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Volumn 11, Issue 8, 2015, Pages

Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; NIBRIN; PROTEIN MSH2; RNA POLYMERASE II; AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); CELL CYCLE PROTEIN; CYTIDINE DEAMINASE; NIJMEGEN BREAKAGE SYNDROME 1 PROTEIN, MOUSE; NUCLEAR PROTEIN; PROTEIN BINDING; SPACER DNA;

EID: 84940748541     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005438     Document Type: Article
Times cited : (14)

References (96)
  • 1
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, et al. (2000) Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102: 553–563. 11007474
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5
  • 2
    • 0034264851 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
    • Revy P, Muto T, Levy Y, Geissmann F, Plebani A, et al. (2000) Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell 102: 565–575. 11007475
    • (2000) Cell , vol.102 , pp. 565-575
    • Revy, P.1    Muto, T.2    Levy, Y.3    Geissmann, F.4    Plebani, A.5
  • 3
    • 0037019315 scopus 로고    scopus 로고
    • AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
    • Petersen-Mahrt SK, Harris RS, Neuberger MS, (2002) AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 418: 99–104. 12097915
    • (2002) Nature , vol.418 , pp. 99-104
    • Petersen-Mahrt, S.K.1    Harris, R.S.2    Neuberger, M.S.3
  • 4
    • 0037108463 scopus 로고    scopus 로고
    • Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    • Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, et al. (2002) Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr Biol 12: 1748–1755. 12401169
    • (2002) Curr Biol , vol.12 , pp. 1748-1755
    • Rada, C.1    Williams, G.T.2    Nilsen, H.3    Barnes, D.E.4    Lindahl, T.5
  • 5
    • 84912535553 scopus 로고    scopus 로고
    • IgH Chain Class Switch Recombination: Mechanism and Regulation
    • Stavnezer J, Schrader CE, (2014) IgH Chain Class Switch Recombination: Mechanism and Regulation. J Immunol 193: 5370–5378. doi: 10.4049/jimmunol.1401849 25411432
    • (2014) J Immunol , vol.193 , pp. 5370-5378
    • Stavnezer, J.1    Schrader, C.E.2
  • 6
    • 2642623612 scopus 로고    scopus 로고
    • Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
    • Shen HM, Peters A, Baron B, Zhu X, Storb U, (1998) Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science 280: 1750–1752. 9624052
    • (1998) Science , vol.280 , pp. 1750-1752
    • Shen, H.M.1    Peters, A.2    Baron, B.3    Zhu, X.4    Storb, U.5
  • 7
    • 13144259651 scopus 로고    scopus 로고
    • BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci
    • Pasqualucci L, Migliazza A, Fracchiolla N, William C, Neri A, et al. (1998) BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc Natl Acad Sci U S A 95: 11816–11821. 9751748
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11816-11821
    • Pasqualucci, L.1    Migliazza, A.2    Fracchiolla, N.3    William, C.4    Neri, A.5
  • 8
    • 0035913362 scopus 로고    scopus 로고
    • Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
    • Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti RS, et al. (2001) Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 412: 341–346. 11460166
    • (2001) Nature , vol.412 , pp. 341-346
    • Pasqualucci, L.1    Neumeister, P.2    Goossens, T.3    Nanjangud, G.4    Chaganti, R.S.5
  • 9
    • 39149099085 scopus 로고    scopus 로고
    • Two levels of protection for the B cell genome during somatic hypermutation
    • Liu M, Duke JL, Richter DJ, Vinuesa CG, Goodnow CC, et al. (2008) Two levels of protection for the B cell genome during somatic hypermutation. Nature 451: 841–845. doi: 10.1038/nature06547 18273020
    • (2008) Nature , vol.451 , pp. 841-845
    • Liu, M.1    Duke, J.L.2    Richter, D.J.3    Vinuesa, C.G.4    Goodnow, C.C.5
  • 10
    • 77957239251 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5
    • Pavri R, Gazumyan A, Jankovic M, Di Virgilio M, Klein I, et al. (2010) Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell 143: 122–133. doi: 10.1016/j.cell.2010.09.017 20887897
    • (2010) Cell , vol.143 , pp. 122-133
    • Pavri, R.1    Gazumyan, A.2    Jankovic, M.3    Di Virgilio, M.4    Klein, I.5
  • 11
    • 84876011525 scopus 로고    scopus 로고
    • Multiple transcription factor binding sites predict AID targeting in non-Ig genes
    • Duke JL, Liu M, Yaari G, Khalil AM, Tomayko MM, et al. (2013) Multiple transcription factor binding sites predict AID targeting in non-Ig genes. J Immunol 190: 3878–3888. doi: 10.4049/jimmunol.1202547 23514741
    • (2013) J Immunol , vol.190 , pp. 3878-3888
    • Duke, J.L.1    Liu, M.2    Yaari, G.3    Khalil, A.M.4    Tomayko, M.M.5
  • 12
    • 34548420553 scopus 로고    scopus 로고
    • A role for AID in chromosome translocations between c-myc and the IgH variable region
