.2    Yhlen, B.3    Anggard, E.E.4    Halliwell, B.5
  • 121
    • 56449108741 scopus 로고    scopus 로고
    • Regulation of brain polyunsaturated fatty acid uptake and turnover
    • Chen CT, Green JT, Orr SK, Bazinet RP. Regulation of brain polyunsaturated fatty acid uptake and turnover. Prostag Leukotr Ess 2008; 79(3-5): 85-91.
    • (2008) Prostag Leukotr Ess , vol.79 , Issue.3-5 , pp. 85-91
    • Chen, C.T.1    Green, J.T.2    Orr, S.K.3    Bazinet, R.P.4
  • 123
    • 0032778625 scopus 로고    scopus 로고
    • Transport of fatty acids across membranes by the diffusion mechanism
    • Hamilton JA. Transport of fatty acids across membranes by the diffusion mechanism. Prostag Leukotr Ess 1999; 60(5-6): 291-7.
    • (1999) Prostag Leukotr Ess , vol.60 , Issue.5-6 , pp. 291-297
    • Hamilton, J.A.1
  • 124
    • 0034922738 scopus 로고    scopus 로고
    • Fatty acid transport: The diffusion mechanism in model and biological membranes
    • Hamilton JA, Johnson RA, Corkey B, Kamp F. Fatty acid transport: the diffusion mechanism in model and biological membranes. J Mol Neurosci 2001; 16(2-3): 99-108.
    • (2001) J Mol Neurosci , vol.16 , Issue.2-3 , pp. 99-108
    • Hamilton, J.A.1    Johnson, R.A.2    Corkey, B.3    Kamp, F.4
  • 125
    • 80053611084 scopus 로고    scopus 로고
    • Fatty acid transport into the brain: Of fatty acid fables and lipid tails
    • Mitchell RW, Hatch GM. Fatty acid transport into the brain: of fatty acid fables and lipid tails. Prostag Leukotr Ess 2011; 85(5): 293-302.
    • (2011) Prostag Leukotr Ess , vol.85 , Issue.5 , pp. 293-302
    • Mitchell, R.W.1    Hatch, G.M.2
  • 126
    • 22944483792 scopus 로고    scopus 로고
    • The blood brain barrier neurovascular unit in health and disease
    • Hawkins BT, Davis TP. The blood brain barrier neurovascular unit in health and disease. Pharmacol Rev 2005; 57(2): 173-85.
    • (2005) Pharmacol Rev , vol.57 , Issue.2 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 127
    • 21244454889 scopus 로고    scopus 로고
    • An examination of the blood-brain barrier in health and disease
    • Khan E. An examination of the blood-brain barrier in health and disease. Br J Nursing 2005; 14(9): 509-13.
    • (2005) Br J Nursing , vol.14 , Issue.9 , pp. 509-513
    • Khan, E.1
  • 128
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte endothelial interactions at the blood brain barrier
    • Abbott NJ, Ronnback L, Hansson E. Astrocyte endothelial interactions at the blood brain barrier. Nat Rev Neurosci 2006; 7(1): 41-53.
    • (2006) Nat Rev Neurosci , vol.7 , Issue.1 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 130
    • 0024537497 scopus 로고
    • Brain cell and tissue recovery in rats made deficient in n-3 fatty acids by alteration of dietary fat
    • Bourre JM, Durand G, Pascal G, Youyou A. Brain cell and tissue recovery in rats made deficient in n-3 fatty acids by alteration of dietary fat. J Nutr 1989; 119(1): 15-22.
    • (1989) J Nutr , vol.119 , Issue.1 , pp. 15-22
    • Bourre, J.M.1    Durand, G.2    Pascal, G.3    Youyou, A.4
  • 132
    • 0036319335 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions and blood-brain barrier permeability
    • Abbott NJ. Astrocyte-endothelial interactions and blood-brain barrier permeability. J Anat 2002; 200(6): 629-38.
    • (2002) J Anat , vol.200 , Issue.6 , pp. 629-638
    • Abbott, N.J.1
  • 133
    • 2342471420 scopus 로고    scopus 로고
    • The blood-brain barrier an overview structure, regulation, and clinical implications
    • Ballabh P, Braun A, Nedergaard M. The blood-brain barrier an overview structure, regulation, and clinical implications. Neurobiol Dis 2004; 16(1): 1-13.
    • (2004) Neurobiol Dis , vol.16 , Issue.1 , pp. 1-13
    • Ballabh, P.1    Braun, A.2    Nedergaard, M.3
  • 134
    • 0025265046 scopus 로고
    • An easier, reproducible, and mass production method to study the blood-brain barrier in vitro
    • Dehouck M.P, Meresse S, Delorme P, Fruchart JC, Cecchelli R. An easier, reproducible, and mass production method to study the blood-brain barrier in vitro. J Neurochem 1990; 54(5): 1798-801.
