Omega-3 fatty acids and risk of dementia: The Canadian Study of Health and Aging

American Journal of Clinical Nutrition

Volumn 90, Issue 1, 2009, Pages 184-192

  Kröger, Edeltraut ^a,b,d   Verreault, René ^a,b   Carmichael, Pierre Hugues ^a   Lindsay, Joan ^c   Julien, Pierre ^a,b   Dewailly, Éric ^a,b   Ayotte, Pierre ^a,b   Laurin, Danielle ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; MERCURY; OMEGA 3 FATTY ACID;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CLINICAL EXAMINATION; COHORT ANALYSIS; CONCENTRATION (PARAMETERS); DEMENTIA; ERYTHROCYTE MEMBRANE; FEMALE; FOLLOW UP; FOOD INTAKE; HUMAN; INCIDENCE; INFORMATION; MALE; MENTAL CONCENTRATION; PROSPECTIVE STUDY; RISK; RISK REDUCTION; AGING; BLOOD; CANADA; CLINICAL TRIAL; LONGITUDINAL STUDY; MULTICENTER STUDY; REGRESSION ANALYSIS;

AGED; AGING; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; CANADA; COHORT STUDIES; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; FATTY ACIDS, OMEGA-3; HUMANS; LONGITUDINAL STUDIES; MERCURY; REGRESSION ANALYSIS;

EID: 67649884689     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.3945/ajcn.2008.26987     Document Type: Article

References (73)

