Rhodium-Catalyzed C-H Annulation of Nitrones with Alkynes: A Regiospecific Route to Unsymmetrical 2,3-Diaryl-Substituted Indoles

Angewandte Chemie - International Edition

Volumn 54, Issue 36, 2015, Pages 10613-10617

  Yan, Hao ^a   Wang, Haolong ^a   Li, Xincheng ^a   Xin, Xiaoyi ^a   Wang, Chunxiang ^a   Wan, Boshun ^a  

^a DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

alkynes; C H activation; indoles; nitrones; rhodium

Indexed keywords

ACTIVATION ANALYSIS; CATALYSIS; POLYCYCLIC AROMATIC HYDROCARBONS; REGIOSELECTIVITY; RHODIUM; SUBSTITUTION REACTIONS;

ALKYNES; ARYL SUBSTITUENTS; C-H ACTIVATION; INDOLES; NITRONES; RELATED COMPOUNDS; RHODIUM-CATALYZED; SUBSTITUTED INDOLES;

HYDROCARBONS;

EID: 84940052323     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201503997     Document Type: Article

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139. With 0.25 equivalents of [{CpRhCl2}2] (50 mol % Rh), 4 a was isolated in 35 % yield, and no 3 a was detected.
140. The use of Fe(OAc)2 or Mn(OAc)2 (1 equiv) instead of Cu(OAc)2 did not afford any product. The replacement of Cu(OAc)2 with Cu(OTf)2 (1 equiv) only gave 3 a in 30 % yield.
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145. For the formation of by-product 4 a, see the Supporting Information.