    • Dorsett Y, Robbiani DF, Jankovic M, Reina-San-Martin B, Eisenreich TR, et al. (2007) A role for AID in chromosome translocations between c-myc and the IgH variable region. J Exp Med 204: 2225–2232. 17724134
    • (2007) J Exp Med , vol.204 , pp. 2225-2232
    • Dorsett, Y.1    Robbiani, D.F.2    Jankovic, M.3    Reina-San-Martin, B.4    Eisenreich, T.R.5
  • 13
    • 57149146036 scopus 로고    scopus 로고
    • AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations
    • Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, et al. (2008) AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell 135: 1028–1038. doi: 10.1016/j.cell.2008.09.062 19070574
    • (2008) Cell , vol.135 , pp. 1028-1038
    • Robbiani, D.F.1    Bothmer, A.2    Callen, E.3    Reina-San-Martin, B.4    Dorsett, Y.5
  • 14
    • 77955921194 scopus 로고    scopus 로고
    • Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination
    • Hasham MG, Donghia NM, Coffey E, Maynard J, Snow KJ, et al. (2010) Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination. Nat Immunol 11: 820–826. doi: 10.1038/ni.1909 20657597
    • (2010) Nat Immunol , vol.11 , pp. 820-826
    • Hasham, M.G.1    Donghia, N.M.2    Coffey, E.3    Maynard, J.4    Snow, K.J.5
  • 15
    • 78651468710 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells
    • Staszewski O, Baker RE, Ucher AJ, Martier R, Stavnezer J, et al. (2011) Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells. Mol Cell 41: 232–242. doi: 10.1016/j.molcel.2011.01.007 21255732
    • (2011) Mol Cell , vol.41 , pp. 232-242
    • Staszewski, O.1    Baker, R.E.2    Ucher, A.J.3    Martier, R.4    Stavnezer, J.5
  • 16
    • 78650308767 scopus 로고    scopus 로고
    • Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes
    • Yamane A, Resch W, Kuo N, Kuchen S, Li Z, et al. (2011) Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol 12: 62–69. doi: 10.1038/ni.1964 21113164
    • (2011) Nat Immunol , vol.12 , pp. 62-69
    • Yamane, A.1    Resch, W.2    Kuo, N.3    Kuchen, S.4    Li, Z.5
  • 17
    • 80053502216 scopus 로고    scopus 로고
    • Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes
    • Klein IA, Resch W, Jankovic M, Oliveira T, Yamane A, et al. (2011) Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell 147: 95–106. doi: 10.1016/j.cell.2011.07.048 21962510
    • (2011) Cell , vol.147 , pp. 95-106
    • Klein, I.A.1    Resch, W.2    Jankovic, M.3    Oliveira, T.4    Yamane, A.5
  • 18
    • 80053558376 scopus 로고    scopus 로고
    • Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells
    • Chiarle R, Zhang Y, Frock RL, Lewis SM, Molinie B, et al. (2011) Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell 147: 107–119. doi: 10.1016/j.cell.2011.07.049 21962511
    • (2011) Cell , vol.147 , pp. 107-119
    • Chiarle, R.1    Zhang, Y.2    Frock, R.L.3    Lewis, S.M.4    Molinie, B.5
  • 19
    • 84873125934 scopus 로고    scopus 로고
    • RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle
    • Yamane A, Robbiani DF, Resch W, Bothmer A, Nakahashi H, et al. (2013) RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle. Cell Rep 3: 138–147. doi: 10.1016/j.celrep.2012.12.006 23291097
    • (2013) Cell Rep , vol.3 , pp. 138-147
    • Yamane, A.1    Robbiani, D.F.2    Resch, W.3    Bothmer, A.4    Nakahashi, H.5
  • 20
    • 84919903836 scopus 로고    scopus 로고
    • Convergent Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability
    • Meng FL, Du Z, Federation A, Hu J, Wang Q, et al. (2014) Convergent Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability. Cell 159: 1538–1548. doi: 10.1016/j.cell.2014.11.014 25483776
    • (2014) Cell , vol.159 , pp. 1538-1548
    • Meng, F.L.1    Du, Z.2    Federation, A.3    Hu, J.4    Wang, Q.5
  • 21
    • 84919941546 scopus 로고    scopus 로고
    • B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity
    • Qian J, Wang Q, Dose M, Pruett N, Kieffer-Kwon KR, et al. (2014) B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity. Cell 159: 1524–1537. doi: 10.1016/j.cell.2014.11.013 25483777
    • (2014) Cell , vol.159 , pp. 1524-1537
    • Qian, J.1    Wang, Q.2    Dose, M.3    Pruett, N.4    Kieffer-Kwon, K.R.5
  • 22
    • 84924352927 scopus 로고    scopus 로고
    • Epigenetic targeting of activation-induced cytidine deaminase
    • Wang Q, Oliveira T, Jankovic M, Silva IT, Hakim O, et al. (2014) Epigenetic targeting of activation-induced cytidine deaminase. Proc Natl Acad Sci U S A 111: 18667–18672. doi: 10.1073/pnas.1420575111 25512519
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 18667-18672
    • Wang, Q.1    Oliveira, T.2    Jankovic, M.3    Silva, I.T.4    Hakim, O.5
  • 23
    • 51649111684 scopus 로고    scopus 로고
    • Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
    • Lenz G, Wright GW, Emre NC, Kohlhammer H, Dave SS, et al. (2008) Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. Proc Natl Acad Sci U S A 105: 13520–13525. doi: 10.1073/pnas.0804295105 18765795
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13520-13525
