Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino Acids

ACS Chemical Biology

Volumn 10, Issue 8, 2015, Pages 1805-1816

  Frost, John R ^a   Jacob, Nicholas T ^a   Papa, Louis J ^a   Owens, Andrew E ^a   Fasan, Rudi ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM LITHIUM HYDRIDE; AMINO ACID; AMINO ACID TRANSFER RNA LIGASE; AMINOTHIOL; CYCLOPEPTIDE; IODOACETAMIDE; MACROCYCLIC COMPOUND; PROTEIN PRECURSOR; PYRUVIC ACID; STREPTAVIDIN; TRANSFER RNA; PEPTIDE; PEPTIDE LIBRARY; THIOL DERIVATIVE;

AMINO ACID SEQUENCE; ARTICLE; BROMINATION; CHEMICAL COMPOSITION; COLORIMETRY; COMPARATIVE STUDY; CONTROLLED STUDY; CYCLIZATION; DECARBOXYLATION; ESCHERICHIA COLI; HYDROGENATION; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; NONHUMAN; NUCLEOPHILICITY; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REDUCTION; STOP CODON; SYNTHESIS; AMINATION; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; PEPTIDE LIBRARY; RIBOSOME;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

AMINATION; AMINO ACID SEQUENCE; AMINO ACIDS; AMINO ACYL-TRNA SYNTHETASES; CYCLIZATION; ESCHERICHIA COLI; MACROCYCLIC COMPOUNDS; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PEPTIDES; PEPTIDES, CYCLIC; RIBOSOMES; STREPTAVIDIN; SULFHYDRYL COMPOUNDS;

EID: 84939805312     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00119     Document Type: Article

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