Plasma and brain fatty acid profiles in mild cognitive impairment and alzheimer's disease

Journal of Alzheimer's Disease

Volumn 29, Issue 3, 2012, Pages 691-697

  Cunnane, Stephen C ^a   Schneider, Julie A ^b,c   Tangney, Christine ^c   Tremblay Mercier, Jennifer ^a   Fortier, Mélanie ^a   Bennett, David A ^b,c   Morris, Martha Clare ^c  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; brain lipids; docosahexaenoic acid; free fatty acids; memory and aging project; mild cognitive impairment; oleic acid; omega 3 fatty acids; phospholipids; polyunsaturates

Indexed keywords

DOCOSAHEXAENOIC ACID; FATTY ACID; LIPID; OMEGA 3 FATTY ACID; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID;

AGED; AGING; ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DEMENTIA; DIETARY INTAKE; FATTY ACID ANALYSIS; FATTY ACID BLOOD LEVEL; FEMALE; FISH; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; LIPID METABOLISM; MALE; MEMORY; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; PLASMA; PRIORITY JOURNAL; TEMPORAL CORTEX;

EID: 84859374049     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-110629     Document Type: Article

References (32)

1. Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Wilson RS, Aggarwal N, Schneider J (2003) Consumption of fish and n-3 fatty acids and riskof incident Alzheimer disease. Arch Neurol 60, 940-946. (Pubitemid 36858352)
2. Maclean CH, Issa AM, Newberry SJ, Mojica WA, Morton SC, Garland RH, Hilton LG, Traina SB, Shekelle PG (2005) Effects of omega-3 fatty acids on cognitive function with aging, dementia, and neurological diseases. Evid Rep Technol Assess (Summ) 1-3.
3. Gillette Guyonnet S, Abellan Van Kan G, Andrieu S, Bar-berger Gateau P, Berr C, Bonnefoy M, Dartigues JF, de Groot L, Ferry M, Galan P, Hercberg S, Jeandel C, Morris MC, Nourhashemi F, Payette H, Poulain JP, Portet F, Roussel AM, Ritz P, Rolland Y, Vellas B (2007) IANA task force on nutrition and cognitive decline with aging. J Nutr Health Aging 11, 132-152. (Pubitemid 46725290)
4. Boudrault C, Bazinet RP, Ma DW (2009) Experimental models and mechanisms underlying the protective effects of n-3 polyunsaturated fatty acids in Alzheimer's disease. J Nutr Biochem 20, 1-10.
5. Fotuhi M, Mohassel P, Yaffe K (2009) Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: A complex association. Nat Clin Pract Neurol 5, 140-152.
6. Morris MC (2009) The role of nutrition in Alzheimer's disease: Epidemiological evidence. Eur J Neurol 16 (Suppl 1), 1-7.
7. Schaefer EJ, Bongard V, Beiser AS, Lamon-Fava S, Robins SJ, Au R, Tucker KL, Kyle DJ, Wilson PW, Wolf PA (2006) Plasma phosphatidylcholine docosahexaenoic acid content and riskofdementia and Alzheimer disease: The Framingham Heart Study. Arch Neurol 63, 1545-1550. (Pubitemid 44748796)
8. Sanders TA, Ellis FR, Dickerson JW (1978) Studiesofvegans: The fatty acid composition of plasma choline phosphoglyc-erides, erythrocytes, adipose tissue, and breast milk, and some indicatorsof susceptibilityto ischemic heart diseasein vegans and omnivore controls. Am J Clin Nutr 31, 805-813. (Pubitemid 8348930)
9. Arterburn LM, Hall EB, Oken H (2006) Distribution, inter-conversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr 83, S1467-S1476.
10. Heude B, Ducimetiere P, Berr C (2003) Cognitive decline and fatty acid composition of erythrocyte membranes-The EVA Study. Am J Clin Nutr 77, 803-808.
11. Beydoun MA, Kaufman JS, Satia JA, Rosamond W, Folsom AR (2007) Plama n-3 fatty acids and the risk of cognitive decline in older adults; the Atherosclerosis Risk in Communities Study. Am J Clin Nutr 85, 1103-1111. (Pubitemid 46557928)
12. Whalley LJ, Deary IJ, Starr JM, Wahle KW, Rance KA, Bourne VJ, Fox HC (2008) n-3 Fatty acid erythrocyte membrane content, ApoE e4, and cognitive variation: An observational follow-up study in late adulthood. Am J Clin Nutr 87, 449-454. (Pubitemid 351226084)