    • Lenz, G.1    Wright, G.W.2    Emre, N.C.3    Kohlhammer, H.4    Dave, S.S.5
  • 24
    • 34147180434 scopus 로고    scopus 로고
    • Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
    • Matsumoto Y, Marusawa H, Kinoshita K, Endo Y, Kou T, et al. (2007) Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat Med 13: 470–476. 17401375
    • (2007) Nat Med , vol.13 , pp. 470-476
    • Matsumoto, Y.1    Marusawa, H.2    Kinoshita, K.3    Endo, Y.4    Kou, T.5
  • 25
    • 71249101060 scopus 로고    scopus 로고
    • Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer
    • Lin C, Yang L, Tanasa B, Hutt K, Ju BG, et al. (2009) Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell 139: 1069–1083. doi: 10.1016/j.cell.2009.11.030 19962179
    • (2009) Cell , vol.139 , pp. 1069-1083
    • Lin, C.1    Yang, L.2    Tanasa, B.3    Hutt, K.4    Ju, B.G.5
  • 26
    • 0035818990 scopus 로고    scopus 로고
    • AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching
    • Petersen S, Casellas R, Reina-San-Martin B, Chen HT, Difilippantonio MJ, et al. (2001) AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature 414: 660–665. 11740565
    • (2001) Nature , vol.414 , pp. 660-665
    • Petersen, S.1    Casellas, R.2    Reina-San-Martin, B.3    Chen, H.T.4    Difilippantonio, M.J.5
  • 27
    • 0036152242 scopus 로고    scopus 로고
    • Mechanism and control of class-switch recombination
    • Manis JP, Tian M, Alt FW, (2002) Mechanism and control of class-switch recombination. Trends Immunol 23: 31–39. 11801452
    • (2002) Trends Immunol , vol.23 , pp. 31-39
    • Manis, J.P.1    Tian, M.2    Alt, F.W.3
  • 29
    • 84888330687 scopus 로고    scopus 로고
    • Alternative End-Joining and Classical Nonhomologous End-Joining Pathways Repair Different Types of Double-Strand Breaks during Class-Switch Recombination
    • Cortizas EM, Zahn A, Hajjar ME, Patenaude AM, Di Noia JM, et al. (2013) Alternative End-Joining and Classical Nonhomologous End-Joining Pathways Repair Different Types of Double-Strand Breaks during Class-Switch Recombination. J Immunol 191: 5751–5763. doi: 10.4049/jimmunol.1301300 24146042
    • (2013) J Immunol , vol.191 , pp. 5751-5763
    • Cortizas, E.M.1    Zahn, A.2    Hajjar, M.E.3    Patenaude, A.M.4    Di Noia, J.M.5
  • 30
    • 68249135624 scopus 로고    scopus 로고
    • Multiple functions of MRN in end-joining pathways during isotype class switching
    • Dinkelmann M, Spehalski E, Stoneham T, Buis J, Wu Y, et al. (2009) Multiple functions of MRN in end-joining pathways during isotype class switching. Nat Struct Mol Biol 16: 808–813. doi: 10.1038/nsmb.1639 19633670
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 808-813
    • Dinkelmann, M.1    Spehalski, E.2    Stoneham, T.3    Buis, J.4    Wu, Y.5
  • 31
    • 78650988959 scopus 로고    scopus 로고
    • CtIP promotes microhomology-mediated alternative end joining during class-switch recombination
    • Lee-Theilen M, Matthews AJ, Kelly D, Zheng S, Chaudhuri J, (2011) CtIP promotes microhomology-mediated alternative end joining during class-switch recombination. Nat Struct Mol Biol 18: 75–79. doi: 10.1038/nsmb.1942 21131982
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 75-79
    • Lee-Theilen, M.1    Matthews, A.J.2    Kelly, D.3    Zheng, S.4    Chaudhuri, J.5
  • 32
    • 54849404458 scopus 로고    scopus 로고
    • MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings
    • McVey M, Lee SE, (2008) MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings. Trends Genet 24: 529–538. doi: 10.1016/j.tig.2008.08.007 18809224
    • (2008) Trends Genet , vol.24 , pp. 529-538
    • McVey, M.1    Lee, S.E.2
  • 33
    • 84908045717 scopus 로고    scopus 로고
    • Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks
    • Cannavo E, Cejka P, (2014) Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks. Nature 514: 122–125. doi: 10.1038/nature13771 25231868
    • (2014) Nature , vol.514 , pp. 122-125
    • Cannavo, E.1    Cejka, P.2
  • 34
    • 84877321963 scopus 로고    scopus 로고
    • Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells
    • Truong LN, Li Y, Shi LZ, Hwang PY, He J, et al. (2013) Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Proc Natl Acad Sci U S A 110: 7720–7725. doi: 10.1073/pnas.1213431110 23610439
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 7720-7725
    • Truong, L.N.1    Li, Y.2    Shi, L.Z.3    Hwang, P.Y.4    He, J.5
  • 35
    • 84879793595 scopus 로고    scopus 로고
    • The Ku heterodimer and the metabolism of single-ended DNA double-strand breaks
    • Balestrini A, Ristic D, Dionne I, Liu XZ, Wyman C, et al. (2013) The Ku heterodimer and the metabolism of single-ended DNA double-strand breaks. Cell Rep 3: 2033–2045. doi: 10.1016/j.celrep.2013.05.026 23770241
    • (2013) Cell Rep , vol.3 , pp. 2033-2045
    • Balestrini, A.1    Ristic, D.2    Dionne, I.3    Liu, X.Z.4    Wyman, C.5
  • 36
