F4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease

Journal of Neurochemistry

Volumn 72, Issue 2, 1999, Pages 734-740

  Nourooz Zadeh, Jaffar ^d   Liu, Edwin H C ^a   Yhlen, B ^b   Änggård, Erik E ^c   Halliwell, Barry ^a,e  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

^c ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Alzheimer's disease; Arachidonic acid; Docosahexaenoic acid; Isoprostanes; Lipid peroxidation

Indexed keywords

2,2' AZOBIS(2 AMIDINOPROPANE); ARACHIDONIC ACID; BIOCHEMICAL MARKER; DOCOSAHEXAENOIC ACID; F3 ISOPROSTANE DERIVATIVE; F4 ISOPROSTANE DERIVATIVE; FREE RADICAL; ICOSAPENTAENOIC ACID; ISOPROSTANE DERIVATIVE; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; ESTER; LIPID;

ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DEGENERATIVE DISEASE; HUMAN; HUMAN TISSUE; LIPID PEROXIDATION; PRIORITY JOURNAL; BRAIN LEVEL; CHEMISTRY; MASS FRAGMENTOGRAPHY; METABOLISM; PHYSIOLOGY;

ALZHEIMER DISEASE; ARACHIDONIC ACID; BIOLOGICAL MARKERS; BRAIN CHEMISTRY; CEREBRAL CORTEX; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; ESTERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; LIPID PEROXIDATION; LIPIDS;

EID: 0032586942     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0720734.x     Document Type: Article

References (25)

1. Beal M. F. (1996) Mitochondria, free radicals and neurodegeneration. Curr. Opin. Neurol. 6, 661-666.
2. Cosgrove J. P., Church D. F., and Pryor W. A. (1987) The kinetics of the autoxidation of polyunsaturated fatty acids. Lipids 22, 299-304.
3. 2-isoprostanes during aortic endothelial cell-mediated oxidation of low density lipoprotein. FEBS Lett. 348, 297-300.
4. 2-isoprostanes during the oxidative modification of low density lipoprotein. Biochem. Biophys. Res. Commun. 200, 338-343.
5. 2α levels are elevated in individuals with non-insulin dependent diabetes mellitus. FEBS Lett. 368, 225-229.
6. Guan Z. Z., Söderberg M., Sindelar P., and Edlund C. (1994) Content and fatty acid composition of cardiolipin in the brain of patients with Alzheimer's disease. Neurochem. Int. 25, 295-300.
7. Halliwell B. (1992) Reactive oxygen species and the central nervous system. J. Neurochem. 59, 1609-1623.
8. Halliwell B. (1996) Oxidative stress, nutrition and health: experimental strategies for optimization of nutritional antioxidant intake in humans. Free Radic. Res. 25, 57-74.
9. Lyras L., Cairns N. J., Jenner A., Jenner P., and Halliwell B. (1997) An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease. J. Neurochem. 68, 2061-2069.
10. Markesbery W. R. (1997) Oxidative stress hypothesis in Alzheimer's disease. Free Radic. Biol. Med. 23, 134-147.
11. Martinez M. (1992) Abnormal profiles of polyunsaturated fatty acids in the brain, liver, kidney and retina of patients with peroxisomal disorders. Brain Res. 583, 171-182.
12. 2-isoprostanes produced by non-cyclooxygenase free radical-catalyzed mechanism. Methods Enzymol. 233, 163-174.
13. 2-like compounds are produced in vivo in human by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc. Natl. Acad. Sci. USA 87, 9383-9387.
14. Noguchi N., Gotoh N., and Niki E. (1993) Dynamics of the oxidation of low density lipoprotein induced by free radicals. Biochim. Biophys. Acta 1168, 348-357.
15. 2-isoprostanes as indicators of non-enzymatic lipid peroxidation in vivo by gas chromatography - mass spectrometry: development of solid-phase extraction procedure. J. Chromatogr. B. Biomed. Appl. 667, 199-205.
16. 3-isoprostanes during peroxidalion of eicosapentaenoic acid. Biochem. Biophys. Res. Commun. 236, 467-472.
17. 4-isoprostanes: a novel class of prostanoids formed during peroxidation of docosahexaenoic acid. Biochem. Biophys. Res. Commun. 242, 338-344.
18. 2+- and ascorbic acid-stimulated lipid peroxidation in vitro. J. Neurochem. 34, 1630-1638.
19. Reilly M., Delanty N., Lawson J. A., and FitzGerald G. A. (1996) Modulation of oxidant stress in vivo in chronic cigarette smokers. Circulation 94, 19-25.
20. Reiter R. J. (1995) Oxidative processes and antioxidant defence mechanisms in the ageing brain. FASEB J. 9, 526-533.
21. Roberts L. J. II and Morrow J. D. (1997) The generation and actions of isoprostanes. Biochim. Biophys. Acta 1345, 121-135.
22. Roberts L. J. II, Montine T. J., Markesbery W. R., Tappert A. R., Hardy P., Chemtob S., Dettbarn W. D., and Morrow J. D. (1998) Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid. J. Biol. Chem. 273, 13605-13612.
23. Söderberg M., Edlund C., Kristensson K., and Dallner G. (1991) Fatty acid composition of brain phospholipids in ageing and in Alzheimer's disease. Lipids 26, 421-425.
24. Wilson R. and Sargent J. R. (1993) Lipid and fatty acid composition of brain tissue from adrenoleukodystrophy patients. J. Neurochem. 61, 290-297.
25. Wilson R. and Tocher D. R. (1991) Lipid and fatty acid composition is altered in plaque tissue from multiple sclerosis brain compared with normal brain white matter. Lipids 26, 9-15.