1. Gillette Guyonnet S, Abellan Van Kan G, Andrieu S, et al. IANA task force on nutrition and cognitive decline with aging. J Nutr Health Aging 2007;11:132-152 (Pubitemid 46725290)
2. Youdim KA, Martin A, Joseph JA. Essential fatty acids and the brain: possible health implications. Int J Dev Neurosci 2000;18:383-399 (Pubitemid 30244351)
3. Kou W, Luchtman D, Song C. Eicosapentaenoic acid (EPA) increases cell viability and expression of neurotrophin receptors in retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cells. Eur J Nutr 2008;47:104-113 (Pubitemid 351667054)
4. Freemantle E, Vandal M, Tremblay-Mercier J, et al. Omega-3 fatty acids, energy substrates, and brain function during aging. Prostaglandins Leukot Essent Fatty Acids 2006;75:213-220 (Pubitemid 44292526)
5. Calon F, Cole G. Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. Prostaglandins Leukot Essent Fatty Acids 2007;77:287-293 (Pubitemid 350198857)
6. Lim WS, Gammack JK, Van Niekerk J, Dangour AD. Omega 3 fatty acid for the prevention of dementia. Cochrane Database Syst Rev 2006;CD005379.
7. Issa AM, Mojica WA, Morton SC, et al. The efficacy of omega-3 fatty acids on cognitive function in aging and dementia: a systematic review. Dement Geriatr Cogn Disord 2006;21:88-96.
8. Freund-Levi Y, Eriksdotter-Jonhagen M, Cederholm T, et al. Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. Arch Neurol 2006;63:1402-1408 (Pubitemid 44547551)
9. Boston PF, Bennett A, Horrobin DF, Bennett CN. Ethyl-EPA in Alzheimer's disease - a pilot study. Prostaglandins Leukot Essent Fatty Acids 2004;71:341-346 (Pubitemid 39233559)
10. Kotani S, Sakaguchi E, Warashina S, et al. Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. Neurosci Res 2006;56:159-164 (Pubitemid 44374788)
11. van de Rest O, Geleijnse JM, Kok FJ, et al. Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial. Neurology 2008;71:430-438
12. Rogers PJ, Appleton KM, Kessler D, et al. No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial. Br J Nutr 2008;99:421-431
13. Schaefer EJ, Bongard V, Beiser AS, et al. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Arch Neurol 2006;63:1545-1550 (Pubitemid 44748796)
14. Samieri C, Feart C, Letenneur L, et al. Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk. Am J Clin Nutr 2008;88:714-721
15. Heude B, Ducimetiere P, Berr C, Study EVA. Cognitive decline and fatty acid composition of erythrocyte membranes - the EVA Study. Am J Clin Nutr 2003;77:803-808
16. Laurin D, Verreault R, Lindsay J, Dewailly E, Holub BJ. Omega-3 fatty acids and risk of cognitive impairment and dementia. J Alzheimers Dis 2003;5:315-322 (Pubitemid 37411779)
17. Harnly M, Seidel S, Rojas P, et al. Biological monitoring for mercury within a community with soil and fish contamination. Environ Health Perspect 1997;105:424-429 (Pubitemid 27279835)
18. Shim SM, Lasrado JA, Dorworth LE, Santerre CR. Mercury and omega-3 fatty acids in retail fish sandwiches. J Food Prot 2005;68:633-635
19. Olivieri G, Brack C, Muller-Spahn F, et al. Mercury induces cell cytotoxicity and oxidative stress and increases beta-amyloid secretion and tau phosphorylation in SHSY5Y neuroblastoma cells. J Neurochem 2000;74:231-236 (Pubitemid 30012773)
20. Monnet-Tschudi F, Zurich MG, Boschat C, Corbaz A, Honegger P. Involvement of environmental mercury and lead in the etiology of neurodegenerative diseases. Rev Environ Health 2006;21:105-117 (Pubitemid 44077520)
21. Björkman L, Lundekvam BF, Laegreid T, et al. Mercury in human brain, blood, muscle and toenails in relation to exposure: an autopsy study. Environ Health 2007;6:30.
22. Latshaw MW, Glass T, Parsons P, Hidalgo J, Schwartz B. Predictors of blood mercury levels in older urban residents. J Occup Environ Med 2006;48:715-722 (Pubitemid 44091502)
23. Schober SE, Sinks TH, Jones RL, et al. Blood mercury levels in US children and women of childbearing age, 1999-2000. JAMA 2003;289:1667-1674
24. Budtz-Jorgensen E, Grandjean P, Weihe P. Separation of risks and benefits of seafood intake. Environ Health Perspect 2007;115:323-327 (Pubitemid 46554428)
25. Whalley LJ, Deary IJ, Starr JM, et al. n-3 Fatty acid erythrocyte membrane content, APOE ε4, and cognitive variation: an observational follow-up study in late adulthood. Am J Clin Nutr 2008;87:449-454