    • 84862777619 scopus 로고    scopus 로고
    • The E3 ligase RNF8 regulates KU80 removal and NHEJ repair
    • Feng L, Chen J, (2012) The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat Struct Mol Biol 19: 201–206. doi: 10.1038/nsmb.2211 22266820
    • (2012) Nat Struct Mol Biol , vol.19 , pp. 201-206
    • Feng, L.1    Chen, J.2
  • 37
    • 77649267656 scopus 로고    scopus 로고
    • Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70
    • Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, et al. (2010) Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A 107: 3034–3039. doi: 10.1073/pnas.0915067107 20133803
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 3034-3039
    • Boboila, C.1    Jankovic, M.2    Yan, C.T.3    Wang, J.H.4    Wesemann, D.R.5
  • 38
    • 34748863465 scopus 로고    scopus 로고
    • IgH class switching and translocations use a robust non-classical end-joining pathway
    • Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, et al. (2007) IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 449: 478–482. 17713479
    • (2007) Nature , vol.449 , pp. 478-482
    • Yan, C.T.1    Boboila, C.2    Souza, E.K.3    Franco, S.4    Hickernell, T.R.5
  • 39
    • 78650995499 scopus 로고    scopus 로고
    • An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway
    • Zhang Y, Jasin M, (2011) An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway. Nat Struct Mol Biol 18: 80–84. doi: 10.1038/nsmb.1940 21131978
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 80-84
    • Zhang, Y.1    Jasin, M.2
  • 40
    • 84892369333 scopus 로고    scopus 로고
    • DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities
    • Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, et al. (2014) DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell 53: 7–18. doi: 10.1016/j.molcel.2013.11.003 24316220
    • (2014) Mol Cell , vol.53 , pp. 7-18
    • Shibata, A.1    Moiani, D.2    Arvai, A.S.3    Perry, J.4    Harding, S.M.5
  • 41
    • 79952762235 scopus 로고    scopus 로고
    • Factors determining DNA double-strand break repair pathway choice in G2 phase
    • Shibata A, Conrad S, Birraux J, Geuting V, Barton O, et al. (2011) Factors determining DNA double-strand break repair pathway choice in G2 phase. EMBO J 30: 1079–1092. doi: 10.1038/emboj.2011.27 21317870
    • (2011) EMBO J , vol.30 , pp. 1079-1092
    • Shibata, A.1    Conrad, S.2    Birraux, J.3    Geuting, V.4    Barton, O.5
  • 43
    • 77952567987 scopus 로고    scopus 로고
    • Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
    • Heinz S, Benner C, Spann N, Bertolino E, Lin YC, et al. (2010) Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell 38: 576–589. doi: 10.1016/j.molcel.2010.05.004 20513432
    • (2010) Mol Cell , vol.38 , pp. 576-589
    • Heinz, S.1    Benner, C.2    Spann, N.3    Bertolino, E.4    Lin, Y.C.5
  • 44
    • 0141992113 scopus 로고    scopus 로고
    • C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion
    • Barreto V, Reina-San-Martin B, Ramiro AR, McBride KM, Nussenzweig MC, (2003) C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol Cell 12: 501–508. 14536088
    • (2003) Mol Cell , vol.12 , pp. 501-508
    • Barreto, V.1    Reina-San-Martin, B.2    Ramiro, A.R.3    McBride, K.M.4    Nussenzweig, M.C.5
  • 45
    • 36549008815 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair
    • Schrader CE, Guikema JE, Linehan EK, Selsing E, Stavnezer J, (2007) Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair. J Immunol 179: 6064–6071. 17947680
    • (2007) J Immunol , vol.179 , pp. 6064-6071
    • Schrader, C.E.1    Guikema, J.E.2    Linehan, E.K.3    Selsing, E.4    Stavnezer, J.5
  • 46
    • 84901260711 scopus 로고    scopus 로고
    • ATM Increases Activation-Induced Cytidine Deaminase Activity at Downstream S Regions during Class-Switch Recombination
    • Khair L, Guikema JE, Linehan EK, Ucher AJ, Leus NG, et al. (2014) ATM Increases Activation-Induced Cytidine Deaminase Activity at Downstream S Regions during Class-Switch Recombination. J Immunol 192: 4887–4896. doi: 10.4049/jimmunol.1303481 24729610
    • (2014) J Immunol , vol.192 , pp. 4887-4896
    • Khair, L.1    Guikema, J.E.2    Linehan, E.K.3    Ucher, A.J.4    Leus, N.G.5
  • 47
    • 0242473148 scopus 로고    scopus 로고
    • Mutations occur in the Ig Sμ region but rarely in Sγ regions prior to class switch recombination
    • Schrader CE, Bradley SP, Vardo J, Mochegova SN, Flanagan E, et al. (2003) Mutations occur in the Ig Sμ region but rarely in Sγ regions prior to class switch recombination. Embo J 22: 5893–5903. 14592986
    • (2003) Embo J , vol.22 , pp. 5893-5903
    • Schrader, C.E.1    Bradley, S.P.2    Vardo, J.3    Mochegova, S.N.4    Flanagan, E.5
  • 48
    • 84906091086 scopus 로고    scopus 로고
    • Mismatch Repair Proteins and AID Activity Are Required for the Dominant Negative Function of C-Terminally Deleted AID in Class Switching