13. Cunnane SC, Plourde M, Pifferi F, Bégin M, Féart C, Barberger-Gateau P (2009) Fish, docosahexaenoic acid and Alzheimer's disease. Prog Lipid Res 48, 239-256.
14. Corrigan FM, Van Rhijn A, Horrobin DF (1991) Essential fatty acids in Alzheimer's disease. Ann N Y Acad Sci 640, 250-252.
15. Conquer JA, Tierney MC, Zecevic J, Bettger WJ, Fisher RH (2000) Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment. Lipids 35, 1305-1312. (Pubitemid 32064179)
16. Tully AM, Roche HM, Doyle R, Fallon C, Bruce I, Lawlor B, Coakley D, Gibney MJ (2003) Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: A case-control study. Br J Nutr 89, 483-489. (Pubitemid 36582118)
17. Laurin D, Verreault R, Lindsay J, Dewailly E, Holub BJ (2003) Omega-3 fatty acids and risk of cognitive impairment and dementia. J Alzheimers Dis 5, 315-322. (Pubitemid 37411779)
18. Fraser T, Tayler H, Love S (2009) Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer's disease. Neurochem Res 35, 503-513.
19. Crawford MA (2006) Docosahexaenoic acid in neural signaling systems. Nutr Health 18, 263-276.
20. Umhau J, Zhou W, Carson RE, Rapoport SI, Polozova A, Demar J, Hussein N, Bhattacharjee AK, Ma K, Esposito G, Majchrzak S, Hercovitch P, Eckelman WC, Kurdziel KA, Salem N Jr (2009) Imaging incorporation of circulating docosahexaenoic acid into the brain using positron emission tomography. J Lipid Res 50, 1259-1268.
21. Bennett DA, Schneider JA, Buchman AS, Mendes de Leon C, Bienias JL, Wilson RS (2005) The Rush Memory and Aging Project: Study design and baseline characteristics of the study cohort. Neuroepidemiology 25, 163-175. (Pubitemid 41540657)
22. Vandal M, Freemantle E, Tremblay-Mercier J, Plourde M, Fortier M, Bruneau J, Gagnon J, Tremblay S, Bégin M, Cun-nane SC (2008) Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly. Lipids 43, 1085-1089.
23. Kim HY, Akbar M, Kim YS (2010) Phosphatidylserine-dependent neuroprotective signaling promotedbydocosahex-aenoic acid. Prostaglandins Leukot Essent Fatty Acids 82, 165-172.
24. deGroot RH, van Boxtel MP, Schiepers OJ, Hornstra G, Jolles J (2009) Age dependence of plasma phospholipid fatty acid levels: Potential role of linoleic acid in the age-associated increase in docosahexaenoic acid and eicosapentaenoic acid concentrations. Br J Nutr 102, 1058-1064.
25. Fortier M, Tremblay-Mercier J, Plourde M, Chouinard-Watkins R, Vandal M, Pifferi F, Freemantle E, Cunnane SC (2010) Higher plasma n-3 fatty acid status in the moderately healthy elderly in southern Quebec: Higher fish intake or aging-related change in n-3 fatty acid metabolism? Prostaglandins Leukot Essent Fatty Acids 82, 277-280.
26. 13C-docosahexaenoic acid in the elderly. Nutr Metabol 8, 5.
27. Chen CT, Liu Z, Bazinet RP (2011) Rapid de-esterification and loss of eicosapentaenoic acid from rat brain phospho-lipids: An intraventricular study. J Neurochem 116, 363-373.
28. Bazan NG, Molina MF, Gordon WC (2011) Docosahexaenoic acid signalolipidomics in nutrition: Significance in aging, neuroinflammation, macular degneration, Alzheimer's, and other neurodegenerative diseases. Ann Rev Nutr 31, 321-351.
29. Devore EE, Grodstein F, van Rooij FJ, Hofman A, Rosner B, Stampfer MJ, Witteman JC, Breteler MM (2009) Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. Am J Clin Nutr 90, 170-176.
30. Kroger E, Verreault R, Carmichael PH, Lindsay J, Julien P, Dewailly E, Ayotte P, Laurin D (2009) Omega-3 fatty acids and risk of dementia: The Canadian Study of Health and Aging. Am J Clin Nutr 90, 184-192.
31. Quinn JF, Raman R, Thomas RG, Yurko-Mauro K, Nelson EB, Van Dyck C, Galvin JE, Emond J, Jack CR Jr, Weiner M, Shinto L, Aisen PS (2010) Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: A randomized trial. JAMA 304, 1903-1911.
32. Yurko-Mauro K, McCarthy D, Rom D, Nelson EB, Ryan AS, Blackwell A, Salem N Jr, Stedman M (2010) Benefical effects of docosahexaenoic acidoncognition inage-related cognitive decline. Alzheimers Dementia 6, 456-464.