Attenuating homologous recombination stimulates an AID-induced antileukemic effect

Journal of Experimental Medicine

Volumn 210, Issue 5, 2013, Pages 1021-1033

  Lamont, Kristin R ^a   Hasham, Muneer G ^a   Donghia, Nina M ^a   Branca, Jane ^a   Chavaree, Margaret ^b   Chase, Betsy ^c   Breggia, Anne ^d   Hedlund, Jacquelyn ^c   Emery, Ivette ^d   Cavallo, Francesca ^e   Jasin, Maria ^e   Rüter, Jens ^b   Mills, Kevin D ^a  

^a JACKSON LABORATORY   (United States)

^b EASTERN MAINE MEDICAL CENTER   (United States)

^c Maine Center for Cancer Medicine and Blood Disorders   (United States)

^d Maine Medical Center Research Institute   (United States)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ACTIVATION INDUCED CYTIDINE DEAMINASE; RAD51 PROTEIN; AICDA (ACTIVATION INDUCED CYTIDINE DEAMINASE); AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); CYTIDINE DEAMINASE; H2AFX PROTEIN, HUMAN; HISTONE;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND BREAKAGE; DRUG MECHANISM; DRUG TARGETING; ENZYME INHIBITION; FEMALE; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ACTIVE TRANSPORT; ANIMAL; B LYMPHOCYTE; CELL DEATH; CELL LINE; CELL NUCLEUS; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; IONIZING RADIATION; METABOLISM; PATHOLOGY; RADIATION EXPOSURE; TUMOR CELL LINE;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; B-LYMPHOCYTES; CELL DEATH; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL NUCLEUS; CYTIDINE DEAMINASE; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; GENE EXPRESSION REGULATION, LEUKEMIC; HISTONES; HOMOLOGOUS RECOMBINATION; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MICE; RAD51 RECOMBINASE; RADIATION, IONIZING;

MLCS; MLOWN;

EID: 84879559329     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20121258     Document Type: Article

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