    • Ucher AJ, Ranjit S, Kadungure T, Linehan EK, Khair L, et al. (2014) Mismatch Repair Proteins and AID Activity Are Required for the Dominant Negative Function of C-Terminally Deleted AID in Class Switching. J Immunol 193: 1440–1450. doi: 10.4049/jimmunol.1400365 24973444
    • (2014) J Immunol , vol.193 , pp. 1440-1450
    • Ucher, A.J.1    Ranjit, S.2    Kadungure, T.3    Linehan, E.K.4    Khair, L.5
  • 49
    • 84865431974 scopus 로고    scopus 로고
    • Reassessing genomic targeting of AID
    • Hogenbirk MA, Velds A, Kerkhoven RM, Jacobs H, (2012) Reassessing genomic targeting of AID. Nat Immunol 13: 797–798; author reply 798–800. doi: 10.1038/ni.2367 22910380
    • (2012) Nat Immunol , vol.13 , pp. 797-798
    • Hogenbirk, M.A.1    Velds, A.2    Kerkhoven, R.M.3    Jacobs, H.4
  • 50
    • 67449161835 scopus 로고    scopus 로고
    • Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation
    • Rajagopal D, Maul RW, Ghosh A, Chakraborty T, Khamlichi AA, et al. (2009) Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation. J Exp Med 206: 1237–1244. doi: 10.1084/jem.20082514 19433618
    • (2009) J Exp Med , vol.206 , pp. 1237-1244
    • Rajagopal, D.1    Maul, R.W.2    Ghosh, A.3    Chakraborty, T.4    Khamlichi, A.A.5
  • 51
    • 68149158825 scopus 로고    scopus 로고
    • S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination
    • Wang L, Wuerffel R, Feldman S, Khamlichi AA, Kenter AL, (2009) S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination. J Exp Med 206: 1817–1830. doi: 10.1084/jem.20081678 19596805
    • (2009) J Exp Med , vol.206 , pp. 1817-1830
    • Wang, L.1    Wuerffel, R.2    Feldman, S.3    Khamlichi, A.A.4    Kenter, A.L.5
  • 52
    • 79959345878 scopus 로고    scopus 로고
    • Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination
    • Skourti-Stathaki K, Proudfoot NJ, Gromak N, (2011) Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination. Mol Cell 42: 794–805. doi: 10.1016/j.molcel.2011.04.026 21700224
    • (2011) Mol Cell , vol.42 , pp. 794-805
    • Skourti-Stathaki, K.1    Proudfoot, N.J.2    Gromak, N.3
  • 53
    • 84863806091 scopus 로고    scopus 로고
    • Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase
    • Sharbeen G, Yee CW, Smith AL, Jolly CJ, (2012) Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase. J Exp Med 209: 965–974. doi: 10.1084/jem.20112379 22529268
    • (2012) J Exp Med , vol.209 , pp. 965-974
    • Sharbeen, G.1    Yee, C.W.2    Smith, A.L.3    Jolly, C.J.4
  • 54
    • 84865419410 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase
    • Hasham MG, Snow KJ, Donghia NM, Branca JA, Lessard MD, et al. (2012) Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase. J Immunol 189: 2374–2382. doi: 10.4049/jimmunol.1200414 22826323
    • (2012) J Immunol , vol.189 , pp. 2374-2382
    • Hasham, M.G.1    Snow, K.J.2    Donghia, N.M.3    Branca, J.A.4    Lessard, M.D.5
  • 55
    • 84879559329 scopus 로고    scopus 로고
    • Attenuating homologous recombination stimulates an AID-induced antileukemic effect
    • Lamont KR, Hasham MG, Donghia NM, Branca J, Chavaree M, et al. (2013) Attenuating homologous recombination stimulates an AID-induced antileukemic effect. J Exp Med 210: 1021–1033. 23589568
    • (2013) J Exp Med , vol.210 , pp. 1021-1033
    • Lamont, K.R.1    Hasham, M.G.2    Donghia, N.M.3    Branca, J.4    Chavaree, M.5
  • 56
    • 84892743776 scopus 로고    scopus 로고
    • Break-induced replication repair of damaged forks induces genomic duplications in human cells
    • Costantino L, Sotiriou SK, Rantala JK, Magin S, Mladenov E, et al. (2014) Break-induced replication repair of damaged forks induces genomic duplications in human cells. Science 343: 88–91. doi: 10.1126/science.1243211 24310611
    • (2014) Science , vol.343 , pp. 88-91
    • Costantino, L.1    Sotiriou, S.K.2    Rantala, J.K.3    Magin, S.4    Mladenov, E.5
  • 57
    • 84924352840 scopus 로고    scopus 로고
    • DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining
    • Howard SM, Yanez DA, Stark JM, (2015) DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining. PLoS Genet 11: e1004943. doi: 10.1371/journal.pgen.1004943 25629353
    • (2015) PLoS Genet , vol.11 , pp. 1004943
    • Howard, S.M.1    Yanez, D.A.2    Stark, J.M.3
  • 58
    • 0142250490 scopus 로고    scopus 로고
    • The Sm tandem repeat region is critical for isotype switching in the absence of Msh2
    • Min I, Schrader C, Vardo J, D'Avirro N, Luby T, et al. (2003) The Sm tandem repeat region is critical for isotype switching in the absence of Msh2. Immunity 19: 515–524. 14563316
    • (2003) Immunity , vol.19 , pp. 515-524
    • Min, I.1    Schrader, C.2    Vardo, J.3    D'Avirro, N.4    Luby, T.5
  • 59
    • 42649123314 scopus 로고    scopus 로고
    • Mechanism and regulation of class switch recombination
    • Stavnezer J, Guikema JEJ, Schrader CE, (2008) Mechanism and regulation of class switch recombination. Ann Rev Immunol 26: 261–292.