26. Canadian Study of Health and Aging Working Group. Canadian Study of Health and Aging: study methods and prevalence of dementia. Can Med Assoc J 1994;150:899-913.
27. Lindsay J, Sykes E, McDowell I, Verreault R, Laurin D. More than the epidemiology of Alzheimer's disease: contributions of the Canadian Study of Health and Aging. Can J Psychiatry 2004;49:83-91. (Pubitemid 38387417)
28. Teng EL, Chui HC. The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry 1987;48:314-318
29. Hébert R, Bravo G, Girouard D. Validation de l'adaptation Française du Modified Mini-Mental State (3MS). [Validation of the French adaptation of the Modified Mini-Mental State Exam (3MS).] Revue Geriatr 1992;17:443-450 (in French).
30. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 3rd ed revised. Washington, DC: American Psychiatric Association, 1987.
31. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDAWork Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944 (Pubitemid 14076461)
32. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association, 1994.
33. Shaikh NA, Downar E. Time course of changes in porcine myocardial phospholipid levels during ischemia. A reassessment of the lysolipid hypothesis. Circ Res 1981;49:316-325
34. Lepage G, Roy CC. Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res 1986;27:114-120 (Pubitemid 16045295)
35. Orton HD, Szabo NJ, Clare-Salzler M, Norris JM. Comparison between omega-3 and omega-6 polyunsaturated fatty acid intakes as assessed by a food frequency questionnaire and erythrocyte membrane fatty acid composition in young children. Eur J Clin Nutr 2008;62:733-738 (Pubitemid 351803582)
36. Sun Q, Ma J, Campos H, Hankinson SE, Hu FB. Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in US women. Am J Clin Nutr 2007;86:74-81. (Pubitemid 47041595)
37. McLeod D, Arnott B, Gaudreault N, Boudreau S, Sevigny P. A comparison of two methods for routine, accurate determination of apolipoprotein E genotypes. Alzheimers Rep 1998;1:211-215 (Pubitemid 128742498)
38. Hosmer DWJ, Lemeshow S. Applied survival analysis. Regression modeling of time to event data. New York, NY: Wiley-Interscience, 1999.
39. Klein J, Moeschberger M. Survival analysis: techniques for censored and truncated data. 2nd ed. New York, NY: Springer, 2003.
40. Allison P. Survival analysis using SAS: a practical guide. Cary, NC: SAS Publishing, 1995.
41. Schisterman EF, Vexler A, Whitcomb BW, Liu A. The limitations due to exposure detection limits for regression models. Am J Epidemiol 2006;163:374-383 (Pubitemid 43238432)
42. Commenges D, Letenneur L, Joly P, Alioum A, Dartigues J. Modelling age-specific risk: application to dementia. Stat Med 1998;17:1973-1988 (Pubitemid 28425261)
43. Lin DY, Wei J, Ying Z. Checking the Cox model with cumulative sums of martingale-based residuals. Biometrika 1993;80:557-572
44. Mahaffey KR, Clickner RP, Jeffries RA. Methylmercury and omega-3 fatty acids: co-occurrence of dietary sources with emphasis on fish and shellfish. Environ Res 2007;107:20-29
45. Conquer JA, Tierney M, Zecevic J, Bettger W, Fisher R. Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment. Lipids 2000;35:1305-1312 (Pubitemid 32064179)
46. Tully AM, Roche HM, Doyle R, et al. Low serum cholesteryl esterdocosahexaenoic acid levels in Alzheimer's disease: a case-control study. Br J Nutr 2003;89:483-489 (Pubitemid 36582118)
47. Cherubini A, Andres-Lacueva C, Martin A, et al. Low plasma n-3 fatty acids and dementia in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 2007;62:1120-1126
48. Manzato E, Roselli della Rovere G, Zambon S, et al. Cognitive functions are not affected by dietary fatty acids in elderly subjects in the Pro.V.A. study population. Aging Clin Exp Res 2003;15:83-86 (Pubitemid 36675442)
49. Beydoun MA, Kaufman JS, Satia JA, Rosamond W, Folsom AR. Plasma n-3 fatty acids and the risk of cognitive decline in older adults: the Atherosclerosis Risk in Communities Study. Am J Clin Nutr 2007;85:1103-1111 (Pubitemid 46557928)
50. Dullemeijer C, Durga J, Brouwer IA, et al. N-3 fatty acid proportions in plasma and cognitive performance in older adults. Am J Clin Nutr 2007;86:1479-1485 (Pubitemid 350126254)
