E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells

Genes and Development

Volumn 27, Issue 16, 2013, Pages 1821-1833

  Sun, Jianbo ^a   Keim, Celia D ^a   Wang, Jiguang ^a   Kazadi, David ^a   Oliver, Paula M ^b   Rabadan, Raul ^a   Basu, Uttiya ^a  

^a Columbia University ^*  (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Activation induced deaminase; Immunoglobulin locus transcription; Nedd4; Noncoding RNA; RNA polymerase II stalling; RNA polymerase II ubiquitination

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; DNA; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; RNA; RNA POLYMERASE II; UBIQUITIN PROTEIN LIGASE NEDD4;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CHROMATIN IMMUNOPRECIPITATION; CLASS SWITCH RECOMBINATION; CONTROLLED STUDY; ENZYME ACTIVITY; EXOSOME; GENE MUTATION; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; GENOME; IMMUNOGLOBULIN LOCUS TRANSCRIPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; SOMATIC HYPERMUTATION; SPLEEN CELL;

ACTIVATION-INDUCED DEAMINASE; IMMUNOGLOBULIN LOCUS TRANSCRIPTION; NEDD4; NONCODING RNA; RNA POLYMERASE II STALLING; RNA POLYMERASE II UBIQUITINATION;

ANIMALS; B-LYMPHOCYTES; CELL LINE, TUMOR; CELLS, CULTURED; CYTIDINE DEAMINASE; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; EXOSOME MULTIENZYME RIBONUCLEASE COMPLEX; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN SWITCH REGION; MICE; NUCLEAR PROTEINS; PROTEIN BINDING; RNA POLYMERASE II; TRANSCRIPTIONAL ELONGATION FACTORS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84882566900     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.210211.112     Document Type: Article

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