    • (2008) Ann Rev Immunol , vol.26 , pp. 261-292
    • Stavnezer, J.1    Guikema, J.E.J.2    Schrader, C.E.3
  • 60
    • 84866265794 scopus 로고    scopus 로고
    • Noncanonical mismatch repair as a source of genomic instability in human cells
    • Pena-Diaz J, Bregenhorn S, Ghodgaonkar M, Follonier C, Artola-Boran M, et al. (2012) Noncanonical mismatch repair as a source of genomic instability in human cells. Mol Cell 47: 669–680. doi: 10.1016/j.molcel.2012.07.006 22864113
    • (2012) Mol Cell , vol.47 , pp. 669-680
    • Pena-Diaz, J.1    Bregenhorn, S.2    Ghodgaonkar, M.3    Follonier, C.4    Artola-Boran, M.5
  • 61
    • 84906280949 scopus 로고    scopus 로고
    • The dual nature of mismatch repair as antimutator and mutator: for better or for worse
    • Bak ST, Sakellariou D, Pena-Diaz J, (2014) The dual nature of mismatch repair as antimutator and mutator: for better or for worse. Front Genet 5: 287. doi: 10.3389/fgene.2014.00287 25191341
    • (2014) Front Genet , vol.5 , pp. 287
    • Bak, S.T.1    Sakellariou, D.2    Pena-Diaz, J.3
  • 62
    • 84884273290 scopus 로고    scopus 로고
    • DNA repair genes are selectively mutated in diffuse large B cell lymphomas
    • de Miranda NF, Peng R, Georgiou K, Wu C, Falk Sorqvist E, et al. (2013) DNA repair genes are selectively mutated in diffuse large B cell lymphomas. J Exp Med 210: 1729–1742. doi: 10.1084/jem.20122842 23960188
    • (2013) J Exp Med , vol.210 , pp. 1729-1742
    • de Miranda, N.F.1    Peng, R.2    Georgiou, K.3    Wu, C.4    Falk, S.E.5
  • 63
    • 0029101616 scopus 로고
    • Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
    • DeWind N, Dekker M, Berns A, Radman M, TeRiele H, (1995) Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell 82: 321–330. 7628020
    • (1995) Cell , vol.82 , pp. 321-330
    • DeWind, N.1    Dekker, M.2    Berns, A.3    Radman, M.4    TeRiele, H.5
  • 64
    • 0030709433 scopus 로고    scopus 로고
    • Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
    • Edelmann W, Yang K, Umar A, Heyer J, Lau K, et al. (1997) Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell 91: 467–477. 9390556
    • (1997) Cell , vol.91 , pp. 467-477
    • Edelmann, W.1    Yang, K.2    Umar, A.3    Heyer, J.4    Lau, K.5
  • 65
    • 34447551681 scopus 로고    scopus 로고
    • Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
    • Berkovich E, Monnat RJ, Jr.Kastan MB, (2007) Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol 9: 683–690. 17486112
    • (2007) Nat Cell Biol , vol.9 , pp. 683-690
    • Berkovich, E.1    Monnat, R.J.2    Kastan, M.B.3
  • 66
    • 0345552286 scopus 로고
    • The sequence (dC-dA)n X (dG-dT)n forms left-handed Z-DNA in negatively supercoiled plasmids
    • Nordheim A, Rich A, (1983) The sequence (dC-dA)n X (dG-dT)n forms left-handed Z-DNA in negatively supercoiled plasmids. Proc Natl Acad Sci U S A 80: 1821–1825. 6572943
    • (1983) Proc Natl Acad Sci U S A , vol.80 , pp. 1821-1825
    • Nordheim, A.1    Rich, A.2
  • 67
    • 0028087782 scopus 로고
    • The non-B-DNA structure of d(CA/TG)n does not differ from that of Z-DNA
    • Ho PS, (1994) The non-B-DNA structure of d(CA/TG)n does not differ from that of Z-DNA. Proc Natl Acad Sci U S A 91: 9549–9553. 7937803
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 9549-9553
    • Ho, P.S.1
  • 68
    • 27144542066 scopus 로고    scopus 로고
    • Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases
    • Ha SC, Lowenhaupt K, Rich A, Kim YG, Kim KK, (2005) Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases. Nature 437: 1183–1186. 16237447
    • (2005) Nature , vol.437 , pp. 1183-1186
    • Ha, S.C.1    Lowenhaupt, K.2    Rich, A.3    Kim, Y.G.4    Kim, K.K.5
  • 69
    • 84925096261 scopus 로고    scopus 로고
    • Short Inverted Repeats Are Hotspots for Genetic Instability: Relevance to Cancer Genomes
    • Lu S, Wang G, Bacolla A, Zhao J, Spitser S, et al. (2015) Short Inverted Repeats Are Hotspots for Genetic Instability: Relevance to Cancer Genomes. Cell Rep 10: 1674–1680.
    • (2015) Cell Rep , vol.10 , pp. 1674-1680
    • Lu, S.1    Wang, G.2    Bacolla, A.3    Zhao, J.4    Spitser, S.5
  • 70
    • 84866870443 scopus 로고    scopus 로고
    • Close proximity to Igh is a contributing factor to AID-mediated translocations
    • Rocha PP, Micsinai M, Kim JR, Hewitt SL, Souza PP, et al. (2012) Close proximity to Igh is a contributing factor to AID-mediated translocations. Mol Cell 47: 873–885. doi: 10.1016/j.molcel.2012.06.036 22864115
    • (2012) Mol Cell , vol.47 , pp. 873-885
    • Rocha, P.P.1    Micsinai, M.2    Kim, J.R.3    Hewitt, S.L.4    Souza, P.P.5
  • 71
    • 0021023904 scopus 로고
    • Identification of reciprocal translocation sites within the c-myc oncogene and immunoglobulin mu locus in a Burkitt lymphoma
    • Gelmann EP, Psallidopoulos MC, Papas TS, Dalla-Favera R, (1983) Identification of reciprocal translocation sites within the c-myc oncogene and immunoglobulin mu locus in a Burkitt lymphoma. Nature 306: 799–803. 6419123
    • (1983) Nature , vol.306 , pp. 799-803