51. de Groot RH, Hornstra G, Jolles J. Exploratory study into the relation between plasma phospholipid fatty acid status and cognitive performance. Prostaglandins Leukot Essent Fatty Acids 2007;76:165-172 (Pubitemid 46366657)
52. Luchsinger JA, Mayeux R. Dietary factors and Alzheimer's disease. Lancet Neurol 2004;3:579-587
53. Cunnane S, Plourde M, Vandal M, Freemantle E. Linking low docosahexaenoic acid intake to Alzheimer's disease: caution recommended. Oléaginuex. Corps Gras, Lipides 2007;14:177-181
54. Katan MB, Deslypere JP, van Birgelen AP, Penders M, Zegwaard M. Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study. J Lipid Res 1997;38:2012-2022 (Pubitemid 27468010)
55. Harris WS, Von Schacky C. The Omega-3 Index: a new risk factor for death from coronary heart disease? Prev Med 2004;39:212-220
56. Arab L. Biomarkers of fat and fatty acid intake. J Nutr 2003;133(suppl 3):925S-32S. (Pubitemid 36262800)
57. van Gelder BM, Tijhuis M, Kalmijn S, Kromhout D. Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study. Am J Clin Nutr 2007;85:1142-1147 (Pubitemid 46557933)
58. Kalmijn S, van Boxtel MP, Ocke M, Verschuren WM, Kromhout D, Launer LJ. Dietary intake of fatty acids and fish in relation to cognitive performance at middle age. Neurology 2004;62:275-280 (Pubitemid 38167138)
59. Kalmijn S, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol 1997;42:776-782 (Pubitemid 27481550)
60. Morris MC, Evans D, Bienias J, et al. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol 2003;60:940-946 (Pubitemid 36858352)
61. Engelhart MJ, Geerlings MI, Ruitenberg A, et al. Diet and risk of dementia: does fat matter? The Rotterdam Study. Neurology 2002;59:1915-1921 (Pubitemid 36076564)
62. Huang TL, Zandi PP, Tucker KL, et al. Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4. Neurology 2005;65:1409-1414
63. Welch AA, Bingham SA, Ive J, et al. Dietary fish intake and plasma phospholipid n-3 polyunsaturated fatty acid concentrations in men and women in the European Prospective Investigation into Cancer-Norfolk United Kingdom cohort. Am J Clin Nutr 2006;84:1330-1339 (Pubitemid 44912814)
64. Weil M, Bressler J, Parsons P, Bolla K, Glass T, Schwartz B. Blood mercury levels and neurobehavioral function. JAMA 2005;293:1875-1882 (Pubitemid 40548184)
65. Johansson N, Basun H, Winblad B, Nordberg M. Relationship between mercury concentration in blood, cognitive performance, and blood pressure, in an elderly urban population. Biometals 2002;15:189-195 (Pubitemid 34494242)
66. Institut National de Santé Publique du Québec Q. É tude sur l'etablissement de valeurs de référence d'eléments traces et de métaux dans le sang, le sérum et l'urine de la population de la grande région de Québec. (Study on the establishment of reference values for trace elements and metals in blood, serum and urine in the population of the greater Quebec City area.) 2004:38 (in French).
67. US Environmental Protection Agency. Mercury Study Report to Congress. Vol 1. Executive Summary, 1997. Washington, DC: US Environmental Protection Agency, 1997. (Publication EPA-452/R-97-003.)
68. Chung H, Nettleton JA, Lemaitre RN, et al. Frequency and type of seafood consumed influence plasma (n-3) fatty acid concentrations. J Nutr 2008;138:2422-2427
69. Dewailly E, Ayotte P, Lucas M, Blanchet C. Risk and benefits from consuming salmon and trout: a Canadian perspective. Food Chem Toxicol 2007;45:1343-1348 (Pubitemid 47031380)
70. Harris WS. n-3 Fatty acids and health: DaVinci's code. Am J Clin Nutr 2008;88:595-596
71. Arendash GW, Jensen MT, Salem N Jr, et al. A diet high in omega-3 fatty acids does not improve or protect cognitive performance in Alzheimer's transgenic mice. Neuroscience 2007;149:286-302.
72. Elias MF, Beiser A, Wolf PA, Au R, White RF, D'Agostino RB. The preclinical phase of Alzheimer disease: a 22-year prospective study of the Framingham Cohort. Arch Neurol 2000;57:808-813 (Pubitemid 30397182)
73. Kawas CH, Corrada MM, Brookmeyer R, et al. Visual memory predicts Alzheimer's disease more than a decade before diagnosis. Neurology 2003;60:1089-1093 (Pubitemid 36418765)