    • (1990) J Neurochem , vol.54 , Issue.5 , pp. 1798-1801
    • Dehouck, M.P.1    Meresse, S.2    Delorme, P.3    Fruchart, J.C.4    Cecchelli, R.5
  • 135
  • 136
    • 17644363679 scopus 로고    scopus 로고
    • In search of the astrocytic factors modulating blood brain barrier functions in brain capillary endothelial cells in vitro
    • Haseloff RF, Blasig IE, Bauer HC, Bauer H. In search of the astrocytic factors modulating blood brain barrier functions in brain capillary endothelial cells in vitro. Cell Mol Neurobiol 2005; 25(1): 25-39.
    • (2005) Cell Mol Neurobiol , vol.25 , Issue.1 , pp. 25-39
    • Haseloff, R.F.1    Blasig, I.E.2    Bauer, H.C.3    Bauer, H.4
  • 137
    • 0031036530 scopus 로고    scopus 로고
    • Induction of various blood brain barrier properties in non neural endothelial cells by close apposition to cocultured astrocytes
    • Hayashi Y, Nomura M, Yamagishi S, Harada S, Yamashita J, Yamamoto H. Induction of various blood brain barrier properties in non neural endothelial cells by close apposition to cocultured astrocytes. Glia 1997; 19(1): 13-26.
    • (1997) Glia , vol.19 , Issue.1 , pp. 13-26
    • Hayashi, Y.1    Nomura, M.2    Yamagishi, S.3    Harada, S.4    Yamashita, J.5    Yamamoto, H.6
  • 138
    • 0035282791 scopus 로고    scopus 로고
    • Induction of astrocyte differentiation by endothelial cells
    • Mi H, Haeberle H, Barres BA. Induction of astrocyte differentiation by endothelial cells. J Neurosci 2001; 21(5): 1538-47.
    • (2001) J Neurosci , vol.21 , Issue.5 , pp. 1538-1547
    • Mi, H.1    Haeberle, H.2    Barres, B.A.3
  • 139
    • 0026322983 scopus 로고
    • A cell culture model of the blood-brain barrier
    • Rubin LL, Hall DE, Porter S, et al. A cell culture model of the blood-brain barrier. J Cell Biol 1991; 115(6): 1725-35.
    • (1991) J Cell Biol , vol.115 , Issue.6 , pp. 1725-1735
    • Rubin, L.L.1    Hall, D.E.2    Porter, S.3
  • 141
    • 0033973460 scopus 로고    scopus 로고
    • Tight junctions of the blood-brain barrier
    • Kniesel U, Wolburg H. Tight junctions of the blood-brain barrier. Cell Mol Neurobiol 2000; 20(1): 57-76.
    • (2000) Cell Mol Neurobiol , vol.20 , Issue.1 , pp. 57-76
    • Kniesel, U.1    Wolburg, H.2
  • 143
    • 0020081135 scopus 로고
    • Electrical resistance of brain microvascular endothelium
    • Crone C, Olesen SP. Electrical resistance of brain microvascular endothelium. Brain Res 1982; 241(1): 49-55.
    • (1982) Brain Res , vol.241 , Issue.1 , pp. 49-55
    • Crone, C.1    Olesen, S.P.2
  • 144
    • 0141620181 scopus 로고    scopus 로고
    • Structural and functional aspects of the blood-brain barrier
    • Begley DJ, Brightman MW. Structural and functional aspects of the blood-brain barrier. Prog Drug Res 2003; 61: 39-78.
    • (2003) Prog Drug Res , vol.61 , pp. 39-78
    • Begley, D.J.1    Brightman, M.W.2
  • 145
    • 0036627481 scopus 로고    scopus 로고
    • Drug delivery to brain via the blood–brain barrier
    • Scherrmann JM. Drug delivery to brain via the blood–brain barrier. Vascular Pharmacol 2002; 38(6): 349-54.
    • (2002) Vascular Pharmacol , vol.38 , Issue.6 , pp. 349-354
    • Scherrmann, J.M.1
  • 146
    • 33644758151 scopus 로고    scopus 로고
    • Methods to assess drug permeability across the blood brain barrier
    • Nicolazzo JA, Charman SA, Charman WN. Methods to assess drug permeability across the blood brain barrier. J Pharm Pharmacol 2006; 58(3): 281-93.