    • Gelmann, E.P.1    Psallidopoulos, M.C.2    Papas, T.S.3    Dalla-Favera, R.4
  • 72
    • 16844381831 scopus 로고    scopus 로고
    • Mechanisms of B-cell lymphoma pathogenesis
    • Kuppers R, (2005) Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 5: 251–262. 15803153
    • (2005) Nat Rev Cancer , vol.5 , pp. 251-262
    • Kuppers, R.1
  • 73
    • 33747893961 scopus 로고    scopus 로고
    • Myc translocations in B cell and plasma cell neoplasms
    • Janz S, (2006) Myc translocations in B cell and plasma cell neoplasms. DNA Repair 5: 1213–1224. 16815105
    • (2006) DNA Repair , vol.5 , pp. 1213-1224
    • Janz, S.1
  • 74
    • 33644643189 scopus 로고    scopus 로고
    • Role of genomic instability and p53 in AID-induced c-myc-Igh translocations
    • Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, et al. (2006) Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 440: 105–109. 16400328
    • (2006) Nature , vol.440 , pp. 105-109
    • Ramiro, A.R.1    Jankovic, M.2    Callen, E.3    Difilippantonio, S.4    Chen, H.T.5
  • 75
    • 84876222028 scopus 로고    scopus 로고
    • Selective inhibition of tumor oncogenes by disruption of super-enhancers
    • Loven J, Hoke HA, Lin CY, Lau A, Orlando DA, et al. (2013) Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell 153: 320–334. doi: 10.1016/j.cell.2013.03.036 23582323
    • (2013) Cell , vol.153 , pp. 320-334
    • Loven, J.1    Hoke, H.A.2    Lin, C.Y.3    Lau, A.4    Orlando, D.A.5
  • 76
    • 84876216563 scopus 로고    scopus 로고
    • Master transcription factors and mediator establish super-enhancers at key cell identity genes
    • Whyte WA, Orlando DA, Hnisz D, Abraham BJ, Lin CY, et al. (2013) Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell 153: 307–319. doi: 10.1016/j.cell.2013.03.035 23582322
    • (2013) Cell , vol.153 , pp. 307-319
    • Whyte, W.A.1    Orlando, D.A.2    Hnisz, D.3    Abraham, B.J.4    Lin, C.Y.5
  • 77
    • 79551681406 scopus 로고    scopus 로고
    • The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates
    • Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, et al. (2011) The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates. Cell 144: 353–363. doi: 10.1016/j.cell.2011.01.001 21255825
    • (2011) Cell , vol.144 , pp. 353-363
    • Basu, U.1    Meng, F.L.2    Keim, C.3    Grinstein, V.4    Pefanis, E.5
  • 78
    • 84908162142 scopus 로고    scopus 로고
    • Noncoding RNA transcription targets AID to divergently transcribed loci in B cells
    • Pefanis E, Wang J, Rothschild G, Lim J, Chao J, et al. (2014) Noncoding RNA transcription targets AID to divergently transcribed loci in B cells. Nature 514: 389–393. doi: 10.1038/nature13580 25119026
    • (2014) Nature , vol.514 , pp. 389-393
    • Pefanis, E.1    Wang, J.2    Rothschild, G.3    Lim, J.4    Chao, J.5
  • 79
    • 84902075114 scopus 로고    scopus 로고
    • Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability
    • Wang G, Vasquez KM, (2014) Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability. DNA Repair (Amst) 19: 143–151.
    • (2014) DNA Repair (Amst) , vol.19 , pp. 143-151
    • Wang, G.1    Vasquez, K.M.2
  • 80
    • 33644543741 scopus 로고    scopus 로고
    • Z-DNA-forming sequences generate large-scale deletions in mammalian cells
    • Wang G, Christensen LA, Vasquez KM, (2006) Z-DNA-forming sequences generate large-scale deletions in mammalian cells. Proc Natl Acad Sci U S A 103: 2677–2682. 16473937
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2677-2682
    • Wang, G.1    Christensen, L.A.2    Vasquez, K.M.3
  • 81
    • 77951931039 scopus 로고    scopus 로고
    • Pathways for double-strand break repair in genetically unstable Z-DNA-forming sequences
    • Kha DT, Wang G, Natrajan N, Harrison L, Vasquez KM, (2010) Pathways for double-strand break repair in genetically unstable Z-DNA-forming sequences. J Mol Biol 398: 471–480. doi: 10.1016/j.jmb.2010.03.035 20347845
    • (2010) J Mol Biol , vol.398 , pp. 471-480
    • Kha, D.T.1    Wang, G.2    Natrajan, N.3    Harrison, L.4    Vasquez, K.M.5
  • 82
    • 84255177502 scopus 로고    scopus 로고
    • RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability
    • Wahba L, Amon JD, Koshland D, Vuica-Ross M, (2011) RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability. Mol Cell 44: 978–988. doi: 10.1016/j.molcel.2011.10.017 22195970
    • (2011) Mol Cell , vol.44 , pp. 978-988
    • Wahba, L.1    Amon, J.D.2    Koshland, D.3    Vuica-Ross, M.4
  • 83
    • 84882566900 scopus 로고    scopus 로고
    • E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells
    • Sun J, Keim CD, Wang J, Kazadi D, Oliver PM, et al. (2013) E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells. Genes Dev 27: 1821–1833. doi: 10.1101/gad.210211.112 23964096
    • (2013) Genes Dev , vol.27 , pp. 1821-1833
    • Sun, J.1    Keim, C.D.2    Wang, J.3    Kazadi, D.4    Oliver, P.M.5
  • 84
    • 84928942103 scopus 로고    scopus 로고
    • RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity
    • Pefanis E, Wang J, Rothschild G, Lim J, Kazadi D, et al. (2015) RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity. Cell 161: 774–789. doi: 10.1016/j.cell.2015.04.034 25957685
    • (2015) Cell , vol.161 , pp. 774-789
    • Pefanis, E.1    Wang, J.2    Rothschild, G.3    Lim, J.4    Kazadi, D.5
  • 85
    • 84918791689 scopus 로고    scopus 로고
    • Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability
    • Sollier J, Stork CT, Garcia-Rubio ML, Paulsen RD, Aguilera A, et al. (2014) Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability. Mol Cell 56: 777–785. doi: 10.1016/j.molcel.2014.10.020 25435140
    • (2014) Mol Cell , vol.56 , pp. 777-785
    • Sollier, J.1    Stork, C.T.2    Garcia-Rubio, M.L.3    Paulsen, R.D.4    Aguilera, A.5
  • 86
    • 84873310832 scopus 로고    scopus 로고
    • Identification of early replicating fragile sites that contribute to genome instability
    • Barlow JH, Faryabi RB, Callen E, Wong N, Malhowski A, et al. (2013) Identification of early replicating fragile sites that contribute to genome instability. Cell 152: 620–632. doi: 10.1016/j.cell.2013.01.006 23352430
    • (2013) Cell , vol.152 , pp. 620-632
    • Barlow, J.H.1    Faryabi, R.B.2    Callen, E.3    Wong, N.4    Malhowski, A.5
  • 87
    • 84922147486 scopus 로고    scopus 로고
    • Ligand-dependent enhancer activation regulated by topoisomerase-I activity
    • Puc J, Kozbial P, Li W, Tan Y, Liu Z, et al. (2015) Ligand-dependent enhancer activation regulated by topoisomerase-I activity. Cell 160: 367–380. doi: 10.1016/j.cell.2014.12.023 25619691
    • (2015) Cell , vol.160 , pp. 367-380
    • Puc, J.1    Kozbial, P.2    Li, W.3    Tan, Y.4    Liu, Z.5
  • 88
    • 77953425540 scopus 로고    scopus 로고
    • p53 Represses Class Switch Recombination to IgG2a through Its Antioxidant Function
    • Guikema JE, Schrader CE, Brodsky MH, Linehan EK, Richards A, et al. (2010) p53 Represses Class Switch Recombination to IgG2a through Its Antioxidant Function. J Immunol 184: 6177–6187. doi: 10.4049/jimmunol.0904085 20483782
    • (2010) J Immunol , vol.184 , pp. 6177-6187
    • Guikema, J.E.1    Schrader, C.E.2    Brodsky, M.H.3    Linehan, E.K.4    Richards, A.5
  • 89
    • 8944262831 scopus 로고    scopus 로고
    • MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis
    • Reitmair AH, Cai JC, Bjerknes M, Redston M, Cheng H, et al. (1996) MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis. Cancer Res 56: 2922–2926. 8674041
    • (1996) Cancer Res , vol.56 , pp. 2922-2926
    • Reitmair, A.H.1    Cai, J.C.2    Bjerknes, M.3    Redston, M.4    Cheng, H.5
  • 90
    • 0029111463 scopus 로고
    • MSH2 deficient mice are viable and susceptible to lymphoid tumours
    • Reitmair AH, Schmits R, Ewel A, Bapat B, Redston M, et al. (1995) MSH2 deficient mice are viable and susceptible to lymphoid tumours. Nat Genet 11: 64–70. 7550317
    • (1995) Nat Genet , vol.11 , pp. 64-70
    • Reitmair, A.H.1    Schmits, R.2    Ewel, A.3    Bapat, B.4    Redston, M.5
  • 91
    • 80052678086 scopus 로고    scopus 로고
    • AID binds cooperatively with UNG and Msh2-Msh6 to Ig switch regions dependent upon the AID C terminus
    • Ranjit S, Khair L, Linehan EK, Ucher AJ, Chakrabarti M, et al. (2011) AID binds cooperatively with UNG and Msh2-Msh6 to Ig switch regions dependent upon the AID C terminus. J Immunol 187: 2464–2475. doi: 10.4049/jimmunol.1101406 21804017
    • (2011) J Immunol , vol.187 , pp. 2464-2475
    • Ranjit, S.1    Khair, L.2    Linehan, E.K.3    Ucher, A.J.4    Chakrabarti, M.5
  • 93
    • 60849117520 scopus 로고    scopus 로고
    • Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks
    • Nix DA, Courdy SJ, Boucher KM, (2008) Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks. BMC Bioinformatics 9: 523. doi: 10.1186/1471-2105-9-523 19061503
    • (2008) BMC Bioinformatics , vol.9 , pp. 523
    • Nix, D.A.1    Courdy, S.J.2    Boucher, K.M.3
  • 94
    • 0033555906 scopus 로고    scopus 로고
    • Tandem repeats finder: a program to analyze DNA sequences
    • Benson G, (1999) Tandem repeats finder: a program to analyze DNA sequences. Nucleic Acids Res 27: 573–580. 9862982
    • (1999) Nucleic Acids Res , vol.27 , pp. 573-580
    • Benson, G.1
  • 95
    • 67650711619 scopus 로고    scopus 로고
    • A clustering approach for identification of enriched domains from histone modification ChIP-Seq data
    • Zang C, Schones DE, Zeng C, Cui K, Zhao K, et al. (2009) A clustering approach for identification of enriched domains from histone modification ChIP-Seq data. Bioinformatics 25: 1952–1958. doi: 10.1093/bioinformatics/btp340 19505939
    • (2009) Bioinformatics , vol.25 , pp. 1952-1958
    • Zang, C.1    Schones, D.E.2    Zeng, C.3    Cui, K.4    Zhao, K.5
  • 96
    • 0034201441 scopus 로고    scopus 로고
    • EMBOSS: the European Molecular Biology Open Software Suite
    • Rice P, Longden I, Bleasby A, (2000) EMBOSS: the European Molecular Biology Open Software Suite. Trends Genet 16: 276–277. 10827456
    • (2000) Trends Genet , vol.16 , pp. 276-277
    • Rice, P.1    Longden, I.2    Bleasby, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.