Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: A randomized, double-blind, controlled trial

American Journal of Clinical Nutrition

Volumn 91, Issue 6, 2010, Pages 1725-1732

  Dangour, Alan D ^a   Allen, Elizabeth ^a   Elbourne, Diana ^a   Fasey, Nicky ^b   Fletcher, Astrid E ^a   Hardy, Pollyanna ^c   Holder, Graham E ^d   Knight, Rosemary ^a   Letley, Louise ^b   Richards, Marcus ^b   Uauy, Ricardo ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^d MOORFIELDS EYE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; OLIVE OIL; OMEGA 3 FATTY ACID; POLYUNSATURATED FATTY ACID;

AGE DISTRIBUTION; AGED; ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEATH; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; EDUCATION; FEMALE; GENERAL PRACTICE; HUMAN; LEARNING; MALE; NORMAL HUMAN; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SEX DIFFERENCE; SEX RATIO; SPATIAL MEMORY; UNITED KINGDOM;

AGED; COGNITION; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FATTY ACIDS, OMEGA-3; FEMALE; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PATIENT COMPLIANCE;

EID: 77953066352     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.2009.29121     Document Type: Article

References (55)

1. Personal Social Services Research Unit. Dementia UK. London, United Kingdom: Alzheimer's Society, 2007.
2. Ferri CP, Prince M, Brayne C, et al. Global prevalence of dementia: a Delphi consensus study. Lancet 2005;366:2112-2117
3. Gillette Guyonnet S, Abellan Van Kan G, Andrieu S, et al. IANA task force on nutrition and cognitive decline with aging. J Nutr Health Aging 2007;11:132-152
4. Luchsinger JA, Mayeux R. Dietary factors and Alzheimer's disease. Lancet Neurol 2004;3:579-587
5. Futterman S, Andrews JS. The fatty acid composition of human retinal vitamin a ester and the lipids of human retinal tissue. Invest Ophthalmol 1964;3:441-444
6. Svennerholm L. Distribution and fatty acid composition of phosphoglycerides in normal human brain. J Lipid Res 1968;9:570-579
7. Bazan NG. Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors. Trends Neurosci 2006;29:263-271
8. Uauy R, Dangour AD. Nutrition in brain development and aging: role of essential fatty acids. Nutr Rev 2006;64:S24-33; discussion S72-91.
9. Ortega RM, Requejo AM, Andres P, et al. Dietary intake and cognitive function in a group of elderly people. Am J Clin Nutr 1997;66:803-809 (Pubitemid 27415562)
10. Kalmijn S, van Boxtel MP, Ocke M, Verschuren WM, Kromhout D, Launer LJ. Dietary intake of fatty acids and fish in relation to cognitive performance at middle age. Neurology 2004;62:275-280 (Pubitemid 38167138)
11. Feart C, Samieri C, Rondeau V, et al. Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA 2009;302:638-648
12. Barberger-Gateau P, Letenneur L, Deschamps V, Peres K, Dartigues JF, Renaud S. Fish, meat, and risk of dementia: cohort study. BMJ 2002;325:932-933 (Pubitemid 35265208)
13. Morris MC, Evans DA, Bienias JL, et al. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol 2003;60:940-946 (Pubitemid 36858352)
14. Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS. Fish consumption and cognitive decline with age in a large community study. Arch Neurol 2005;62:1849-1853 (Pubitemid 41785078)
15. Huang TL, Zandi PP, Tucker KL, et al. Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4. Neurology 2005;65:1409-1414
16. van Gelder BM, Tijhuis M, Kalmijn S, Kromhout D. Fish consumption, n23 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study. Am J Clin Nutr 2007;85:1142-1147 (Pubitemid 46557933)
17. Albanese E, Dangour AD, Uauy R, et al. Dietary fish and meat intake and dementia in Latin America, China, and India: a 10/66 Dementia Research Group population-based study. Am J Clin Nutr 2009;90:392-400.
18. Laurin D, Verreault R, Lindsay J, Dewailly E, Holub BJ. Omega-3 fatty acids and risk of cognitive impairment and dementia. J Alzheimers Dis 2003;5:315-322
19. Engelhart MJ, Geerlings MI, Ruitenberg A, et al. Diet and risk of dementia: does fat matter?: the Rotterdam Study. Neurology 2002;59:1915-1921
20. Devore EE, Grodstein F, van Rooij FJ, et al. Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. Am J Clin Nutr 2009;90:170-176
21. Kroger E, Verreault R, Carmichael PH, et al. Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and Aging. Am J Clin Nutr 2009;90:184-192
22. van de Rest O, Geleijnse JM, Kok FJ, et al. Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial. Neurology 2008;71:430-438
23. Lim WS, Gammack JK, Van Niekerk J, Dangour AD. Omega 3 fatty acid for the prevention of dementia. Cochrane Database Syst Rev 2006; CD005379.
24. Dangour AD, Clemens F, Elbourne D, et al. A randomised controlled trial investigating the effect of n23 long-chain polyunsaturated fatty acid supplementation on cognitive and retinal function in cognitively healthy older people: the Older People And n-3 Long-chain poly-unsaturated fatty acids (OPAL) study protocol [ISRCTN72331636]. Nutr J 2006;5:20.
25. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198
26. Scientific Advisory Committee on Nutrition. Advice on fish consumption: benefits and risks. London, United Kingdom: The Stationary Office, 2004.
27. Kris-Etherton PM, Harris WS, Appel LJ. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002;106:2747-2757
28. Department of Education and Science. Burnham further education committee grading courses. London, United Kingdom: HMSO, 1972.
29. Dangour AD, Allen E, Elbourne D, Fletcher A, Richards M, Uauy R. Fish consumption and cognitive function among older people in the UK: baseline data from the OPAL study. J Nutr Health Aging 2009;13:198-202.
30. Goldberg D. The detection of psychiatric illness by questionnaire. London, United Kingdom: Oxford University Press, 1972.
31. Vellas B, Andrieu S, Sampaio C, Coley N, Wilcock G. Endpoints for trials in Alzheimer's disease: a European task force consensus. Lancet Neurol 2008;7:436-450
32. Delis DC, Kramer JH, Kaplan E, Ober BA. California Verbal Learning Test. New York, NY: Psychological Corporation, 1987.
33. Tierney MC, Oh P, Moineddin R, et al. A randomized double-blind trial of the effects of hormone therapy on delayed verbal recall in older women. Psychoneuroendocrinology 2009;34:1065-1074
34. Durga J, van Boxtel MP, Schouten EG, et al. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007;369:208-216
35. Wechsler D. Wechsler memory scale-revised manual. San Antonio, TX: Psychological Corporation, 1987.
36. van Niekerk JK, Nielsen TA, Pasu S, Shore S, Huppert FA. The development of new tests of source memory and a new approach to the testing of equivalence of parallel versions. Aging Neuropsychol Cogn 2004;11:416-427
37. Richards M, Kuh D, Hardy R, Wadsworth M. Lifetime cognitive function and timing of the natural menopause. Neurology 1999;53:308-314
38. Smith A. Symbol letter modalities test. Revised manual. Los Angeles, CA: Western Psychological Services, 1982.
39. Cox BD, Huppert FA, Whichelow MJ. The Health and Lifestyle Survey: seven years on. Aldershot, United Kingdom: Dartmouth Pub Co, 1993.
40. Wechsler D. Wechsler adult intelligence scale-revised. New York, NY: The Psychological Corporation, 1981.
41. Goodglass H, Kaplan E. Assessment of dysphasia and related disorders. Philadelphia, PA: Lea and Febiger, 1983.
42. Maylor EA. Aging and forgetting in prospective and retrospective memory tasks. Psychol Aging 1993;8:420-428
43. London School of Hygiene and Tropical Medicine. The OPAL study. Homepage. Available from: http://opal-study.org.uk (cited 15 September 2009).
44. Connor SL, Zhu N, Anderson GJ, et al. Cheek cell phospholipids in human infants: a marker of docosahexaenoic and arachidonic acids in the diet, plasma, and red blood cells. Am J Clin Nutr 2000;71:21-27
45. Hoffman DR, Birch EE, Birch DG, Uauy R. Fatty acid profile of buccal cheek cell phospholipids as an index for dietary intake of docosahexaenoic acid in preterm infants. Lipids 1999;34:337-342
46. Lepage G, Roy CC. Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res 1986;27:114-120
47. Samsa G, Edelman D, Rothman ML, Williams GR, Lipscomb J, Matchar D. Determining clinically important differences in health status measures: a general approach with illustration to the Health Utilities Index Mark II. Pharmacoeconomics 1999;15:141-155
48. Norman MA, Evans JD, Miller WS, Heaton RK. Demographically corrected norms for the California Verbal Learning Test. J Clin Exp Neuropsychol 2000;22:80-94.
49. Goldberg DP, Gater R, Sartorius N, et al. The validity of two versions of the GHQ in the WHO study of mental illness in general health care. Psychol Med 1997;27:191-197
50. McMahon JA, Green TJ, Skeaff CM, Knight RG, Mann JI, Williams SM. A controlled trial of homocysteine lowering and cognitive performance. N Engl J Med 2006;354:2764-2772
51. Neuringer M, Connor WE, Lin DS, Barstad L, Luck S. Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc Natl Acad Sci USA 1986;83:4021-4025
52. World Cancer Research Fund/American Institute for Cancer Research. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Washington, DC: American Institute for Cancer Research, 2007.
53. Hennekens CH, Demets D. The need for large-scale randomized evidence without undue emphasis on small trials, meta-analyses, or subgroup analyses. JAMA 2009;302:2361-2362
54. Freund-Levi Y, Eriksdotter-Jonhagen M, Cederholm T, et al. Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. Arch Neurol 2006;63:1402-1408
55. Gillette-Guyonnet S, Andrieu S, Dantoine T, Dartigues JF, Touchon J, Vellas B. Commentary on "A roadmap for the prevention of dementia II. Leon Thal Symposium 2008." The Multidomain Alzheimer Preventive Trial (MAPT): a new approach to the prevention of Alzheimer's disease. Alzheimers Dement 2009;5:114-121