    • (2006) J Pharm Pharmacol , vol.58 , Issue.3 , pp. 281-293
    • Nicolazzo, J.A.1    Charman, S.A.2    Charman, W.N.3
  • 147
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    • Zlokovic BV. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci 2011; 12(12): 723-38.
    • (2011) Nat Rev Neurosci , vol.12 , Issue.12 , pp. 723-738
    • Zlokovic, B.V.1
  • 148
    • 0034988945 scopus 로고    scopus 로고
    • Delivery and turnover of plasma derived essential PUFAs in mammalian brain
    • Rapoport SI, Chang MC, Spector AA. Delivery and turnover of plasma derived essential PUFAs in mammalian brain. J Lipid Res 2001; 42(5): 678-85.
    • (2001) J Lipid Res , vol.42 , Issue.5 , pp. 678-685
    • Rapoport, S.I.1    Chang, M.C.2    Spector, A.A.3
  • 149
    • 36749082536 scopus 로고    scopus 로고
    • Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver
    • Rapoport SI, Rao JS, Igarashi M. Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. Prostag Leukotr Ess. 2007; 77(5-6): 251-61.
    • (2007) Prostag Leukotr Ess , vol.77 , Issue.5-6 , pp. 251-261
    • Rapoport, S.I.1    Rao, J.S.2    Igarashi, M.3
  • 150
    • 0034912811 scopus 로고    scopus 로고
    • Essential polyunsaturated fatty acids and the barrier to the brain: The components of a model for transport
    • Edmond J. Essential polyunsaturated fatty acids and the barrier to the brain: the components of a model for transport. J Mol Neurosci 2001; 16(2-3): 181-93.
    • (2001) J Mol Neurosci , vol.16 , Issue.2-3 , pp. 181-193
    • Edmond, J.1
  • 151
    • 33747887952 scopus 로고    scopus 로고
    • Effect of docosahexaenoic acid on tissue targeting and metabolism of plasma lipoproteins
    • Polozova A, Gionfriddo E, Salem N. Effect of docosahexaenoic acid on tissue targeting and metabolism of plasma lipoproteins. Prostag Leukotr Ess 2006; 75(3): 183-90.
    • (2006) Prostag Leukotr Ess , vol.75 , Issue.3 , pp. 183-190
    • Polozova, A.1    Gionfriddo, E.2    Salem, N.3
  • 152
    • 77951630116 scopus 로고    scopus 로고
    • The very low density lipoprotein receptor is not necessary for maintaining brain polyunsaturated fatty acid concentrations
    • Rahman T, Taha AY, Song BJ, et al. The very low density lipoprotein receptor is not necessary for maintaining brain polyunsaturated fatty acid concentrations. Prostag Leukotr Ess 2010; 82(2-3): 141-5.
    • (2010) Prostag Leukotr Ess , vol.82 , Issue.2-3 , pp. 141-145
    • Rahman, T.1    Taha, A.Y.2    Song, B.J.3
  • 153
    • 0028821009 scopus 로고
    • Unbound free fatty acid levels in human serum
    • Richieri GV, Kleinfeld AM. Unbound free fatty acid levels in human serum. J Lipid Res 1995; 36(2): 229-40.
    • (1995) J Lipid Res , vol.36 , Issue.2 , pp. 229-240
    • Richieri, G.V.1    Kleinfeld, A.M.2
  • 154
    • 0037047373 scopus 로고    scopus 로고
    • Effects of lipoprotein lipase on uptake and transcytosis of low density lipoprotein and LDL associated alpha tocopherol in a porcine in vitro blood brain barrier model
    • Goti D, Balazs Z, Panzenboeck U, et al. Effects of lipoprotein lipase on uptake and transcytosis of low density lipoprotein and LDL associated alpha tocopherol in a porcine in vitro blood brain barrier model. J Biol Chem 2002; 277(32): 28537-44.
    • (2002) J Biol Chem , vol.277 , Issue.32 , pp. 28537-28544
    • Goti, D.1    Balazs, Z.2    Panzenboeck, U.3
  • 155
    • 0019124032 scopus 로고
    • Relationship of octanol water partition coefficient and molecular weight to rat brain capillary permeability
    • Levin VA. Relationship of octanol water partition coefficient and molecular weight to rat brain capillary permeability. J Med Chem 1980; 23(6): 682-4.
    • (1980) J Med Chem , vol.23 , Issue.6 , pp. 682-684
    • Levin, V.A.1
  • 156
    • 0037424401 scopus 로고    scopus 로고
    • Rapid flip flop of oleic acid across the plasma membrane of adipocytes
    • Kamp F, Guo W, Souto R, Pilch PF, Corkey BE, Hamilton JA. Rapid flip flop of oleic acid across the plasma membrane of adipocytes. J Biol Chem 2003; 278(10): 7988-95.
    • (2003) J Biol Chem , vol.278 , Issue.10 , pp. 7988-7995
    • Kamp, F.1    Guo, W.2    Souto, R.3    Pilch, P.F.4    Corkey, B.E.5    Hamilton, J.A.6
  • 157
    • 69349087207 scopus 로고    scopus 로고
    • Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood brain barrier An in situ cerebral perfusion study
    • Ouellet M, Emond V, Chen CT, Julien C, Bourasset F, Oddo S, et al. Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood brain barrier An in situ cerebral perfusion study. Neurochem Int 2009; 55(7): 476-82.
    • (2009) Neurochem Int , vol.55 , Issue.7 , pp. 476-482
    • Ouellet, M.1    Emond, V.2    Chen, C.T.3    Julien, C.4    Bourasset, F.5    Oddo, S.6
  • 158
    • 84886098063 scopus 로고    scopus 로고
    • Altered brain uptake of therapeutics in a triple transgenic mouse model of Alzheimer’s disease
    • Mehta DC, Short JL, Nicolazzo JA. Altered brain uptake of therapeutics in a triple transgenic mouse model of Alzheimer’s disease. Pharm Res 2013; 30(11): 2868-79.
    • (2013) Pharm Res , vol.30 , Issue.11 , pp. 2868-2879
    • Mehta, D.C.1    Short, J.L.2    Nicolazzo, J.A.3
  • 159
    • 79954988524 scopus 로고    scopus 로고
    • Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells
    • Mitchell RW, On NH, Del Bigio MR, Miller DW, Hatch GM. Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells. J Neurochem 2011; 117(4): 735-46.
    • (2011) J Neurochem , vol.117 , Issue.4 , pp. 735-746
    • Mitchell, R.W.1    On, N.H.2    Del Bigio, M.R.3    Miller, D.W.4    Hatch, G.M.5
  • 160
    • 0027411821 scopus 로고
    • Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins isolation and amino terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids
    • Harmon CM, Abumrad NA. Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins isolation and amino terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids. J Membrane Biol 1993; 133(1): 43-9.
    • (1993) J Membrane Biol , vol.133 , Issue.1 , pp. 43-49
    • Harmon, C.M.1    Abumrad, N.A.2
  • 161
    • 0034693232 scopus 로고    scopus 로고
    • Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice
    • Coburn CT, Knapp FF, Febbraio M, Beets AL, Silverstein RL, Abumrad NA. Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice. J Biol Chem 2000; 275(42): 32523-9.
    • (2000) J Biol Chem , vol.275 , Issue.42 , pp. 32523-32529
    • Coburn, C.T.1    Knapp, F.F.2    Febbraio, M.3    Beets, A.L.4    Silverstein, R.L.5    Abumrad, N.A.6
  • 162
    • 0033516477 scopus 로고    scopus 로고
    • A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism
    • Febbraio M, Abumrad NA, Hajjar DP, et al. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem 1999; 274(27): 19055-62.
    • (1999) J Biol Chem , vol.274 , Issue.27 , pp. 19055-19062
    • Febbraio, M.1    Abumrad, N.A.2    Hajjar, D.P.3
  • 163
    • 0033578604 scopus 로고    scopus 로고
    • Muscle specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle reduces plasma triglycerides and fatty acids and increases plasma glucose and insulin
    • Ibrahimi A, Bonen A, Blinn WD, et al. Muscle specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle reduces plasma triglycerides and fatty acids and increases plasma glucose and insulin. J Biol Chem 1999; 274(38): 26761-6.
    • (1999) J Biol Chem , vol.274 , Issue.38 , pp. 26761-26766
    • Ibrahimi, A.1    Bonen, A.2    Blinn, W.D.3
  • 164
    • 0033929797 scopus 로고    scopus 로고
    • Lipid transporters membrane transport systems for cholesterol and fatty acids
    • Abumrad NA, Sfeir Z, Connelly MA, Coburn C. Lipid transporters membrane transport systems for cholesterol and fatty acids. Curr Opin Clin Nutr Metab Care. 2000; 3(4): 255-62.
    • (2000) Curr Opin Clin Nutr Metab Care , vol.3 , Issue.4 , pp. 255-262
    • Abumrad, N.A.1    Sfeir, Z.2    Connelly, M.A.3    Coburn, C.4
  • 165
    • 0028152492 scopus 로고
    • Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein
    • Schaffer JE, Lodish HF. Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell 1994; 79(3): 427-36.
    • (1994) Cell , vol.79 , Issue.3 , pp. 427-436
    • Schaffer, J.E.1    Lodish, H.F.2
  • 166
    • 0033579432 scopus 로고    scopus 로고
    • The fatty acid transport protein (FATP1) is a very long chain acyl-CoA synthetase
    • Coe NR, Smith AJ, Frohnert BI, Watkins PA, Bernlohr DA. The fatty acid transport protein (FATP1) is a very long chain acyl-CoA synthetase. J Biol Chem. 1999; 274(51): 36300-4.
    • (1999) J Biol Chem , vol.274 , Issue.51 , pp. 36300-36304
    • Coe, N.R.1    Smith, A.J.2    Frohnert, B.I.3    Watkins, P.A.4    Bernlohr, D.A.5
  • 167
    • 0242384922 scopus 로고    scopus 로고
    • Characterization of the Acyl-CoA synthetase activity of purified murine fatty acid transport protein 1
    • Hall AM, Smith AJ, Bernlohr DA. Characterization of the Acyl-CoA synthetase activity of purified murine fatty acid transport protein 1. J Biol Chem 2003; 278(44): 43008-13.
    • (2003) J Biol Chem , vol.278 , Issue.44 , pp. 43008-43013
    • Hall, A.M.1    Smith, A.J.2    Bernlohr, D.A.3
  • 168
    • 38349101032 scopus 로고    scopus 로고
    • Very long chain acyl-CoA synthetases
    • Watkins PA. Very long chain acyl-CoA synthetases. J Biol Chem 2008; 283(4): 1773-7.
    • (2008) J Biol Chem , vol.283 , Issue.4 , pp. 1773-1777
    • Watkins, P.A.1
  • 169
    • 37249092959 scopus 로고    scopus 로고
    • Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome
    • Watkins PA, Maiguel D, Jia Z, Pevsner J. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. J Lipid Res 2007; 48(12): 2736-50.
    • (2007) J Lipid Res , vol.48 , Issue.12 , pp. 2736-2750
    • Watkins, P.A.1    Maiguel, D.2    Jia, Z.3    Pevsner, J.4
  • 170
    • 34547117903 scopus 로고    scopus 로고
    • Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts
    • Jia Z, Moulson CL, Pei Z, Miner JH, Watkins PA. Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts. J Biol Chem 2007; 282(28): 20573-83.
    • (2007) J Biol Chem , vol.282 , Issue.28 , pp. 20573-20583
    • Jia, Z.1    Moulson, C.L.2    Pei, Z.3    Miner, J.H.4    Watkins, P.A.5
  • 171
    • 67650434926 scopus 로고    scopus 로고
    • On the mechanism of oleate transport across human brain microvessel endothelial cells
    • Mitchell RW, Edmundson CL, Miller DW, Hatch GM. On the mechanism of oleate transport across human brain microvessel endothelial cells. J Neurochem 2009; 110(3): 1049-57.
    • (2009) J Neurochem , vol.110 , Issue.3 , pp. 1049-1057
    • Mitchell, R.W.1    Edmundson, C.L.2    Miller, D.W.3    Hatch, G.M.4
  • 172
    • 0033762304 scopus 로고    scopus 로고
    • Regulation of fatty acid transport protein and mitochondrial and peroxisomal beta-oxidation gene expression by fatty acids in developing rats
    • Ouali F, Djouadi F, Merlet-Benichou C, Riveau B, Bastin J. Regulation of fatty acid transport protein and mitochondrial and peroxisomal beta-oxidation gene expression by fatty acids in developing rats. Pediatr Res 2000; 48(5): 691-6.
    • (2000) Pediatr Res , vol.48 , Issue.5 , pp. 691-696
    • Ouali, F.1    Djouadi, F.2    Merlet-Benichou, C.3    Riveau, B.4    Bastin, J.5
  • 173
    • 0036228690 scopus 로고    scopus 로고
    • Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes
    • Stahl A, Evans JG, Pattel S, Hirsch D, Lodish HF. Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes. Dev Cell 2002; 2(4): 477-88.
    • (2002) Dev Cell , vol.2 , Issue.4 , pp. 477-488
    • Stahl, A.1    Evans, J.G.2    Pattel, S.3    Hirsch, D.4    Lodish, H.F.5
  • 174
    • 84901260638 scopus 로고    scopus 로고
    • Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
    • Nguyen LN, Ma D, Shui G, et al. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature 2014; 509(7501): 503-6.
    • (2014) Nature , vol.509 , Issue.7501 , pp. 503-506
    • Nguyen, L.N.1    Ma, D.2    Shui, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.